Ontology type: schema:ScholarlyArticle
2004-01-08
AUTHORSJoachim Boldt, Michael Ducke, Bernhard Kumle, Michael Papsdorf, Ernst-Ludwig Zurmeyer
ABSTRACTObjectiveAdequate restoration of intravascular volume remains an important maneuver in the management of the surgical patient. Influence of different volume replacement regimens on inflammation/endothelial activation in elderly surgical patients was assessed.DesignProspective, randomized study.SettingSurgical intensive care unit of a university-affiliated hospital.PatientsSixty-six patients >65 years undergoing major abdominal surgery.InterventionsRinger’s lactate (RL; n=22), normal saline solution (NS; n=22) or a low-molecular HES (mean molecular weight 130 kD) with a low degree of substitution (0.4; HES 130/0.4; n=22) were administered after induction of anesthesia until the 1st postoperative day (POD) to keep central venous pressure between 8–12 mmHg.Measurements and resultsC-reactive protein, interleukins (IL-6, IL-8), adhesion molecules [endothelial leukocyte adhesion molecule-1 (ELAM-1) and intercellular adhesion molecule-1 (ICAM-1)] were measured prior to volume therapy at the end of surgery, 5 h after surgery and at the morning of the 1st POD. RL patients received 10,150±1,660 ml of RL, NS patients 10,220±1,770 ml of NS and the HES-treated group 2,850±300 ml of HES 130/0.4 and 2,810±350 ml of RL. Hemodynamics were similar in all groups. CRP, IL-6 and IL-8 plasma levels increased significantly higher in both crystalloid groups (IL-6 in the NS group: increase to 407±33 pg/ml; RL: increase to 377±35 pg/dl) than in the HES-130 treated group (IL-6: increase to 197±20 pg/dl). Plasma levels of ELAM-1 and ICAM remained almost unchanged in the HES 130-, but significantly increased in the RL- and NS-treated patients.ConclusionsIn elderly patients, markers of inflammation and endothelial injury and activation were significantly higher after crystalloid- than after HES 130/0.4-based volume replacement regimens. More... »
PAGES416-422
http://scigraph.springernature.com/pub.10.1007/s00134-003-2110-7
DOIhttp://dx.doi.org/10.1007/s00134-003-2110-7
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1019887304
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/14712346
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Abdomen",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Analysis of Variance",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Adhesion Molecules",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Crystalloid Solutions",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Endothelium",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Fluid Therapy",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Hydroxyethyl Starch Derivatives",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Inflammation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Isotonic Solutions",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Perioperative Care",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Plasma Substitutes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Prospective Studies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Statistics, Nonparametric",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Department of Anesthesiology and Intensive Care Medicine, Klinikum der Stadt Ludwigshafen, Bremserstr. 79, 67063, Ludwigshafen, Germany",
"id": "http://www.grid.ac/institutes/grid.413225.3",
"name": [
"Department of Anesthesiology and Intensive Care Medicine, Klinikum der Stadt Ludwigshafen, Bremserstr. 79, 67063, Ludwigshafen, Germany"
],
"type": "Organization"
},
"familyName": "Boldt",
"givenName": "Joachim",
"id": "sg:person.01230376335.52",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230376335.52"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Anesthesiology and Intensive Care Medicine, Klinikum der Stadt Ludwigshafen, Bremserstr. 79, 67063, Ludwigshafen, Germany",
"id": "http://www.grid.ac/institutes/grid.413225.3",
"name": [
"Department of Anesthesiology and Intensive Care Medicine, Klinikum der Stadt Ludwigshafen, Bremserstr. 79, 67063, Ludwigshafen, Germany"
],
"type": "Organization"
},
"familyName": "Ducke",
"givenName": "Michael",
"id": "sg:person.0673260716.30",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673260716.30"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Anesthesiology and Intensive Care Medicine, Klinikum der Stadt Ludwigshafen, Bremserstr. 79, 67063, Ludwigshafen, Germany",
"id": "http://www.grid.ac/institutes/grid.413225.3",
"name": [
"Department of Anesthesiology and Intensive Care Medicine, Klinikum der Stadt Ludwigshafen, Bremserstr. 79, 67063, Ludwigshafen, Germany"
],
"type": "Organization"
},
"familyName": "Kumle",
"givenName": "Bernhard",
"id": "sg:person.0667135136.80",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667135136.80"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Anesthesiology and Intensive Care Medicine, Klinikum der Stadt Ludwigshafen, Bremserstr. 79, 67063, Ludwigshafen, Germany",
"id": "http://www.grid.ac/institutes/grid.413225.3",
"name": [
"Department of Anesthesiology and Intensive Care Medicine, Klinikum der Stadt Ludwigshafen, Bremserstr. 79, 67063, Ludwigshafen, Germany"
],
"type": "Organization"
},
"familyName": "Papsdorf",
"givenName": "Michael",
"id": "sg:person.01302464363.49",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302464363.49"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Surgery, Klinikum der Stadt Ludwigshafen, Ludwigshafen, Germany",
"id": "http://www.grid.ac/institutes/grid.413225.3",
"name": [
"Department of Surgery, Klinikum der Stadt Ludwigshafen, Ludwigshafen, Germany"
],
"type": "Organization"
},
"familyName": "Zurmeyer",
"givenName": "Ernst-Ludwig",
"id": "sg:person.01055622516.79",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055622516.79"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1186/cc346",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033387661",
"https://doi.org/10.1186/cc346"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/cc1510",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020023808",
"https://doi.org/10.1186/cc1510"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s001340050644",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047827913",
"https://doi.org/10.1007/s001340050644"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s001010050814",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047328477",
"https://doi.org/10.1007/s001010050814"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf02425053",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011814785",
"https://doi.org/10.1007/bf02425053"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00390-002-0336-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045957630",
"https://doi.org/10.1007/s00390-002-0336-1"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00134-001-1126-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050918576",
"https://doi.org/10.1007/s00134-001-1126-0"
],
"type": "CreativeWork"
}
],
"datePublished": "2004-01-08",
"datePublishedReg": "2004-01-08",
"description": "ObjectiveAdequate restoration of intravascular volume remains an important maneuver in the management of the surgical patient. Influence of different volume replacement regimens on inflammation/endothelial activation in elderly surgical patients was assessed.DesignProspective, randomized study.SettingSurgical intensive care unit of a university-affiliated hospital.PatientsSixty-six patients >65\u00a0years undergoing major abdominal surgery.InterventionsRinger\u2019s lactate (RL; n=22), normal saline solution (NS; n=22) or a low-molecular HES (mean molecular weight 130\u00a0kD) with a low degree of substitution (0.4; HES 130/0.4; n=22) were administered after induction of anesthesia until the 1st postoperative day (POD) to keep central venous pressure between 8\u201312\u00a0mmHg.Measurements and resultsC-reactive protein, interleukins (IL-6, IL-8), adhesion molecules [endothelial leukocyte adhesion molecule-1 (ELAM-1) and intercellular adhesion molecule-1 (ICAM-1)] were measured prior to volume therapy at the end of surgery, 5\u00a0h after surgery and at the morning of the 1st POD. RL patients received 10,150\u00b11,660\u00a0ml of RL, NS patients 10,220\u00b11,770\u00a0ml of NS and the HES-treated group 2,850\u00b1300\u00a0ml of HES 130/0.4 and 2,810\u00b1350\u00a0ml of RL. Hemodynamics were similar in all groups. CRP, IL-6 and IL-8 plasma levels increased significantly higher in both crystalloid groups (IL-6 in the NS group: increase to 407\u00b133\u00a0pg/ml; RL: increase to 377\u00b135\u00a0pg/dl) than in the HES-130 treated group (IL-6: increase to 197\u00b120\u00a0pg/dl). Plasma levels of ELAM-1 and ICAM remained almost unchanged in the HES 130-, but significantly increased in the RL- and NS-treated patients.ConclusionsIn elderly patients, markers of inflammation and endothelial injury and activation were significantly higher after crystalloid- than after HES 130/0.4-based volume replacement regimens.",
"genre": "article",
"id": "sg:pub.10.1007/s00134-003-2110-7",
"inLanguage": "en",
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1313639",
"issn": [
"0342-4642",
"1432-1238"
],
"name": "Intensive Care Medicine",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "3",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "30"
}
],
"keywords": [
"major abdominal surgery",
"postoperative day",
"abdominal surgery",
"surgical patients",
"endothelial activation",
"plasma levels",
"university-affiliated hospital",
"elderly surgical patients",
"central venous pressure",
"end of surgery",
"induction of anesthesia",
"markers of inflammation",
"intensive care unit",
"IL-8 plasma levels",
"volume replacement strategy",
"normal saline solution",
"volume therapy",
"elderly patients",
"replacement regimens",
"randomized study",
"venous pressure",
"crystalloid group",
"intravascular volume",
"care unit",
"endothelial injury",
"RL patients",
"HES 130",
"HES 130/0.4",
"NS patients",
"volume replacement",
"patients",
"surgery",
"adhesion molecules",
"important maneuver",
"inflammation",
"saline solution",
"activation",
"HES",
"group",
"lactate",
"DesignProspective",
"regimens",
"anesthesia",
"mmHg",
"interleukin",
"hemodynamics",
"IL-6",
"CRP",
"therapy",
"hospital",
"injury",
"ELAM-1",
"crystalloids",
"ICAM",
"replacement strategies",
"levels",
"markers",
"days",
"induction",
"morning",
"years",
"maneuvers",
"RL",
"replacement",
"management",
"NS",
"restoration",
"study",
"protein",
"volume",
"pressure",
"low degree",
"strategies",
"end",
"units",
"degree",
"influence",
"molecules",
"substitution",
"measurements",
"solution",
"ObjectiveAdequate restoration",
"different volume replacement",
"inflammation/endothelial activation",
"SettingSurgical intensive care unit",
"InterventionsRinger\u2019s lactate",
"low-molecular HES",
"resultsC-reactive protein",
"HES-130",
"ConclusionsIn elderly patients",
"HES 130/0.4-based volume replacement regimens",
"volume replacement regimens",
"different volume replacement strategies",
"elderly undergoing major abdominal surgery",
"undergoing major abdominal surgery"
],
"name": "RETRACTED ARTICLE: Influence of different volume replacement strategies on inflammation and endothelial activation in the elderly undergoing major abdominal surgery",
"pagination": "416-422",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1019887304"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s00134-003-2110-7"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"14712346"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s00134-003-2110-7",
"https://app.dimensions.ai/details/publication/pub.1019887304"
],
"sdDataset": "articles",
"sdDatePublished": "2022-01-01T18:13",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_392.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1007/s00134-003-2110-7"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00134-003-2110-7'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00134-003-2110-7'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00134-003-2110-7'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00134-003-2110-7'
This table displays all metadata directly associated to this object as RDF triples.
283 TRIPLES
22 PREDICATES
145 URIs
130 LITERALS
24 BLANK NODES