Effect of bicarbonate and lactate buffer on glucose and lactate metabolism during hemodiafiltration in patients with multiple organ failure View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2004-03-27

AUTHORS

Marc-Daniel Bollmann, Jean-Pierre Revelly, Luc Tappy, Mette M. Berger, Marie-Denise Schaller, Marie-Christine Cayeux, Alexandre Martinez, René-Louis Chioléro

ABSTRACT

ObjectiveTo compare the effects of sodium bicarbonate and lactate for continuous veno-venous hemodiafiltration (CVVHDF) in critically ill patients.Design and settingsProspective crossed-over controlled trial in the surgical and medical ICUs of a university hospital.PatientsEight patients with multiple organ dysfunction syndrome (MODS) requiring CVVHDF.InterventionEach patient received the two buffers in a randomized sequence over two consecutive days.Measurements and resultsThe following variables were determined: acid-base parameters, lactate production and utilization (13C lactate infusion), glucose turnover (6,62H2-glucose), gas exchange (indirect calorimetry). No side effect was observed during lactate administration. Baseline arterial acid-base variables were equal with the two buffers. Arterial lactate (2.9 versus 1.5 mmol/l), glycemia (+18%) and glucose turnover (+23%) were higher in the lactate period. Bicarbonate and glucose losses in CVVHDF were substantial, but not lactate elimination. Infusing 13C lactate increased plasma lactate levels equally with the two buffers. Lactate clearance (7.8±0.8 vs 7.5±0.8 ml/kg per min in the bicarbonate and lactate periods) and endogenous production rates (14.0±2.6 vs 13.6±2.6 mmol/kg per min) were similar. 13C lactate was used as a metabolic substrate, as shown by 13CO2 excretion. Glycemia and metabolic rate increased significantly and similarly during the two periods during lactate infusion.ConclusionLactate was rapidly cleared from the blood of critically ill patients without acute liver failure requiring CVVHDF, being transformed into glucose or oxidized. Lactate did not exert undesirable effects, except moderate hyperglycemia, and achieved comparable effects on acid-base balance to bicarbonate. More... »

PAGES

1103-1110

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00134-004-2251-3

DOI

http://dx.doi.org/10.1007/s00134-004-2251-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043825573

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15048552


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Acid-Base Equilibrium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Analysis of Variance", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Glucose", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Buffers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cross-Over Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hemodiafiltration", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lactic Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Metabolic Clearance Rate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Multiple Organ Failure", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sodium Bicarbonate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Water-Electrolyte Balance", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Surgical Intensive Care Unit, University Hospital CHUV, 1011, Lausanne, Switzerland", 
          "id": "http://www.grid.ac/institutes/grid.8515.9", 
          "name": [
            "Surgical Intensive Care Unit, University Hospital CHUV, 1011, Lausanne, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bollmann", 
        "givenName": "Marc-Daniel", 
        "id": "sg:person.01242044707.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242044707.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Surgical Intensive Care Unit, University Hospital CHUV, 1011, Lausanne, Switzerland", 
          "id": "http://www.grid.ac/institutes/grid.8515.9", 
          "name": [
            "Surgical Intensive Care Unit, University Hospital CHUV, 1011, Lausanne, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Revelly", 
        "givenName": "Jean-Pierre", 
        "id": "sg:person.0725460421.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725460421.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Human Physiology, University of Lausanne, 1005, Lausanne, Switzerland", 
          "id": "http://www.grid.ac/institutes/grid.9851.5", 
          "name": [
            "Institute of Human Physiology, University of Lausanne, 1005, Lausanne, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tappy", 
        "givenName": "Luc", 
        "id": "sg:person.01171031441.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171031441.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Surgical Intensive Care Unit, University Hospital CHUV, 1011, Lausanne, Switzerland", 
          "id": "http://www.grid.ac/institutes/grid.8515.9", 
          "name": [
            "Surgical Intensive Care Unit, University Hospital CHUV, 1011, Lausanne, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Berger", 
        "givenName": "Mette M.", 
        "id": "sg:person.01160620574.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160620574.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical Intensive Care Unit, University Hospital CHUV, 1011, Lausanne, Switzerland", 
          "id": "http://www.grid.ac/institutes/grid.8515.9", 
          "name": [
            "Medical Intensive Care Unit, University Hospital CHUV, 1011, Lausanne, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schaller", 
        "givenName": "Marie-Denise", 
        "id": "sg:person.0640737277.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640737277.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Surgical Intensive Care Unit, University Hospital CHUV, 1011, Lausanne, Switzerland", 
          "id": "http://www.grid.ac/institutes/grid.8515.9", 
          "name": [
            "Surgical Intensive Care Unit, University Hospital CHUV, 1011, Lausanne, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cayeux", 
        "givenName": "Marie-Christine", 
        "id": "sg:person.01330464750.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330464750.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Surgical Intensive Care Unit, University Hospital CHUV, 1011, Lausanne, Switzerland", 
          "id": "http://www.grid.ac/institutes/grid.8515.9", 
          "name": [
            "Surgical Intensive Care Unit, University Hospital CHUV, 1011, Lausanne, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Martinez", 
        "givenName": "Alexandre", 
        "id": "sg:person.01225271076.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225271076.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Surgical Intensive Care Unit, University Hospital CHUV, 1011, Lausanne, Switzerland", 
          "id": "http://www.grid.ac/institutes/grid.8515.9", 
          "name": [
            "Surgical Intensive Care Unit, University Hospital CHUV, 1011, Lausanne, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chiol\u00e9ro", 
        "givenName": "Ren\u00e9-Louis", 
        "id": "sg:person.01121362247.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121362247.08"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s001340051052", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049346943", 
          "https://doi.org/10.1007/s001340051052"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01709751", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052044737", 
          "https://doi.org/10.1007/bf01709751"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2004-03-27", 
    "datePublishedReg": "2004-03-27", 
    "description": "ObjectiveTo compare the effects of sodium bicarbonate and lactate for continuous veno-venous hemodiafiltration (CVVHDF) in critically ill patients.Design and settingsProspective crossed-over controlled trial in the surgical and medical ICUs of a university hospital.PatientsEight patients with multiple organ dysfunction syndrome (MODS) requiring CVVHDF.InterventionEach patient received the two buffers in a randomized sequence over two consecutive days.Measurements and resultsThe following variables were determined: acid-base parameters, lactate production and utilization (13C lactate infusion), glucose turnover (6,62H2-glucose), gas exchange (indirect calorimetry). No side effect was observed during lactate administration. Baseline arterial acid-base variables were equal with the two buffers. Arterial lactate (2.9 versus 1.5\u00a0mmol/l), glycemia (+18%) and glucose turnover (+23%) were higher in the lactate period. Bicarbonate and glucose losses in CVVHDF were substantial, but not lactate elimination. Infusing 13C lactate increased plasma lactate levels equally with the two buffers. Lactate clearance (7.8\u00b10.8 vs 7.5\u00b10.8\u00a0ml/kg per min in the bicarbonate and lactate periods) and endogenous production rates (14.0\u00b12.6 vs 13.6\u00b12.6\u00a0mmol/kg per min) were similar. 13C lactate was used as a metabolic substrate, as shown by 13CO2 excretion. Glycemia and metabolic rate increased significantly and similarly during the two periods during lactate infusion.ConclusionLactate was rapidly cleared from the blood of critically ill patients without acute liver failure requiring CVVHDF, being transformed into glucose or oxidized. Lactate did not exert undesirable effects, except moderate hyperglycemia, and achieved comparable effects on acid-base balance to bicarbonate.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00134-004-2251-3", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1313639", 
        "issn": [
          "0342-4642", 
          "1432-1238"
        ], 
        "name": "Intensive Care Medicine", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "30"
      }
    ], 
    "keywords": [
      "continuous veno-venous hemodiafiltration", 
      "multiple organ dysfunction syndrome", 
      "ill patients", 
      "organ dysfunction syndrome", 
      "multiple organ failure", 
      "veno-venous hemodiafiltration", 
      "acute liver failure", 
      "plasma lactate levels", 
      "endogenous production rate", 
      "acid-base balance", 
      "PatientsEight patients", 
      "medical ICU", 
      "acid-base variables", 
      "dysfunction syndrome", 
      "liver failure", 
      "organ failure", 
      "lactate administration", 
      "arterial lactate", 
      "moderate hyperglycemia", 
      "University Hospital", 
      "lactate clearance", 
      "acid-base parameters", 
      "lactate infusion", 
      "lactate levels", 
      "side effects", 
      "patients", 
      "consecutive days", 
      "glucose turnover", 
      "glucose loss", 
      "randomized sequence", 
      "metabolic substrates", 
      "comparable effects", 
      "hemodiafiltration", 
      "lactate", 
      "sodium bicarbonate", 
      "metabolic rate", 
      "effect of bicarbonate", 
      "glucose", 
      "gas exchange", 
      "bicarbonate", 
      "ICU", 
      "glycemia", 
      "hyperglycemia", 
      "failure", 
      "syndrome", 
      "infusion", 
      "hospital", 
      "ObjectiveTo", 
      "excretion", 
      "blood", 
      "administration", 
      "trials", 
      "clearance", 
      "ResultsThe", 
      "effect", 
      "undesirable effects", 
      "period", 
      "metabolism", 
      "days", 
      "rate", 
      "turnover", 
      "levels", 
      "variables", 
      "elimination", 
      "loss", 
      "balance", 
      "utilization", 
      "buffer", 
      "production", 
      "measurements", 
      "parameters", 
      "sequence", 
      "design", 
      "exchange", 
      "production rate", 
      "substrate"
    ], 
    "name": "Effect of bicarbonate and lactate buffer on glucose and lactate metabolism during hemodiafiltration in patients with multiple organ failure", 
    "pagination": "1103-1110", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1043825573"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00134-004-2251-3"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "15048552"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00134-004-2251-3", 
      "https://app.dimensions.ai/details/publication/pub.1043825573"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:32", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_391.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00134-004-2251-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00134-004-2251-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00134-004-2251-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00134-004-2251-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00134-004-2251-3'


 

This table displays all metadata directly associated to this object as RDF triples.

267 TRIPLES      21 PREDICATES      120 URIs      110 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00134-004-2251-3 schema:about N00db3030db3e428aa7ce24d12f7b279f
2 N0e6d6bdb8afe4314bebc4e7b7a5a45c2
3 N1521ef57cbf8401597c220547755f351
4 N1c41e65a24944c49bce944aa5cc828c7
5 N22c1e1564d3b47d390afc64e89cc3eae
6 N2b72c80e63464c018e3c3742801cd62b
7 N41a814bbc7c8467fb318bfd05660df3e
8 N441ee20da78c45dc8eb2690e63c1941d
9 N5cfa1f5b57994cc0bd09ace035410f07
10 N73fe5fcf2e18485ca923993c6237e659
11 N8654ba6dd6ea49f49b26bb072d2364b0
12 N96af55009dee414d88e8083faf670be5
13 Na65dff8e98124cbfbfe889b9b9771a48
14 Nb48f6b77011d42ada622e7ebd4a2ad07
15 Ndb1f56e90c7a417e9ef3aef9addc03eb
16 Neaa983e029b947c5bbe827aa00b8a27c
17 Nff2a0b8cdd284266a988f0b896656fcf
18 anzsrc-for:11
19 anzsrc-for:1103
20 schema:author N93a7f79b7991412cbd2df740153cdfb8
21 schema:citation sg:pub.10.1007/bf01709751
22 sg:pub.10.1007/s001340051052
23 schema:datePublished 2004-03-27
24 schema:datePublishedReg 2004-03-27
25 schema:description ObjectiveTo compare the effects of sodium bicarbonate and lactate for continuous veno-venous hemodiafiltration (CVVHDF) in critically ill patients.Design and settingsProspective crossed-over controlled trial in the surgical and medical ICUs of a university hospital.PatientsEight patients with multiple organ dysfunction syndrome (MODS) requiring CVVHDF.InterventionEach patient received the two buffers in a randomized sequence over two consecutive days.Measurements and resultsThe following variables were determined: acid-base parameters, lactate production and utilization (13C lactate infusion), glucose turnover (6,62H2-glucose), gas exchange (indirect calorimetry). No side effect was observed during lactate administration. Baseline arterial acid-base variables were equal with the two buffers. Arterial lactate (2.9 versus 1.5 mmol/l), glycemia (+18%) and glucose turnover (+23%) were higher in the lactate period. Bicarbonate and glucose losses in CVVHDF were substantial, but not lactate elimination. Infusing 13C lactate increased plasma lactate levels equally with the two buffers. Lactate clearance (7.8±0.8 vs 7.5±0.8 ml/kg per min in the bicarbonate and lactate periods) and endogenous production rates (14.0±2.6 vs 13.6±2.6 mmol/kg per min) were similar. 13C lactate was used as a metabolic substrate, as shown by 13CO2 excretion. Glycemia and metabolic rate increased significantly and similarly during the two periods during lactate infusion.ConclusionLactate was rapidly cleared from the blood of critically ill patients without acute liver failure requiring CVVHDF, being transformed into glucose or oxidized. Lactate did not exert undesirable effects, except moderate hyperglycemia, and achieved comparable effects on acid-base balance to bicarbonate.
26 schema:genre article
27 schema:isAccessibleForFree true
28 schema:isPartOf N43b7f712a58c491c81bbf4584d388cde
29 N733f7c6931fa4704852943a5ab0a4bdd
30 sg:journal.1313639
31 schema:keywords ICU
32 ObjectiveTo
33 PatientsEight patients
34 ResultsThe
35 University Hospital
36 acid-base balance
37 acid-base parameters
38 acid-base variables
39 acute liver failure
40 administration
41 arterial lactate
42 balance
43 bicarbonate
44 blood
45 buffer
46 clearance
47 comparable effects
48 consecutive days
49 continuous veno-venous hemodiafiltration
50 days
51 design
52 dysfunction syndrome
53 effect
54 effect of bicarbonate
55 elimination
56 endogenous production rate
57 exchange
58 excretion
59 failure
60 gas exchange
61 glucose
62 glucose loss
63 glucose turnover
64 glycemia
65 hemodiafiltration
66 hospital
67 hyperglycemia
68 ill patients
69 infusion
70 lactate
71 lactate administration
72 lactate clearance
73 lactate infusion
74 lactate levels
75 levels
76 liver failure
77 loss
78 measurements
79 medical ICU
80 metabolic rate
81 metabolic substrates
82 metabolism
83 moderate hyperglycemia
84 multiple organ dysfunction syndrome
85 multiple organ failure
86 organ dysfunction syndrome
87 organ failure
88 parameters
89 patients
90 period
91 plasma lactate levels
92 production
93 production rate
94 randomized sequence
95 rate
96 sequence
97 side effects
98 sodium bicarbonate
99 substrate
100 syndrome
101 trials
102 turnover
103 undesirable effects
104 utilization
105 variables
106 veno-venous hemodiafiltration
107 schema:name Effect of bicarbonate and lactate buffer on glucose and lactate metabolism during hemodiafiltration in patients with multiple organ failure
108 schema:pagination 1103-1110
109 schema:productId N088617c24d5c486ab8145b2611f817d4
110 Nacbe82875b174dcca1fb33f9a9e993da
111 Nc296ca65ed774bb6a81babb65e9d6e5c
112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043825573
113 https://doi.org/10.1007/s00134-004-2251-3
114 schema:sdDatePublished 2022-10-01T06:32
115 schema:sdLicense https://scigraph.springernature.com/explorer/license/
116 schema:sdPublisher N8402051db03c47d48ec5409638fae92f
117 schema:url https://doi.org/10.1007/s00134-004-2251-3
118 sgo:license sg:explorer/license/
119 sgo:sdDataset articles
120 rdf:type schema:ScholarlyArticle
121 N00db3030db3e428aa7ce24d12f7b279f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Male
123 rdf:type schema:DefinedTerm
124 N088617c24d5c486ab8145b2611f817d4 schema:name doi
125 schema:value 10.1007/s00134-004-2251-3
126 rdf:type schema:PropertyValue
127 N0e6d6bdb8afe4314bebc4e7b7a5a45c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Sodium Bicarbonate
129 rdf:type schema:DefinedTerm
130 N1521ef57cbf8401597c220547755f351 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Lactic Acid
132 rdf:type schema:DefinedTerm
133 N1c41e65a24944c49bce944aa5cc828c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Acid-Base Equilibrium
135 rdf:type schema:DefinedTerm
136 N22c1e1564d3b47d390afc64e89cc3eae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Analysis of Variance
138 rdf:type schema:DefinedTerm
139 N2b72c80e63464c018e3c3742801cd62b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Multiple Organ Failure
141 rdf:type schema:DefinedTerm
142 N39a8a2f77b5c44b5b8fb11d1c248b325 rdf:first sg:person.0725460421.52
143 rdf:rest Nb03e7fb04341429bacab22fdceebaaa0
144 N41a814bbc7c8467fb318bfd05660df3e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Female
146 rdf:type schema:DefinedTerm
147 N43b7f712a58c491c81bbf4584d388cde schema:volumeNumber 30
148 rdf:type schema:PublicationVolume
149 N441ee20da78c45dc8eb2690e63c1941d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Blood Glucose
151 rdf:type schema:DefinedTerm
152 N5cfa1f5b57994cc0bd09ace035410f07 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Hemodiafiltration
154 rdf:type schema:DefinedTerm
155 N733f7c6931fa4704852943a5ab0a4bdd schema:issueNumber 6
156 rdf:type schema:PublicationIssue
157 N73fe5fcf2e18485ca923993c6237e659 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Metabolic Clearance Rate
159 rdf:type schema:DefinedTerm
160 N8402051db03c47d48ec5409638fae92f schema:name Springer Nature - SN SciGraph project
161 rdf:type schema:Organization
162 N8654ba6dd6ea49f49b26bb072d2364b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Cross-Over Studies
164 rdf:type schema:DefinedTerm
165 N93a7f79b7991412cbd2df740153cdfb8 rdf:first sg:person.01242044707.37
166 rdf:rest N39a8a2f77b5c44b5b8fb11d1c248b325
167 N96af55009dee414d88e8083faf670be5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Middle Aged
169 rdf:type schema:DefinedTerm
170 N9954bf3c8c6c4a16871b3d97ffa23130 rdf:first sg:person.0640737277.45
171 rdf:rest Nced26f2b366941189361c807359b3a5c
172 Na65dff8e98124cbfbfe889b9b9771a48 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Prospective Studies
174 rdf:type schema:DefinedTerm
175 Nacbe82875b174dcca1fb33f9a9e993da schema:name dimensions_id
176 schema:value pub.1043825573
177 rdf:type schema:PropertyValue
178 Nb03e7fb04341429bacab22fdceebaaa0 rdf:first sg:person.01171031441.29
179 rdf:rest Nece2d5c952e24432b17a3561fa332244
180 Nb48f6b77011d42ada622e7ebd4a2ad07 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Humans
182 rdf:type schema:DefinedTerm
183 Nc296ca65ed774bb6a81babb65e9d6e5c schema:name pubmed_id
184 schema:value 15048552
185 rdf:type schema:PropertyValue
186 Nc4cb7c9d7e884a678054f9df18921dfa rdf:first sg:person.01121362247.08
187 rdf:rest rdf:nil
188 Ncac4e2168c01460481aae20ae9fb1e12 rdf:first sg:person.01225271076.20
189 rdf:rest Nc4cb7c9d7e884a678054f9df18921dfa
190 Nced26f2b366941189361c807359b3a5c rdf:first sg:person.01330464750.99
191 rdf:rest Ncac4e2168c01460481aae20ae9fb1e12
192 Ndb1f56e90c7a417e9ef3aef9addc03eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Water-Electrolyte Balance
194 rdf:type schema:DefinedTerm
195 Neaa983e029b947c5bbe827aa00b8a27c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name Aged
197 rdf:type schema:DefinedTerm
198 Nece2d5c952e24432b17a3561fa332244 rdf:first sg:person.01160620574.24
199 rdf:rest N9954bf3c8c6c4a16871b3d97ffa23130
200 Nff2a0b8cdd284266a988f0b896656fcf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Buffers
202 rdf:type schema:DefinedTerm
203 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
204 schema:name Medical and Health Sciences
205 rdf:type schema:DefinedTerm
206 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
207 schema:name Clinical Sciences
208 rdf:type schema:DefinedTerm
209 sg:journal.1313639 schema:issn 0342-4642
210 1432-1238
211 schema:name Intensive Care Medicine
212 schema:publisher Springer Nature
213 rdf:type schema:Periodical
214 sg:person.01121362247.08 schema:affiliation grid-institutes:grid.8515.9
215 schema:familyName Chioléro
216 schema:givenName René-Louis
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121362247.08
218 rdf:type schema:Person
219 sg:person.01160620574.24 schema:affiliation grid-institutes:grid.8515.9
220 schema:familyName Berger
221 schema:givenName Mette M.
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160620574.24
223 rdf:type schema:Person
224 sg:person.01171031441.29 schema:affiliation grid-institutes:grid.9851.5
225 schema:familyName Tappy
226 schema:givenName Luc
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171031441.29
228 rdf:type schema:Person
229 sg:person.01225271076.20 schema:affiliation grid-institutes:grid.8515.9
230 schema:familyName Martinez
231 schema:givenName Alexandre
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225271076.20
233 rdf:type schema:Person
234 sg:person.01242044707.37 schema:affiliation grid-institutes:grid.8515.9
235 schema:familyName Bollmann
236 schema:givenName Marc-Daniel
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242044707.37
238 rdf:type schema:Person
239 sg:person.01330464750.99 schema:affiliation grid-institutes:grid.8515.9
240 schema:familyName Cayeux
241 schema:givenName Marie-Christine
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330464750.99
243 rdf:type schema:Person
244 sg:person.0640737277.45 schema:affiliation grid-institutes:grid.8515.9
245 schema:familyName Schaller
246 schema:givenName Marie-Denise
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640737277.45
248 rdf:type schema:Person
249 sg:person.0725460421.52 schema:affiliation grid-institutes:grid.8515.9
250 schema:familyName Revelly
251 schema:givenName Jean-Pierre
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725460421.52
253 rdf:type schema:Person
254 sg:pub.10.1007/bf01709751 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052044737
255 https://doi.org/10.1007/bf01709751
256 rdf:type schema:CreativeWork
257 sg:pub.10.1007/s001340051052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049346943
258 https://doi.org/10.1007/s001340051052
259 rdf:type schema:CreativeWork
260 grid-institutes:grid.8515.9 schema:alternateName Medical Intensive Care Unit, University Hospital CHUV, 1011, Lausanne, Switzerland
261 Surgical Intensive Care Unit, University Hospital CHUV, 1011, Lausanne, Switzerland
262 schema:name Medical Intensive Care Unit, University Hospital CHUV, 1011, Lausanne, Switzerland
263 Surgical Intensive Care Unit, University Hospital CHUV, 1011, Lausanne, Switzerland
264 rdf:type schema:Organization
265 grid-institutes:grid.9851.5 schema:alternateName Institute of Human Physiology, University of Lausanne, 1005, Lausanne, Switzerland
266 schema:name Institute of Human Physiology, University of Lausanne, 1005, Lausanne, Switzerland
267 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...