Helium-oxygen reduces work of breathing in mechanically ventilated patients with chronic obstructive pulmonary disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-07-25

AUTHORS

Marc Gainnier, Jean-Michel Arnal, Patrick Gerbeaux, Stéphane Donati, Laurent Papazian, Jean-Marie Sainty

ABSTRACT

ObjectiveTo evaluate whether helium-oxygen mixture reduces inspiratory work of breathing (WOB) in sedated, paralyzed, and mechanically ventilated patients with acute exacerbation of chronic obstructive pulmonary disease (COPD).Design and settingOpen, prospective, randomized, crossover study in the medical intensive care unit in a university hospital.Patients and participants23 patients admitted for acute exacerbation of COPD and mechanically ventilated.MeasurementsTotal WOB (WOBt), elastic WOB (WOBel), resistive WOB (WOBres), and WOB due to PEEPi (WOBPeepi) were measured. Static intrinsic positive end expiratory pressure (PEEPi), static compliance (Crs), inspiratory resistance (Rins), inspiratory (tinsp) and expiratory time constant (texp) were also measured. These variables were compared between air-oxygen and helium-oxygen mixtures.ResultsWOBt significantly decreased with helium-oxygen (2.34±1.04 to 1.85±1.01 J/l, p<0.001). This reduction was significant for WOBel (1.02±0.61 J/l to 0.87±0.47, p<0.01), WOBPeepi (0.77±0.38 J/l to 0.54±0.38, p<0.001), and WOBres (0.55±0.19 J/l to 0.44±0.24, p<0.05). PEEPi, Rins, tinsp and texp significantly decreased. Crs was unchanged.ConclusionsHelium-oxygen mixture decreases WOB in mechanically ventilated COPD patients. Helium-oxygen mixture could be useful to reduce the burden of ventilation. More... »

PAGES

1666-1670

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00134-003-1911-z

DOI

http://dx.doi.org/10.1007/s00134-003-1911-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040083965

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12897990


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