Depression predicts persistence of paranoia in clinical high-risk patients to psychosis: results of the EPOS project View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-12-07

AUTHORS

Raimo K. R. Salokangas, Frauke Schultze-Lutter, Jarmo Hietala, Markus Heinimaa, Tiina From, Tuula Ilonen, Eliisa Löyttyniemi, Heinrich Graf von Reventlow, Georg Juckel, Don Linszen, Peter Dingemans, Max Birchwood, Paul Patterson, Joachim Klosterkötter, Stephan Ruhrmann, The EPOS Group

ABSTRACT

BackgroundThe link between depression and paranoia has long been discussed in psychiatric literature. Because the causality of this association is difficult to study in patients with full-blown psychosis, we aimed to investigate how clinical depression relates to the presence and occurrence of paranoid symptoms in clinical high-risk (CHR) patients.MethodsIn all, 245 young help-seeking CHR patients were assessed for suspiciousness and paranoid symptoms with the structured interview for prodromal syndromes at baseline, 9- and 18-month follow-up. At baseline, clinical diagnoses were assessed by the Structured Clinical Interview for DSM-IV, childhood adversities by the Trauma and Distress Scale, trait-like suspiciousness by the Schizotypal Personality Questionnaire, and anxiety and depressiveness by the Positive and Negative Syndrome Scale.ResultsAt baseline, 54.3 % of CHR patients reported at least moderate paranoid symptoms. At 9- and 18-month follow-ups, the corresponding figures were 28.3 and 24.4 %. Depressive, obsessive–compulsive and somatoform disorders, emotional and sexual abuse, and anxiety and suspiciousness associated with paranoid symptoms. In multivariate modelling, depressive and obsessive–compulsive disorders, sexual abuse, and anxiety predicted persistence of paranoid symptoms.ConclusionDepressive disorder was one of the major clinical factors predicting persistence of paranoid symptoms in CHR patients. In addition, obsessive–compulsive disorder, childhood sexual abuse, and anxiety associated with paranoia. Effective pharmacological and psychotherapeutic treatment of these disorders and anxiety may reduce paranoid symptoms in CHR patients. More... »

PAGES

247-257

References to SciGraph publications

Journal

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00127-015-1160-9

DOI

http://dx.doi.org/10.1007/s00127-015-1160-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042353049

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26643940


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27 schema:description BackgroundThe link between depression and paranoia has long been discussed in psychiatric literature. Because the causality of this association is difficult to study in patients with full-blown psychosis, we aimed to investigate how clinical depression relates to the presence and occurrence of paranoid symptoms in clinical high-risk (CHR) patients.MethodsIn all, 245 young help-seeking CHR patients were assessed for suspiciousness and paranoid symptoms with the structured interview for prodromal syndromes at baseline, 9- and 18-month follow-up. At baseline, clinical diagnoses were assessed by the Structured Clinical Interview for DSM-IV, childhood adversities by the Trauma and Distress Scale, trait-like suspiciousness by the Schizotypal Personality Questionnaire, and anxiety and depressiveness by the Positive and Negative Syndrome Scale.ResultsAt baseline, 54.3 % of CHR patients reported at least moderate paranoid symptoms. At 9- and 18-month follow-ups, the corresponding figures were 28.3 and 24.4 %. Depressive, obsessive–compulsive and somatoform disorders, emotional and sexual abuse, and anxiety and suspiciousness associated with paranoid symptoms. In multivariate modelling, depressive and obsessive–compulsive disorders, sexual abuse, and anxiety predicted persistence of paranoid symptoms.ConclusionDepressive disorder was one of the major clinical factors predicting persistence of paranoid symptoms in CHR patients. In addition, obsessive–compulsive disorder, childhood sexual abuse, and anxiety associated with paranoia. Effective pharmacological and psychotherapeutic treatment of these disorders and anxiety may reduce paranoid symptoms in CHR patients.
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34 schema:keywords CHR patients
35 Clinical Interview
36 ConclusionDepressive disorder
37 DSM
38 Distress Scale
39 EPOS project
40 MethodsIn
41 Negative Syndrome Scale
42 Personality Questionnaire
43 Prodromal Syndromes
44 ResultsAt baseline
45 Schizotypal Personality Questionnaire
46 Structured Clinical Interview
47 Syndrome Scale
48 abuse
49 addition
50 adversity
51 anxiety
52 association
53 baseline
54 causality
55 childhood adversity
56 childhood sexual abuse
57 clinical depression
58 clinical diagnosis
59 clinical factors
60 clinical high-risk patients
61 corresponding figure
62 depression
63 depressiveness
64 diagnosis
65 disorders
66 factors
67 figures
68 help-seeking CHR patients
69 high-risk patients
70 interviews
71 least moderate paranoid symptoms
72 link
73 literature
74 major clinical factors
75 modelling
76 moderate paranoid symptoms
77 multivariate modelling
78 obsessive-compulsive disorder
79 occurrence
80 paranoia
81 paranoid symptoms
82 patients
83 persistence
84 persistence of paranoia
85 presence
86 project
87 psychiatric literature
88 psychosis
89 psychotherapeutic treatment
90 questionnaire
91 results
92 scale
93 sexual abuse
94 somatoform disorders
95 structured interviews
96 suspiciousness
97 symptoms
98 syndrome
99 trait-like suspiciousness
100 trauma
101 treatment
102 young help-seeking CHR patients
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