Blunting the response to endotoxin in healthy subjects: effects of various doses of intravenous fish oil View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-10-21

AUTHORS

Yann K. Pittet, Mette M. Berger, Thomas-Thi Pluess, Pierre Voirol, Jean-Pierre Revelly, Luc Tappy, René L. Chioléro

ABSTRACT

ObjectiveTo test the dose response effect of infused fish oil (FO) rich in n-3 PUFAs on the inflammatory response to endotoxin (LPS) and on membrane incorporation of fatty acids in healthy subjects.DesignProspective, sequential investigation comparing three different FO doses.SubjectsThree groups of male subjects aged 26.8 ± 3.2 years (BMI 22.5 ± 2.1).InterventionOne of three FO doses (Omegaven®10%) as a slow infusion before LPS: 0.5 g/kg 1 day before LPS, 0.2 g/kg 1 day before, or 0.2 g/kg 2 h before.Measurements and resultsTemperature, hemodynamic variables, indirect calorimetry and blood samples (TNF-α, stress hormones) were collected. After LPS temperature, ACTH and TNF-α concentrations increased in the three groups: the responses were significantly blunted (p < 0.0001) compared with the control group of the Pluess et al. trial. Cortisol was unchanged. Lowest plasma ACTH, TNF-α and temperature AUC values were observed after a single 0.2 g/kg dose of FO. EPA incorporation into platelet membranes was dose-dependent.ConclusionsHaving previously shown that the response to LPS was reproducible, this study shows that three FO doses blunted it to various degrees. The 0.2 g/kg perfusion immediately before LPS was the most efficient in blunting the responses, suggesting LPS capture in addition to the systemic and membrane effects. More... »

PAGES

289-295

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00134-009-1689-8

DOI

http://dx.doi.org/10.1007/s00134-009-1689-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006857932

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19844694


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