Endothelin receptor antagonist attenuates inflammatory response and prolongs the survival time in a neonatal sepsis model View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-12

AUTHORS

Tatenobu Goto, Mohamed Hamed Hussein, Shin Kato, Ghada Abdel-Hamid Daoud, Takenori Kato, Hiroki Kakita, Haruo Mizuno, Masaki Imai, Tetsuya Ito, Ineko Kato, Satoshi Suzuki, Noriko Okada, Hajime Togari, Hidechika Okada

ABSTRACT

PURPOSE: To evaluate effects of endothelin receptor antagonist ETR-P1/fl in a neonatal sepsis model. METHOD: Eighteen anesthetized and mechanically ventilated 3-day-old piglets were divided into three groups. Six piglets received cecal ligation and perforation (CLP group). Six piglets were administrated a continuous infusion of ETR-P1/fl (0.05 mg/kg/h), an antisense homology box-derived peptide with an endothelin A receptor antagonist effect, starting 30 min after CLP (ETR-P1/fl group). Six piglets acted as the sham group. Mean arterial pressure (MAP), heart rate, cardiac output, arterial blood gas, body temp (BT), serum nitrite and nitrate (NOx), tumor necrosis factor (TNF)-α, and high-mobility group box 1 (HMGB-1) were measured before CLP and at 1, 3, 6, and 9 h after CLP. RESULTS: Cecal ligation and perforation exposure evoked a state of shock and showed deteriorated cardiac output, pulmonary hypertension, decreased MAP, low oxygen saturation, and base excess (BE) with elevated TNF-α, NOx, and HMGB1. ETR-P1/fl administration resulted in higher MAP at 6 and 9 h after CLP, less negative BE, lower mean pulmonary arterial pressure (mPAP)/MAP ratio at 9 h after CLP, and lower TNF-α, NOx, and HMGB-1 compared to the CLP group. BT showed no differences between the groups. Survival time in the ETR-P1/fl group was longer than in the CLP group (18.9 ± 2.3 h vs. 9.0 ± 0.8 h, p < 0.01). CONCLUSIONS: ETR-P1/fl treatment significantly attenuated the elevation of NOx, TNF-α, and HMGB-1, which improved the systemic hypotension, pulmonary hypertension, and blood gases, thereby causing improvement of survival time in a progressive neonatal sepsis CLP model. More... »

PAGES

2132-2139

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00134-010-2040-0

DOI

http://dx.doi.org/10.1007/s00134-010-2040-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041760837

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20845025


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1116", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Physiology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals, Newborn", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endothelin Receptor Antagonists", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Inflammation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sepsis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Swine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Nagoya City University", 
          "id": "https://www.grid.ac/institutes/grid.260433.0", 
          "name": [
            "Department of Pediatrics and Neonatology, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, 467-8601, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Goto", 
        "givenName": "Tatenobu", 
        "id": "sg:person.01344761737.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344761737.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fujita Health University", 
          "id": "https://www.grid.ac/institutes/grid.256115.4", 
          "name": [
            "Research Center, VACSERA, Giza, Egypt", 
            "Department of Pediatric Surgery and Liver Transplantation, Fujita Health University School of Medicine, Toyoake, Aichi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hussein", 
        "givenName": "Mohamed Hamed", 
        "id": "sg:person.01214576014.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214576014.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagoya City University", 
          "id": "https://www.grid.ac/institutes/grid.260433.0", 
          "name": [
            "Department of Pediatrics and Neonatology, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, 467-8601, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kato", 
        "givenName": "Shin", 
        "id": "sg:person.0706547170.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706547170.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vacsera (Egypt)", 
          "id": "https://www.grid.ac/institutes/grid.463319.a", 
          "name": [
            "Department of Obstetrics and Gynecology, VACSERA, Giza, Egypt"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Daoud", 
        "givenName": "Ghada Abdel-Hamid", 
        "id": "sg:person.01321565770.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321565770.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagoya City University", 
          "id": "https://www.grid.ac/institutes/grid.260433.0", 
          "name": [
            "Department of Pediatrics and Neonatology, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, 467-8601, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kato", 
        "givenName": "Takenori", 
        "id": "sg:person.01104210514.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104210514.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagoya City University", 
          "id": "https://www.grid.ac/institutes/grid.260433.0", 
          "name": [
            "Department of Pediatrics and Neonatology, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, 467-8601, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kakita", 
        "givenName": "Hiroki", 
        "id": "sg:person.01111305455.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111305455.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagoya City University", 
          "id": "https://www.grid.ac/institutes/grid.260433.0", 
          "name": [
            "Department of Pediatrics and Neonatology, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, 467-8601, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mizuno", 
        "givenName": "Haruo", 
        "id": "sg:person.01061000714.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061000714.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagoya City University", 
          "id": "https://www.grid.ac/institutes/grid.260433.0", 
          "name": [
            "Department of Immunology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Imai", 
        "givenName": "Masaki", 
        "id": "sg:person.014357750301.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014357750301.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagoya City University", 
          "id": "https://www.grid.ac/institutes/grid.260433.0", 
          "name": [
            "Department of Pediatrics and Neonatology, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, 467-8601, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ito", 
        "givenName": "Tetsuya", 
        "id": "sg:person.010356557122.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010356557122.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagoya City University", 
          "id": "https://www.grid.ac/institutes/grid.260433.0", 
          "name": [
            "Department of Pediatrics and Neonatology, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, 467-8601, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kato", 
        "givenName": "Ineko", 
        "id": "sg:person.01353347650.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353347650.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagoya City University", 
          "id": "https://www.grid.ac/institutes/grid.260433.0", 
          "name": [
            "Department of Pediatrics and Neonatology, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, 467-8601, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Suzuki", 
        "givenName": "Satoshi", 
        "id": "sg:person.0663235714.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663235714.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagoya City University", 
          "id": "https://www.grid.ac/institutes/grid.260433.0", 
          "name": [
            "Department of Immunology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Okada", 
        "givenName": "Noriko", 
        "id": "sg:person.01070654545.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070654545.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagoya City University", 
          "id": "https://www.grid.ac/institutes/grid.260433.0", 
          "name": [
            "Department of Pediatrics and Neonatology, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, 467-8601, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Togari", 
        "givenName": "Hajime", 
        "id": "sg:person.01120230645.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120230645.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Choju Medical Institute", 
          "id": "https://www.grid.ac/institutes/grid.474271.3", 
          "name": [
            "Department of Immunology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan", 
            "Fukushimura Hospital Choju Medical Institute, Toyohashi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Okada", 
        "givenName": "Hidechika", 
        "id": "sg:person.0711472310.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711472310.08"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1515/jpm.2004.126", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000198984"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ccm.0000114575.08269.f6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001053690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ccm.0000114575.08269.f6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001053690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0016-5085(98)70638-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003370823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0016-5085(98)70638-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003370823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.pcc.0000137357.52609.f0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004653835"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.pcc.0000137357.52609.f0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004653835"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci116338", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006854721"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1203/01.pdr.0000169995.25333.f7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007335436", 
          "https://doi.org/10.1203/01.pdr.0000169995.25333.f7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1203/01.pdr.0000169995.25333.f7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007335436", 
          "https://doi.org/10.1203/01.pdr.0000169995.25333.f7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1203/01.pdr.0000169995.25333.f7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007335436", 
          "https://doi.org/10.1203/01.pdr.0000169995.25333.f7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1203/01.pdr.0000169995.25333.f7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007335436", 
          "https://doi.org/10.1203/01.pdr.0000169995.25333.f7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001340051154", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011242444", 
          "https://doi.org/10.1007/s001340051154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.00048.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013123725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20052203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014822532"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0995-894", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016734169", 
          "https://doi.org/10.1038/nm0995-894"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s003950050170", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018986995", 
          "https://doi.org/10.1007/s003950050170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1203/00006450-200212000-00017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021661807", 
          "https://doi.org/10.1203/00006450-200212000-00017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00024382-200404000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030254860"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00024382-200404000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030254860"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.0000105701.98663.d4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031460836"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00024382-199803000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032210253"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00024382-199803000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032210253"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0196-9781(97)00370-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034964299"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.97.8.752", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036845245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/09031936.99.13114599", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036995175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00011-007-7224-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037771823", 
          "https://doi.org/10.1007/s00011-007-7224-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-3476(05)81552-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039010386"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.192.4.565", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039202020"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/332411a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040537366", 
          "https://doi.org/10.1038/332411a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-008-1032-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044811196", 
          "https://doi.org/10.1007/s00134-008-1032-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-008-1032-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044811196", 
          "https://doi.org/10.1007/s00134-008-1032-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.43.4.480", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046102852"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00024382-199808000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047972176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00024382-199808000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047972176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.bjp.0703691", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048709377"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-007-0691-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051687194", 
          "https://doi.org/10.1007/s00134-007-0691-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199103000-00014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052421632"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199103000-00014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052421632"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-007-0980-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053339775", 
          "https://doi.org/10.1007/s00134-007-0980-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-007-0980-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053339775", 
          "https://doi.org/10.1007/s00134-007-0980-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0002-9378(85)90162-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053540765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.285.5425.248", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062565884"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1556/aphysiol.95.2008.3.3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067880750"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082573900", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082825761", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jappl.1995.79.6.2122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082974265"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083203293", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083335812", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-12", 
    "datePublishedReg": "2010-12-01", 
    "description": "PURPOSE: To evaluate effects of endothelin receptor antagonist ETR-P1/fl in a neonatal sepsis model.\nMETHOD: Eighteen anesthetized and mechanically ventilated 3-day-old piglets were divided into three groups. Six piglets received cecal ligation and perforation (CLP group). Six piglets were administrated a continuous infusion of ETR-P1/fl (0.05 mg/kg/h), an antisense homology box-derived peptide with an endothelin A receptor antagonist effect, starting 30 min after CLP (ETR-P1/fl group). Six piglets acted as the sham group. Mean arterial pressure (MAP), heart rate, cardiac output, arterial blood gas, body temp (BT), serum nitrite and nitrate (NOx), tumor necrosis factor (TNF)-\u03b1, and high-mobility group box 1 (HMGB-1) were measured before CLP and at 1, 3, 6, and 9 h after CLP.\nRESULTS: Cecal ligation and perforation exposure evoked a state of shock and showed deteriorated cardiac output, pulmonary hypertension, decreased MAP, low oxygen saturation, and base excess (BE) with elevated TNF-\u03b1, NOx, and HMGB1. ETR-P1/fl administration resulted in higher MAP at 6 and 9 h after CLP, less negative BE, lower mean pulmonary arterial pressure (mPAP)/MAP ratio at 9 h after CLP, and lower TNF-\u03b1, NOx, and HMGB-1 compared to the CLP group. BT showed no differences between the groups. Survival time in the ETR-P1/fl group was longer than in the CLP group (18.9 \u00b1 2.3 h vs. 9.0 \u00b1 0.8 h, p < 0.01).\nCONCLUSIONS: ETR-P1/fl treatment significantly attenuated the elevation of NOx, TNF-\u03b1, and HMGB-1, which improved the systemic hypotension, pulmonary hypertension, and blood gases, thereby causing improvement of survival time in a progressive neonatal sepsis CLP model.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00134-010-2040-0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1313639", 
        "issn": [
          "0342-4642", 
          "1432-1238"
        ], 
        "name": "Intensive Care Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "12", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "36"
      }
    ], 
    "name": "Endothelin receptor antagonist attenuates inflammatory response and prolongs the survival time in a neonatal sepsis model", 
    "pagination": "2132-2139", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "c6ee24696fd9e11caea3eb12f44e47992a21a8895a6740108850497ddd87aa37"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "20845025"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7704851"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00134-010-2040-0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1041760837"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00134-010-2040-0", 
      "https://app.dimensions.ai/details/publication/pub.1041760837"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:55", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000351_0000000351/records_43266_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s00134-010-2040-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00134-010-2040-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00134-010-2040-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00134-010-2040-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00134-010-2040-0'


 

This table displays all metadata directly associated to this object as RDF triples.

325 TRIPLES      21 PREDICATES      75 URIs      30 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00134-010-2040-0 schema:about N088d8980c8e9482d89ac6009f7f62e42
2 N32ab83c374d0431a943ad7fad46e34b1
3 N4671c73167d946159b539b72db4e0bc7
4 N64e1f5fabba64a8592981e3e4ca41f1e
5 N6d6a4bcef2cd474d8c9d0457189923df
6 N80ce57f8df4c4dbaa558153fc46baec1
7 N988675c79fb247cb89a7c72fa647ab5e
8 Nb0f11d6741074245acb65bdbcf177ff9
9 Nd7ec092dc136415797f7bbec0fe13ce8
10 anzsrc-for:11
11 anzsrc-for:1116
12 schema:author Nba825865da2b4d8db7a18383922e7efc
13 schema:citation sg:pub.10.1007/s00011-007-7224-x
14 sg:pub.10.1007/s00134-007-0691-2
15 sg:pub.10.1007/s00134-007-0980-9
16 sg:pub.10.1007/s00134-008-1032-9
17 sg:pub.10.1007/s001340051154
18 sg:pub.10.1007/s003950050170
19 sg:pub.10.1038/332411a0
20 sg:pub.10.1038/nm0995-894
21 sg:pub.10.1203/00006450-200212000-00017
22 sg:pub.10.1203/01.pdr.0000169995.25333.f7
23 https://app.dimensions.ai/details/publication/pub.1082573900
24 https://app.dimensions.ai/details/publication/pub.1082825761
25 https://app.dimensions.ai/details/publication/pub.1083203293
26 https://app.dimensions.ai/details/publication/pub.1083335812
27 https://doi.org/10.1016/0002-9378(85)90162-0
28 https://doi.org/10.1016/s0016-5085(98)70638-9
29 https://doi.org/10.1016/s0022-3476(05)81552-5
30 https://doi.org/10.1016/s0196-9781(97)00370-7
31 https://doi.org/10.1038/sj.bjp.0703691
32 https://doi.org/10.1084/jem.192.4.565
33 https://doi.org/10.1084/jem.20052203
34 https://doi.org/10.1097/00000658-199103000-00014
35 https://doi.org/10.1097/00024382-199803000-00004
36 https://doi.org/10.1097/00024382-199808000-00007
37 https://doi.org/10.1097/00024382-200404000-00007
38 https://doi.org/10.1097/01.ccm.0000114575.08269.f6
39 https://doi.org/10.1097/01.pcc.0000137357.52609.f0
40 https://doi.org/10.1126/science.285.5425.248
41 https://doi.org/10.1152/ajpheart.00048.2004
42 https://doi.org/10.1152/jappl.1995.79.6.2122
43 https://doi.org/10.1161/01.cir.0000105701.98663.d4
44 https://doi.org/10.1161/01.cir.43.4.480
45 https://doi.org/10.1161/01.cir.97.8.752
46 https://doi.org/10.1172/jci116338
47 https://doi.org/10.1183/09031936.99.13114599
48 https://doi.org/10.1515/jpm.2004.126
49 https://doi.org/10.1556/aphysiol.95.2008.3.3
50 schema:datePublished 2010-12
51 schema:datePublishedReg 2010-12-01
52 schema:description PURPOSE: To evaluate effects of endothelin receptor antagonist ETR-P1/fl in a neonatal sepsis model. METHOD: Eighteen anesthetized and mechanically ventilated 3-day-old piglets were divided into three groups. Six piglets received cecal ligation and perforation (CLP group). Six piglets were administrated a continuous infusion of ETR-P1/fl (0.05 mg/kg/h), an antisense homology box-derived peptide with an endothelin A receptor antagonist effect, starting 30 min after CLP (ETR-P1/fl group). Six piglets acted as the sham group. Mean arterial pressure (MAP), heart rate, cardiac output, arterial blood gas, body temp (BT), serum nitrite and nitrate (NOx), tumor necrosis factor (TNF)-α, and high-mobility group box 1 (HMGB-1) were measured before CLP and at 1, 3, 6, and 9 h after CLP. RESULTS: Cecal ligation and perforation exposure evoked a state of shock and showed deteriorated cardiac output, pulmonary hypertension, decreased MAP, low oxygen saturation, and base excess (BE) with elevated TNF-α, NOx, and HMGB1. ETR-P1/fl administration resulted in higher MAP at 6 and 9 h after CLP, less negative BE, lower mean pulmonary arterial pressure (mPAP)/MAP ratio at 9 h after CLP, and lower TNF-α, NOx, and HMGB-1 compared to the CLP group. BT showed no differences between the groups. Survival time in the ETR-P1/fl group was longer than in the CLP group (18.9 ± 2.3 h vs. 9.0 ± 0.8 h, p < 0.01). CONCLUSIONS: ETR-P1/fl treatment significantly attenuated the elevation of NOx, TNF-α, and HMGB-1, which improved the systemic hypotension, pulmonary hypertension, and blood gases, thereby causing improvement of survival time in a progressive neonatal sepsis CLP model.
53 schema:genre research_article
54 schema:inLanguage en
55 schema:isAccessibleForFree false
56 schema:isPartOf N59bb2ac04b294ab583fbf805165000ea
57 N8afa0a74e68e42699c1933a97b88d4af
58 sg:journal.1313639
59 schema:name Endothelin receptor antagonist attenuates inflammatory response and prolongs the survival time in a neonatal sepsis model
60 schema:pagination 2132-2139
61 schema:productId N0c554793377047cea9c683d1c0160ef9
62 N31d0c1b3aa9f46e597bebe0bca47a8b8
63 N6a656f9aff77489b905225f8cf0bf8cf
64 N97e177a6e6a54a999a5d0d909fb85253
65 Nc239cb14e8c040aa94f905e89d9172ef
66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041760837
67 https://doi.org/10.1007/s00134-010-2040-0
68 schema:sdDatePublished 2019-04-11T10:55
69 schema:sdLicense https://scigraph.springernature.com/explorer/license/
70 schema:sdPublisher Naa433cddd8804539bfd6993fc701b5fb
71 schema:url http://link.springer.com/10.1007/s00134-010-2040-0
72 sgo:license sg:explorer/license/
73 sgo:sdDataset articles
74 rdf:type schema:ScholarlyArticle
75 N00f6be98c2594159a31cdb15fe01fc83 rdf:first sg:person.01353347650.44
76 rdf:rest Necc22f89099e46bf907706cfc35928d5
77 N088d8980c8e9482d89ac6009f7f62e42 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Time Factors
79 rdf:type schema:DefinedTerm
80 N0c554793377047cea9c683d1c0160ef9 schema:name nlm_unique_id
81 schema:value 7704851
82 rdf:type schema:PropertyValue
83 N22e16319c5414f1eb5a8dea00eacc549 rdf:first sg:person.014357750301.11
84 rdf:rest Nf7e16d45a82d4038831d41bdb43907e3
85 N31d0c1b3aa9f46e597bebe0bca47a8b8 schema:name doi
86 schema:value 10.1007/s00134-010-2040-0
87 rdf:type schema:PropertyValue
88 N32ab83c374d0431a943ad7fad46e34b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Disease Models, Animal
90 rdf:type schema:DefinedTerm
91 N3c4bea901ef34c0e87591e87c1636efd rdf:first sg:person.01111305455.71
92 rdf:rest Nbd1c6b90e3a74c41baaac5c1a8a494d0
93 N4671c73167d946159b539b72db4e0bc7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Animals
95 rdf:type schema:DefinedTerm
96 N544bc4859cdc420ca5c7b8649310befb rdf:first sg:person.01214576014.68
97 rdf:rest Ncfe99360e18d4206895b42377c288626
98 N59bb2ac04b294ab583fbf805165000ea schema:volumeNumber 36
99 rdf:type schema:PublicationVolume
100 N5a9048fe66be49e5ae068e1accaec41b rdf:first sg:person.01070654545.06
101 rdf:rest Naec2d418735f40cca6a69ca7b344be57
102 N64e1f5fabba64a8592981e3e4ca41f1e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Animals, Newborn
104 rdf:type schema:DefinedTerm
105 N6a656f9aff77489b905225f8cf0bf8cf schema:name pubmed_id
106 schema:value 20845025
107 rdf:type schema:PropertyValue
108 N6d6a4bcef2cd474d8c9d0457189923df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Sepsis
110 rdf:type schema:DefinedTerm
111 N80ce57f8df4c4dbaa558153fc46baec1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Endothelin Receptor Antagonists
113 rdf:type schema:DefinedTerm
114 N8afa0a74e68e42699c1933a97b88d4af schema:issueNumber 12
115 rdf:type schema:PublicationIssue
116 N97e177a6e6a54a999a5d0d909fb85253 schema:name dimensions_id
117 schema:value pub.1041760837
118 rdf:type schema:PropertyValue
119 N988675c79fb247cb89a7c72fa647ab5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Survival Rate
121 rdf:type schema:DefinedTerm
122 Naa433cddd8804539bfd6993fc701b5fb schema:name Springer Nature - SN SciGraph project
123 rdf:type schema:Organization
124 Naec2d418735f40cca6a69ca7b344be57 rdf:first sg:person.01120230645.81
125 rdf:rest Nd8ac44b2dc4040f5a1a2c324313594d5
126 Nb0f11d6741074245acb65bdbcf177ff9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Swine
128 rdf:type schema:DefinedTerm
129 Nba825865da2b4d8db7a18383922e7efc rdf:first sg:person.01344761737.66
130 rdf:rest N544bc4859cdc420ca5c7b8649310befb
131 Nbb7de17c4e5949fe9b794442e13b1315 rdf:first sg:person.01321565770.29
132 rdf:rest Ne9924f12cc7c474f8bad7fa43f03b7b1
133 Nbd1c6b90e3a74c41baaac5c1a8a494d0 rdf:first sg:person.01061000714.76
134 rdf:rest N22e16319c5414f1eb5a8dea00eacc549
135 Nc239cb14e8c040aa94f905e89d9172ef schema:name readcube_id
136 schema:value c6ee24696fd9e11caea3eb12f44e47992a21a8895a6740108850497ddd87aa37
137 rdf:type schema:PropertyValue
138 Ncfe99360e18d4206895b42377c288626 rdf:first sg:person.0706547170.96
139 rdf:rest Nbb7de17c4e5949fe9b794442e13b1315
140 Nd7ec092dc136415797f7bbec0fe13ce8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Inflammation
142 rdf:type schema:DefinedTerm
143 Nd8ac44b2dc4040f5a1a2c324313594d5 rdf:first sg:person.0711472310.08
144 rdf:rest rdf:nil
145 Ne9924f12cc7c474f8bad7fa43f03b7b1 rdf:first sg:person.01104210514.44
146 rdf:rest N3c4bea901ef34c0e87591e87c1636efd
147 Necc22f89099e46bf907706cfc35928d5 rdf:first sg:person.0663235714.43
148 rdf:rest N5a9048fe66be49e5ae068e1accaec41b
149 Nf7e16d45a82d4038831d41bdb43907e3 rdf:first sg:person.010356557122.85
150 rdf:rest N00f6be98c2594159a31cdb15fe01fc83
151 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
152 schema:name Medical and Health Sciences
153 rdf:type schema:DefinedTerm
154 anzsrc-for:1116 schema:inDefinedTermSet anzsrc-for:
155 schema:name Medical Physiology
156 rdf:type schema:DefinedTerm
157 sg:journal.1313639 schema:issn 0342-4642
158 1432-1238
159 schema:name Intensive Care Medicine
160 rdf:type schema:Periodical
161 sg:person.010356557122.85 schema:affiliation https://www.grid.ac/institutes/grid.260433.0
162 schema:familyName Ito
163 schema:givenName Tetsuya
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010356557122.85
165 rdf:type schema:Person
166 sg:person.01061000714.76 schema:affiliation https://www.grid.ac/institutes/grid.260433.0
167 schema:familyName Mizuno
168 schema:givenName Haruo
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061000714.76
170 rdf:type schema:Person
171 sg:person.01070654545.06 schema:affiliation https://www.grid.ac/institutes/grid.260433.0
172 schema:familyName Okada
173 schema:givenName Noriko
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070654545.06
175 rdf:type schema:Person
176 sg:person.01104210514.44 schema:affiliation https://www.grid.ac/institutes/grid.260433.0
177 schema:familyName Kato
178 schema:givenName Takenori
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104210514.44
180 rdf:type schema:Person
181 sg:person.01111305455.71 schema:affiliation https://www.grid.ac/institutes/grid.260433.0
182 schema:familyName Kakita
183 schema:givenName Hiroki
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111305455.71
185 rdf:type schema:Person
186 sg:person.01120230645.81 schema:affiliation https://www.grid.ac/institutes/grid.260433.0
187 schema:familyName Togari
188 schema:givenName Hajime
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120230645.81
190 rdf:type schema:Person
191 sg:person.01214576014.68 schema:affiliation https://www.grid.ac/institutes/grid.256115.4
192 schema:familyName Hussein
193 schema:givenName Mohamed Hamed
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214576014.68
195 rdf:type schema:Person
196 sg:person.01321565770.29 schema:affiliation https://www.grid.ac/institutes/grid.463319.a
197 schema:familyName Daoud
198 schema:givenName Ghada Abdel-Hamid
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321565770.29
200 rdf:type schema:Person
201 sg:person.01344761737.66 schema:affiliation https://www.grid.ac/institutes/grid.260433.0
202 schema:familyName Goto
203 schema:givenName Tatenobu
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344761737.66
205 rdf:type schema:Person
206 sg:person.01353347650.44 schema:affiliation https://www.grid.ac/institutes/grid.260433.0
207 schema:familyName Kato
208 schema:givenName Ineko
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353347650.44
210 rdf:type schema:Person
211 sg:person.014357750301.11 schema:affiliation https://www.grid.ac/institutes/grid.260433.0
212 schema:familyName Imai
213 schema:givenName Masaki
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014357750301.11
215 rdf:type schema:Person
216 sg:person.0663235714.43 schema:affiliation https://www.grid.ac/institutes/grid.260433.0
217 schema:familyName Suzuki
218 schema:givenName Satoshi
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663235714.43
220 rdf:type schema:Person
221 sg:person.0706547170.96 schema:affiliation https://www.grid.ac/institutes/grid.260433.0
222 schema:familyName Kato
223 schema:givenName Shin
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706547170.96
225 rdf:type schema:Person
226 sg:person.0711472310.08 schema:affiliation https://www.grid.ac/institutes/grid.474271.3
227 schema:familyName Okada
228 schema:givenName Hidechika
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711472310.08
230 rdf:type schema:Person
231 sg:pub.10.1007/s00011-007-7224-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037771823
232 https://doi.org/10.1007/s00011-007-7224-x
233 rdf:type schema:CreativeWork
234 sg:pub.10.1007/s00134-007-0691-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051687194
235 https://doi.org/10.1007/s00134-007-0691-2
236 rdf:type schema:CreativeWork
237 sg:pub.10.1007/s00134-007-0980-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053339775
238 https://doi.org/10.1007/s00134-007-0980-9
239 rdf:type schema:CreativeWork
240 sg:pub.10.1007/s00134-008-1032-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044811196
241 https://doi.org/10.1007/s00134-008-1032-9
242 rdf:type schema:CreativeWork
243 sg:pub.10.1007/s001340051154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011242444
244 https://doi.org/10.1007/s001340051154
245 rdf:type schema:CreativeWork
246 sg:pub.10.1007/s003950050170 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018986995
247 https://doi.org/10.1007/s003950050170
248 rdf:type schema:CreativeWork
249 sg:pub.10.1038/332411a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040537366
250 https://doi.org/10.1038/332411a0
251 rdf:type schema:CreativeWork
252 sg:pub.10.1038/nm0995-894 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016734169
253 https://doi.org/10.1038/nm0995-894
254 rdf:type schema:CreativeWork
255 sg:pub.10.1203/00006450-200212000-00017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021661807
256 https://doi.org/10.1203/00006450-200212000-00017
257 rdf:type schema:CreativeWork
258 sg:pub.10.1203/01.pdr.0000169995.25333.f7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007335436
259 https://doi.org/10.1203/01.pdr.0000169995.25333.f7
260 rdf:type schema:CreativeWork
261 https://app.dimensions.ai/details/publication/pub.1082573900 schema:CreativeWork
262 https://app.dimensions.ai/details/publication/pub.1082825761 schema:CreativeWork
263 https://app.dimensions.ai/details/publication/pub.1083203293 schema:CreativeWork
264 https://app.dimensions.ai/details/publication/pub.1083335812 schema:CreativeWork
265 https://doi.org/10.1016/0002-9378(85)90162-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053540765
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1016/s0016-5085(98)70638-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003370823
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/s0022-3476(05)81552-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039010386
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/s0196-9781(97)00370-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034964299
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1038/sj.bjp.0703691 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048709377
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1084/jem.192.4.565 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039202020
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1084/jem.20052203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014822532
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1097/00000658-199103000-00014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052421632
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1097/00024382-199803000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032210253
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1097/00024382-199808000-00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047972176
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1097/00024382-200404000-00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030254860
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1097/01.ccm.0000114575.08269.f6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001053690
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1097/01.pcc.0000137357.52609.f0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004653835
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1126/science.285.5425.248 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062565884
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1152/ajpheart.00048.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013123725
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1152/jappl.1995.79.6.2122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082974265
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1161/01.cir.0000105701.98663.d4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031460836
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1161/01.cir.43.4.480 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046102852
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1161/01.cir.97.8.752 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036845245
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1172/jci116338 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006854721
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1183/09031936.99.13114599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036995175
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1515/jpm.2004.126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000198984
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1556/aphysiol.95.2008.3.3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067880750
310 rdf:type schema:CreativeWork
311 https://www.grid.ac/institutes/grid.256115.4 schema:alternateName Fujita Health University
312 schema:name Department of Pediatric Surgery and Liver Transplantation, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
313 Research Center, VACSERA, Giza, Egypt
314 rdf:type schema:Organization
315 https://www.grid.ac/institutes/grid.260433.0 schema:alternateName Nagoya City University
316 schema:name Department of Immunology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan
317 Department of Pediatrics and Neonatology, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, 467-8601, Nagoya, Japan
318 rdf:type schema:Organization
319 https://www.grid.ac/institutes/grid.463319.a schema:alternateName Vacsera (Egypt)
320 schema:name Department of Obstetrics and Gynecology, VACSERA, Giza, Egypt
321 rdf:type schema:Organization
322 https://www.grid.ac/institutes/grid.474271.3 schema:alternateName Choju Medical Institute
323 schema:name Department of Immunology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan
324 Fukushimura Hospital Choju Medical Institute, Toyohashi, Japan
325 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...