The accelerator hypothesis: weight gain as the missing link between Type I and Type II diabetes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2001-07

AUTHORS

T. J. Wilkin

ABSTRACT

Blood glucose concentrations are controlled by a loop incorporating two components, the beta cells which secrete insulin and the insulin-sensitive tissues (liver, muscle, adipose) which respond to it. Loss of blood glucose control might result from failure of the beta cells to secrete insulin, resistance of the tissues to its action, or a combination of both. The distinctions between Type I (insulin-dependent) and Type II (non-insulin-dependent) diabetes mellitus are becoming increasingly blurred both clinically and aetiologically, where beta-cell insufficiency is the shared characteristic. The 'Accelerator Hypothesis' identifies three processes which variably accelerate the loss of beta cells through apoptosis: constitution, insulin resistance and autoimmunity. None of the accelerators leads to diabetes without excess weight gain, a trend which the 'Accelerator Hypothesis' deems central to the rising incidence of both types of diabetes in the industrially developed world. Weight gain causes an increase in insulin resistance, which results in the weakening of glucose control. The rising blood glucose (glucotoxicity) accelerates beta-cell apoptosis directly in all and, by inducing beta-cell immunogens, further accelerates it in a subset genetically predisposed to autoimmunity. Rather than overlap between two types of diabetes, the 'Accelerator Hypothesis' envisages overlay. Body mass is central to the development and rising incidence of all diabetes. Only tempo distinguishes the 'types'. The control of weight gain, and with it insulin resistance, could be the means of minimising both. More... »

PAGES

914-922

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s001250100548

DOI

http://dx.doi.org/10.1007/s001250100548

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048570619

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11508279


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Glucose", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Developed Countries", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diabetes Mellitus, Type 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diabetes Mellitus, Type 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin Resistance", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Biological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phagocytosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prevalence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Weight Gain", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Derriford Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413628.a", 
          "name": [
            "Department of Medicine, Postgraduate Medical School, Derriford Hospital, Plymouth, UK, GB"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wilkin", 
        "givenName": "T. J.", 
        "id": "sg:person.01317760305.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317760305.49"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1093/oxfordjournals.bmb.a011611", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000394892"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001250050933", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004097017", 
          "https://doi.org/10.1007/s001250050933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001250050933", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004097017", 
          "https://doi.org/10.1007/s001250050933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)65596-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004945045"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0899-9007(97)00191-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007918066"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bmb/60.1.5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008380755"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0168-8227(97)00055-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009050476"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(98)07546-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012666811"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0167-5699(83)90169-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014201870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1651-2227.1998.tb01244.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017162212"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1651-2227.1998.tb01244.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017162212"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1056-8727(96)00090-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017948816"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00400806", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019234499", 
          "https://doi.org/10.1007/bf00400806"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00400806", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019234499", 
          "https://doi.org/10.1007/bf00400806"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00400806", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019234499", 
          "https://doi.org/10.1007/bf00400806"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1096-9136(199711)14:11<989::aid-dia482>3.0.co;2-c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020469838"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.ijo.0801125", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020673777", 
          "https://doi.org/10.1038/sj.ijo.0801125"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.ijo.0801125", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020673777", 
          "https://doi.org/10.1038/sj.ijo.0801125"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1464-5491.1999.00175.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021294864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1464-5491.1994.tb02035.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022594498"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1464-5491.1994.tb02035.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022594498"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dmr.5610090202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024085624"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dmr.5610090202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024085624"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.23.12.1755", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024304475"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1464-5491.1999.00044.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025140157"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci116110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026173810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1569-2582(97)80028-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027229561"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00280883", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027902786", 
          "https://doi.org/10.1007/bf00280883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00280883", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027902786", 
          "https://doi.org/10.1007/bf00280883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00280883", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027902786", 
          "https://doi.org/10.1007/bf00280883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00265396", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027951505", 
          "https://doi.org/10.1007/bf00265396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00265396", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027951505", 
          "https://doi.org/10.1007/bf00265396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00265396", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027951505", 
          "https://doi.org/10.1007/bf00265396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.5.2498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029456947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.49.1.32", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030716651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001250051132", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035896250", 
          "https://doi.org/10.1007/s001250051132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001250051132", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035896250", 
          "https://doi.org/10.1007/s001250051132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.306.6873.283", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036592495"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00428783", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037343631", 
          "https://doi.org/10.1007/bf00428783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00428783", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037343631", 
          "https://doi.org/10.1007/bf00428783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00400734", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038578635", 
          "https://doi.org/10.1007/bf00400734"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00400734", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038578635", 
          "https://doi.org/10.1007/bf00400734"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00400734", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038578635", 
          "https://doi.org/10.1007/bf00400734"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006676-199904000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040166729"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006676-199904000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040166729"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1699-0463.1999.tb01469.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041054180"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1699-0463.1999.tb01469.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041054180"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0026-0495(99)90234-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041591913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(97)03062-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044239979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.307.6897.155", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045052271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(82)91753-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045759419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(82)91753-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045759419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001250050822", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046557332", 
          "https://doi.org/10.1007/s001250050822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001250050822", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046557332", 
          "https://doi.org/10.1007/s001250050822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02221682", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048998297", 
          "https://doi.org/10.1007/bf02221682"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02221682", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048998297", 
          "https://doi.org/10.1007/bf02221682"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02221682", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048998297", 
          "https://doi.org/10.1007/bf02221682"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/07315724.1997.10718694", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050040185"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2796.2000.00625.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052401466"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/000992289803700208", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053998828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/000992289803700208", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053998828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ije/24.5.984", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059675726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.272.5258.50", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062552669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.311.7002.437", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062772937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.311.7002.437", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062772937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.312.7044.1456", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062776061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.312.7044.1456", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062776061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/endo.140.10.7042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064282691"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jcem.75.6.1464667", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064317881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diab.46.7.1133", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070738229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.47.10.1537", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070743696"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.48.1.94", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070743981"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.48.10.2039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070744002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.48.12.2398", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070744048"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.48.3.460", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070744093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.48.4.738", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070744133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.20.2.233b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070747571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.21.1.190", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070747887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.22.12.1961", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070748584"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.22.2.345", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070748651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.8.1.s10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070749910"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2001-07", 
    "datePublishedReg": "2001-07-01", 
    "description": "Blood glucose concentrations are controlled by a loop incorporating two components, the beta cells which secrete insulin and the insulin-sensitive tissues (liver, muscle, adipose) which respond to it. Loss of blood glucose control might result from failure of the beta cells to secrete insulin, resistance of the tissues to its action, or a combination of both. The distinctions between Type I (insulin-dependent) and Type II (non-insulin-dependent) diabetes mellitus are becoming increasingly blurred both clinically and aetiologically, where beta-cell insufficiency is the shared characteristic. The 'Accelerator Hypothesis' identifies three processes which variably accelerate the loss of beta cells through apoptosis: constitution, insulin resistance and autoimmunity. None of the accelerators leads to diabetes without excess weight gain, a trend which the 'Accelerator Hypothesis' deems central to the rising incidence of both types of diabetes in the industrially developed world. Weight gain causes an increase in insulin resistance, which results in the weakening of glucose control. The rising blood glucose (glucotoxicity) accelerates beta-cell apoptosis directly in all and, by inducing beta-cell immunogens, further accelerates it in a subset genetically predisposed to autoimmunity. Rather than overlap between two types of diabetes, the 'Accelerator Hypothesis' envisages overlay. Body mass is central to the development and rising incidence of all diabetes. Only tempo distinguishes the 'types'. The control of weight gain, and with it insulin resistance, could be the means of minimising both.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s001250100548", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1001482", 
        "issn": [
          "0012-186X", 
          "1432-0428"
        ], 
        "name": "Diabetologia", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "44"
      }
    ], 
    "name": "The accelerator hypothesis: weight gain as the missing link between Type I and Type II diabetes", 
    "pagination": "914-922", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e761de069790bd9e106835565b769d6718a75a9977a3a645665203bae23387b4"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "11508279"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0006777"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s001250100548"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1048570619"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s001250100548", 
      "https://app.dimensions.ai/details/publication/pub.1048570619"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:34", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000349_0000000349/records_113664_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs001250100548"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s001250100548'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s001250100548'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s001250100548'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s001250100548'


 

This table displays all metadata directly associated to this object as RDF triples.

298 TRIPLES      21 PREDICATES      98 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s001250100548 schema:about N024d68c09cb2438ea089b34cd4be0513
2 N05015cfc79b8453db274e73ec4fa3985
3 N092bde9bdec845d69e056c76a294d94a
4 N4183fabe612d403b85362d0e20887ea5
5 N6ecd4f7962934bd599664e7e24e674cd
6 N784ae57b548846e6a71d046a6c20a9e8
7 N7b10f2dfc0d14873a41acaae1c45c008
8 Nad4f182d141e44ab95a761aedb20dce6
9 Naf3a060f72b94d58901759bbf9b1004c
10 Nb2e2677ffc9945a784f07fc8b70f5458
11 Ndbc2dbf602674ef09a0dfebbd61a4d95
12 Nfee5a81ad25a4d7ab3d3cb06ecd02652
13 anzsrc-for:11
14 anzsrc-for:1103
15 schema:author N20d7024d24054340b25a3afb48f3ce3d
16 schema:citation sg:pub.10.1007/bf00265396
17 sg:pub.10.1007/bf00280883
18 sg:pub.10.1007/bf00400734
19 sg:pub.10.1007/bf00400806
20 sg:pub.10.1007/bf00428783
21 sg:pub.10.1007/bf02221682
22 sg:pub.10.1007/s001250050822
23 sg:pub.10.1007/s001250050933
24 sg:pub.10.1007/s001250051132
25 sg:pub.10.1038/sj.ijo.0801125
26 https://doi.org/10.1002/(sici)1096-9136(199711)14:11<989::aid-dia482>3.0.co;2-c
27 https://doi.org/10.1002/dmr.5610090202
28 https://doi.org/10.1016/0167-5699(83)90169-x
29 https://doi.org/10.1016/s0002-9440(10)65596-4
30 https://doi.org/10.1016/s0026-0495(99)90234-2
31 https://doi.org/10.1016/s0140-6736(82)91753-6
32 https://doi.org/10.1016/s0140-6736(97)03062-6
33 https://doi.org/10.1016/s0140-6736(98)07546-1
34 https://doi.org/10.1016/s0168-8227(97)00055-7
35 https://doi.org/10.1016/s0899-9007(97)00191-3
36 https://doi.org/10.1016/s1056-8727(96)00090-6
37 https://doi.org/10.1016/s1569-2582(97)80028-1
38 https://doi.org/10.1046/j.1365-2796.2000.00625.x
39 https://doi.org/10.1046/j.1464-5491.1999.00044.x
40 https://doi.org/10.1046/j.1464-5491.1999.00175.x
41 https://doi.org/10.1073/pnas.95.5.2498
42 https://doi.org/10.1080/07315724.1997.10718694
43 https://doi.org/10.1093/bmb/60.1.5
44 https://doi.org/10.1093/ije/24.5.984
45 https://doi.org/10.1093/oxfordjournals.bmb.a011611
46 https://doi.org/10.1097/00006676-199904000-00007
47 https://doi.org/10.1111/j.1464-5491.1994.tb02035.x
48 https://doi.org/10.1111/j.1651-2227.1998.tb01244.x
49 https://doi.org/10.1111/j.1699-0463.1999.tb01469.x
50 https://doi.org/10.1126/science.272.5258.50
51 https://doi.org/10.1136/bmj.306.6873.283
52 https://doi.org/10.1136/bmj.307.6897.155
53 https://doi.org/10.1136/bmj.311.7002.437
54 https://doi.org/10.1136/bmj.312.7044.1456
55 https://doi.org/10.1172/jci116110
56 https://doi.org/10.1177/000992289803700208
57 https://doi.org/10.1210/endo.140.10.7042
58 https://doi.org/10.1210/jcem.75.6.1464667
59 https://doi.org/10.2337/diab.46.7.1133
60 https://doi.org/10.2337/diabetes.47.10.1537
61 https://doi.org/10.2337/diabetes.48.1.94
62 https://doi.org/10.2337/diabetes.48.10.2039
63 https://doi.org/10.2337/diabetes.48.12.2398
64 https://doi.org/10.2337/diabetes.48.3.460
65 https://doi.org/10.2337/diabetes.48.4.738
66 https://doi.org/10.2337/diabetes.49.1.32
67 https://doi.org/10.2337/diacare.20.2.233b
68 https://doi.org/10.2337/diacare.21.1.190
69 https://doi.org/10.2337/diacare.22.12.1961
70 https://doi.org/10.2337/diacare.22.2.345
71 https://doi.org/10.2337/diacare.23.12.1755
72 https://doi.org/10.2337/diacare.8.1.s10
73 schema:datePublished 2001-07
74 schema:datePublishedReg 2001-07-01
75 schema:description Blood glucose concentrations are controlled by a loop incorporating two components, the beta cells which secrete insulin and the insulin-sensitive tissues (liver, muscle, adipose) which respond to it. Loss of blood glucose control might result from failure of the beta cells to secrete insulin, resistance of the tissues to its action, or a combination of both. The distinctions between Type I (insulin-dependent) and Type II (non-insulin-dependent) diabetes mellitus are becoming increasingly blurred both clinically and aetiologically, where beta-cell insufficiency is the shared characteristic. The 'Accelerator Hypothesis' identifies three processes which variably accelerate the loss of beta cells through apoptosis: constitution, insulin resistance and autoimmunity. None of the accelerators leads to diabetes without excess weight gain, a trend which the 'Accelerator Hypothesis' deems central to the rising incidence of both types of diabetes in the industrially developed world. Weight gain causes an increase in insulin resistance, which results in the weakening of glucose control. The rising blood glucose (glucotoxicity) accelerates beta-cell apoptosis directly in all and, by inducing beta-cell immunogens, further accelerates it in a subset genetically predisposed to autoimmunity. Rather than overlap between two types of diabetes, the 'Accelerator Hypothesis' envisages overlay. Body mass is central to the development and rising incidence of all diabetes. Only tempo distinguishes the 'types'. The control of weight gain, and with it insulin resistance, could be the means of minimising both.
76 schema:genre research_article
77 schema:inLanguage en
78 schema:isAccessibleForFree true
79 schema:isPartOf N136e502d8d00479184125f9773dd5996
80 Ne31d5e3e14bc45abbd0782d7ba933cfb
81 sg:journal.1001482
82 schema:name The accelerator hypothesis: weight gain as the missing link between Type I and Type II diabetes
83 schema:pagination 914-922
84 schema:productId N2358136287414842a43d2fc22e703580
85 N4381537459fc43b8904caa8a617fa5fc
86 Na337614b0cb64733984338ad37bedaec
87 Nd16bd718d3b94345ab975756bf113a76
88 Nfcf8952486f4478ca0029ab308ec3d44
89 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048570619
90 https://doi.org/10.1007/s001250100548
91 schema:sdDatePublished 2019-04-11T10:34
92 schema:sdLicense https://scigraph.springernature.com/explorer/license/
93 schema:sdPublisher Nd1dcfea6420c403e9d8d6228ae97bf63
94 schema:url https://link.springer.com/10.1007%2Fs001250100548
95 sgo:license sg:explorer/license/
96 sgo:sdDataset articles
97 rdf:type schema:ScholarlyArticle
98 N024d68c09cb2438ea089b34cd4be0513 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Phagocytosis
100 rdf:type schema:DefinedTerm
101 N05015cfc79b8453db274e73ec4fa3985 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Apoptosis
103 rdf:type schema:DefinedTerm
104 N092bde9bdec845d69e056c76a294d94a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Developed Countries
106 rdf:type schema:DefinedTerm
107 N136e502d8d00479184125f9773dd5996 schema:volumeNumber 44
108 rdf:type schema:PublicationVolume
109 N20d7024d24054340b25a3afb48f3ce3d rdf:first sg:person.01317760305.49
110 rdf:rest rdf:nil
111 N2358136287414842a43d2fc22e703580 schema:name doi
112 schema:value 10.1007/s001250100548
113 rdf:type schema:PropertyValue
114 N4183fabe612d403b85362d0e20887ea5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Humans
116 rdf:type schema:DefinedTerm
117 N4381537459fc43b8904caa8a617fa5fc schema:name readcube_id
118 schema:value e761de069790bd9e106835565b769d6718a75a9977a3a645665203bae23387b4
119 rdf:type schema:PropertyValue
120 N6ecd4f7962934bd599664e7e24e674cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Risk Factors
122 rdf:type schema:DefinedTerm
123 N784ae57b548846e6a71d046a6c20a9e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Models, Biological
125 rdf:type schema:DefinedTerm
126 N7b10f2dfc0d14873a41acaae1c45c008 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Blood Glucose
128 rdf:type schema:DefinedTerm
129 Na337614b0cb64733984338ad37bedaec schema:name dimensions_id
130 schema:value pub.1048570619
131 rdf:type schema:PropertyValue
132 Nad4f182d141e44ab95a761aedb20dce6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Weight Gain
134 rdf:type schema:DefinedTerm
135 Naf3a060f72b94d58901759bbf9b1004c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Prevalence
137 rdf:type schema:DefinedTerm
138 Nb2e2677ffc9945a784f07fc8b70f5458 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Insulin Resistance
140 rdf:type schema:DefinedTerm
141 Nd16bd718d3b94345ab975756bf113a76 schema:name pubmed_id
142 schema:value 11508279
143 rdf:type schema:PropertyValue
144 Nd1dcfea6420c403e9d8d6228ae97bf63 schema:name Springer Nature - SN SciGraph project
145 rdf:type schema:Organization
146 Ndbc2dbf602674ef09a0dfebbd61a4d95 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Diabetes Mellitus, Type 1
148 rdf:type schema:DefinedTerm
149 Ne31d5e3e14bc45abbd0782d7ba933cfb schema:issueNumber 7
150 rdf:type schema:PublicationIssue
151 Nfcf8952486f4478ca0029ab308ec3d44 schema:name nlm_unique_id
152 schema:value 0006777
153 rdf:type schema:PropertyValue
154 Nfee5a81ad25a4d7ab3d3cb06ecd02652 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Diabetes Mellitus, Type 2
156 rdf:type schema:DefinedTerm
157 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
158 schema:name Medical and Health Sciences
159 rdf:type schema:DefinedTerm
160 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
161 schema:name Clinical Sciences
162 rdf:type schema:DefinedTerm
163 sg:journal.1001482 schema:issn 0012-186X
164 1432-0428
165 schema:name Diabetologia
166 rdf:type schema:Periodical
167 sg:person.01317760305.49 schema:affiliation https://www.grid.ac/institutes/grid.413628.a
168 schema:familyName Wilkin
169 schema:givenName T. J.
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317760305.49
171 rdf:type schema:Person
172 sg:pub.10.1007/bf00265396 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027951505
173 https://doi.org/10.1007/bf00265396
174 rdf:type schema:CreativeWork
175 sg:pub.10.1007/bf00280883 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027902786
176 https://doi.org/10.1007/bf00280883
177 rdf:type schema:CreativeWork
178 sg:pub.10.1007/bf00400734 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038578635
179 https://doi.org/10.1007/bf00400734
180 rdf:type schema:CreativeWork
181 sg:pub.10.1007/bf00400806 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019234499
182 https://doi.org/10.1007/bf00400806
183 rdf:type schema:CreativeWork
184 sg:pub.10.1007/bf00428783 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037343631
185 https://doi.org/10.1007/bf00428783
186 rdf:type schema:CreativeWork
187 sg:pub.10.1007/bf02221682 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048998297
188 https://doi.org/10.1007/bf02221682
189 rdf:type schema:CreativeWork
190 sg:pub.10.1007/s001250050822 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046557332
191 https://doi.org/10.1007/s001250050822
192 rdf:type schema:CreativeWork
193 sg:pub.10.1007/s001250050933 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004097017
194 https://doi.org/10.1007/s001250050933
195 rdf:type schema:CreativeWork
196 sg:pub.10.1007/s001250051132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035896250
197 https://doi.org/10.1007/s001250051132
198 rdf:type schema:CreativeWork
199 sg:pub.10.1038/sj.ijo.0801125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020673777
200 https://doi.org/10.1038/sj.ijo.0801125
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1002/(sici)1096-9136(199711)14:11<989::aid-dia482>3.0.co;2-c schema:sameAs https://app.dimensions.ai/details/publication/pub.1020469838
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1002/dmr.5610090202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024085624
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1016/0167-5699(83)90169-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014201870
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1016/s0002-9440(10)65596-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004945045
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/s0026-0495(99)90234-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041591913
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1016/s0140-6736(82)91753-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045759419
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1016/s0140-6736(97)03062-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044239979
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1016/s0140-6736(98)07546-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012666811
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1016/s0168-8227(97)00055-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009050476
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1016/s0899-9007(97)00191-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007918066
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1016/s1056-8727(96)00090-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017948816
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1016/s1569-2582(97)80028-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027229561
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1046/j.1365-2796.2000.00625.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052401466
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1046/j.1464-5491.1999.00044.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1025140157
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1046/j.1464-5491.1999.00175.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021294864
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1073/pnas.95.5.2498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029456947
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1080/07315724.1997.10718694 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050040185
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1093/bmb/60.1.5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008380755
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1093/ije/24.5.984 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059675726
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1093/oxfordjournals.bmb.a011611 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000394892
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1097/00006676-199904000-00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040166729
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1111/j.1464-5491.1994.tb02035.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022594498
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1111/j.1651-2227.1998.tb01244.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017162212
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1111/j.1699-0463.1999.tb01469.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041054180
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1126/science.272.5258.50 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062552669
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1136/bmj.306.6873.283 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036592495
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1136/bmj.307.6897.155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045052271
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1136/bmj.311.7002.437 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062772937
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1136/bmj.312.7044.1456 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062776061
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1172/jci116110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026173810
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1177/000992289803700208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053998828
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1210/endo.140.10.7042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064282691
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1210/jcem.75.6.1464667 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064317881
267 rdf:type schema:CreativeWork
268 https://doi.org/10.2337/diab.46.7.1133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070738229
269 rdf:type schema:CreativeWork
270 https://doi.org/10.2337/diabetes.47.10.1537 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070743696
271 rdf:type schema:CreativeWork
272 https://doi.org/10.2337/diabetes.48.1.94 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070743981
273 rdf:type schema:CreativeWork
274 https://doi.org/10.2337/diabetes.48.10.2039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070744002
275 rdf:type schema:CreativeWork
276 https://doi.org/10.2337/diabetes.48.12.2398 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070744048
277 rdf:type schema:CreativeWork
278 https://doi.org/10.2337/diabetes.48.3.460 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070744093
279 rdf:type schema:CreativeWork
280 https://doi.org/10.2337/diabetes.48.4.738 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070744133
281 rdf:type schema:CreativeWork
282 https://doi.org/10.2337/diabetes.49.1.32 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030716651
283 rdf:type schema:CreativeWork
284 https://doi.org/10.2337/diacare.20.2.233b schema:sameAs https://app.dimensions.ai/details/publication/pub.1070747571
285 rdf:type schema:CreativeWork
286 https://doi.org/10.2337/diacare.21.1.190 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070747887
287 rdf:type schema:CreativeWork
288 https://doi.org/10.2337/diacare.22.12.1961 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070748584
289 rdf:type schema:CreativeWork
290 https://doi.org/10.2337/diacare.22.2.345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070748651
291 rdf:type schema:CreativeWork
292 https://doi.org/10.2337/diacare.23.12.1755 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024304475
293 rdf:type schema:CreativeWork
294 https://doi.org/10.2337/diacare.8.1.s10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070749910
295 rdf:type schema:CreativeWork
296 https://www.grid.ac/institutes/grid.413628.a schema:alternateName Derriford Hospital
297 schema:name Department of Medicine, Postgraduate Medical School, Derriford Hospital, Plymouth, UK, GB
298 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...