The influence of corticosteroids on the release of novel biomarkers in human endotoxemia View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-12-14

AUTHORS

Martijn D. de Kruif, Lucienne C. Lemaire, Ida A. Giebelen, Joachim Struck, Nils G. Morgenthaler, Jana Papassotiriou, Peter J. Elliott, Tom van der Poll

ABSTRACT

ObjectiveSepsis intervention studies need better patient stratification methods, and one way to realize this is the introduction of stable biomarkers. A set of recently developed novel biomarkers, based upon precursor-fragments of short-lived hormones, was previously shown to be increased during sepsis. However, it is not known whether these biomarkers are influenced by sepsis intervention strategies. Therefore we investigated the markers in a model of human endotoxemia intervened by increasing doses of prednisolone.Design and settingProspective, open-label study in a specialized clinical research unit of a university hospital.SubjectsThirty-two healthy male volunteers.InterventionsSubjects received prednisolone orally at doses of 0, 3, 10 or 30 mg (n = 8 per group) at 2 h before intravenous injection of Escherichia coli lipopolysaccharide (LPS) (4 ng/kg). Blood samples were drawn during 24 h after LPS injection.Measurements and resultsLPS injection caused an increase in levels of midregional pro-adrenomedullin (MR-proADM), midregional pro-atrial natriuretic peptide (MR-proANP), C-terminal pro-arginine–vasopressin (CT-proAVP) and procalcitonin (PCT). Prednisolone caused a dose dependent inhibition of MR-proADM, MR-proANP and CT-proAVP levels.ConclusionsThese results show that a set of novel, highly stable sepsis biomarkers was increased during human endotoxemia and was dose-dependently inhibited by corticosteroid pre-treatment. More... »

PAGES

518-522

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00134-007-0955-x

DOI

http://dx.doi.org/10.1007/s00134-007-0955-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003678834

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18080111


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Administration, Oral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adrenomedullin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Arginine Vasopressin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Atrial Natriuretic Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcitonin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcitonin Gene-Related Peptide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dose-Response Relationship, Drug", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endotoxemia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Inflammation Mediators", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Injections, Intravenous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lipopolysaccharides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peptide Hormones", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prednisolone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Precursors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sepsis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Severity of Illness Index", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Center for Experimental and Molecular Medicine, Room G2-132, Academic Medical Center, Meibergdreef 9, 1105, Amsterdam, AZ, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.5650.6", 
          "name": [
            "Center for Experimental and Molecular Medicine, Room G2-132, Academic Medical Center, Meibergdreef 9, 1105, Amsterdam, AZ, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Kruif", 
        "givenName": "Martijn D.", 
        "id": "sg:person.0634575610.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634575610.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Anesthesiology, University Medical Center Utrecht, P.O. Box 85500, 3508, Utrecht, GA, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.7692.a", 
          "name": [
            "Department of Anesthesiology, University Medical Center Utrecht, P.O. Box 85500, 3508, Utrecht, GA, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lemaire", 
        "givenName": "Lucienne C.", 
        "id": "sg:person.01350275561.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350275561.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105, Amsterdam, AZ, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.7177.6", 
          "name": [
            "Center for Experimental and Molecular Medicine, Room G2-132, Academic Medical Center, Meibergdreef 9, 1105, Amsterdam, AZ, The Netherlands", 
            "Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105, Amsterdam, AZ, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Giebelen", 
        "givenName": "Ida A.", 
        "id": "sg:person.0721446327.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721446327.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Research Department, Brahms AG, Neuendorfstrasse 25, 16761, Hennigsdorf/Berlin, Germany", 
          "id": "http://www.grid.ac/institutes/grid.424957.9", 
          "name": [
            "Research Department, Brahms AG, Neuendorfstrasse 25, 16761, Hennigsdorf/Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Struck", 
        "givenName": "Joachim", 
        "id": "sg:person.01136323224.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136323224.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Research Department, Brahms AG, Neuendorfstrasse 25, 16761, Hennigsdorf/Berlin, Germany", 
          "id": "http://www.grid.ac/institutes/grid.424957.9", 
          "name": [
            "Research Department, Brahms AG, Neuendorfstrasse 25, 16761, Hennigsdorf/Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morgenthaler", 
        "givenName": "Nils G.", 
        "id": "sg:person.0707647370.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707647370.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Research Department, Brahms AG, Neuendorfstrasse 25, 16761, Hennigsdorf/Berlin, Germany", 
          "id": "http://www.grid.ac/institutes/grid.424957.9", 
          "name": [
            "Research Department, Brahms AG, Neuendorfstrasse 25, 16761, Hennigsdorf/Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Papassotiriou", 
        "givenName": "Jana", 
        "id": "sg:person.01320374536.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320374536.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sirtris Pharmaceuticals, 790 Memorial Drive, 02139, Cambridge, MA, USA", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "CombinatoRx, Inc., 245 st., 16th floor, 02142, Cambridge, MA, USA", 
            "Sirtris Pharmaceuticals, 790 Memorial Drive, 02139, Cambridge, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Elliott", 
        "givenName": "Peter J.", 
        "id": "sg:person.01334124356.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334124356.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105, Amsterdam, AZ, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.7177.6", 
          "name": [
            "Center for Experimental and Molecular Medicine, Room G2-132, Academic Medical Center, Meibergdreef 9, 1105, Amsterdam, AZ, The Netherlands", 
            "Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105, Amsterdam, AZ, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van der Poll", 
        "givenName": "Tom", 
        "id": "sg:person.01065476534.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065476534.34"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/cc3885", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044042016", 
          "https://doi.org/10.1186/cc3885"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc3015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004179597", 
          "https://doi.org/10.1186/cc3015"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2007-12-14", 
    "datePublishedReg": "2007-12-14", 
    "description": "ObjectiveSepsis intervention studies need better patient stratification methods, and one way to realize this is the introduction of stable biomarkers. A\u00a0set of recently developed novel biomarkers, based upon precursor-fragments of short-lived hormones, was previously shown to be increased during sepsis. However, it is not known whether these biomarkers are influenced by sepsis intervention strategies. Therefore we investigated the markers in a\u00a0model of human endotoxemia intervened by increasing doses of prednisolone.Design and settingProspective, open-label study in a\u00a0specialized clinical research unit of a\u00a0university hospital.SubjectsThirty-two healthy male volunteers.InterventionsSubjects received prednisolone orally at doses of 0, 3, 10 or 30\u202fmg (n\u202f=\u202f8 per group) at 2\u202fh before intravenous injection of Escherichia coli lipopolysaccharide (LPS) (4\u202fng/kg). Blood samples were drawn during 24\u202fh after LPS injection.Measurements and resultsLPS injection caused an increase in levels of midregional pro-adrenomedullin (MR-proADM), midregional pro-atrial natriuretic peptide (MR-proANP), C-terminal pro-arginine\u2013vasopressin (CT-proAVP) and procalcitonin (PCT). Prednisolone caused a\u00a0dose dependent inhibition of MR-proADM, MR-proANP and CT-proAVP levels.ConclusionsThese results show that a\u00a0set of novel, highly stable sepsis biomarkers was increased during human endotoxemia and was dose-dependently inhibited by corticosteroid pre-treatment.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00134-007-0955-x", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1313639", 
        "issn": [
          "0342-4642", 
          "1432-1238"
        ], 
        "name": "Intensive Care Medicine", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "34"
      }
    ], 
    "keywords": [
      "human endotoxemia", 
      "novel biomarkers", 
      "midregional pro-atrial natriuretic peptide", 
      "pro-atrial natriuretic peptide", 
      "open-label study", 
      "doses of prednisolone", 
      "influence of corticosteroids", 
      "clinical research unit", 
      "Escherichia coli lipopolysaccharide", 
      "dose-dependent inhibition", 
      "patient stratification methods", 
      "MR-proANP", 
      "MR-proADM", 
      "LPS injection", 
      "natriuretic peptide", 
      "University Hospital", 
      "sepsis biomarkers", 
      "intravenous injection", 
      "coli lipopolysaccharide", 
      "blood samples", 
      "intervention studies", 
      "endotoxemia", 
      "prednisolone", 
      "dependent inhibition", 
      "ConclusionsThese results", 
      "biomarkers", 
      "stable biomarkers", 
      "intervention strategies", 
      "procalcitonin", 
      "injection", 
      "lipopolysaccharide", 
      "doses", 
      "stratification method", 
      "sepsis", 
      "corticosteroids", 
      "hospital", 
      "Research Unit", 
      "vasopressin", 
      "dose", 
      "hormone", 
      "levels", 
      "InterventionsSubjects", 
      "inhibition", 
      "markers", 
      "study", 
      "peptides", 
      "release", 
      "increase", 
      "samples", 
      "strategies", 
      "units", 
      "results", 
      "set of novel", 
      "introduction", 
      "method", 
      "measurements", 
      "influence", 
      "model", 
      "novel", 
      "design", 
      "way", 
      "set"
    ], 
    "name": "The influence of corticosteroids on the release of novel biomarkers in human endotoxemia", 
    "pagination": "518-522", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1003678834"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00134-007-0955-x"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18080111"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00134-007-0955-x", 
      "https://app.dimensions.ai/details/publication/pub.1003678834"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-11-24T20:52", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/article/article_437.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00134-007-0955-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00134-007-0955-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00134-007-0955-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00134-007-0955-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00134-007-0955-x'


 

This table displays all metadata directly associated to this object as RDF triples.

278 TRIPLES      21 PREDICATES      110 URIs      100 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00134-007-0955-x schema:about N01830c75386c4ebba54bc7456455d93d
2 N1874181a21174db68169c74e6e173b8f
3 N2010332608c942edb4ec2606494a2d2b
4 N495e2921da8c4c78876d4e96dc8918eb
5 N6a6ef0f93edb46809c3532ebe1f6eec2
6 N6df2b7d4a8be47e2b57b221cce8e2f41
7 N71dbd4f844d24724a7047c8f15327e70
8 N734cf7f2d7e44d979d0eb742f79b9c10
9 N7e1963a6300048a79f04f3d452c3b6d4
10 N8554f4e795ca4f91a2610babede9f12b
11 N9162f9ba056a4c3b9e9ba91a4d5a98c0
12 N98e01998c6d943d68ad8fce5cb113606
13 N9d1af5ce0a6a49a59d8105ada2d06574
14 Nb744c66349d943cbbfef0ccc97a83fc2
15 Nb82980e5ecab4020a0364d1083841f95
16 Nca9d9a59c7f54594a4e61d31242512ed
17 Ncfdf239436454c2d99de4ed119707415
18 Ne0f4d4a83f2e426580ed2e5cbc10821a
19 Nee954b3a1f3f4bc59fea092aa166ed65
20 Nf1dc55a6e2bd46a19bbf22a5e5e77990
21 Nf57d3111eae349268d1faddf31be8717
22 anzsrc-for:11
23 anzsrc-for:1103
24 schema:author N13e5fb3cd79d46778b17d127f314cbce
25 schema:citation sg:pub.10.1186/cc3015
26 sg:pub.10.1186/cc3885
27 schema:datePublished 2007-12-14
28 schema:datePublishedReg 2007-12-14
29 schema:description ObjectiveSepsis intervention studies need better patient stratification methods, and one way to realize this is the introduction of stable biomarkers. A set of recently developed novel biomarkers, based upon precursor-fragments of short-lived hormones, was previously shown to be increased during sepsis. However, it is not known whether these biomarkers are influenced by sepsis intervention strategies. Therefore we investigated the markers in a model of human endotoxemia intervened by increasing doses of prednisolone.Design and settingProspective, open-label study in a specialized clinical research unit of a university hospital.SubjectsThirty-two healthy male volunteers.InterventionsSubjects received prednisolone orally at doses of 0, 3, 10 or 30 mg (n = 8 per group) at 2 h before intravenous injection of Escherichia coli lipopolysaccharide (LPS) (4 ng/kg). Blood samples were drawn during 24 h after LPS injection.Measurements and resultsLPS injection caused an increase in levels of midregional pro-adrenomedullin (MR-proADM), midregional pro-atrial natriuretic peptide (MR-proANP), C-terminal pro-arginine–vasopressin (CT-proAVP) and procalcitonin (PCT). Prednisolone caused a dose dependent inhibition of MR-proADM, MR-proANP and CT-proAVP levels.ConclusionsThese results show that a set of novel, highly stable sepsis biomarkers was increased during human endotoxemia and was dose-dependently inhibited by corticosteroid pre-treatment.
30 schema:genre article
31 schema:isAccessibleForFree true
32 schema:isPartOf N281fed059e0748b7a0db143b620c5d98
33 Na80e3e5a600e45c585be05002589aa22
34 sg:journal.1313639
35 schema:keywords ConclusionsThese results
36 Escherichia coli lipopolysaccharide
37 InterventionsSubjects
38 LPS injection
39 MR-proADM
40 MR-proANP
41 Research Unit
42 University Hospital
43 biomarkers
44 blood samples
45 clinical research unit
46 coli lipopolysaccharide
47 corticosteroids
48 dependent inhibition
49 design
50 dose
51 dose-dependent inhibition
52 doses
53 doses of prednisolone
54 endotoxemia
55 hormone
56 hospital
57 human endotoxemia
58 increase
59 influence
60 influence of corticosteroids
61 inhibition
62 injection
63 intervention strategies
64 intervention studies
65 intravenous injection
66 introduction
67 levels
68 lipopolysaccharide
69 markers
70 measurements
71 method
72 midregional pro-atrial natriuretic peptide
73 model
74 natriuretic peptide
75 novel
76 novel biomarkers
77 open-label study
78 patient stratification methods
79 peptides
80 prednisolone
81 pro-atrial natriuretic peptide
82 procalcitonin
83 release
84 results
85 samples
86 sepsis
87 sepsis biomarkers
88 set
89 set of novel
90 stable biomarkers
91 strategies
92 stratification method
93 study
94 units
95 vasopressin
96 way
97 schema:name The influence of corticosteroids on the release of novel biomarkers in human endotoxemia
98 schema:pagination 518-522
99 schema:productId N8394e4a584ae4077b1e8f4dfa1199b19
100 Ne7a3fc99e3944b0a962616a11d3c11c7
101 Nf681fac3b7e64270b0bbd9bcbccfea45
102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003678834
103 https://doi.org/10.1007/s00134-007-0955-x
104 schema:sdDatePublished 2022-11-24T20:52
105 schema:sdLicense https://scigraph.springernature.com/explorer/license/
106 schema:sdPublisher Nbe4fcec550b14078bfcf50fefc14f2db
107 schema:url https://doi.org/10.1007/s00134-007-0955-x
108 sgo:license sg:explorer/license/
109 sgo:sdDataset articles
110 rdf:type schema:ScholarlyArticle
111 N01830c75386c4ebba54bc7456455d93d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Adult
113 rdf:type schema:DefinedTerm
114 N13e5fb3cd79d46778b17d127f314cbce rdf:first sg:person.0634575610.77
115 rdf:rest Ne0251a9eb2b94dee800507d78022dd95
116 N1874181a21174db68169c74e6e173b8f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Peptide Hormones
118 rdf:type schema:DefinedTerm
119 N1988e1c514704fea9862bb779847a56a rdf:first sg:person.01320374536.30
120 rdf:rest N95c03b1f89f74d9187d940acd66a159f
121 N2010332608c942edb4ec2606494a2d2b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Calcitonin Gene-Related Peptide
123 rdf:type schema:DefinedTerm
124 N2240ffb81f664941ada1844a9df07126 rdf:first sg:person.0707647370.62
125 rdf:rest N1988e1c514704fea9862bb779847a56a
126 N281fed059e0748b7a0db143b620c5d98 schema:volumeNumber 34
127 rdf:type schema:PublicationVolume
128 N2d4ec8aa72074e0296226770e84fe8ab rdf:first sg:person.0721446327.90
129 rdf:rest N60df2411a0e94dbcbcad0d83400151ce
130 N495e2921da8c4c78876d4e96dc8918eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Adrenomedullin
132 rdf:type schema:DefinedTerm
133 N60df2411a0e94dbcbcad0d83400151ce rdf:first sg:person.01136323224.23
134 rdf:rest N2240ffb81f664941ada1844a9df07126
135 N6a6ef0f93edb46809c3532ebe1f6eec2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Male
137 rdf:type schema:DefinedTerm
138 N6df2b7d4a8be47e2b57b221cce8e2f41 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Prednisolone
140 rdf:type schema:DefinedTerm
141 N71dbd4f844d24724a7047c8f15327e70 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Injections, Intravenous
143 rdf:type schema:DefinedTerm
144 N734cf7f2d7e44d979d0eb742f79b9c10 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Dose-Response Relationship, Drug
146 rdf:type schema:DefinedTerm
147 N7e1963a6300048a79f04f3d452c3b6d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Inflammation Mediators
149 rdf:type schema:DefinedTerm
150 N8394e4a584ae4077b1e8f4dfa1199b19 schema:name doi
151 schema:value 10.1007/s00134-007-0955-x
152 rdf:type schema:PropertyValue
153 N8554f4e795ca4f91a2610babede9f12b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Biomarkers
155 rdf:type schema:DefinedTerm
156 N9162f9ba056a4c3b9e9ba91a4d5a98c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Arginine Vasopressin
158 rdf:type schema:DefinedTerm
159 N95c03b1f89f74d9187d940acd66a159f rdf:first sg:person.01334124356.07
160 rdf:rest Nab6a64ec0c0f485bbda9153b49aa936d
161 N98e01998c6d943d68ad8fce5cb113606 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Prospective Studies
163 rdf:type schema:DefinedTerm
164 N9d1af5ce0a6a49a59d8105ada2d06574 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Calcitonin
166 rdf:type schema:DefinedTerm
167 Na80e3e5a600e45c585be05002589aa22 schema:issueNumber 3
168 rdf:type schema:PublicationIssue
169 Nab6a64ec0c0f485bbda9153b49aa936d rdf:first sg:person.01065476534.34
170 rdf:rest rdf:nil
171 Nb744c66349d943cbbfef0ccc97a83fc2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Protein Precursors
173 rdf:type schema:DefinedTerm
174 Nb82980e5ecab4020a0364d1083841f95 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Sepsis
176 rdf:type schema:DefinedTerm
177 Nbe4fcec550b14078bfcf50fefc14f2db schema:name Springer Nature - SN SciGraph project
178 rdf:type schema:Organization
179 Nca9d9a59c7f54594a4e61d31242512ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Atrial Natriuretic Factor
181 rdf:type schema:DefinedTerm
182 Ncfdf239436454c2d99de4ed119707415 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Severity of Illness Index
184 rdf:type schema:DefinedTerm
185 Ne0251a9eb2b94dee800507d78022dd95 rdf:first sg:person.01350275561.40
186 rdf:rest N2d4ec8aa72074e0296226770e84fe8ab
187 Ne0f4d4a83f2e426580ed2e5cbc10821a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Administration, Oral
189 rdf:type schema:DefinedTerm
190 Ne7a3fc99e3944b0a962616a11d3c11c7 schema:name pubmed_id
191 schema:value 18080111
192 rdf:type schema:PropertyValue
193 Nee954b3a1f3f4bc59fea092aa166ed65 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Endotoxemia
195 rdf:type schema:DefinedTerm
196 Nf1dc55a6e2bd46a19bbf22a5e5e77990 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Lipopolysaccharides
198 rdf:type schema:DefinedTerm
199 Nf57d3111eae349268d1faddf31be8717 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Humans
201 rdf:type schema:DefinedTerm
202 Nf681fac3b7e64270b0bbd9bcbccfea45 schema:name dimensions_id
203 schema:value pub.1003678834
204 rdf:type schema:PropertyValue
205 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
206 schema:name Medical and Health Sciences
207 rdf:type schema:DefinedTerm
208 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
209 schema:name Clinical Sciences
210 rdf:type schema:DefinedTerm
211 sg:journal.1313639 schema:issn 0342-4642
212 1432-1238
213 schema:name Intensive Care Medicine
214 schema:publisher Springer Nature
215 rdf:type schema:Periodical
216 sg:person.01065476534.34 schema:affiliation grid-institutes:grid.7177.6
217 schema:familyName van der Poll
218 schema:givenName Tom
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065476534.34
220 rdf:type schema:Person
221 sg:person.01136323224.23 schema:affiliation grid-institutes:grid.424957.9
222 schema:familyName Struck
223 schema:givenName Joachim
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136323224.23
225 rdf:type schema:Person
226 sg:person.01320374536.30 schema:affiliation grid-institutes:grid.424957.9
227 schema:familyName Papassotiriou
228 schema:givenName Jana
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320374536.30
230 rdf:type schema:Person
231 sg:person.01334124356.07 schema:affiliation grid-institutes:None
232 schema:familyName Elliott
233 schema:givenName Peter J.
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334124356.07
235 rdf:type schema:Person
236 sg:person.01350275561.40 schema:affiliation grid-institutes:grid.7692.a
237 schema:familyName Lemaire
238 schema:givenName Lucienne C.
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350275561.40
240 rdf:type schema:Person
241 sg:person.0634575610.77 schema:affiliation grid-institutes:grid.5650.6
242 schema:familyName de Kruif
243 schema:givenName Martijn D.
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634575610.77
245 rdf:type schema:Person
246 sg:person.0707647370.62 schema:affiliation grid-institutes:grid.424957.9
247 schema:familyName Morgenthaler
248 schema:givenName Nils G.
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707647370.62
250 rdf:type schema:Person
251 sg:person.0721446327.90 schema:affiliation grid-institutes:grid.7177.6
252 schema:familyName Giebelen
253 schema:givenName Ida A.
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721446327.90
255 rdf:type schema:Person
256 sg:pub.10.1186/cc3015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004179597
257 https://doi.org/10.1186/cc3015
258 rdf:type schema:CreativeWork
259 sg:pub.10.1186/cc3885 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044042016
260 https://doi.org/10.1186/cc3885
261 rdf:type schema:CreativeWork
262 grid-institutes:None schema:alternateName Sirtris Pharmaceuticals, 790 Memorial Drive, 02139, Cambridge, MA, USA
263 schema:name CombinatoRx, Inc., 245 st., 16th floor, 02142, Cambridge, MA, USA
264 Sirtris Pharmaceuticals, 790 Memorial Drive, 02139, Cambridge, MA, USA
265 rdf:type schema:Organization
266 grid-institutes:grid.424957.9 schema:alternateName Research Department, Brahms AG, Neuendorfstrasse 25, 16761, Hennigsdorf/Berlin, Germany
267 schema:name Research Department, Brahms AG, Neuendorfstrasse 25, 16761, Hennigsdorf/Berlin, Germany
268 rdf:type schema:Organization
269 grid-institutes:grid.5650.6 schema:alternateName Center for Experimental and Molecular Medicine, Room G2-132, Academic Medical Center, Meibergdreef 9, 1105, Amsterdam, AZ, The Netherlands
270 schema:name Center for Experimental and Molecular Medicine, Room G2-132, Academic Medical Center, Meibergdreef 9, 1105, Amsterdam, AZ, The Netherlands
271 rdf:type schema:Organization
272 grid-institutes:grid.7177.6 schema:alternateName Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105, Amsterdam, AZ, The Netherlands
273 schema:name Center for Experimental and Molecular Medicine, Room G2-132, Academic Medical Center, Meibergdreef 9, 1105, Amsterdam, AZ, The Netherlands
274 Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105, Amsterdam, AZ, The Netherlands
275 rdf:type schema:Organization
276 grid-institutes:grid.7692.a schema:alternateName Department of Anesthesiology, University Medical Center Utrecht, P.O. Box 85500, 3508, Utrecht, GA, The Netherlands
277 schema:name Department of Anesthesiology, University Medical Center Utrecht, P.O. Box 85500, 3508, Utrecht, GA, The Netherlands
278 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...