High or low doses of almitrine bismesylate in ARDS patients responding to inhaled NO and receiving norepinephrine? View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-10-30

AUTHORS

A. Roch, L. Papazian, F. Bregeon, M. Gainnier, P. Michelet, X. Thirion, P. Saux, P. Thomas, Y. Jammes, J.-P. Auffray

ABSTRACT

.Objective: To evaluate the effects on oxygenation and pulmonary haemodynamics of almitrine bismesylate (AB) 5 µg/kg per minute and 16 µg/kg per minute in ARDS patients responding to and receiving inhaled NO (iNO) and presenting septic shock requiring norepinephrine, while no difference was observed in a previous trial including iNO responders and nonresponders. Design: Prospective, cohort study. Setting: Adult medico-surgical intensive care unit of a university hospital. Patients: Fifteen patients with ARDS receiving and responding to iNO (10 ppm) and presenting septic shock requiring norepinephrine (mean 0.5±0.45 µg/kg per minute, range 0.08– 2.08). Interventions: The protocol consisted of two consecutive phases in a fixed order: continuous intravenous infusion of AB 5 µg/kg per minute for 30 min, and continuous intravenous infusion of AB 16 µg/kg per minute for 30 min. Measurements and main results: AB 5 µg/kg per minute significantly increased PaO2/FiO2 (P<0.05) compared with iNO alone [160 (range 77–450) mmHg vs 122 (range 70–225) mmHg]. AB 16 µg/kg per minute produced a greater increase of PaO2/FiO2 (P<0.05) when compared with 5 µg/kg per minute [227 (range 84–501) mmHg]. AB did not improve shunt at any dose regimen. AB produced an increase in mean pulmonary arterial pressure (MPAP) from 22±5 to 25±4 mmHg (P<0.03). MPAP did not significantly increase between the two doses. Pulmonary vascular resistances and other haemodynamic and respiratory parameters were not affected by almitrine bismesylate. Conclusions: These results suggest that it is possible to obtain a further improvement in oxygenation by increasing AB infusion rate in ARDS patients iNO responders receiving norepinephrine. Due to the potential deleterious effects of AB, this strategy should be used in the most severely hypoxaemic patients. More... »

PAGES

1737-1743

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00134-001-1128-y

DOI

http://dx.doi.org/10.1007/s00134-001-1128-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031470244

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11810116


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Administration, Inhalation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adrenergic alpha-Agonists", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Almitrine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Analysis of Variance", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bronchodilator Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hemodynamics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Infusions, Intravenous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nitric Oxide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Norepinephrine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oxygen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pulmonary Gas Exchange", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Respiratory Distress Syndrome, Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Respiratory System Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Shock, Septic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Service de R\u00e9animation Polyvalente, H\u00f4pitaux Sud, Marseille, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Service de R\u00e9animation Polyvalente, H\u00f4pitaux Sud, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roch", 
        "givenName": "A.", 
        "id": "sg:person.01167425103.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167425103.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "R\u00e9animation M\u00e9dicale, H\u00f4pital Sainte-Marguerite, 13274 Marseille, France", 
          "id": "http://www.grid.ac/institutes/grid.414438.e", 
          "name": [
            "R\u00e9animation M\u00e9dicale, H\u00f4pital Sainte-Marguerite, 13274 Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Papazian", 
        "givenName": "L.", 
        "id": "sg:person.0632223703.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632223703.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratoire de Physiopathologie Respiratoire, UPRES EA 2201, Universit\u00e9 de la M\u00e9diterran\u00e9e, France", 
          "id": "http://www.grid.ac/institutes/grid.5399.6", 
          "name": [
            "Laboratoire de Physiopathologie Respiratoire, UPRES EA 2201, Universit\u00e9 de la M\u00e9diterran\u00e9e, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bregeon", 
        "givenName": "F.", 
        "id": "sg:person.01300600215.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300600215.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de R\u00e9animation M\u00e9dicale, H\u00f4pitaux Sud, Marseille, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Service de R\u00e9animation M\u00e9dicale, H\u00f4pitaux Sud, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gainnier", 
        "givenName": "M.", 
        "id": "sg:person.01213542764.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213542764.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de R\u00e9animation Polyvalente, H\u00f4pitaux Sud, Marseille, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Service de R\u00e9animation Polyvalente, H\u00f4pitaux Sud, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Michelet", 
        "givenName": "P.", 
        "id": "sg:person.01104615171.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104615171.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service d'Information M\u00e9dicale, H\u00f4pitaux Sud, Marseille, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Service d'Information M\u00e9dicale, H\u00f4pitaux Sud, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thirion", 
        "givenName": "X.", 
        "id": "sg:person.01116402557.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116402557.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de R\u00e9animation Polyvalente, H\u00f4pitaux Sud, Marseille, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Service de R\u00e9animation Polyvalente, H\u00f4pitaux Sud, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saux", 
        "givenName": "P.", 
        "id": "sg:person.01075032773.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075032773.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratoire de Physiopathologie Respiratoire, UPRES EA 2201, Universit\u00e9 de la M\u00e9diterran\u00e9e, France", 
          "id": "http://www.grid.ac/institutes/grid.5399.6", 
          "name": [
            "Laboratoire de Physiopathologie Respiratoire, UPRES EA 2201, Universit\u00e9 de la M\u00e9diterran\u00e9e, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thomas", 
        "givenName": "P.", 
        "id": "sg:person.0746300333.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746300333.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratoire de Physiopathologie Respiratoire, UPRES EA 2201, Universit\u00e9 de la M\u00e9diterran\u00e9e, France", 
          "id": "http://www.grid.ac/institutes/grid.5399.6", 
          "name": [
            "Laboratoire de Physiopathologie Respiratoire, UPRES EA 2201, Universit\u00e9 de la M\u00e9diterran\u00e9e, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jammes", 
        "givenName": "Y.", 
        "id": "sg:person.0741261020.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741261020.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de R\u00e9animation Polyvalente, H\u00f4pitaux Sud, Marseille, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Service de R\u00e9animation Polyvalente, H\u00f4pitaux Sud, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Auffray", 
        "givenName": "J.-P.", 
        "id": "sg:person.01333643241.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333643241.97"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf01708960", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047569036", 
          "https://doi.org/10.1007/bf01708960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00693790", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026407894", 
          "https://doi.org/10.1007/bf00693790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001340051178", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035579547", 
          "https://doi.org/10.1007/s001340051178"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00314214", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030092953", 
          "https://doi.org/10.1007/bf00314214"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001340050982", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052421043", 
          "https://doi.org/10.1007/s001340050982"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2001-10-30", 
    "datePublishedReg": "2001-10-30", 
    "description": "Abstract.Objective: To evaluate the effects on oxygenation and pulmonary haemodynamics of almitrine bismesylate (AB) 5\u00a0\u00b5g/kg per minute and 16\u00a0\u00b5g/kg per minute in ARDS patients responding to and receiving inhaled NO (iNO) and presenting septic shock requiring norepinephrine, while no difference was observed in a previous trial including iNO responders and nonresponders. Design: Prospective, cohort study. Setting: Adult medico-surgical intensive care unit of a university hospital. Patients: Fifteen patients with ARDS receiving and responding to iNO (10\u00a0ppm) and presenting septic shock requiring norepinephrine (mean 0.5\u00b10.45 \u00b5g/kg per minute, range 0.08\u2013 2.08). Interventions: The protocol consisted of two consecutive phases in a fixed order: continuous intravenous infusion of AB 5\u00a0\u00b5g/kg per minute for 30\u00a0min, and continuous intravenous infusion of AB 16\u00a0\u00b5g/kg per minute for 30\u00a0min. Measurements and main results: AB 5\u00a0\u00b5g/kg per minute significantly increased PaO2/FiO2 (P<0.05) compared with iNO alone [160 (range 77\u2013450) mmHg vs 122 (range 70\u2013225) mmHg]. AB 16\u00a0\u00b5g/kg per minute produced a greater increase of PaO2/FiO2 (P<0.05) when compared with 5\u00a0\u00b5g/kg per minute [227 (range 84\u2013501) mmHg]. AB did not improve shunt at any dose regimen. AB produced an increase in mean pulmonary arterial pressure (MPAP) from 22\u00b15 to 25\u00b14\u00a0mmHg (P<0.03). MPAP did not significantly increase between the two doses. Pulmonary vascular resistances and other haemodynamic and respiratory parameters were not affected by almitrine bismesylate. Conclusions: These results suggest that it is possible to obtain a further improvement in oxygenation by increasing AB infusion rate in ARDS patients iNO responders receiving norepinephrine. Due to the potential deleterious effects of AB, this strategy should be used in the most severely hypoxaemic patients.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00134-001-1128-y", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1313639", 
        "issn": [
          "0342-4642", 
          "1432-1238"
        ], 
        "name": "Intensive Care Medicine", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "11", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "27"
      }
    ], 
    "keywords": [
      "mean pulmonary arterial pressure", 
      "PaO2/FiO2", 
      "continuous intravenous infusion", 
      "ARDS patients", 
      "septic shock", 
      "intravenous infusion", 
      "almitrine bismesylate", 
      "medico-surgical intensive care unit", 
      "pulmonary vascular resistance", 
      "pulmonary arterial pressure", 
      "intensive care unit", 
      "iNO responders", 
      "hypoxaemic patients", 
      "vascular resistance", 
      "ARDS patients", 
      "pulmonary haemodynamics", 
      "cohort study", 
      "dose regimen", 
      "arterial pressure", 
      "care unit", 
      "University Hospital", 
      "potential deleterious effects", 
      "infusion rate", 
      "respiratory parameters", 
      "patients", 
      "low doses", 
      "norepinephrine", 
      "previous trials", 
      "FiO2", 
      "infusion", 
      "greater increase", 
      "responders", 
      "deleterious effects", 
      "minutes", 
      "doses", 
      "oxygenation", 
      "iNO", 
      "Ab", 
      "nonresponders", 
      "regimen", 
      "haemodynamics", 
      "mmHg", 
      "min", 
      "hospital", 
      "shunt", 
      "trials", 
      "consecutive phases", 
      "shock", 
      "increase", 
      "main results", 
      "effect", 
      "ARD", 
      "NO", 
      "differences", 
      "study", 
      "further improvement", 
      "protocol", 
      "rate", 
      "resistance", 
      "pressure", 
      "improvement", 
      "results", 
      "strategies", 
      "units", 
      "measurements", 
      "phase", 
      "parameters", 
      "order", 
      "almitrine bismesylate (AB) 5", 
      "bismesylate (AB) 5", 
      "Adult medico-surgical intensive care unit", 
      "AB 5", 
      "AB 16", 
      "bismesylate", 
      "AB infusion rate"
    ], 
    "name": "High or low doses of almitrine bismesylate in ARDS patients responding to inhaled NO and receiving norepinephrine?", 
    "pagination": "1737-1743", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1031470244"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00134-001-1128-y"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "11810116"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00134-001-1128-y", 
      "https://app.dimensions.ai/details/publication/pub.1031470244"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:11", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_348.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00134-001-1128-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00134-001-1128-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00134-001-1128-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00134-001-1128-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00134-001-1128-y'


 

This table displays all metadata directly associated to this object as RDF triples.

309 TRIPLES      22 PREDICATES      125 URIs      112 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00134-001-1128-y schema:about N0f7df84a028b4c21bc5e4b0379a6b3d0
2 N1a58b461bf97494cb119647252d6f7c4
3 N2ed666385fa34952a0621e50b86e613e
4 N3bd35467b28f44f987a3499569673d46
5 N5440f01958334d12af7d763db86a5ad8
6 N5fdeaa6da8d54a219133676a07f4c055
7 N6f75552ab2b14f12b3159a166059d6dd
8 N748c987f59c748429151739d82ef154e
9 N85e66b388615444ab320d2b6c3f3e8c8
10 N904ca999a0434d069e022da69509139c
11 N9917c205c4ba4a808b9a08cc8f56d280
12 N9ad28d416af943928e4222651938d45a
13 Na9776e18f51f48fd9cdfd83a75c6e5d7
14 Nb2fe828e195d4986afc5a94abf972f22
15 Nd4e2478e768b46b08c7e4963d6cde46f
16 Ndf928b76121a4141932dce64f64a3d6a
17 Ne5e1dba569944a03b41d9932668c809a
18 Ne754c68cf22b496d86c9dc7937ac74f3
19 Ne9b97142532e46c4a3f98d9adaec5e8e
20 Nf2c9669032f84b2c9f125e86881e9b8c
21 anzsrc-for:11
22 anzsrc-for:1103
23 schema:author N87cc1c3d95a74cc9983d6e0be40ea9a8
24 schema:citation sg:pub.10.1007/bf00314214
25 sg:pub.10.1007/bf00693790
26 sg:pub.10.1007/bf01708960
27 sg:pub.10.1007/s001340050982
28 sg:pub.10.1007/s001340051178
29 schema:datePublished 2001-10-30
30 schema:datePublishedReg 2001-10-30
31 schema:description Abstract.Objective: To evaluate the effects on oxygenation and pulmonary haemodynamics of almitrine bismesylate (AB) 5 µg/kg per minute and 16 µg/kg per minute in ARDS patients responding to and receiving inhaled NO (iNO) and presenting septic shock requiring norepinephrine, while no difference was observed in a previous trial including iNO responders and nonresponders. Design: Prospective, cohort study. Setting: Adult medico-surgical intensive care unit of a university hospital. Patients: Fifteen patients with ARDS receiving and responding to iNO (10 ppm) and presenting septic shock requiring norepinephrine (mean 0.5±0.45 µg/kg per minute, range 0.08– 2.08). Interventions: The protocol consisted of two consecutive phases in a fixed order: continuous intravenous infusion of AB 5 µg/kg per minute for 30 min, and continuous intravenous infusion of AB 16 µg/kg per minute for 30 min. Measurements and main results: AB 5 µg/kg per minute significantly increased PaO2/FiO2 (P<0.05) compared with iNO alone [160 (range 77–450) mmHg vs 122 (range 70–225) mmHg]. AB 16 µg/kg per minute produced a greater increase of PaO2/FiO2 (P<0.05) when compared with 5 µg/kg per minute [227 (range 84–501) mmHg]. AB did not improve shunt at any dose regimen. AB produced an increase in mean pulmonary arterial pressure (MPAP) from 22±5 to 25±4 mmHg (P<0.03). MPAP did not significantly increase between the two doses. Pulmonary vascular resistances and other haemodynamic and respiratory parameters were not affected by almitrine bismesylate. Conclusions: These results suggest that it is possible to obtain a further improvement in oxygenation by increasing AB infusion rate in ARDS patients iNO responders receiving norepinephrine. Due to the potential deleterious effects of AB, this strategy should be used in the most severely hypoxaemic patients.
32 schema:genre article
33 schema:inLanguage en
34 schema:isAccessibleForFree false
35 schema:isPartOf N62022461c5a5413da39f8b0c055e6580
36 N7dd8a76c6fc34f7a810dd5b9678d9c9f
37 sg:journal.1313639
38 schema:keywords AB 16
39 AB 5
40 AB infusion rate
41 ARD
42 ARDS patients
43 Ab
44 Adult medico-surgical intensive care unit
45 FiO2
46 NO
47 PaO2/FiO2
48 University Hospital
49 almitrine bismesylate
50 almitrine bismesylate (AB) 5
51 arterial pressure
52 bismesylate
53 bismesylate (AB) 5
54 care unit
55 cohort study
56 consecutive phases
57 continuous intravenous infusion
58 deleterious effects
59 differences
60 dose regimen
61 doses
62 effect
63 further improvement
64 greater increase
65 haemodynamics
66 hospital
67 hypoxaemic patients
68 iNO
69 iNO responders
70 improvement
71 increase
72 infusion
73 infusion rate
74 intensive care unit
75 intravenous infusion
76 low doses
77 main results
78 mean pulmonary arterial pressure
79 measurements
80 medico-surgical intensive care unit
81 min
82 minutes
83 mmHg
84 nonresponders
85 norepinephrine
86 order
87 oxygenation
88 parameters
89 patients
90 phase
91 potential deleterious effects
92 pressure
93 previous trials
94 protocol
95 pulmonary arterial pressure
96 pulmonary haemodynamics
97 pulmonary vascular resistance
98 rate
99 regimen
100 resistance
101 respiratory parameters
102 responders
103 results
104 septic shock
105 shock
106 shunt
107 strategies
108 study
109 trials
110 units
111 vascular resistance
112 schema:name High or low doses of almitrine bismesylate in ARDS patients responding to inhaled NO and receiving norepinephrine?
113 schema:pagination 1737-1743
114 schema:productId N13e3811f7f4e40e9bc87008c3d2ddab9
115 N5e96e9920ec648d8a186cb4d2962f3c4
116 N6854bd6498314591a77a35e94a773008
117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031470244
118 https://doi.org/10.1007/s00134-001-1128-y
119 schema:sdDatePublished 2022-01-01T18:11
120 schema:sdLicense https://scigraph.springernature.com/explorer/license/
121 schema:sdPublisher N0616bc86a411496d80bedba82ab92594
122 schema:url https://doi.org/10.1007/s00134-001-1128-y
123 sgo:license sg:explorer/license/
124 sgo:sdDataset articles
125 rdf:type schema:ScholarlyArticle
126 N0616bc86a411496d80bedba82ab92594 schema:name Springer Nature - SN SciGraph project
127 rdf:type schema:Organization
128 N0f7df84a028b4c21bc5e4b0379a6b3d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Analysis of Variance
130 rdf:type schema:DefinedTerm
131 N13e3811f7f4e40e9bc87008c3d2ddab9 schema:name doi
132 schema:value 10.1007/s00134-001-1128-y
133 rdf:type schema:PropertyValue
134 N1a58b461bf97494cb119647252d6f7c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Almitrine
136 rdf:type schema:DefinedTerm
137 N2ed666385fa34952a0621e50b86e613e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Pulmonary Gas Exchange
139 rdf:type schema:DefinedTerm
140 N3bd35467b28f44f987a3499569673d46 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Adrenergic alpha-Agonists
142 rdf:type schema:DefinedTerm
143 N54014bf2b8e447b0865e4ca8513ba657 rdf:first sg:person.01116402557.54
144 rdf:rest N7ff729c4907d4e1a9fe631a95b8a2000
145 N5440f01958334d12af7d763db86a5ad8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Norepinephrine
147 rdf:type schema:DefinedTerm
148 N555af1756144491bb7c798dcd4d20aba rdf:first sg:person.01300600215.72
149 rdf:rest Nf131c43b82d6431f863605c39f1c92da
150 N5e96e9920ec648d8a186cb4d2962f3c4 schema:name dimensions_id
151 schema:value pub.1031470244
152 rdf:type schema:PropertyValue
153 N5fdeaa6da8d54a219133676a07f4c055 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Respiratory Distress Syndrome, Adult
155 rdf:type schema:DefinedTerm
156 N62022461c5a5413da39f8b0c055e6580 schema:issueNumber 11
157 rdf:type schema:PublicationIssue
158 N6854bd6498314591a77a35e94a773008 schema:name pubmed_id
159 schema:value 11810116
160 rdf:type schema:PropertyValue
161 N6f75552ab2b14f12b3159a166059d6dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Female
163 rdf:type schema:DefinedTerm
164 N748c987f59c748429151739d82ef154e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Oxygen
166 rdf:type schema:DefinedTerm
167 N7dd8a76c6fc34f7a810dd5b9678d9c9f schema:volumeNumber 27
168 rdf:type schema:PublicationVolume
169 N7ff729c4907d4e1a9fe631a95b8a2000 rdf:first sg:person.01075032773.26
170 rdf:rest Nda68495288c5429fbbe318284d613f7a
171 N85e66b388615444ab320d2b6c3f3e8c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Hemodynamics
173 rdf:type schema:DefinedTerm
174 N87cc1c3d95a74cc9983d6e0be40ea9a8 rdf:first sg:person.01167425103.01
175 rdf:rest Nbcd5376e6fda47089fba063837f04b29
176 N8e6a3e0c08914f78acf9ddc8311257e8 rdf:first sg:person.01104615171.57
177 rdf:rest N54014bf2b8e447b0865e4ca8513ba657
178 N904ca999a0434d069e022da69509139c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Prospective Studies
180 rdf:type schema:DefinedTerm
181 N9917c205c4ba4a808b9a08cc8f56d280 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Nitric Oxide
183 rdf:type schema:DefinedTerm
184 N9ad28d416af943928e4222651938d45a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Respiratory System Agents
186 rdf:type schema:DefinedTerm
187 Na9776e18f51f48fd9cdfd83a75c6e5d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Bronchodilator Agents
189 rdf:type schema:DefinedTerm
190 Nb02f67634a6a401cb27e849d7bb3d0bf rdf:first sg:person.0741261020.00
191 rdf:rest Nc93e180806ce47a8b5833f8b6e8d56dc
192 Nb2fe828e195d4986afc5a94abf972f22 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Middle Aged
194 rdf:type schema:DefinedTerm
195 Nbcd5376e6fda47089fba063837f04b29 rdf:first sg:person.0632223703.37
196 rdf:rest N555af1756144491bb7c798dcd4d20aba
197 Nc93e180806ce47a8b5833f8b6e8d56dc rdf:first sg:person.01333643241.97
198 rdf:rest rdf:nil
199 Nd4e2478e768b46b08c7e4963d6cde46f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Male
201 rdf:type schema:DefinedTerm
202 Nda68495288c5429fbbe318284d613f7a rdf:first sg:person.0746300333.01
203 rdf:rest Nb02f67634a6a401cb27e849d7bb3d0bf
204 Ndf928b76121a4141932dce64f64a3d6a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name Treatment Outcome
206 rdf:type schema:DefinedTerm
207 Ne5e1dba569944a03b41d9932668c809a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
208 schema:name Humans
209 rdf:type schema:DefinedTerm
210 Ne754c68cf22b496d86c9dc7937ac74f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
211 schema:name Infusions, Intravenous
212 rdf:type schema:DefinedTerm
213 Ne9b97142532e46c4a3f98d9adaec5e8e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
214 schema:name Shock, Septic
215 rdf:type schema:DefinedTerm
216 Nf131c43b82d6431f863605c39f1c92da rdf:first sg:person.01213542764.59
217 rdf:rest N8e6a3e0c08914f78acf9ddc8311257e8
218 Nf2c9669032f84b2c9f125e86881e9b8c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
219 schema:name Administration, Inhalation
220 rdf:type schema:DefinedTerm
221 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
222 schema:name Medical and Health Sciences
223 rdf:type schema:DefinedTerm
224 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
225 schema:name Clinical Sciences
226 rdf:type schema:DefinedTerm
227 sg:journal.1313639 schema:issn 0342-4642
228 1432-1238
229 schema:name Intensive Care Medicine
230 schema:publisher Springer Nature
231 rdf:type schema:Periodical
232 sg:person.01075032773.26 schema:affiliation grid-institutes:None
233 schema:familyName Saux
234 schema:givenName P.
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075032773.26
236 rdf:type schema:Person
237 sg:person.01104615171.57 schema:affiliation grid-institutes:None
238 schema:familyName Michelet
239 schema:givenName P.
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104615171.57
241 rdf:type schema:Person
242 sg:person.01116402557.54 schema:affiliation grid-institutes:None
243 schema:familyName Thirion
244 schema:givenName X.
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116402557.54
246 rdf:type schema:Person
247 sg:person.01167425103.01 schema:affiliation grid-institutes:None
248 schema:familyName Roch
249 schema:givenName A.
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167425103.01
251 rdf:type schema:Person
252 sg:person.01213542764.59 schema:affiliation grid-institutes:None
253 schema:familyName Gainnier
254 schema:givenName M.
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213542764.59
256 rdf:type schema:Person
257 sg:person.01300600215.72 schema:affiliation grid-institutes:grid.5399.6
258 schema:familyName Bregeon
259 schema:givenName F.
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300600215.72
261 rdf:type schema:Person
262 sg:person.01333643241.97 schema:affiliation grid-institutes:None
263 schema:familyName Auffray
264 schema:givenName J.-P.
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333643241.97
266 rdf:type schema:Person
267 sg:person.0632223703.37 schema:affiliation grid-institutes:grid.414438.e
268 schema:familyName Papazian
269 schema:givenName L.
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632223703.37
271 rdf:type schema:Person
272 sg:person.0741261020.00 schema:affiliation grid-institutes:grid.5399.6
273 schema:familyName Jammes
274 schema:givenName Y.
275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741261020.00
276 rdf:type schema:Person
277 sg:person.0746300333.01 schema:affiliation grid-institutes:grid.5399.6
278 schema:familyName Thomas
279 schema:givenName P.
280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746300333.01
281 rdf:type schema:Person
282 sg:pub.10.1007/bf00314214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030092953
283 https://doi.org/10.1007/bf00314214
284 rdf:type schema:CreativeWork
285 sg:pub.10.1007/bf00693790 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026407894
286 https://doi.org/10.1007/bf00693790
287 rdf:type schema:CreativeWork
288 sg:pub.10.1007/bf01708960 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047569036
289 https://doi.org/10.1007/bf01708960
290 rdf:type schema:CreativeWork
291 sg:pub.10.1007/s001340050982 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052421043
292 https://doi.org/10.1007/s001340050982
293 rdf:type schema:CreativeWork
294 sg:pub.10.1007/s001340051178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035579547
295 https://doi.org/10.1007/s001340051178
296 rdf:type schema:CreativeWork
297 grid-institutes:None schema:alternateName Service d'Information Médicale, Hôpitaux Sud, Marseille, France
298 Service de Réanimation Médicale, Hôpitaux Sud, Marseille, France
299 Service de Réanimation Polyvalente, Hôpitaux Sud, Marseille, France
300 schema:name Service d'Information Médicale, Hôpitaux Sud, Marseille, France
301 Service de Réanimation Médicale, Hôpitaux Sud, Marseille, France
302 Service de Réanimation Polyvalente, Hôpitaux Sud, Marseille, France
303 rdf:type schema:Organization
304 grid-institutes:grid.414438.e schema:alternateName Réanimation Médicale, Hôpital Sainte-Marguerite, 13274 Marseille, France
305 schema:name Réanimation Médicale, Hôpital Sainte-Marguerite, 13274 Marseille, France
306 rdf:type schema:Organization
307 grid-institutes:grid.5399.6 schema:alternateName Laboratoire de Physiopathologie Respiratoire, UPRES EA 2201, Université de la Méditerranée, France
308 schema:name Laboratoire de Physiopathologie Respiratoire, UPRES EA 2201, Université de la Méditerranée, France
309 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...