Association between 4G/5G polymorphism of the plasminogen activator inhibitor 1 gene with stroke or encephalopathy after cardiac surgery View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-05

AUTHORS

Gonzalo Sirgo, José Luis Pérez-Vela, Pablo Morales, Manuel Del Rey, Joan Vendrell, Cristina Gutierrez, Jordi Rello

ABSTRACT

OBJECTIVE: To evaluate whether the 4G/5G polymorphism of the plasminogen activator inhibitor 1 gene increases the risk of thromboembolic neurological complications, and, if so, whether these complications lengthen the period of mechanical ventilation and hospital stay. DESIGN: Prospective, case-control study in a 14 bed surgical intensive care unit of a university hospital. PATIENTS: 260 consecutive patients who underwent cardiac surgery with cardiopulmonary bypass and 111 controls. INTERVENTIONS: DNA was isolated and 4G/5G polymorphism was typed using RFLP methodology. MEASUREMENTS AND RESULTS: Genetic analysis revealed 4G/5G in 131 patients (50.4%), 5G/5G genotype in 82 (31.5%), and 4G/4G in only 47 (18.1%). Prevalence of neurological complications was 20.8% (n=54) (stroke 5.4%, n=14; encephalopathy 15.4%, n=40]. A trend towards higher risk of developing stroke (8.5% vs. 4.7%, RR 1.9) and a significant twofold increase in encephalopathy (27.7% vs. 12.7%; RR 2.6) was documented in 4G/4G carriers. Multivariate analysis showed that development of stroke or encephalopathy was independently associated with prolonged mechanical ventilation (OR 20), and that neurological complication (OR 2.4) and 4G/4G genotype (OR 2.6) were independently associated with hospital stay of 2 weeks or longer. CONCLUSIONS: The 4G/4G genotype can increase the risk of thromboembolic neurological complications after cardiac surgery with cardiopulmonary by-pass. The neurological complications result in longer time on ventilator and longer hospital stay. More... »

PAGES

668-675

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00134-006-0092-y

DOI

http://dx.doi.org/10.1007/s00134-006-0092-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051262016

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16508752


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00134-006-0092-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00134-006-0092-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00134-006-0092-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00134-006-0092-y'


 

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