Resistance of Candida spp. to antifungal drugs in the ICU: where are we now? View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-08-05

AUTHORS

Danièle Maubon, Cécile Garnaud, Thierry Calandra, Dominique Sanglard, Muriel Cornet

ABSTRACT

Current increases in antifungal drug resistance in Candida spp. and clinical treatment failures are of concern, as invasive candidiasis is a significant cause of mortality in intensive care units (ICUs). This trend reflects the large and expanding use of newer broad-spectrum antifungal agents, such as triazoles and echinocandins. In this review, we firstly present an overview of the mechanisms of action of the drugs and of resistance in pathogenic yeasts, subsequently focusing on recent changes in the epidemiology of antifungal resistance in ICU. Then, we emphasize the clinical impacts of these current trends. The emergence of clinical treatment failures due to resistant isolates is described. We also consider the clinical usefulness of recent advances in the interpretation of antifungal susceptibility testing and in molecular detection of the mutations underlying acquired resistance. We pay particular attention to practical issues relating to ICU patient management, taking into account the growing threat of antifungal drug resistance. More... »

PAGES

1241-1255

References to SciGraph publications

  • 2014-04-10. What’s new in the clinical and diagnostic management of invasive candidiasis in critically ill patients in INTENSIVE CARE MEDICINE
  • 2014-05-08. A multicenter study of septic shock due to candidemia: outcomes and predictors of mortality in INTENSIVE CARE MEDICINE
  • 2010. Canadian Clinical Practice Guidelines for Invasive Candidiasis in Adults in CANADIAN JOURNAL OF INFECTIOUS DISEASES AND MEDICAL MICROBIOLOGY
  • 1992-02. Effects of fluconazole on the sterol and carbohydrate composition of four species ofCandida in EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
  • 2011-08-08. ECIL 3-2009 update guidelines for antifungal management in BONE MARROW TRANSPLANTATION
  • 2008-10-30. Management of invasive candidiasis and candidemia in adult non-neutropenic intensive care unit patients: Part II. Treatment in INTENSIVE CARE MEDICINE
  • 2013-08-25. Recent insights into Candida albicans biofilm resistance mechanisms in CURRENT GENETICS
  • 2009-08-14. Rapid detection of ERG11 gene mutations in clinical Candida albicans isolates with reduced susceptibility to fluconazole by rolling circle amplification and DNA sequencing in BMC MICROBIOLOGY
  • 2013-03-06. Epidemiology of invasive fungal infections in the intensive care unit: results of a multicenter Italian survey (AURORA Project) in INFECTION
  • 2014-03-30. Amphotericin forms an extramembranous and fungicidal sterol sponge in NATURE CHEMICAL BIOLOGY
  • 2005-11-03. The trend of susceptibilities to amphotericin B and fluconazole of Candida species from 1999 to 2002 in Taiwan in BMC INFECTIOUS DISEASES
  • 2013-08-15. Breakthrough invasive fungal diseases during echinocandin treatment in high-risk hospitalized hematologic patients in ANNALS OF HEMATOLOGY
  • 2014-02-13. Assessment of caspofungin susceptibility of Candida glabrata by the Etest®, CLSI, and EUCAST methods, and detection of FKS1 and FKS2 mutations in EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
  • 2009-02. Liposomal Amphotericin B in DRUGS
  • 2005-06-10. Evolution of antifungal-drug resistance: mechanisms and pathogen fitness in NATURE REVIEWS MICROBIOLOGY
  • 2013-06-01. Amphotericin B Formulations: A Comparative Review of Efficacy and Toxicity in DRUGS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00134-014-3404-7

    DOI

    http://dx.doi.org/10.1007/s00134-014-3404-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1027227129

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25091787


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