Candidemia and candiduria in critically ill patients admitted to intensive care units in France: incidence, molecular diversity, management and outcome View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-10-02

AUTHORS

Marie-Elisabeth Bougnoux, Guillaume Kac, Philippe Aegerter, Christophe d’Enfert, Jean-Yves Fagon, CandiRea Study Group

ABSTRACT

ObjectiveTo determine the concomitant incidence, molecular diversity, management and outcome of nosocomial candidemia and candiduria in intensive care unit (ICU) patients in France.DesignA 1-year prospective observational study in 24 adult ICUs.PatientsTwo hundred and sixty-two patients with nosocomial candidemia and/or candiduria.Measurements and resultsBlood and urine samples were collected when signs of sepsis were present. Antifungal susceptibility of Candida strains was determined; in addition, all blood and 72% of urine C. albicans isolates were analyzed by using multi-locus sequence type (MLST). The mean incidences of candidemia and candiduria were 6.7 and 27.4/1000 admissions, respectively. Eight percent of candiduric patients developed candidemia with the same species. The mean interval between ICU admission and candidemia was 19.0 ± 2.9 days, and 17.2 ± 1.1 days for candiduria. C. albicans and C. glabrata were isolated in 54.2% and 17% of blood and 66.5% and 21.6% of urine Candida-positive cultures, respectively. Fluconazole was the most frequently prescribed agent. In all candidemic patients, the prescribed curative antifungal agent was active in vitro against the responsible identified strain. Crude ICU mortality was 61.8% for candidemic and 31.3% for candiduric patients. Seventy-five percent of the patients were infected with a unique C. albicans strain; cross-transmission between seven patients was suggested in one hospital.ConclusionsCandidemia is late-onset ICU-acquired infection associated with high mortality. No difference in susceptibility and genetic background were found between blood and urine strains of Candida species. More... »

PAGES

292-299

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00134-007-0865-y

DOI

http://dx.doi.org/10.1007/s00134-007-0865-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004256795

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17909746


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