Sedation depth and long-term mortality in mechanically ventilated critically ill adults: a prospective longitudinal multicentre cohort study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-05

AUTHORS

Yahya Shehabi, Lucy Chan, Suhaini Kadiman, Anita Alias, Wan Nasrudin Ismail, Mohd Ali T. Ismail Tan, Tien Meng Khoo, Saedah Binti Ali, Mat Ariffin Saman, Ahmad Shaltut, Cheng Cheng Tan, Cow Yen Yong, Michael Bailey, The Sedation Practice in Intensive Care Evaluation (SPICE) Study Group investigators

ABSTRACT

PURPOSE: To ascertain the relationship among early (first 48 h) deep sedation, time to extubation, delirium and long-term mortality. METHODS: We conducted a multicentre prospective longitudinal cohort study in 11 Malaysian hospitals including medical/surgical patients (n = 259) who were sedated and ventilated ≥24 h. Patients were followed from ICU admission up to 28 days in ICU with 4-hourly sedation and daily delirium assessments and 180-day mortality. Deep sedation was defined as Richmond Agitation Sedation Score (RASS) ≤-3. RESULTS: The cohort had a mean (SD) age of 53.1 (15.9) years and APACHE II score of 21.3 (8.2) with hospital and 180-day mortality of 82 (31.7%) and 110/237 (46.4%). Patients were followed for 2,657 ICU days and underwent 13,836 RASS assessments. Midazolam prescription was predominant compared to propofol, given to 241 (93%) versus 72 (28%) patients (P < 0.0001) for 966 (39.6%) versus 183 (7.5%) study days respectively. Deep sedation occurred in (182/257) 71% patients at first assessment and in 159 (61%) patients and 1,658 (59%) of all RASS assessments at 48 h. Multivariable Cox proportional hazard regression analysis adjusting for a priori assigned covariates including sedative agents, diagnosis, age, APACHE II score, operative, elective, vasopressors and dialysis showed that early deep sedation was independently associated with longer time to extubation [hazard ratio (HR) 0.93, 95% confidence interval (CI) 0.89-0.97, P = 0.003], hospital death (HR 1.11, 95% CI 1.05-1.18, P < 0.001) and 180-day mortality (HR 1.09, 95% CI 1.04-1.15, P = 0.002), but not time to delirium (HR 0.98, P = 0.23). Delirium occurred in 114 (44%) of patients. CONCLUSION: Irrespective of sedative choice, early deep sedation was independently associated with delayed extubation and higher mortality, and thus was a potentially modifiable risk in interventional trials. More... »

PAGES

910-918

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00134-013-2830-2

DOI

http://dx.doi.org/10.1007/s00134-013-2830-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021295774

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23344834


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "APACHE", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chi-Square Distribution", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Critical Illness", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Deep Sedation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Delirium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypnotics and Sedatives", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intensive Care Units", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Longitudinal Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Malaysia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proportional Hazards Models", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Respiration, Artificial", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Prince of Wales Hospital", 
          "id": "https://www.grid.ac/institutes/grid.415193.b", 
          "name": [
            "Department of Intensive Care, University New South Wales Clinical School, The Prince of Wales Hospital, Barker St., 2031, Randwick, NSW, Australia", 
            "University New South Wales, Prince of Wales Hospital, Sydney, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shehabi", 
        "givenName": "Yahya", 
        "id": "sg:person.0641143724.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641143724.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Malaya", 
          "id": "https://www.grid.ac/institutes/grid.10347.31", 
          "name": [
            "Department of Anesthesiology, Faculty of Medicine, University of Malaya, Lembah Pantai, 50603, Kuala Lumpur, Malaysia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chan", 
        "givenName": "Lucy", 
        "id": "sg:person.0712711212.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712711212.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Heart Institute", 
          "id": "https://www.grid.ac/institutes/grid.419388.f", 
          "name": [
            "National Heart Institute (Institut Jantung Negara), 145 Jalan Tun Razak, 50400, Kuala Lumpur, Malaysia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kadiman", 
        "givenName": "Suhaini", 
        "id": "sg:person.01014751605.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014751605.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Malacca General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.461040.7", 
          "name": [
            "Department of Anesthesia and Intensive Care, Hospital Melaka, Jalan Mufti Hj Khalil, 75400, Melaka, Malaysia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alias", 
        "givenName": "Anita", 
        "id": "sg:person.01027137612.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027137612.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Raja Perempuan Zainab II", 
          "id": "https://www.grid.ac/institutes/grid.500264.5", 
          "name": [
            "Hospital Raja Perempuan Zainab II Kota Bahru\u2013HKB, Kelantan, Malaysia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ismail", 
        "givenName": "Wan Nasrudin", 
        "id": "sg:person.01075253012.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075253012.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Kuala Lumpur", 
          "id": "https://www.grid.ac/institutes/grid.412516.5", 
          "name": [
            "Department of Anesthesia and Intensive Care, General ICU, Kuala Lumpur General Hospital, Jalan Pahang, 50586, Kuala Lumpur, Malaysia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tan", 
        "givenName": "Mohd Ali T. Ismail", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Anesthesiology and Intensive Care, Hospital Queen Elizabeth, 88586, Kota Kinabalu, Sabah, Malaysia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Khoo", 
        "givenName": "Tien Meng", 
        "id": "sg:person.01211501412.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211501412.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Universiti Sains Malaysia", 
          "id": "https://www.grid.ac/institutes/grid.428821.5", 
          "name": [
            "Department of Anesthesiology, School of Medicine, Hospital University Sains Malaysia, Health Campus, 16150, Kota Bahru, Kelantan, Malaysia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ali", 
        "givenName": "Saedah Binti", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sarawak General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.415281.b", 
          "name": [
            "Department of Anesthesiology and Intensive Care, Sarawak General Hospital, Jalan Hospital, 93586, Kuching, Sarawak, Malaysia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saman", 
        "givenName": "Mat Ariffin", 
        "id": "sg:person.0744336243.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744336243.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Sultanah Bahiyah", 
          "id": "https://www.grid.ac/institutes/grid.452819.3", 
          "name": [
            "Hospital Sultanah Bahiyah, Alor Setar, HAS, Kedah, Malaysia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shaltut", 
        "givenName": "Ahmad", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sultanah Aminah Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413461.5", 
          "name": [
            "ICU Selatan, 2nd Floor, Hospital Sultanah Aminah, Jalan Persiaran Abu Bakar, Johor Bahru, Johor, Malaysia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tan", 
        "givenName": "Cheng Cheng", 
        "id": "sg:person.0622613130.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622613130.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Penang General Hospital, PGH, Penang, Malaysia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yong", 
        "givenName": "Cow Yen", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Monash University", 
          "id": "https://www.grid.ac/institutes/grid.1002.3", 
          "name": [
            "Australian New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine Monash University, Melbourne, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bailey", 
        "givenName": "Michael", 
        "id": "sg:person.0677173700.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677173700.38"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "The Sedation Practice in Intensive Care Evaluation (SPICE) Study Group investigators", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/cc7141", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002361177", 
          "https://doi.org/10.1186/cc7141"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc7141", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002361177", 
          "https://doi.org/10.1186/cc7141"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-006-0399-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003258397", 
          "https://doi.org/10.1007/s00134-006-0399-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-006-0399-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003258397", 
          "https://doi.org/10.1007/s00134-006-0399-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.201101-0065oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003870970"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc8212", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005080269", 
          "https://doi.org/10.1186/cc8212"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.287.3.345", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006458934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.2107138", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013441079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccell.2005.04.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015801234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1213/ane.0b013e3181d7e1b8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017352983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1213/ane.0b013e3181d7e1b8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017352983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1213/ane.0b013e3181d7e1b8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017352983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1213/ane.0b013e3181d7e1b8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017352983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2012.304", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018681920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-008-1186-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020684281", 
          "https://doi.org/10.1007/s00134-008-1186-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-008-1186-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020684281", 
          "https://doi.org/10.1007/s00134-008-1186-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.286.21.2703", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023293188"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003246-200201000-00020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025932689"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003246-200201000-00020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025932689"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(08)60105-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026479220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccc.2009.04.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028321363"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(09)62072-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036169635"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ccm.0b013e3181a5689f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037934770"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ccm.0b013e3181a5689f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037934770"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003246-198510000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039110630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003246-198510000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039110630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mcc.0b013e32830280b3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039117681"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mcc.0b013e32830280b3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039117681"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.201203-0522oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041214075"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc6189", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042343063", 
          "https://doi.org/10.1186/cc6189"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2012.13872", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042399008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc6908", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045163880", 
          "https://doi.org/10.1186/cc6908"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.anes.0000264747.09017.da", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047168166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.anes.0000264747.09017.da", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047168166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2009.56", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047864460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm200005183422002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051418418"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.201102-0273ci", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052360739"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077693076", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0310057x0803600423", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077693076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0310057x0803600423", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077693076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0310057x0803600423", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077693076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078410492", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0310057x1103900310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078410492"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0310057x1103900310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078410492"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0310057x1103900310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078410492"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078482643", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-05", 
    "datePublishedReg": "2013-05-01", 
    "description": "PURPOSE: To ascertain the relationship among early (first 48 h) deep sedation, time to extubation, delirium and long-term mortality.\nMETHODS: We conducted a multicentre prospective longitudinal cohort study in 11 Malaysian hospitals including medical/surgical patients (n = 259) who were sedated and ventilated \u226524 h. Patients were followed from ICU admission up to 28 days in ICU with 4-hourly sedation and daily delirium assessments and 180-day mortality. Deep sedation was defined as Richmond Agitation Sedation Score (RASS) \u2264-3.\nRESULTS: The cohort had a mean (SD) age of 53.1 (15.9) years and APACHE II score of 21.3 (8.2) with hospital and 180-day mortality of 82 (31.7%) and 110/237 (46.4%). Patients were followed for 2,657 ICU days and underwent 13,836 RASS assessments. Midazolam prescription was predominant compared to propofol, given to 241 (93%) versus 72 (28%) patients (P < 0.0001) for 966 (39.6%) versus 183 (7.5%) study days respectively. Deep sedation occurred in (182/257) 71% patients at first assessment and in 159 (61%) patients and 1,658 (59%) of all RASS assessments at 48 h. Multivariable Cox proportional hazard regression analysis adjusting for a priori assigned covariates including sedative agents, diagnosis, age, APACHE II score, operative, elective, vasopressors and dialysis showed that early deep sedation was independently associated with longer time to extubation [hazard ratio (HR) 0.93, 95% confidence interval (CI) 0.89-0.97, P = 0.003], hospital death (HR 1.11, 95% CI 1.05-1.18, P < 0.001) and 180-day mortality (HR 1.09, 95% CI 1.04-1.15, P = 0.002), but not time to delirium (HR 0.98, P = 0.23). Delirium occurred in 114 (44%) of patients.\nCONCLUSION: Irrespective of sedative choice, early deep sedation was independently associated with delayed extubation and higher mortality, and thus was a potentially modifiable risk in interventional trials.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00134-013-2830-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1313639", 
        "issn": [
          "0342-4642", 
          "1432-1238"
        ], 
        "name": "Intensive Care Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "39"
      }
    ], 
    "name": "Sedation depth and long-term mortality in mechanically ventilated critically ill adults: a prospective longitudinal multicentre cohort study", 
    "pagination": "910-918", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "6576a8418219d67cf0083bfa3ee5a04a51430292dfdde7fbe62538f34986d0c0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23344834"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7704851"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00134-013-2830-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1021295774"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00134-013-2830-2", 
      "https://app.dimensions.ai/details/publication/pub.1021295774"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:02", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000347_0000000347/records_89822_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s00134-013-2830-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00134-013-2830-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00134-013-2830-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00134-013-2830-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00134-013-2830-2'


 

This table displays all metadata directly associated to this object as RDF triples.

348 TRIPLES      21 PREDICATES      76 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00134-013-2830-2 schema:about N0008b32fe4484b088f68202c0ab37010
2 N05d27ee3991c499e90af86272047c9ca
3 N06c5dc3792b7428d8ac6f39750926751
4 N11cc4d981d6442b28e2a099f7d8d55b4
5 N21f2249d563347ccbfff63e0aa76bf1d
6 N436dcdc09bbe4d23afdfc1d10cb25121
7 N5a07cfa5a421460483d6e02645c25120
8 N76a4c9eb241d49a6a04545a11c46cb63
9 N87a39321a91142d6b79e878adbf9f56a
10 N9471159eac124bc0be42930888d2a934
11 N9c0386c8e44b491e9254d3847e5be883
12 Nac5294987929426a81a6dcf9d37a5c2c
13 Nbb59e6150aec4991a340ed18bd36149e
14 Nd3b57a4628824364adffddcea82dd50d
15 Nd88edd73bd8b46d2936b9410f4a201f8
16 Nf9a5ffe0550d45459a6d75e59e1d25e2
17 anzsrc-for:11
18 anzsrc-for:1103
19 schema:author Nfa468c178aa94e91959cf4a49f494576
20 schema:citation sg:pub.10.1007/s00134-006-0399-8
21 sg:pub.10.1007/s00134-008-1186-5
22 sg:pub.10.1186/cc6189
23 sg:pub.10.1186/cc6908
24 sg:pub.10.1186/cc7141
25 sg:pub.10.1186/cc8212
26 https://app.dimensions.ai/details/publication/pub.1077693076
27 https://app.dimensions.ai/details/publication/pub.1078410492
28 https://app.dimensions.ai/details/publication/pub.1078482643
29 https://doi.org/10.1001/jama.2009.56
30 https://doi.org/10.1001/jama.2012.13872
31 https://doi.org/10.1001/jama.2012.304
32 https://doi.org/10.1001/jama.286.21.2703
33 https://doi.org/10.1001/jama.287.3.345
34 https://doi.org/10.1016/j.ccc.2009.04.001
35 https://doi.org/10.1016/j.ccell.2005.04.012
36 https://doi.org/10.1016/s0140-6736(08)60105-1
37 https://doi.org/10.1016/s0140-6736(09)62072-9
38 https://doi.org/10.1056/nejm200005183422002
39 https://doi.org/10.1097/00003246-198510000-00009
40 https://doi.org/10.1097/00003246-200201000-00020
41 https://doi.org/10.1097/01.anes.0000264747.09017.da
42 https://doi.org/10.1097/ccm.0b013e3181a5689f
43 https://doi.org/10.1097/mcc.0b013e32830280b3
44 https://doi.org/10.1164/rccm.201101-0065oc
45 https://doi.org/10.1164/rccm.201102-0273ci
46 https://doi.org/10.1164/rccm.201203-0522oc
47 https://doi.org/10.1164/rccm.2107138
48 https://doi.org/10.1177/0310057x0803600423
49 https://doi.org/10.1177/0310057x1103900310
50 https://doi.org/10.1213/ane.0b013e3181d7e1b8
51 schema:datePublished 2013-05
52 schema:datePublishedReg 2013-05-01
53 schema:description PURPOSE: To ascertain the relationship among early (first 48 h) deep sedation, time to extubation, delirium and long-term mortality. METHODS: We conducted a multicentre prospective longitudinal cohort study in 11 Malaysian hospitals including medical/surgical patients (n = 259) who were sedated and ventilated ≥24 h. Patients were followed from ICU admission up to 28 days in ICU with 4-hourly sedation and daily delirium assessments and 180-day mortality. Deep sedation was defined as Richmond Agitation Sedation Score (RASS) ≤-3. RESULTS: The cohort had a mean (SD) age of 53.1 (15.9) years and APACHE II score of 21.3 (8.2) with hospital and 180-day mortality of 82 (31.7%) and 110/237 (46.4%). Patients were followed for 2,657 ICU days and underwent 13,836 RASS assessments. Midazolam prescription was predominant compared to propofol, given to 241 (93%) versus 72 (28%) patients (P < 0.0001) for 966 (39.6%) versus 183 (7.5%) study days respectively. Deep sedation occurred in (182/257) 71% patients at first assessment and in 159 (61%) patients and 1,658 (59%) of all RASS assessments at 48 h. Multivariable Cox proportional hazard regression analysis adjusting for a priori assigned covariates including sedative agents, diagnosis, age, APACHE II score, operative, elective, vasopressors and dialysis showed that early deep sedation was independently associated with longer time to extubation [hazard ratio (HR) 0.93, 95% confidence interval (CI) 0.89-0.97, P = 0.003], hospital death (HR 1.11, 95% CI 1.05-1.18, P < 0.001) and 180-day mortality (HR 1.09, 95% CI 1.04-1.15, P = 0.002), but not time to delirium (HR 0.98, P = 0.23). Delirium occurred in 114 (44%) of patients. CONCLUSION: Irrespective of sedative choice, early deep sedation was independently associated with delayed extubation and higher mortality, and thus was a potentially modifiable risk in interventional trials.
54 schema:genre research_article
55 schema:inLanguage en
56 schema:isAccessibleForFree true
57 schema:isPartOf N95b1a7ac0de641f2b15d4ece50ef5448
58 Nb1f2c7109b6147d6b3c3ce68f8156f93
59 sg:journal.1313639
60 schema:name Sedation depth and long-term mortality in mechanically ventilated critically ill adults: a prospective longitudinal multicentre cohort study
61 schema:pagination 910-918
62 schema:productId N41e3f130032442d3ada40a21ea00c4c8
63 N690cc11624c443a19dcfbf205962869b
64 N706b12a4f718495ea31e9946119ec6c4
65 N71c3b8081c734a85a93bec7fcc311634
66 Naa6066fc25354749a842390adc35f3da
67 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021295774
68 https://doi.org/10.1007/s00134-013-2830-2
69 schema:sdDatePublished 2019-04-11T10:02
70 schema:sdLicense https://scigraph.springernature.com/explorer/license/
71 schema:sdPublisher Naaeab55253ce455f913278e2d8387bbc
72 schema:url http://link.springer.com/10.1007/s00134-013-2830-2
73 sgo:license sg:explorer/license/
74 sgo:sdDataset articles
75 rdf:type schema:ScholarlyArticle
76 N0008b32fe4484b088f68202c0ab37010 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Critical Illness
78 rdf:type schema:DefinedTerm
79 N05d27ee3991c499e90af86272047c9ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Female
81 rdf:type schema:DefinedTerm
82 N06c5dc3792b7428d8ac6f39750926751 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Hypnotics and Sedatives
84 rdf:type schema:DefinedTerm
85 N070e59a553744988bd56b2425f11cae4 rdf:first Ne13c895cc0804ee7911a085d44b21b5e
86 rdf:rest Nbb4cc68ed248497f89d7e7967f72396d
87 N11cc4d981d6442b28e2a099f7d8d55b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Delirium
89 rdf:type schema:DefinedTerm
90 N21f2249d563347ccbfff63e0aa76bf1d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Deep Sedation
92 rdf:type schema:DefinedTerm
93 N41e3f130032442d3ada40a21ea00c4c8 schema:name dimensions_id
94 schema:value pub.1021295774
95 rdf:type schema:PropertyValue
96 N436dcdc09bbe4d23afdfc1d10cb25121 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Malaysia
98 rdf:type schema:DefinedTerm
99 N5a07cfa5a421460483d6e02645c25120 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name APACHE
101 rdf:type schema:DefinedTerm
102 N613f097adb564925911f6fd548921bb8 rdf:first N6f5fe1e21ca94b1daf9fcd5e02fbe0dd
103 rdf:rest Nd206de632dd1401e895e5196eb68ba80
104 N690cc11624c443a19dcfbf205962869b schema:name pubmed_id
105 schema:value 23344834
106 rdf:type schema:PropertyValue
107 N6f5fe1e21ca94b1daf9fcd5e02fbe0dd schema:affiliation https://www.grid.ac/institutes/grid.428821.5
108 schema:familyName Ali
109 schema:givenName Saedah Binti
110 rdf:type schema:Person
111 N706b12a4f718495ea31e9946119ec6c4 schema:name nlm_unique_id
112 schema:value 7704851
113 rdf:type schema:PropertyValue
114 N71c3b8081c734a85a93bec7fcc311634 schema:name readcube_id
115 schema:value 6576a8418219d67cf0083bfa3ee5a04a51430292dfdde7fbe62538f34986d0c0
116 rdf:type schema:PropertyValue
117 N76a4c9eb241d49a6a04545a11c46cb63 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Respiration, Artificial
119 rdf:type schema:DefinedTerm
120 N7c69addf60814f4694e67541d903f84a rdf:first Ne2efef34b6e04fde968504fd48c231d6
121 rdf:rest rdf:nil
122 N7dadd1ccb3444e56974e584e3bdc02ad schema:name Penang General Hospital, PGH, Penang, Malaysia
123 rdf:type schema:Organization
124 N7e00b9d643e041a58bf2e2213a4e78de rdf:first Ne1d46e63abe341e68d25df40624c734a
125 rdf:rest N92c2e0a6aff44db0af78d5a4cafbf998
126 N87a39321a91142d6b79e878adbf9f56a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Prospective Studies
128 rdf:type schema:DefinedTerm
129 N8e038994caa74cb0a702b9c5b01626bb rdf:first sg:person.01027137612.19
130 rdf:rest Ne25fb2e573e048cfbfb435f4b3358957
131 N92c2e0a6aff44db0af78d5a4cafbf998 rdf:first sg:person.0622613130.40
132 rdf:rest N070e59a553744988bd56b2425f11cae4
133 N9471159eac124bc0be42930888d2a934 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Male
135 rdf:type schema:DefinedTerm
136 N952283e9567e40f992b1b9c0f73353b6 schema:name Department of Anesthesiology and Intensive Care, Hospital Queen Elizabeth, 88586, Kota Kinabalu, Sabah, Malaysia
137 rdf:type schema:Organization
138 N95837dbbc07d4abc8bb43ad727b535b4 schema:affiliation https://www.grid.ac/institutes/grid.412516.5
139 schema:familyName Tan
140 schema:givenName Mohd Ali T. Ismail
141 rdf:type schema:Person
142 N95b1a7ac0de641f2b15d4ece50ef5448 schema:issueNumber 5
143 rdf:type schema:PublicationIssue
144 N9c0386c8e44b491e9254d3847e5be883 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Longitudinal Studies
146 rdf:type schema:DefinedTerm
147 N9f4013ed9506438282dabd53c523d94e rdf:first sg:person.0712711212.43
148 rdf:rest Nd0f3947e3a1e43859f777f2c65fd95bb
149 Naa6066fc25354749a842390adc35f3da schema:name doi
150 schema:value 10.1007/s00134-013-2830-2
151 rdf:type schema:PropertyValue
152 Naaeab55253ce455f913278e2d8387bbc schema:name Springer Nature - SN SciGraph project
153 rdf:type schema:Organization
154 Nac5294987929426a81a6dcf9d37a5c2c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Middle Aged
156 rdf:type schema:DefinedTerm
157 Nb1f2c7109b6147d6b3c3ce68f8156f93 schema:volumeNumber 39
158 rdf:type schema:PublicationVolume
159 Nbb4cc68ed248497f89d7e7967f72396d rdf:first sg:person.0677173700.38
160 rdf:rest N7c69addf60814f4694e67541d903f84a
161 Nbb59e6150aec4991a340ed18bd36149e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Chi-Square Distribution
163 rdf:type schema:DefinedTerm
164 Ncfbb188c8ff94f2b80d5eb0d324bea3e rdf:first sg:person.01211501412.28
165 rdf:rest N613f097adb564925911f6fd548921bb8
166 Nd0f3947e3a1e43859f777f2c65fd95bb rdf:first sg:person.01014751605.85
167 rdf:rest N8e038994caa74cb0a702b9c5b01626bb
168 Nd1c336fcedcb4549a24e19fcafc18278 rdf:first N95837dbbc07d4abc8bb43ad727b535b4
169 rdf:rest Ncfbb188c8ff94f2b80d5eb0d324bea3e
170 Nd206de632dd1401e895e5196eb68ba80 rdf:first sg:person.0744336243.50
171 rdf:rest N7e00b9d643e041a58bf2e2213a4e78de
172 Nd3b57a4628824364adffddcea82dd50d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Humans
174 rdf:type schema:DefinedTerm
175 Nd88edd73bd8b46d2936b9410f4a201f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Proportional Hazards Models
177 rdf:type schema:DefinedTerm
178 Ne13c895cc0804ee7911a085d44b21b5e schema:affiliation N7dadd1ccb3444e56974e584e3bdc02ad
179 schema:familyName Yong
180 schema:givenName Cow Yen
181 rdf:type schema:Person
182 Ne1d46e63abe341e68d25df40624c734a schema:affiliation https://www.grid.ac/institutes/grid.452819.3
183 schema:familyName Shaltut
184 schema:givenName Ahmad
185 rdf:type schema:Person
186 Ne25fb2e573e048cfbfb435f4b3358957 rdf:first sg:person.01075253012.53
187 rdf:rest Nd1c336fcedcb4549a24e19fcafc18278
188 Ne2efef34b6e04fde968504fd48c231d6 schema:familyName The Sedation Practice in Intensive Care Evaluation (SPICE) Study Group investigators
189 rdf:type schema:Person
190 Nf9a5ffe0550d45459a6d75e59e1d25e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Intensive Care Units
192 rdf:type schema:DefinedTerm
193 Nfa468c178aa94e91959cf4a49f494576 rdf:first sg:person.0641143724.27
194 rdf:rest N9f4013ed9506438282dabd53c523d94e
195 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
196 schema:name Medical and Health Sciences
197 rdf:type schema:DefinedTerm
198 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
199 schema:name Clinical Sciences
200 rdf:type schema:DefinedTerm
201 sg:journal.1313639 schema:issn 0342-4642
202 1432-1238
203 schema:name Intensive Care Medicine
204 rdf:type schema:Periodical
205 sg:person.01014751605.85 schema:affiliation https://www.grid.ac/institutes/grid.419388.f
206 schema:familyName Kadiman
207 schema:givenName Suhaini
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014751605.85
209 rdf:type schema:Person
210 sg:person.01027137612.19 schema:affiliation https://www.grid.ac/institutes/grid.461040.7
211 schema:familyName Alias
212 schema:givenName Anita
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027137612.19
214 rdf:type schema:Person
215 sg:person.01075253012.53 schema:affiliation https://www.grid.ac/institutes/grid.500264.5
216 schema:familyName Ismail
217 schema:givenName Wan Nasrudin
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075253012.53
219 rdf:type schema:Person
220 sg:person.01211501412.28 schema:affiliation N952283e9567e40f992b1b9c0f73353b6
221 schema:familyName Khoo
222 schema:givenName Tien Meng
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211501412.28
224 rdf:type schema:Person
225 sg:person.0622613130.40 schema:affiliation https://www.grid.ac/institutes/grid.413461.5
226 schema:familyName Tan
227 schema:givenName Cheng Cheng
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622613130.40
229 rdf:type schema:Person
230 sg:person.0641143724.27 schema:affiliation https://www.grid.ac/institutes/grid.415193.b
231 schema:familyName Shehabi
232 schema:givenName Yahya
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641143724.27
234 rdf:type schema:Person
235 sg:person.0677173700.38 schema:affiliation https://www.grid.ac/institutes/grid.1002.3
236 schema:familyName Bailey
237 schema:givenName Michael
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677173700.38
239 rdf:type schema:Person
240 sg:person.0712711212.43 schema:affiliation https://www.grid.ac/institutes/grid.10347.31
241 schema:familyName Chan
242 schema:givenName Lucy
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712711212.43
244 rdf:type schema:Person
245 sg:person.0744336243.50 schema:affiliation https://www.grid.ac/institutes/grid.415281.b
246 schema:familyName Saman
247 schema:givenName Mat Ariffin
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744336243.50
249 rdf:type schema:Person
250 sg:pub.10.1007/s00134-006-0399-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003258397
251 https://doi.org/10.1007/s00134-006-0399-8
252 rdf:type schema:CreativeWork
253 sg:pub.10.1007/s00134-008-1186-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020684281
254 https://doi.org/10.1007/s00134-008-1186-5
255 rdf:type schema:CreativeWork
256 sg:pub.10.1186/cc6189 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042343063
257 https://doi.org/10.1186/cc6189
258 rdf:type schema:CreativeWork
259 sg:pub.10.1186/cc6908 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045163880
260 https://doi.org/10.1186/cc6908
261 rdf:type schema:CreativeWork
262 sg:pub.10.1186/cc7141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002361177
263 https://doi.org/10.1186/cc7141
264 rdf:type schema:CreativeWork
265 sg:pub.10.1186/cc8212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005080269
266 https://doi.org/10.1186/cc8212
267 rdf:type schema:CreativeWork
268 https://app.dimensions.ai/details/publication/pub.1077693076 schema:CreativeWork
269 https://app.dimensions.ai/details/publication/pub.1078410492 schema:CreativeWork
270 https://app.dimensions.ai/details/publication/pub.1078482643 schema:CreativeWork
271 https://doi.org/10.1001/jama.2009.56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047864460
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1001/jama.2012.13872 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042399008
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1001/jama.2012.304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018681920
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1001/jama.286.21.2703 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023293188
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1001/jama.287.3.345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006458934
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/j.ccc.2009.04.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028321363
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/j.ccell.2005.04.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015801234
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/s0140-6736(08)60105-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026479220
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/s0140-6736(09)62072-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036169635
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1056/nejm200005183422002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051418418
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1097/00003246-198510000-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039110630
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1097/00003246-200201000-00020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025932689
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1097/01.anes.0000264747.09017.da schema:sameAs https://app.dimensions.ai/details/publication/pub.1047168166
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1097/ccm.0b013e3181a5689f schema:sameAs https://app.dimensions.ai/details/publication/pub.1037934770
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1097/mcc.0b013e32830280b3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039117681
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1164/rccm.201101-0065oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1003870970
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1164/rccm.201102-0273ci schema:sameAs https://app.dimensions.ai/details/publication/pub.1052360739
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1164/rccm.201203-0522oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1041214075
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1164/rccm.2107138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013441079
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1177/0310057x0803600423 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077693076
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1177/0310057x1103900310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078410492
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1213/ane.0b013e3181d7e1b8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017352983
314 rdf:type schema:CreativeWork
315 https://www.grid.ac/institutes/grid.1002.3 schema:alternateName Monash University
316 schema:name Australian New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine Monash University, Melbourne, Australia
317 rdf:type schema:Organization
318 https://www.grid.ac/institutes/grid.10347.31 schema:alternateName University of Malaya
319 schema:name Department of Anesthesiology, Faculty of Medicine, University of Malaya, Lembah Pantai, 50603, Kuala Lumpur, Malaysia
320 rdf:type schema:Organization
321 https://www.grid.ac/institutes/grid.412516.5 schema:alternateName Hospital Kuala Lumpur
322 schema:name Department of Anesthesia and Intensive Care, General ICU, Kuala Lumpur General Hospital, Jalan Pahang, 50586, Kuala Lumpur, Malaysia
323 rdf:type schema:Organization
324 https://www.grid.ac/institutes/grid.413461.5 schema:alternateName Sultanah Aminah Hospital
325 schema:name ICU Selatan, 2nd Floor, Hospital Sultanah Aminah, Jalan Persiaran Abu Bakar, Johor Bahru, Johor, Malaysia
326 rdf:type schema:Organization
327 https://www.grid.ac/institutes/grid.415193.b schema:alternateName Prince of Wales Hospital
328 schema:name Department of Intensive Care, University New South Wales Clinical School, The Prince of Wales Hospital, Barker St., 2031, Randwick, NSW, Australia
329 University New South Wales, Prince of Wales Hospital, Sydney, Australia
330 rdf:type schema:Organization
331 https://www.grid.ac/institutes/grid.415281.b schema:alternateName Sarawak General Hospital
332 schema:name Department of Anesthesiology and Intensive Care, Sarawak General Hospital, Jalan Hospital, 93586, Kuching, Sarawak, Malaysia
333 rdf:type schema:Organization
334 https://www.grid.ac/institutes/grid.419388.f schema:alternateName National Heart Institute
335 schema:name National Heart Institute (Institut Jantung Negara), 145 Jalan Tun Razak, 50400, Kuala Lumpur, Malaysia
336 rdf:type schema:Organization
337 https://www.grid.ac/institutes/grid.428821.5 schema:alternateName Hospital Universiti Sains Malaysia
338 schema:name Department of Anesthesiology, School of Medicine, Hospital University Sains Malaysia, Health Campus, 16150, Kota Bahru, Kelantan, Malaysia
339 rdf:type schema:Organization
340 https://www.grid.ac/institutes/grid.452819.3 schema:alternateName Hospital Sultanah Bahiyah
341 schema:name Hospital Sultanah Bahiyah, Alor Setar, HAS, Kedah, Malaysia
342 rdf:type schema:Organization
343 https://www.grid.ac/institutes/grid.461040.7 schema:alternateName Malacca General Hospital
344 schema:name Department of Anesthesia and Intensive Care, Hospital Melaka, Jalan Mufti Hj Khalil, 75400, Melaka, Malaysia
345 rdf:type schema:Organization
346 https://www.grid.ac/institutes/grid.500264.5 schema:alternateName Hospital Raja Perempuan Zainab II
347 schema:name Hospital Raja Perempuan Zainab II Kota Bahru–HKB, Kelantan, Malaysia
348 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...