Predictors of successful extracorporeal membrane oxygenation (ECMO) weaning after assistance for refractory cardiogenic shock View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-10-01

AUTHORS

Nadia Aissaoui, Charles-Edouard Luyt, Pascal Leprince, Jean-Louis Trouillet, Philippe Léger, Alain Pavie, Benoit Diebold, Jean Chastre, Alain Combes

ABSTRACT

PurposeDetailed extracorporeal membrane oxygenation (ECMO) weaning strategies and specific predictors of ECMO weaning success are lacking. This study evaluated a weaning strategy following support for refractory cardiogenic shock to identify clinical, hemodynamic, and Doppler echocardiography parameters associated with successful ECMO removal.MethodsHemodynamically stable patients underwent ECMO flow reduction trials to <1.5 L/min under clinical and Doppler echocardiography monitoring. When a patient had partially or fully recovered from severe cardiac dysfunction, tolerated the weaning trial, and had left ventricular ejection fraction (LVEF) >20–25% and aortic time–velocity integral (VTI) >10 cm under minimal ECMO support, device removal was considered.ResultsAmong the 51 patients (34 males, aged 54 ± 14 years) who received ECMO for medical (n = 27), postcardiotomy (n = 11), or posttransplantation (n = 5) cardiogenic shock, 38 tolerated at least one ECMO flow reduction trial and 20 were ultimately weaned. Compared with the 13 patients who tolerated the trial but were not deemed weanable, those successfully weaned had, at each ECMO flow level, higher arterial systolic and pulse pressures, VTI, LVEF, and lateral mitral annulus peak systolic velocity (TDSa). All weaned patients had aortic VTI ≥10 cm, LVEF >20–25%, and TDSa ≥6 cm/s at minimal ECMO flow support. These Doppler echocardiography parameters better separated weaned and nonweaned patients than any other parameters tested.ConclusionsPatients who tolerated a full ECMO weaning trial and had aortic VTI ≥10 cm, LVEF >20–25%, and TDSa ≥6 cm/s at minimal ECMO flow were all successfully weaned. However, further studies are needed to validate these simple and easy-to-acquire Doppler echocardiography parameters as predictors of subsequent ECMO weaning success in patients recovering from severe cardiogenic shock. More... »

PAGES

1738

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00134-011-2358-2

DOI

http://dx.doi.org/10.1007/s00134-011-2358-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018694372

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21965097


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aorta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Device Removal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Echocardiography, Doppler", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Extracorporeal Membrane Oxygenation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Forecasting", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hemodynamics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Outcome Assessment, Health Care", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Paris", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Salvage Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Shock, Cardiogenic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ventilator Weaning", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ventricular Function, Left", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Service de R\u00e9animation M\u00e9dicale, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Assistance Publique-H\u00f4pitaux de Paris, Universit\u00e9 Pierre et Marie Curie, Paris 6, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.462844.8", 
          "name": [
            "Service de R\u00e9animation M\u00e9dicale, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Assistance Publique-H\u00f4pitaux de Paris, Universit\u00e9 Pierre et Marie Curie, Paris 6, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aissaoui", 
        "givenName": "Nadia", 
        "id": "sg:person.01126620525.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126620525.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de R\u00e9animation M\u00e9dicale, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Assistance Publique-H\u00f4pitaux de Paris, Universit\u00e9 Pierre et Marie Curie, Paris 6, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.462844.8", 
          "name": [
            "Service de R\u00e9animation M\u00e9dicale, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Assistance Publique-H\u00f4pitaux de Paris, Universit\u00e9 Pierre et Marie Curie, Paris 6, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Luyt", 
        "givenName": "Charles-Edouard", 
        "id": "sg:person.01310337776.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310337776.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de Chirurgie Cardiaque, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Assistance Publique-H\u00f4pitaux de Paris, Universit\u00e9 Pierre et Marie Curie, Paris 6, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.462844.8", 
          "name": [
            "Service de Chirurgie Cardiaque, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Assistance Publique-H\u00f4pitaux de Paris, Universit\u00e9 Pierre et Marie Curie, Paris 6, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leprince", 
        "givenName": "Pascal", 
        "id": "sg:person.01246012577.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246012577.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de R\u00e9animation M\u00e9dicale, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Assistance Publique-H\u00f4pitaux de Paris, Universit\u00e9 Pierre et Marie Curie, Paris 6, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.462844.8", 
          "name": [
            "Service de R\u00e9animation M\u00e9dicale, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Assistance Publique-H\u00f4pitaux de Paris, Universit\u00e9 Pierre et Marie Curie, Paris 6, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Trouillet", 
        "givenName": "Jean-Louis", 
        "id": "sg:person.01251562312.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251562312.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "D\u00e9partement d\u2019Anesth\u00e9sie-R\u00e9animation, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Assistance Publique-H\u00f4pitaux de Paris, Universit\u00e9 Pierre et Marie Curie, Paris 6, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.462844.8", 
          "name": [
            "D\u00e9partement d\u2019Anesth\u00e9sie-R\u00e9animation, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Assistance Publique-H\u00f4pitaux de Paris, Universit\u00e9 Pierre et Marie Curie, Paris 6, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "L\u00e9ger", 
        "givenName": "Philippe", 
        "id": "sg:person.012566354162.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012566354162.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de Chirurgie Cardiaque, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Assistance Publique-H\u00f4pitaux de Paris, Universit\u00e9 Pierre et Marie Curie, Paris 6, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.462844.8", 
          "name": [
            "Service de Chirurgie Cardiaque, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Assistance Publique-H\u00f4pitaux de Paris, Universit\u00e9 Pierre et Marie Curie, Paris 6, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pavie", 
        "givenName": "Alain", 
        "id": "sg:person.01331322165.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331322165.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de Cardiologie, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique-H\u00f4pitaux de Paris, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.414093.b", 
          "name": [
            "Service de Cardiologie, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Diebold", 
        "givenName": "Benoit", 
        "id": "sg:person.0707065163.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707065163.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de R\u00e9animation M\u00e9dicale, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Assistance Publique-H\u00f4pitaux de Paris, Universit\u00e9 Pierre et Marie Curie, Paris 6, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.462844.8", 
          "name": [
            "Service de R\u00e9animation M\u00e9dicale, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Assistance Publique-H\u00f4pitaux de Paris, Universit\u00e9 Pierre et Marie Curie, Paris 6, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chastre", 
        "givenName": "Jean", 
        "id": "sg:person.0714077601.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714077601.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de R\u00e9animation M\u00e9dicale, Institut de Cardiologie, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, 47, boulevard de l\u2019H\u00f4pital, 75651, Paris Cedex 13, France", 
          "id": "http://www.grid.ac/institutes/grid.411439.a", 
          "name": [
            "Service de R\u00e9animation M\u00e9dicale, Institut de Cardiologie, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, 47, boulevard de l\u2019H\u00f4pital, 75651, Paris Cedex 13, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Combes", 
        "givenName": "Alain", 
        "id": "sg:person.0710520012.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710520012.16"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00134-003-2039-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039306996", 
          "https://doi.org/10.1007/s00134-003-2039-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-007-0923-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015322117", 
          "https://doi.org/10.1007/s00134-007-0923-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001340101006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033225491", 
          "https://doi.org/10.1007/s001340101006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01709751", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052044737", 
          "https://doi.org/10.1007/bf01709751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-007-0568-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005303650", 
          "https://doi.org/10.1007/s00134-007-0568-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-009-1739-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000440297", 
          "https://doi.org/10.1007/s00134-009-1739-2"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-10-01", 
    "datePublishedReg": "2011-10-01", 
    "description": "PurposeDetailed extracorporeal membrane oxygenation (ECMO) weaning strategies and specific predictors of ECMO weaning success are lacking. This study evaluated a weaning strategy following support for refractory cardiogenic shock to identify clinical, hemodynamic, and Doppler echocardiography parameters associated with successful ECMO removal.MethodsHemodynamically stable patients underwent ECMO flow reduction trials to <1.5\u00a0L/min under clinical and Doppler echocardiography monitoring. When a patient had partially or fully recovered from severe cardiac dysfunction, tolerated the weaning trial, and had left ventricular ejection fraction (LVEF) >20\u201325% and aortic time\u2013velocity integral (VTI) >10\u00a0cm under minimal ECMO support, device removal was considered.ResultsAmong the 51 patients (34 males, aged 54\u00a0\u00b1\u00a014\u00a0years) who received ECMO for medical (n\u00a0=\u00a027), postcardiotomy (n\u00a0=\u00a011), or posttransplantation (n\u00a0=\u00a05) cardiogenic shock, 38 tolerated at least one ECMO flow reduction trial and 20 were ultimately weaned. Compared with the 13 patients who tolerated the trial but were not deemed weanable, those successfully weaned had, at each ECMO flow level, higher arterial systolic and pulse pressures, VTI, LVEF, and lateral mitral annulus peak systolic velocity (TDSa). All weaned patients had aortic VTI \u226510\u00a0cm, LVEF >20\u201325%, and TDSa \u22656\u00a0cm/s at minimal ECMO flow support. These Doppler echocardiography parameters better separated weaned and nonweaned patients than any other parameters tested.ConclusionsPatients who tolerated a full ECMO weaning trial and had aortic VTI \u226510\u00a0cm, LVEF >20\u201325%, and TDSa \u22656\u00a0cm/s at minimal ECMO flow were all successfully weaned. However, further studies are needed to validate these simple and easy-to-acquire Doppler echocardiography parameters as predictors of subsequent ECMO weaning success in patients recovering from severe cardiogenic shock.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00134-011-2358-2", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1313639", 
        "issn": [
          "0342-4642", 
          "1432-1238"
        ], 
        "name": "Intensive Care Medicine", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "11", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "37"
      }
    ], 
    "keywords": [
      "extracorporeal membrane oxygenation", 
      "Doppler echocardiography parameters", 
      "refractory cardiogenic shock", 
      "cardiogenic shock", 
      "echocardiography parameters", 
      "aortic VTI", 
      "Reduction Trial", 
      "aortic time velocity integral", 
      "successful extracorporeal membrane oxygenation", 
      "severe cardiogenic shock", 
      "ventricular ejection fraction", 
      "severe cardiac dysfunction", 
      "time-velocity integral", 
      "peak systolic velocity", 
      "ECMO removal", 
      "echocardiography monitoring", 
      "ECMO support", 
      "ECMO flow", 
      "stable patients", 
      "ejection fraction", 
      "membrane oxygenation", 
      "cardiac dysfunction", 
      "arterial systolic", 
      "pulse pressure", 
      "systolic velocity", 
      "patients", 
      "device removal", 
      "LVEF", 
      "weaning strategies", 
      "trials", 
      "specific predictors", 
      "Further studies", 
      "predictors", 
      "flow support", 
      "postcardiotomy", 
      "ConclusionsPatients", 
      "systolic", 
      "ResultsAmong", 
      "dysfunction", 
      "VTI", 
      "shock", 
      "oxygenation", 
      "study", 
      "min", 
      "support", 
      "levels", 
      "strategies", 
      "removal", 
      "success", 
      "pressure", 
      "monitoring", 
      "assistance", 
      "fraction", 
      "parameters", 
      "flow", 
      "velocity", 
      "integrals", 
      "TDSA"
    ], 
    "name": "Predictors of successful extracorporeal membrane oxygenation (ECMO) weaning after assistance for refractory cardiogenic shock", 
    "pagination": "1738", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1018694372"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00134-011-2358-2"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21965097"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00134-011-2358-2", 
      "https://app.dimensions.ai/details/publication/pub.1018694372"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T15:54", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_533.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00134-011-2358-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00134-011-2358-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00134-011-2358-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00134-011-2358-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00134-011-2358-2'


 

This table displays all metadata directly associated to this object as RDF triples.

281 TRIPLES      21 PREDICATES      107 URIs      93 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00134-011-2358-2 schema:about N07236d6bb4f84e32bf108900fc0119bc
2 N1a1fe0ae16a1492ba2fb6cd95405d372
3 N317adf0b680a4b638017c60e07eceb30
4 N5dac2c16f18748a1860047121da6e701
5 N6b103b59ed2f46fc89135c276f15a590
6 N8445d379edc8401888f363bd83ec9e63
7 N8f01dd64832246938abfb2adeb544964
8 N90e62a7f31f441d0a2f1d3a91c9a8beb
9 N913b1a99ef4745c1ba2780c117371010
10 N91f5210a57e84212bf3b74e43996635a
11 N92c408bc99814f0b9c335d58b7174183
12 Nc3f3bd083b0041328c5dce44d6c2856c
13 Nc81b6b188de04a939a28e15fd01a7c32
14 Nc90cfa98c017472abfd88874b28ca520
15 Ncd65ed30c2164272bd4b80031659190f
16 Nd6a781e88c214c0ea8aa73dbd3753ee3
17 Nec482683170f40d1979648371be37e5c
18 Nfa3e4ec51deb4650a779979d98b3373e
19 anzsrc-for:11
20 anzsrc-for:1103
21 schema:author N02e552102e8140e387f6f6b7b70552d0
22 schema:citation sg:pub.10.1007/bf01709751
23 sg:pub.10.1007/s00134-003-2039-x
24 sg:pub.10.1007/s00134-007-0568-4
25 sg:pub.10.1007/s00134-007-0923-5
26 sg:pub.10.1007/s00134-009-1739-2
27 sg:pub.10.1007/s001340101006
28 schema:datePublished 2011-10-01
29 schema:datePublishedReg 2011-10-01
30 schema:description PurposeDetailed extracorporeal membrane oxygenation (ECMO) weaning strategies and specific predictors of ECMO weaning success are lacking. This study evaluated a weaning strategy following support for refractory cardiogenic shock to identify clinical, hemodynamic, and Doppler echocardiography parameters associated with successful ECMO removal.MethodsHemodynamically stable patients underwent ECMO flow reduction trials to <1.5 L/min under clinical and Doppler echocardiography monitoring. When a patient had partially or fully recovered from severe cardiac dysfunction, tolerated the weaning trial, and had left ventricular ejection fraction (LVEF) >20–25% and aortic time–velocity integral (VTI) >10 cm under minimal ECMO support, device removal was considered.ResultsAmong the 51 patients (34 males, aged 54 ± 14 years) who received ECMO for medical (n = 27), postcardiotomy (n = 11), or posttransplantation (n = 5) cardiogenic shock, 38 tolerated at least one ECMO flow reduction trial and 20 were ultimately weaned. Compared with the 13 patients who tolerated the trial but were not deemed weanable, those successfully weaned had, at each ECMO flow level, higher arterial systolic and pulse pressures, VTI, LVEF, and lateral mitral annulus peak systolic velocity (TDSa). All weaned patients had aortic VTI ≥10 cm, LVEF >20–25%, and TDSa ≥6 cm/s at minimal ECMO flow support. These Doppler echocardiography parameters better separated weaned and nonweaned patients than any other parameters tested.ConclusionsPatients who tolerated a full ECMO weaning trial and had aortic VTI ≥10 cm, LVEF >20–25%, and TDSa ≥6 cm/s at minimal ECMO flow were all successfully weaned. However, further studies are needed to validate these simple and easy-to-acquire Doppler echocardiography parameters as predictors of subsequent ECMO weaning success in patients recovering from severe cardiogenic shock.
31 schema:genre article
32 schema:isAccessibleForFree false
33 schema:isPartOf N4d0a26a2951d4f99bad5ac1c08469bc3
34 N979324b15ee947bcbad4843f02e04eec
35 sg:journal.1313639
36 schema:keywords ConclusionsPatients
37 Doppler echocardiography parameters
38 ECMO flow
39 ECMO removal
40 ECMO support
41 Further studies
42 LVEF
43 Reduction Trial
44 ResultsAmong
45 TDSA
46 VTI
47 aortic VTI
48 aortic time velocity integral
49 arterial systolic
50 assistance
51 cardiac dysfunction
52 cardiogenic shock
53 device removal
54 dysfunction
55 echocardiography monitoring
56 echocardiography parameters
57 ejection fraction
58 extracorporeal membrane oxygenation
59 flow
60 flow support
61 fraction
62 integrals
63 levels
64 membrane oxygenation
65 min
66 monitoring
67 oxygenation
68 parameters
69 patients
70 peak systolic velocity
71 postcardiotomy
72 predictors
73 pressure
74 pulse pressure
75 refractory cardiogenic shock
76 removal
77 severe cardiac dysfunction
78 severe cardiogenic shock
79 shock
80 specific predictors
81 stable patients
82 strategies
83 study
84 success
85 successful extracorporeal membrane oxygenation
86 support
87 systolic
88 systolic velocity
89 time-velocity integral
90 trials
91 velocity
92 ventricular ejection fraction
93 weaning strategies
94 schema:name Predictors of successful extracorporeal membrane oxygenation (ECMO) weaning after assistance for refractory cardiogenic shock
95 schema:pagination 1738
96 schema:productId N164106a5a0d741ca8cc3c8d472d22935
97 N41d93010b919466a86062912c43e279a
98 Ncf13d024828c4c89ab882ba6bfd3b566
99 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018694372
100 https://doi.org/10.1007/s00134-011-2358-2
101 schema:sdDatePublished 2022-09-02T15:54
102 schema:sdLicense https://scigraph.springernature.com/explorer/license/
103 schema:sdPublisher Nd9a966e47dad4977b172854d1c223268
104 schema:url https://doi.org/10.1007/s00134-011-2358-2
105 sgo:license sg:explorer/license/
106 sgo:sdDataset articles
107 rdf:type schema:ScholarlyArticle
108 N02e552102e8140e387f6f6b7b70552d0 rdf:first sg:person.01126620525.29
109 rdf:rest N572993f587ea412b9211f9bcffb09139
110 N07236d6bb4f84e32bf108900fc0119bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Ventricular Function, Left
112 rdf:type schema:DefinedTerm
113 N160262fdd229424486abc1b3a837345f rdf:first sg:person.01251562312.75
114 rdf:rest Nb87ee70740f645e1a960ba801d60d9ac
115 N164106a5a0d741ca8cc3c8d472d22935 schema:name doi
116 schema:value 10.1007/s00134-011-2358-2
117 rdf:type schema:PropertyValue
118 N1a1fe0ae16a1492ba2fb6cd95405d372 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Device Removal
120 rdf:type schema:DefinedTerm
121 N317adf0b680a4b638017c60e07eceb30 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Humans
123 rdf:type schema:DefinedTerm
124 N41d93010b919466a86062912c43e279a schema:name pubmed_id
125 schema:value 21965097
126 rdf:type schema:PropertyValue
127 N42b24c955c024311a45e98473c43145f rdf:first sg:person.01246012577.20
128 rdf:rest N160262fdd229424486abc1b3a837345f
129 N4d0a26a2951d4f99bad5ac1c08469bc3 schema:issueNumber 11
130 rdf:type schema:PublicationIssue
131 N572993f587ea412b9211f9bcffb09139 rdf:first sg:person.01310337776.72
132 rdf:rest N42b24c955c024311a45e98473c43145f
133 N5dac2c16f18748a1860047121da6e701 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Female
135 rdf:type schema:DefinedTerm
136 N6b103b59ed2f46fc89135c276f15a590 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Paris
138 rdf:type schema:DefinedTerm
139 N8445d379edc8401888f363bd83ec9e63 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Forecasting
141 rdf:type schema:DefinedTerm
142 N8f01dd64832246938abfb2adeb544964 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Extracorporeal Membrane Oxygenation
144 rdf:type schema:DefinedTerm
145 N90e62a7f31f441d0a2f1d3a91c9a8beb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Middle Aged
147 rdf:type schema:DefinedTerm
148 N913b1a99ef4745c1ba2780c117371010 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Adult
150 rdf:type schema:DefinedTerm
151 N91f5210a57e84212bf3b74e43996635a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Echocardiography, Doppler
153 rdf:type schema:DefinedTerm
154 N92c408bc99814f0b9c335d58b7174183 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Outcome Assessment, Health Care
156 rdf:type schema:DefinedTerm
157 N979324b15ee947bcbad4843f02e04eec schema:volumeNumber 37
158 rdf:type schema:PublicationVolume
159 Nb87ee70740f645e1a960ba801d60d9ac rdf:first sg:person.012566354162.52
160 rdf:rest Ne39386771ef64d81961b78908770d080
161 Nc3f3bd083b0041328c5dce44d6c2856c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Ventilator Weaning
163 rdf:type schema:DefinedTerm
164 Nc81b6b188de04a939a28e15fd01a7c32 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Male
166 rdf:type schema:DefinedTerm
167 Nc90cfa98c017472abfd88874b28ca520 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Shock, Cardiogenic
169 rdf:type schema:DefinedTerm
170 Ncd65ed30c2164272bd4b80031659190f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Salvage Therapy
172 rdf:type schema:DefinedTerm
173 Ncf13d024828c4c89ab882ba6bfd3b566 schema:name dimensions_id
174 schema:value pub.1018694372
175 rdf:type schema:PropertyValue
176 Nd6a781e88c214c0ea8aa73dbd3753ee3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Aged
178 rdf:type schema:DefinedTerm
179 Nd9a966e47dad4977b172854d1c223268 schema:name Springer Nature - SN SciGraph project
180 rdf:type schema:Organization
181 Ne39386771ef64d81961b78908770d080 rdf:first sg:person.01331322165.07
182 rdf:rest Nfd0c781bdf41414b8784510e11c6be18
183 Ne824ab84d08f4bdebada3dcc07e9cc68 rdf:first sg:person.0710520012.16
184 rdf:rest rdf:nil
185 Nec482683170f40d1979648371be37e5c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Aorta
187 rdf:type schema:DefinedTerm
188 Nf825ed4fe32948c0a00cae4d66986469 rdf:first sg:person.0714077601.27
189 rdf:rest Ne824ab84d08f4bdebada3dcc07e9cc68
190 Nfa3e4ec51deb4650a779979d98b3373e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Hemodynamics
192 rdf:type schema:DefinedTerm
193 Nfd0c781bdf41414b8784510e11c6be18 rdf:first sg:person.0707065163.78
194 rdf:rest Nf825ed4fe32948c0a00cae4d66986469
195 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
196 schema:name Medical and Health Sciences
197 rdf:type schema:DefinedTerm
198 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
199 schema:name Clinical Sciences
200 rdf:type schema:DefinedTerm
201 sg:journal.1313639 schema:issn 0342-4642
202 1432-1238
203 schema:name Intensive Care Medicine
204 schema:publisher Springer Nature
205 rdf:type schema:Periodical
206 sg:person.01126620525.29 schema:affiliation grid-institutes:grid.462844.8
207 schema:familyName Aissaoui
208 schema:givenName Nadia
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126620525.29
210 rdf:type schema:Person
211 sg:person.01246012577.20 schema:affiliation grid-institutes:grid.462844.8
212 schema:familyName Leprince
213 schema:givenName Pascal
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246012577.20
215 rdf:type schema:Person
216 sg:person.01251562312.75 schema:affiliation grid-institutes:grid.462844.8
217 schema:familyName Trouillet
218 schema:givenName Jean-Louis
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251562312.75
220 rdf:type schema:Person
221 sg:person.012566354162.52 schema:affiliation grid-institutes:grid.462844.8
222 schema:familyName Léger
223 schema:givenName Philippe
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012566354162.52
225 rdf:type schema:Person
226 sg:person.01310337776.72 schema:affiliation grid-institutes:grid.462844.8
227 schema:familyName Luyt
228 schema:givenName Charles-Edouard
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310337776.72
230 rdf:type schema:Person
231 sg:person.01331322165.07 schema:affiliation grid-institutes:grid.462844.8
232 schema:familyName Pavie
233 schema:givenName Alain
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331322165.07
235 rdf:type schema:Person
236 sg:person.0707065163.78 schema:affiliation grid-institutes:grid.414093.b
237 schema:familyName Diebold
238 schema:givenName Benoit
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707065163.78
240 rdf:type schema:Person
241 sg:person.0710520012.16 schema:affiliation grid-institutes:grid.411439.a
242 schema:familyName Combes
243 schema:givenName Alain
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710520012.16
245 rdf:type schema:Person
246 sg:person.0714077601.27 schema:affiliation grid-institutes:grid.462844.8
247 schema:familyName Chastre
248 schema:givenName Jean
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714077601.27
250 rdf:type schema:Person
251 sg:pub.10.1007/bf01709751 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052044737
252 https://doi.org/10.1007/bf01709751
253 rdf:type schema:CreativeWork
254 sg:pub.10.1007/s00134-003-2039-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039306996
255 https://doi.org/10.1007/s00134-003-2039-x
256 rdf:type schema:CreativeWork
257 sg:pub.10.1007/s00134-007-0568-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005303650
258 https://doi.org/10.1007/s00134-007-0568-4
259 rdf:type schema:CreativeWork
260 sg:pub.10.1007/s00134-007-0923-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015322117
261 https://doi.org/10.1007/s00134-007-0923-5
262 rdf:type schema:CreativeWork
263 sg:pub.10.1007/s00134-009-1739-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000440297
264 https://doi.org/10.1007/s00134-009-1739-2
265 rdf:type schema:CreativeWork
266 sg:pub.10.1007/s001340101006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033225491
267 https://doi.org/10.1007/s001340101006
268 rdf:type schema:CreativeWork
269 grid-institutes:grid.411439.a schema:alternateName Service de Réanimation Médicale, Institut de Cardiologie, Groupe Hospitalier Pitié-Salpêtrière, 47, boulevard de l’Hôpital, 75651, Paris Cedex 13, France
270 schema:name Service de Réanimation Médicale, Institut de Cardiologie, Groupe Hospitalier Pitié-Salpêtrière, 47, boulevard de l’Hôpital, 75651, Paris Cedex 13, France
271 rdf:type schema:Organization
272 grid-institutes:grid.414093.b schema:alternateName Service de Cardiologie, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France
273 schema:name Service de Cardiologie, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France
274 rdf:type schema:Organization
275 grid-institutes:grid.462844.8 schema:alternateName Département d’Anesthésie-Réanimation, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Université Pierre et Marie Curie, Paris 6, Paris, France
276 Service de Chirurgie Cardiaque, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Université Pierre et Marie Curie, Paris 6, Paris, France
277 Service de Réanimation Médicale, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Université Pierre et Marie Curie, Paris 6, Paris, France
278 schema:name Département d’Anesthésie-Réanimation, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Université Pierre et Marie Curie, Paris 6, Paris, France
279 Service de Chirurgie Cardiaque, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Université Pierre et Marie Curie, Paris 6, Paris, France
280 Service de Réanimation Médicale, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Université Pierre et Marie Curie, Paris 6, Paris, France
281 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...