Intravenous fish oil blunts the physiological response to endotoxin in healthy subjects View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-03-22

AUTHORS

Thomas-Thi Pluess, Daniel Hayoz, Mette M. Berger, Luc Tappy, Jean-Pierre Revelly, Burkhard Michaeli, Yvon A. Carpentier, René L. Chioléro

ABSTRACT

ObjectiveTo assess the effects of intravenous fish oil fat emulsion on the metabolic alterations induced by lipopolysaccharide (LPS) challenge in healthy volunteers.DesignTwo groups of eight healthy subjects were randomized to receive either two pharmacological doses of intravenous FO fat emulsion or no treatment. The FO group received twice 0.5 g/kg 10% emulsion (Omegaven) 48 and 24 h before investigation. LPS (2 ng/kg) was injected as a bolus on the investigation day. Systemic parameters, indirect calorimetry, heart rate variability, and platelet membrane phospholipid composition were measured.ResultsBasal EPA and DHA content in platelet phospholipids was low (0.28% and 2.54%, respectively) and increased significantly after FO to 1.68% and 3.32%. LPS induced reproducible effects in all subjects. Fever was higher in the FO group than in controls; the difference was significant from t120 until t360. FO blunted the neuroendocrine response: the rise in plasma norepinephrine was sevenfold lower at t120 while the ACTH peak was fourfold lower. Tumor necrosis factor α was significantly lower between t360 and t180 in the FO group.ConclusionsTwo doses of intravenous FO fat emulsion modified the phospholipid composition of platelets in healthy subjects. FO blunted fever and increased the neuroendocrine and the inflammatory responses to LPS. More... »

PAGES

789-797

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00134-007-0591-5

DOI

http://dx.doi.org/10.1007/s00134-007-0591-5

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https://app.dimensions.ai/details/publication/pub.1006746036

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17377770


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