What’s new in the clinical and diagnostic management of invasive candidiasis in critically ill patients View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-04-10

AUTHORS

Cristóbal León, Luis Ostrosky-Zeichner, Mindy Schuster

ABSTRACT

Invasive candidiasis (IC) is a severe complication in the ICU setting. A high proportion of ICU patients become colonized with Candida species, but only 5–30 % develop IC. Progressive colonization and major abdominal surgery are well-known risk factors for Candida infection. IC is difficult to predict and early diagnosis remains a major challenge. In addition, microbiological documentation often occurs late in the course of infection. Delays in initiating appropriate treatment have been associated with increased mortality. In an attempt to decrease Candida-related mortality, an increasing number of critically ill patients without documented IC receive empirical systemic antifungal therapy, leading to concern for antifungal overuse. Scores/predictive rules permit the stratification and selection of IC high-risk patients who may benefit from early antifungal therapy. However, they have a far better negative predictive value than positive predictive value. New IC biomarkers [mannan, anti-mannan, (1,3)-β-d-glucan, and polymerase chain reaction] are being increasingly used to enable earlier diagnosis and, ideally, to provide prognostic information and/or therapeutic monitoring. Although reasonably sensitive and specific, these techniques remain largely investigational, and their clinical usefulness has yet to be established. More... »

PAGES

808-819

References to SciGraph publications

  • 2011-09-01. Diagnosis of invasive candidiasis in the ICU in ANNALS OF INTENSIVE CARE
  • 2012-06-30. Value of β-d-glucan and Candida albicans germ tube antibody for discriminating between Candida colonization and invasive candidiasis in patients with severe abdominal conditions in INTENSIVE CARE MEDICINE
  • 2013-10-24. Intra-abdominal candidiasis: the guidelines—forgotten non-candidemic invasive candidiasis in INTENSIVE CARE MEDICINE
  • 2008-08-29. Fungal colonization and/or infection in non-neutropenic critically ill patients: results of the EPCAN observational study in EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
  • 2006-02-10. Epidemiological trends in nosocomial candidemia in intensive care in BMC INFECTIOUS DISEASES
  • 2011-10-22. Early diagnosis of candidemia in intensive care unit patients with sepsis: a prospective comparison of (1→3)-β-D-glucan assay, Candida score, and colonization index in CRITICAL CARE
  • 2010-12-08. The use of mannan antigen and anti-mannan antibodies in the diagnosis of invasive candidiasis: recommendations from the Third European Conference on Infections in Leukemia in CRITICAL CARE
  • 2009-08-07. The Epidemiology of Intra-Abdominal Flora in Critically Ill Patients with Secondary and Tertiary Abdominal Sepsis in INFECTION
  • 2007-02-27. Multicenter retrospective development and validation of a clinical prediction rule for nosocomial invasive candidiasis in the intensive care setting in EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
  • 2000-09. Nosocomial Candidemia in Non-Neutropenic Patients at an Italian Tertiary Care Hospital in EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
  • 2004-03-13. Economic Impact of Candida Colonization and Candida Infection in the Critically Ill Patient in EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
  • 2005-02-12. Candida spp. colonization significance in critically ill medical patients: a prospective study in INTENSIVE CARE MEDICINE
  • 2011-11-30. Evaluation of "Candida score" in critically ill patients: a prospective, multicenter, observational, cohort study in ANNALS OF INTENSIVE CARE
  • 1997-03. Epidemiology of invasive mycosis in ICU patients: a prospective multicenter study in 435 non-neutropenic patients in INTENSIVE CARE MEDICINE
  • 2013-10-09. A research agenda on the management of intra-abdominal candidiasis: results from a consensus of multinational experts in INTENSIVE CARE MEDICINE
  • 2013-01-30. Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012 in INTENSIVE CARE MEDICINE
  • 2011-03-09. Clinical factors associated with a Candida albicansGerm Tube Antibody positive test in Intensive Care Unit patients in BMC INFECTIOUS DISEASES
  • 2006-06-14. Attributable mortality of candidemia: a systematic review of matched cohort and case-control studies in EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
  • 2007-09-15. Candida parapsilosis fungemia in neonates: genotyping results suggest healthcare workers hands as source, and review of published studies in MYCOPATHOLOGIA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00134-014-3281-0

    DOI

    http://dx.doi.org/10.1007/s00134-014-3281-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1000357999

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24718642


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