Resistance of Candida spp. to antifungal drugs in the ICU: where are we now? View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-08-05

AUTHORS

Danièle Maubon, Cécile Garnaud, Thierry Calandra, Dominique Sanglard, Muriel Cornet

ABSTRACT

Current increases in antifungal drug resistance in Candida spp. and clinical treatment failures are of concern, as invasive candidiasis is a significant cause of mortality in intensive care units (ICUs). This trend reflects the large and expanding use of newer broad-spectrum antifungal agents, such as triazoles and echinocandins. In this review, we firstly present an overview of the mechanisms of action of the drugs and of resistance in pathogenic yeasts, subsequently focusing on recent changes in the epidemiology of antifungal resistance in ICU. Then, we emphasize the clinical impacts of these current trends. The emergence of clinical treatment failures due to resistant isolates is described. We also consider the clinical usefulness of recent advances in the interpretation of antifungal susceptibility testing and in molecular detection of the mutations underlying acquired resistance. We pay particular attention to practical issues relating to ICU patient management, taking into account the growing threat of antifungal drug resistance. More... »

PAGES

1241-1255

References to SciGraph publications

  • 2014-04-10. What’s new in the clinical and diagnostic management of invasive candidiasis in critically ill patients in INTENSIVE CARE MEDICINE
  • 2014-05-08. A multicenter study of septic shock due to candidemia: outcomes and predictors of mortality in INTENSIVE CARE MEDICINE
  • 2010. Canadian Clinical Practice Guidelines for Invasive Candidiasis in Adults in CANADIAN JOURNAL OF INFECTIOUS DISEASES AND MEDICAL MICROBIOLOGY
  • 1992-02. Effects of fluconazole on the sterol and carbohydrate composition of four species ofCandida in EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
  • 2011-08-08. ECIL 3-2009 update guidelines for antifungal management in BONE MARROW TRANSPLANTATION
  • 2008-10-30. Management of invasive candidiasis and candidemia in adult non-neutropenic intensive care unit patients: Part II. Treatment in INTENSIVE CARE MEDICINE
  • 2013-08-25. Recent insights into Candida albicans biofilm resistance mechanisms in CURRENT GENETICS
  • 2009-08-14. Rapid detection of ERG11 gene mutations in clinical Candida albicans isolates with reduced susceptibility to fluconazole by rolling circle amplification and DNA sequencing in BMC MICROBIOLOGY
  • 2013-03-06. Epidemiology of invasive fungal infections in the intensive care unit: results of a multicenter Italian survey (AURORA Project) in INFECTION
  • 2014-03-30. Amphotericin forms an extramembranous and fungicidal sterol sponge in NATURE CHEMICAL BIOLOGY
  • 2005-11-03. The trend of susceptibilities to amphotericin B and fluconazole of Candida species from 1999 to 2002 in Taiwan in BMC INFECTIOUS DISEASES
  • 2013-08-15. Breakthrough invasive fungal diseases during echinocandin treatment in high-risk hospitalized hematologic patients in ANNALS OF HEMATOLOGY
  • 2014-02-13. Assessment of caspofungin susceptibility of Candida glabrata by the Etest®, CLSI, and EUCAST methods, and detection of FKS1 and FKS2 mutations in EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
  • 2009-02. Liposomal Amphotericin B in DRUGS
  • 2005-06-10. Evolution of antifungal-drug resistance: mechanisms and pathogen fitness in NATURE REVIEWS MICROBIOLOGY
  • 2013-06-01. Amphotericin B Formulations: A Comparative Review of Efficacy and Toxicity in DRUGS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00134-014-3404-7

    DOI

    http://dx.doi.org/10.1007/s00134-014-3404-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1027227129

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25091787


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical Microbiology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antifungal Agents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Candida", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Candidiasis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Intensive Care Units", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Microbial Sensitivity Tests", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Laboratoire TIMC-TheREx, UMR 5525 CNRS-UJF, Universit\u00e9 Grenoble Alpes, Grenoble, France", 
              "id": "http://www.grid.ac/institutes/grid.450307.5", 
              "name": [
                "Parasitologie-Mycologie, Institut de Biologie et de Pathologie, CHU de Grenoble, Grenoble, France", 
                "Laboratoire TIMC-TheREx, UMR 5525 CNRS-UJF, Universit\u00e9 Grenoble Alpes, Grenoble, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Maubon", 
            "givenName": "Dani\u00e8le", 
            "id": "sg:person.01056004673.68", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056004673.68"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Laboratoire TIMC-TheREx, UMR 5525 CNRS-UJF, Universit\u00e9 Grenoble Alpes, Grenoble, France", 
              "id": "http://www.grid.ac/institutes/grid.450307.5", 
              "name": [
                "Parasitologie-Mycologie, Institut de Biologie et de Pathologie, CHU de Grenoble, Grenoble, France", 
                "Laboratoire TIMC-TheREx, UMR 5525 CNRS-UJF, Universit\u00e9 Grenoble Alpes, Grenoble, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Garnaud", 
            "givenName": "C\u00e9cile", 
            "id": "sg:person.01167776656.94", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167776656.94"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Infectious Diseases Service, Department of Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland", 
              "id": "http://www.grid.ac/institutes/grid.9851.5", 
              "name": [
                "Infectious Diseases Service, Department of Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Calandra", 
            "givenName": "Thierry", 
            "id": "sg:person.01103701061.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103701061.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Microbiology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland", 
              "id": "http://www.grid.ac/institutes/grid.9851.5", 
              "name": [
                "Institute of Microbiology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sanglard", 
            "givenName": "Dominique", 
            "id": "sg:person.01365001640.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365001640.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Laboratoire TIMC-TheREx, UMR 5525 CNRS-UJF, Universit\u00e9 Grenoble Alpes, Grenoble, France", 
              "id": "http://www.grid.ac/institutes/grid.450307.5", 
              "name": [
                "Parasitologie-Mycologie, Institut de Biologie et de Pathologie, CHU de Grenoble, Grenoble, France", 
                "Laboratoire TIMC-TheREx, UMR 5525 CNRS-UJF, Universit\u00e9 Grenoble Alpes, Grenoble, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cornet", 
            "givenName": "Muriel", 
            "id": "sg:person.01334256475.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334256475.46"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nchembio.1496", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049690615", 
              "https://doi.org/10.1038/nchembio.1496"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00294-013-0400-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041466232", 
              "https://doi.org/10.1007/s00294-013-0400-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-014-3281-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000357999", 
              "https://doi.org/10.1007/s00134-014-3281-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00277-013-1882-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042675123", 
              "https://doi.org/10.1007/s00277-013-1882-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10096-014-2069-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035791354", 
              "https://doi.org/10.1007/s10096-014-2069-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-008-1339-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053260834", 
              "https://doi.org/10.1007/s00134-008-1339-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1155/2010/357076", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011780815", 
              "https://doi.org/10.1155/2010/357076"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrmicro1179", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000015575", 
              "https://doi.org/10.1038/nrmicro1179"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s40265-013-0069-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034177761", 
              "https://doi.org/10.1007/s40265-013-0069-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2180-9-167", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052825739", 
              "https://doi.org/10.1186/1471-2180-9-167"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2165/00003495-200969030-00010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029608751", 
              "https://doi.org/10.2165/00003495-200969030-00010"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s15010-013-0432-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009487949", 
              "https://doi.org/10.1007/s15010-013-0432-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2334-5-99", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021616657", 
              "https://doi.org/10.1186/1471-2334-5-99"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bmt.2011.154", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026557998", 
              "https://doi.org/10.1038/bmt.2011.154"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01967067", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039139948", 
              "https://doi.org/10.1007/bf01967067"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-014-3310-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005581510", 
              "https://doi.org/10.1007/s00134-014-3310-z"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2014-08-05", 
        "datePublishedReg": "2014-08-05", 
        "description": "Current increases in antifungal drug resistance in Candida spp. and clinical treatment failures are of concern, as invasive candidiasis is a significant cause of mortality in intensive care units (ICUs). This trend reflects the large and expanding use of newer broad-spectrum antifungal agents, such as triazoles and echinocandins. In this review, we firstly present an overview of the mechanisms of action of the drugs and of resistance in pathogenic yeasts, subsequently focusing on recent changes in the epidemiology of antifungal resistance in ICU. Then, we emphasize the clinical impacts of these current trends. The emergence of clinical treatment failures due to resistant isolates is described. We also consider the clinical usefulness of recent advances in the interpretation of antifungal susceptibility testing and in molecular detection of the mutations underlying acquired resistance. We pay particular attention to practical issues relating to ICU patient management, taking into account the growing threat of antifungal drug resistance.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s00134-014-3404-7", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1313639", 
            "issn": [
              "0342-4642", 
              "1432-1238"
            ], 
            "name": "Intensive Care Medicine", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "9", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "40"
          }
        ], 
        "keywords": [
          "intensive care unit", 
          "clinical treatment failure", 
          "treatment failure", 
          "antifungal drug resistance", 
          "drug resistance", 
          "Candida spp", 
          "mechanism of action", 
          "care unit", 
          "antifungal susceptibility testing", 
          "new broad-spectrum antifungal agents", 
          "broad-spectrum antifungal agent", 
          "invasive candidiasis", 
          "patient management", 
          "clinical impact", 
          "clinical usefulness", 
          "significant cause", 
          "susceptibility testing", 
          "resistant isolates", 
          "ICU patient management", 
          "antifungal drugs", 
          "antifungal resistance", 
          "antifungal agents", 
          "molecular detection", 
          "drugs", 
          "pathogenic yeasts", 
          "failure", 
          "candidiasis", 
          "mortality", 
          "epidemiology", 
          "echinocandins", 
          "resistance", 
          "recent advances", 
          "cause", 
          "review", 
          "isolates", 
          "spp", 
          "agents", 
          "mutations", 
          "management", 
          "testing", 
          "recent changes", 
          "action", 
          "increase", 
          "usefulness", 
          "current trends", 
          "changes", 
          "trends", 
          "mechanism", 
          "use", 
          "advances", 
          "concern", 
          "detection", 
          "practical issues", 
          "units", 
          "particular attention", 
          "impact", 
          "overview", 
          "emergence", 
          "attention", 
          "triazole", 
          "threat", 
          "issues", 
          "interpretation", 
          "yeast", 
          "account", 
          "current increases"
        ], 
        "name": "Resistance of Candida spp. to antifungal drugs in the ICU: where are we now?", 
        "pagination": "1241-1255", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1027227129"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00134-014-3404-7"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "25091787"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00134-014-3404-7", 
          "https://app.dimensions.ai/details/publication/pub.1027227129"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-08-04T17:02", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_635.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s00134-014-3404-7"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00134-014-3404-7'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00134-014-3404-7'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00134-014-3404-7'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00134-014-3404-7'


     

    This table displays all metadata directly associated to this object as RDF triples.

    249 TRIPLES      21 PREDICATES      113 URIs      89 LITERALS      13 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00134-014-3404-7 schema:about N1c9641f293d143378c606b05b518e049
    2 N34ec51ca992b403f89ae871d4c8732dc
    3 N355b3c2a846048249bcd14b33c9beb0f
    4 N3dcda93f8ee04da7971ec753f47476d1
    5 N8550ca9870b34ecd9aada505c390dc37
    6 Nec1103e046ea4b54b31e7f20fda548c4
    7 anzsrc-for:11
    8 anzsrc-for:1108
    9 schema:author N5c0a7a851282467b8d56348c26224b36
    10 schema:citation sg:pub.10.1007/bf01967067
    11 sg:pub.10.1007/s00134-008-1339-6
    12 sg:pub.10.1007/s00134-014-3281-0
    13 sg:pub.10.1007/s00134-014-3310-z
    14 sg:pub.10.1007/s00277-013-1882-2
    15 sg:pub.10.1007/s00294-013-0400-3
    16 sg:pub.10.1007/s10096-014-2069-z
    17 sg:pub.10.1007/s15010-013-0432-0
    18 sg:pub.10.1007/s40265-013-0069-4
    19 sg:pub.10.1038/bmt.2011.154
    20 sg:pub.10.1038/nchembio.1496
    21 sg:pub.10.1038/nrmicro1179
    22 sg:pub.10.1155/2010/357076
    23 sg:pub.10.1186/1471-2180-9-167
    24 sg:pub.10.1186/1471-2334-5-99
    25 sg:pub.10.2165/00003495-200969030-00010
    26 schema:datePublished 2014-08-05
    27 schema:datePublishedReg 2014-08-05
    28 schema:description Current increases in antifungal drug resistance in Candida spp. and clinical treatment failures are of concern, as invasive candidiasis is a significant cause of mortality in intensive care units (ICUs). This trend reflects the large and expanding use of newer broad-spectrum antifungal agents, such as triazoles and echinocandins. In this review, we firstly present an overview of the mechanisms of action of the drugs and of resistance in pathogenic yeasts, subsequently focusing on recent changes in the epidemiology of antifungal resistance in ICU. Then, we emphasize the clinical impacts of these current trends. The emergence of clinical treatment failures due to resistant isolates is described. We also consider the clinical usefulness of recent advances in the interpretation of antifungal susceptibility testing and in molecular detection of the mutations underlying acquired resistance. We pay particular attention to practical issues relating to ICU patient management, taking into account the growing threat of antifungal drug resistance.
    29 schema:genre article
    30 schema:isAccessibleForFree false
    31 schema:isPartOf N04c4729b1b7c4b74a523a62decd03f8a
    32 Nbf6395e27e35445fa5a90e7f9ec61694
    33 sg:journal.1313639
    34 schema:keywords Candida spp
    35 ICU patient management
    36 account
    37 action
    38 advances
    39 agents
    40 antifungal agents
    41 antifungal drug resistance
    42 antifungal drugs
    43 antifungal resistance
    44 antifungal susceptibility testing
    45 attention
    46 broad-spectrum antifungal agent
    47 candidiasis
    48 care unit
    49 cause
    50 changes
    51 clinical impact
    52 clinical treatment failure
    53 clinical usefulness
    54 concern
    55 current increases
    56 current trends
    57 detection
    58 drug resistance
    59 drugs
    60 echinocandins
    61 emergence
    62 epidemiology
    63 failure
    64 impact
    65 increase
    66 intensive care unit
    67 interpretation
    68 invasive candidiasis
    69 isolates
    70 issues
    71 management
    72 mechanism
    73 mechanism of action
    74 molecular detection
    75 mortality
    76 mutations
    77 new broad-spectrum antifungal agents
    78 overview
    79 particular attention
    80 pathogenic yeasts
    81 patient management
    82 practical issues
    83 recent advances
    84 recent changes
    85 resistance
    86 resistant isolates
    87 review
    88 significant cause
    89 spp
    90 susceptibility testing
    91 testing
    92 threat
    93 treatment failure
    94 trends
    95 triazole
    96 units
    97 use
    98 usefulness
    99 yeast
    100 schema:name Resistance of Candida spp. to antifungal drugs in the ICU: where are we now?
    101 schema:pagination 1241-1255
    102 schema:productId N3ba4be268b7944a591021ce2f1c569fd
    103 N3f698048fd0b4424b762ff7b537a8698
    104 Nd3e9c580b6c14cc5a1df04fd15d5c863
    105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027227129
    106 https://doi.org/10.1007/s00134-014-3404-7
    107 schema:sdDatePublished 2022-08-04T17:02
    108 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    109 schema:sdPublisher Nbc575b626c5e44e8b799cc9c33f96518
    110 schema:url https://doi.org/10.1007/s00134-014-3404-7
    111 sgo:license sg:explorer/license/
    112 sgo:sdDataset articles
    113 rdf:type schema:ScholarlyArticle
    114 N04c4729b1b7c4b74a523a62decd03f8a schema:issueNumber 9
    115 rdf:type schema:PublicationIssue
    116 N1254568af5d844a4a0d0646af27fbf0a rdf:first sg:person.01365001640.19
    117 rdf:rest N6502146400e34e309a35208c4279981e
    118 N1c9641f293d143378c606b05b518e049 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    119 schema:name Humans
    120 rdf:type schema:DefinedTerm
    121 N2bcfe4bb45a043ff90a9a5dd77a10567 rdf:first sg:person.01167776656.94
    122 rdf:rest N4791b87e4efb480e96cac979f1486c12
    123 N34ec51ca992b403f89ae871d4c8732dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    124 schema:name Microbial Sensitivity Tests
    125 rdf:type schema:DefinedTerm
    126 N355b3c2a846048249bcd14b33c9beb0f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    127 schema:name Antifungal Agents
    128 rdf:type schema:DefinedTerm
    129 N3ba4be268b7944a591021ce2f1c569fd schema:name doi
    130 schema:value 10.1007/s00134-014-3404-7
    131 rdf:type schema:PropertyValue
    132 N3dcda93f8ee04da7971ec753f47476d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name Candida
    134 rdf:type schema:DefinedTerm
    135 N3f698048fd0b4424b762ff7b537a8698 schema:name pubmed_id
    136 schema:value 25091787
    137 rdf:type schema:PropertyValue
    138 N4791b87e4efb480e96cac979f1486c12 rdf:first sg:person.01103701061.44
    139 rdf:rest N1254568af5d844a4a0d0646af27fbf0a
    140 N5c0a7a851282467b8d56348c26224b36 rdf:first sg:person.01056004673.68
    141 rdf:rest N2bcfe4bb45a043ff90a9a5dd77a10567
    142 N6502146400e34e309a35208c4279981e rdf:first sg:person.01334256475.46
    143 rdf:rest rdf:nil
    144 N8550ca9870b34ecd9aada505c390dc37 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    145 schema:name Candidiasis
    146 rdf:type schema:DefinedTerm
    147 Nbc575b626c5e44e8b799cc9c33f96518 schema:name Springer Nature - SN SciGraph project
    148 rdf:type schema:Organization
    149 Nbf6395e27e35445fa5a90e7f9ec61694 schema:volumeNumber 40
    150 rdf:type schema:PublicationVolume
    151 Nd3e9c580b6c14cc5a1df04fd15d5c863 schema:name dimensions_id
    152 schema:value pub.1027227129
    153 rdf:type schema:PropertyValue
    154 Nec1103e046ea4b54b31e7f20fda548c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Intensive Care Units
    156 rdf:type schema:DefinedTerm
    157 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    158 schema:name Medical and Health Sciences
    159 rdf:type schema:DefinedTerm
    160 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
    161 schema:name Medical Microbiology
    162 rdf:type schema:DefinedTerm
    163 sg:journal.1313639 schema:issn 0342-4642
    164 1432-1238
    165 schema:name Intensive Care Medicine
    166 schema:publisher Springer Nature
    167 rdf:type schema:Periodical
    168 sg:person.01056004673.68 schema:affiliation grid-institutes:grid.450307.5
    169 schema:familyName Maubon
    170 schema:givenName Danièle
    171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056004673.68
    172 rdf:type schema:Person
    173 sg:person.01103701061.44 schema:affiliation grid-institutes:grid.9851.5
    174 schema:familyName Calandra
    175 schema:givenName Thierry
    176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103701061.44
    177 rdf:type schema:Person
    178 sg:person.01167776656.94 schema:affiliation grid-institutes:grid.450307.5
    179 schema:familyName Garnaud
    180 schema:givenName Cécile
    181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167776656.94
    182 rdf:type schema:Person
    183 sg:person.01334256475.46 schema:affiliation grid-institutes:grid.450307.5
    184 schema:familyName Cornet
    185 schema:givenName Muriel
    186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334256475.46
    187 rdf:type schema:Person
    188 sg:person.01365001640.19 schema:affiliation grid-institutes:grid.9851.5
    189 schema:familyName Sanglard
    190 schema:givenName Dominique
    191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365001640.19
    192 rdf:type schema:Person
    193 sg:pub.10.1007/bf01967067 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039139948
    194 https://doi.org/10.1007/bf01967067
    195 rdf:type schema:CreativeWork
    196 sg:pub.10.1007/s00134-008-1339-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053260834
    197 https://doi.org/10.1007/s00134-008-1339-6
    198 rdf:type schema:CreativeWork
    199 sg:pub.10.1007/s00134-014-3281-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000357999
    200 https://doi.org/10.1007/s00134-014-3281-0
    201 rdf:type schema:CreativeWork
    202 sg:pub.10.1007/s00134-014-3310-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1005581510
    203 https://doi.org/10.1007/s00134-014-3310-z
    204 rdf:type schema:CreativeWork
    205 sg:pub.10.1007/s00277-013-1882-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042675123
    206 https://doi.org/10.1007/s00277-013-1882-2
    207 rdf:type schema:CreativeWork
    208 sg:pub.10.1007/s00294-013-0400-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041466232
    209 https://doi.org/10.1007/s00294-013-0400-3
    210 rdf:type schema:CreativeWork
    211 sg:pub.10.1007/s10096-014-2069-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1035791354
    212 https://doi.org/10.1007/s10096-014-2069-z
    213 rdf:type schema:CreativeWork
    214 sg:pub.10.1007/s15010-013-0432-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009487949
    215 https://doi.org/10.1007/s15010-013-0432-0
    216 rdf:type schema:CreativeWork
    217 sg:pub.10.1007/s40265-013-0069-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034177761
    218 https://doi.org/10.1007/s40265-013-0069-4
    219 rdf:type schema:CreativeWork
    220 sg:pub.10.1038/bmt.2011.154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026557998
    221 https://doi.org/10.1038/bmt.2011.154
    222 rdf:type schema:CreativeWork
    223 sg:pub.10.1038/nchembio.1496 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049690615
    224 https://doi.org/10.1038/nchembio.1496
    225 rdf:type schema:CreativeWork
    226 sg:pub.10.1038/nrmicro1179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000015575
    227 https://doi.org/10.1038/nrmicro1179
    228 rdf:type schema:CreativeWork
    229 sg:pub.10.1155/2010/357076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011780815
    230 https://doi.org/10.1155/2010/357076
    231 rdf:type schema:CreativeWork
    232 sg:pub.10.1186/1471-2180-9-167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052825739
    233 https://doi.org/10.1186/1471-2180-9-167
    234 rdf:type schema:CreativeWork
    235 sg:pub.10.1186/1471-2334-5-99 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021616657
    236 https://doi.org/10.1186/1471-2334-5-99
    237 rdf:type schema:CreativeWork
    238 sg:pub.10.2165/00003495-200969030-00010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029608751
    239 https://doi.org/10.2165/00003495-200969030-00010
    240 rdf:type schema:CreativeWork
    241 grid-institutes:grid.450307.5 schema:alternateName Laboratoire TIMC-TheREx, UMR 5525 CNRS-UJF, Université Grenoble Alpes, Grenoble, France
    242 schema:name Laboratoire TIMC-TheREx, UMR 5525 CNRS-UJF, Université Grenoble Alpes, Grenoble, France
    243 Parasitologie-Mycologie, Institut de Biologie et de Pathologie, CHU de Grenoble, Grenoble, France
    244 rdf:type schema:Organization
    245 grid-institutes:grid.9851.5 schema:alternateName Infectious Diseases Service, Department of Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
    246 Institute of Microbiology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
    247 schema:name Infectious Diseases Service, Department of Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
    248 Institute of Microbiology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
    249 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...