Transcription factor decoy for activator protein-1 (AP-1) inhibits high glucose- and angiotensin II-induced type 1 plasminogen activator inhibitor (PAI-1) gene ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2001-05

AUTHORS

J. D. Ahn, R. Morishita, Y. Kaneda, K. U. Lee, J. Y. Park, Y. J. Jeon, H. S. Song, I. K. Lee

ABSTRACT

AIMS/HYPOTHESIS: Multiple factors, including hyperglycaemia and angiotensin II (Ang II), stimulate plasminogen activator inhibitor-1 (PAI-1) gene expression in human vascular smooth muscle cells. This study tested the hypothesis that hyperglycaemia and Ang II stimulate PAI-1 gene expression through activator protein-1 (AP-1) binding sites. METHODS: We evaluated the role of AP-1 in PAI-1 gene expression in human vascular smooth muscle cells under high D-glucose and Ang II stimulation using a double-stranded cis-element AP-1 oligodeoxynucleotide (decoy ODN). RESULTS: Activator protein 1 activity was stimulated by high glucose and Ang II treatment and the AP-1 decoy ODN, but not a mismatched decoy ODN, competed for AP-1 activity. The increase in PAI-1 expression by high glucose and Ang II was significantly attenuated by the AP-1 decoy ODN (p <0.05 or p < 0.01). The increase in PAI-1 expression by high glucose and Ang II action on AP-1 sites was also confirmed by promoter analysis of PAI-1. Activator protein 1 activation in response to either high glucose or co-stimulation with high glucose and Ang II was inhibited completely by calphostin C (a PKC inhibitor) and partially by genistein (a protein tyrosine kinase inhibitor). CONCLUSION/INTERPRETATION: This study shows that high glucose and Ang II stimulate PAI-1 expression through AP-1 binding sites. Signal transduction after AP-1 activation by both high glucose and Ang II largely depends on PKC activation. These data indicate an important role for AP-1 in PAI-1 expression. More... »

PAGES

713-720

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s001250051680

DOI

http://dx.doi.org/10.1007/s001250051680

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024312144

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11440364


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Angiotensin II", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genistein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glucose", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Muscle, Smooth, Vascular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Naphthalenes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oligonucleotides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plasminogen Activator Inhibitor 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Kinase C", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein-Tyrosine Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factor AP-1", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Keimyung University", 
          "id": "https://www.grid.ac/institutes/grid.412091.f", 
          "name": [
            "Institute for Medical Science, Keimyung University School of Medicine, Taegu, Korea, KR"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ahn", 
        "givenName": "J. D.", 
        "id": "sg:person.01206361263.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206361263.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Osaka University", 
          "id": "https://www.grid.ac/institutes/grid.136593.b", 
          "name": [
            "Division of Gene Therapy Science, Graduate School of Medicine, Osaka University, Suita, Japan, JP"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morishita", 
        "givenName": "R.", 
        "id": "sg:person.01334645231.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334645231.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Osaka University", 
          "id": "https://www.grid.ac/institutes/grid.136593.b", 
          "name": [
            "Division of Gene Therapy Science, Graduate School of Medicine, Osaka University, Suita, Japan, JP"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kaneda", 
        "givenName": "Y.", 
        "id": "sg:person.01241111761.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241111761.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Ulsan", 
          "id": "https://www.grid.ac/institutes/grid.267370.7", 
          "name": [
            "Department of Internal Medicine, University of Ulsan School of Medicine, Seoul, Korea, KR"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "K. U.", 
        "id": "sg:person.01036122220.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036122220.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Ulsan", 
          "id": "https://www.grid.ac/institutes/grid.267370.7", 
          "name": [
            "Department of Internal Medicine, University of Ulsan School of Medicine, Seoul, Korea, KR"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Park", 
        "givenName": "J. Y.", 
        "id": "sg:person.014104715634.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014104715634.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Keimyung University", 
          "id": "https://www.grid.ac/institutes/grid.412091.f", 
          "name": [
            "Department of Internal Medicine, Keimyung University School of Medicine, Taegu, Korea, KR"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jeon", 
        "givenName": "Y. J.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Keimyung University", 
          "id": "https://www.grid.ac/institutes/grid.412091.f", 
          "name": [
            "Department of Internal Medicine, Keimyung University School of Medicine, Taegu, Korea, KR"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Song", 
        "givenName": "H. S.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Keimyung University", 
          "id": "https://www.grid.ac/institutes/grid.412091.f", 
          "name": [
            "Department of Internal Medicine, Keimyung University School of Medicine, Taegu, Korea, KR"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "I. K.", 
        "id": "sg:person.015663503347.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015663503347.24"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/0891-5849(96)00109-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003464017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/abio.1994.1042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004329331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00403280", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004442083", 
          "https://doi.org/10.1007/bf00403280"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00403280", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004442083", 
          "https://doi.org/10.1007/bf00403280"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00403280", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004442083", 
          "https://doi.org/10.1007/bf00403280"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.35.5.1038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005957465"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.82.1.27", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006896880"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000425092", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007030011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.atv.14.5.815", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008820331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.273.14.8225", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009384711"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/1050-1738(91)90001-u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009938262"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.270.28.16483", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010729403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0002-9343(91)90040-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012264113"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.85.8.753", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014367194"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001090050063", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016860240", 
          "https://doi.org/10.1007/s001090050063"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.23.7.888", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018856315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1432-1033.1996.00393.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020688347"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.89.15.6998", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025954637"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci116020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026103107"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.97.11.1071", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027185397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.101.3.264", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027678945"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1046/j.1523-1755.1998.00888.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028031018", 
          "https://doi.org/10.1046/j.1523-1755.1998.00888.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.70.3.593", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033244413"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.31.1.321", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036703032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1432-1033.1994.tb18599.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037767211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.1997.8012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043302959"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1054-3589(08)60993-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043322565"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.273.41.26487", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043349199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci117786", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048477268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.atv.13.12.1822", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048769490"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.33.1.378", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050108788"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/hum.1997.8.17-2133", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059271964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2237444", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062528429"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2526370", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062542273"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.atv.15.10.1584", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063333869"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.80.1.139", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063341003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3949/ccjm.67.4.287", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071759012"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2001-05", 
    "datePublishedReg": "2001-05-01", 
    "description": "AIMS/HYPOTHESIS: Multiple factors, including hyperglycaemia and angiotensin II (Ang II), stimulate plasminogen activator inhibitor-1 (PAI-1) gene expression in human vascular smooth muscle cells. This study tested the hypothesis that hyperglycaemia and Ang II stimulate PAI-1 gene expression through activator protein-1 (AP-1) binding sites.\nMETHODS: We evaluated the role of AP-1 in PAI-1 gene expression in human vascular smooth muscle cells under high D-glucose and Ang II stimulation using a double-stranded cis-element AP-1 oligodeoxynucleotide (decoy ODN).\nRESULTS: Activator protein 1 activity was stimulated by high glucose and Ang II treatment and the AP-1 decoy ODN, but not a mismatched decoy ODN, competed for AP-1 activity. The increase in PAI-1 expression by high glucose and Ang II was significantly attenuated by the AP-1 decoy ODN (p <0.05 or p < 0.01). The increase in PAI-1 expression by high glucose and Ang II action on AP-1 sites was also confirmed by promoter analysis of PAI-1. Activator protein 1 activation in response to either high glucose or co-stimulation with high glucose and Ang II was inhibited completely by calphostin C (a PKC inhibitor) and partially by genistein (a protein tyrosine kinase inhibitor).\nCONCLUSION/INTERPRETATION: This study shows that high glucose and Ang II stimulate PAI-1 expression through AP-1 binding sites. Signal transduction after AP-1 activation by both high glucose and Ang II largely depends on PKC activation. These data indicate an important role for AP-1 in PAI-1 expression.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s001250051680", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1001482", 
        "issn": [
          "0012-186X", 
          "1432-0428"
        ], 
        "name": "Diabetologia", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "44"
      }
    ], 
    "name": "Transcription factor decoy for activator protein-1 (AP-1) inhibits high glucose- and angiotensin II-induced type 1 plasminogen activator inhibitor (PAI-1) gene expression in cultured human vascular smooth muscle cells", 
    "pagination": "713-720", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "73d375a9bb78d1fcb11145f704a1928f531d4677bf65ebc173a445648f49f310"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "11440364"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0006777"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s001250051680"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1024312144"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s001250051680", 
      "https://app.dimensions.ai/details/publication/pub.1024312144"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:37", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000346_0000000346/records_99829_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs001250051680"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s001250051680'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s001250051680'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s001250051680'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s001250051680'


 

This table displays all metadata directly associated to this object as RDF triples.

287 TRIPLES      21 PREDICATES      78 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s001250051680 schema:about N037bb00d5a02482fb5b76979fb822f2c
2 N0fd3735c5ebe492da4f907805ad0daa2
3 N305e55b4e72b4146a29cf65022405544
4 N316e5a621c524d9b9c7b441415944c29
5 N41c40e27be7e4bcea70eae5a0b1907d1
6 N448ed4d7dd534154a6d904b59d5bb06a
7 N4fc36b82bfe0488cbf831f98d7f95b26
8 N56c7e8b53d9e4a8cb55ce8c39e65b438
9 N60bfcb5ab15c488dbdf950824208b9e1
10 N64c1a4071f88478e8b1f9bf815fdc504
11 N78f078b1566e4c4eb2f4feb3575d1b00
12 N8262d3f1242947e0874f513e5b822619
13 Nd384ec73e69c4696b178c22957f7bdb7
14 Nfc2b77d501b94058914fdc3b1bffc345
15 anzsrc-for:06
16 anzsrc-for:0604
17 schema:author Nfdb0185183614ff6bce0e6bd84c02122
18 schema:citation sg:pub.10.1007/bf00403280
19 sg:pub.10.1007/s001090050063
20 sg:pub.10.1046/j.1523-1755.1998.00888.x
21 https://doi.org/10.1006/abio.1994.1042
22 https://doi.org/10.1006/bbrc.1997.8012
23 https://doi.org/10.1016/0002-9343(91)90040-5
24 https://doi.org/10.1016/0891-5849(96)00109-8
25 https://doi.org/10.1016/1050-1738(91)90001-u
26 https://doi.org/10.1016/s1054-3589(08)60993-x
27 https://doi.org/10.1073/pnas.89.15.6998
28 https://doi.org/10.1074/jbc.270.28.16483
29 https://doi.org/10.1074/jbc.273.14.8225
30 https://doi.org/10.1074/jbc.273.41.26487
31 https://doi.org/10.1089/hum.1997.8.17-2133
32 https://doi.org/10.1111/j.1432-1033.1994.tb18599.x
33 https://doi.org/10.1111/j.1432-1033.1996.00393.x
34 https://doi.org/10.1126/science.2237444
35 https://doi.org/10.1126/science.2526370
36 https://doi.org/10.1159/000425092
37 https://doi.org/10.1161/01.atv.13.12.1822
38 https://doi.org/10.1161/01.atv.14.5.815
39 https://doi.org/10.1161/01.atv.15.10.1584
40 https://doi.org/10.1161/01.cir.101.3.264
41 https://doi.org/10.1161/01.cir.82.1.27
42 https://doi.org/10.1161/01.cir.97.11.1071
43 https://doi.org/10.1161/01.hyp.31.1.321
44 https://doi.org/10.1161/01.hyp.33.1.378
45 https://doi.org/10.1161/01.hyp.35.5.1038
46 https://doi.org/10.1161/01.res.70.3.593
47 https://doi.org/10.1161/01.res.80.1.139
48 https://doi.org/10.1161/01.res.85.8.753
49 https://doi.org/10.1172/jci116020
50 https://doi.org/10.1172/jci117786
51 https://doi.org/10.2337/diacare.23.7.888
52 https://doi.org/10.3949/ccjm.67.4.287
53 schema:datePublished 2001-05
54 schema:datePublishedReg 2001-05-01
55 schema:description AIMS/HYPOTHESIS: Multiple factors, including hyperglycaemia and angiotensin II (Ang II), stimulate plasminogen activator inhibitor-1 (PAI-1) gene expression in human vascular smooth muscle cells. This study tested the hypothesis that hyperglycaemia and Ang II stimulate PAI-1 gene expression through activator protein-1 (AP-1) binding sites. METHODS: We evaluated the role of AP-1 in PAI-1 gene expression in human vascular smooth muscle cells under high D-glucose and Ang II stimulation using a double-stranded cis-element AP-1 oligodeoxynucleotide (decoy ODN). RESULTS: Activator protein 1 activity was stimulated by high glucose and Ang II treatment and the AP-1 decoy ODN, but not a mismatched decoy ODN, competed for AP-1 activity. The increase in PAI-1 expression by high glucose and Ang II was significantly attenuated by the AP-1 decoy ODN (p <0.05 or p < 0.01). The increase in PAI-1 expression by high glucose and Ang II action on AP-1 sites was also confirmed by promoter analysis of PAI-1. Activator protein 1 activation in response to either high glucose or co-stimulation with high glucose and Ang II was inhibited completely by calphostin C (a PKC inhibitor) and partially by genistein (a protein tyrosine kinase inhibitor). CONCLUSION/INTERPRETATION: This study shows that high glucose and Ang II stimulate PAI-1 expression through AP-1 binding sites. Signal transduction after AP-1 activation by both high glucose and Ang II largely depends on PKC activation. These data indicate an important role for AP-1 in PAI-1 expression.
56 schema:genre research_article
57 schema:inLanguage en
58 schema:isAccessibleForFree true
59 schema:isPartOf N1b36226f01ab40b2aa448230873b1814
60 Nec94faa7b3af46bfb28811e8e6d154ec
61 sg:journal.1001482
62 schema:name Transcription factor decoy for activator protein-1 (AP-1) inhibits high glucose- and angiotensin II-induced type 1 plasminogen activator inhibitor (PAI-1) gene expression in cultured human vascular smooth muscle cells
63 schema:pagination 713-720
64 schema:productId N0df52fdf2b10410db254c60140ae76dc
65 N24324e3ff9724ea6b59ae57263c6dd6d
66 Naf7ca8e86f4f47c09162935bf855e32d
67 Ncb94d5a2c4b44a9485f545b749c85a29
68 Ncdf231a466b24884a811cd83189239b6
69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024312144
70 https://doi.org/10.1007/s001250051680
71 schema:sdDatePublished 2019-04-11T09:37
72 schema:sdLicense https://scigraph.springernature.com/explorer/license/
73 schema:sdPublisher N7657315a7f2f447a928aa1c8c1a04717
74 schema:url https://link.springer.com/10.1007%2Fs001250051680
75 sgo:license sg:explorer/license/
76 sgo:sdDataset articles
77 rdf:type schema:ScholarlyArticle
78 N037bb00d5a02482fb5b76979fb822f2c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Gene Expression
80 rdf:type schema:DefinedTerm
81 N0d3e64f87aae4dd58eb7b764866a7326 rdf:first sg:person.014104715634.26
82 rdf:rest N4f41dff322a74f50b9cc808fba1b7dcc
83 N0df52fdf2b10410db254c60140ae76dc schema:name dimensions_id
84 schema:value pub.1024312144
85 rdf:type schema:PropertyValue
86 N0fd3735c5ebe492da4f907805ad0daa2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Plasminogen Activator Inhibitor 1
88 rdf:type schema:DefinedTerm
89 N1b36226f01ab40b2aa448230873b1814 schema:volumeNumber 44
90 rdf:type schema:PublicationVolume
91 N24324e3ff9724ea6b59ae57263c6dd6d schema:name pubmed_id
92 schema:value 11440364
93 rdf:type schema:PropertyValue
94 N2c4ba6ce10e54f5b8cb7dc53bbef0df0 schema:affiliation https://www.grid.ac/institutes/grid.412091.f
95 schema:familyName Song
96 schema:givenName H. S.
97 rdf:type schema:Person
98 N2cb5d9b235df47cb8c7e3f00d687db6e rdf:first sg:person.015663503347.24
99 rdf:rest rdf:nil
100 N305e55b4e72b4146a29cf65022405544 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Protein Kinase C
102 rdf:type schema:DefinedTerm
103 N316e5a621c524d9b9c7b441415944c29 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Enzyme Inhibitors
105 rdf:type schema:DefinedTerm
106 N41c40e27be7e4bcea70eae5a0b1907d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Cells, Cultured
108 rdf:type schema:DefinedTerm
109 N448ed4d7dd534154a6d904b59d5bb06a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Naphthalenes
111 rdf:type schema:DefinedTerm
112 N4f41dff322a74f50b9cc808fba1b7dcc rdf:first Nd7ec0da817624927a6c4b59f821bfecd
113 rdf:rest Nf146f047b0ce4ae692787b5446028f13
114 N4fc36b82bfe0488cbf831f98d7f95b26 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Humans
116 rdf:type schema:DefinedTerm
117 N53a73485c0f5438fa21179e6ef4189de rdf:first sg:person.01036122220.21
118 rdf:rest N0d3e64f87aae4dd58eb7b764866a7326
119 N56c7e8b53d9e4a8cb55ce8c39e65b438 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Muscle, Smooth, Vascular
121 rdf:type schema:DefinedTerm
122 N60bfcb5ab15c488dbdf950824208b9e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Glucose
124 rdf:type schema:DefinedTerm
125 N64c1a4071f88478e8b1f9bf815fdc504 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Angiotensin II
127 rdf:type schema:DefinedTerm
128 N7657315a7f2f447a928aa1c8c1a04717 schema:name Springer Nature - SN SciGraph project
129 rdf:type schema:Organization
130 N78f078b1566e4c4eb2f4feb3575d1b00 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Oligonucleotides
132 rdf:type schema:DefinedTerm
133 N8262d3f1242947e0874f513e5b822619 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Transcription Factor AP-1
135 rdf:type schema:DefinedTerm
136 Na6d70988b43f451cb88f5e0f8285ad2e rdf:first sg:person.01334645231.38
137 rdf:rest Na951a50c086c453e9ea7351b2450ea9e
138 Na951a50c086c453e9ea7351b2450ea9e rdf:first sg:person.01241111761.53
139 rdf:rest N53a73485c0f5438fa21179e6ef4189de
140 Naf7ca8e86f4f47c09162935bf855e32d schema:name doi
141 schema:value 10.1007/s001250051680
142 rdf:type schema:PropertyValue
143 Ncb94d5a2c4b44a9485f545b749c85a29 schema:name readcube_id
144 schema:value 73d375a9bb78d1fcb11145f704a1928f531d4677bf65ebc173a445648f49f310
145 rdf:type schema:PropertyValue
146 Ncdf231a466b24884a811cd83189239b6 schema:name nlm_unique_id
147 schema:value 0006777
148 rdf:type schema:PropertyValue
149 Nd384ec73e69c4696b178c22957f7bdb7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Protein-Tyrosine Kinases
151 rdf:type schema:DefinedTerm
152 Nd7ec0da817624927a6c4b59f821bfecd schema:affiliation https://www.grid.ac/institutes/grid.412091.f
153 schema:familyName Jeon
154 schema:givenName Y. J.
155 rdf:type schema:Person
156 Nec94faa7b3af46bfb28811e8e6d154ec schema:issueNumber 6
157 rdf:type schema:PublicationIssue
158 Nf146f047b0ce4ae692787b5446028f13 rdf:first N2c4ba6ce10e54f5b8cb7dc53bbef0df0
159 rdf:rest N2cb5d9b235df47cb8c7e3f00d687db6e
160 Nfc2b77d501b94058914fdc3b1bffc345 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Genistein
162 rdf:type schema:DefinedTerm
163 Nfdb0185183614ff6bce0e6bd84c02122 rdf:first sg:person.01206361263.30
164 rdf:rest Na6d70988b43f451cb88f5e0f8285ad2e
165 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
166 schema:name Biological Sciences
167 rdf:type schema:DefinedTerm
168 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
169 schema:name Genetics
170 rdf:type schema:DefinedTerm
171 sg:journal.1001482 schema:issn 0012-186X
172 1432-0428
173 schema:name Diabetologia
174 rdf:type schema:Periodical
175 sg:person.01036122220.21 schema:affiliation https://www.grid.ac/institutes/grid.267370.7
176 schema:familyName Lee
177 schema:givenName K. U.
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036122220.21
179 rdf:type schema:Person
180 sg:person.01206361263.30 schema:affiliation https://www.grid.ac/institutes/grid.412091.f
181 schema:familyName Ahn
182 schema:givenName J. D.
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206361263.30
184 rdf:type schema:Person
185 sg:person.01241111761.53 schema:affiliation https://www.grid.ac/institutes/grid.136593.b
186 schema:familyName Kaneda
187 schema:givenName Y.
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241111761.53
189 rdf:type schema:Person
190 sg:person.01334645231.38 schema:affiliation https://www.grid.ac/institutes/grid.136593.b
191 schema:familyName Morishita
192 schema:givenName R.
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334645231.38
194 rdf:type schema:Person
195 sg:person.014104715634.26 schema:affiliation https://www.grid.ac/institutes/grid.267370.7
196 schema:familyName Park
197 schema:givenName J. Y.
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014104715634.26
199 rdf:type schema:Person
200 sg:person.015663503347.24 schema:affiliation https://www.grid.ac/institutes/grid.412091.f
201 schema:familyName Lee
202 schema:givenName I. K.
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015663503347.24
204 rdf:type schema:Person
205 sg:pub.10.1007/bf00403280 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004442083
206 https://doi.org/10.1007/bf00403280
207 rdf:type schema:CreativeWork
208 sg:pub.10.1007/s001090050063 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016860240
209 https://doi.org/10.1007/s001090050063
210 rdf:type schema:CreativeWork
211 sg:pub.10.1046/j.1523-1755.1998.00888.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028031018
212 https://doi.org/10.1046/j.1523-1755.1998.00888.x
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1006/abio.1994.1042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004329331
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1006/bbrc.1997.8012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043302959
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1016/0002-9343(91)90040-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012264113
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1016/0891-5849(96)00109-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003464017
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1016/1050-1738(91)90001-u schema:sameAs https://app.dimensions.ai/details/publication/pub.1009938262
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1016/s1054-3589(08)60993-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1043322565
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1073/pnas.89.15.6998 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025954637
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1074/jbc.270.28.16483 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010729403
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1074/jbc.273.14.8225 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009384711
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1074/jbc.273.41.26487 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043349199
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1089/hum.1997.8.17-2133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059271964
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1111/j.1432-1033.1994.tb18599.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037767211
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1111/j.1432-1033.1996.00393.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1020688347
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1126/science.2237444 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062528429
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1126/science.2526370 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062542273
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1159/000425092 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007030011
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1161/01.atv.13.12.1822 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048769490
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1161/01.atv.14.5.815 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008820331
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1161/01.atv.15.10.1584 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063333869
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1161/01.cir.101.3.264 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027678945
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1161/01.cir.82.1.27 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006896880
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1161/01.cir.97.11.1071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027185397
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1161/01.hyp.31.1.321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036703032
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1161/01.hyp.33.1.378 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050108788
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1161/01.hyp.35.5.1038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005957465
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1161/01.res.70.3.593 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033244413
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1161/01.res.80.1.139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063341003
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1161/01.res.85.8.753 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014367194
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1172/jci116020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026103107
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1172/jci117786 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048477268
273 rdf:type schema:CreativeWork
274 https://doi.org/10.2337/diacare.23.7.888 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018856315
275 rdf:type schema:CreativeWork
276 https://doi.org/10.3949/ccjm.67.4.287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071759012
277 rdf:type schema:CreativeWork
278 https://www.grid.ac/institutes/grid.136593.b schema:alternateName Osaka University
279 schema:name Division of Gene Therapy Science, Graduate School of Medicine, Osaka University, Suita, Japan, JP
280 rdf:type schema:Organization
281 https://www.grid.ac/institutes/grid.267370.7 schema:alternateName University of Ulsan
282 schema:name Department of Internal Medicine, University of Ulsan School of Medicine, Seoul, Korea, KR
283 rdf:type schema:Organization
284 https://www.grid.ac/institutes/grid.412091.f schema:alternateName Keimyung University
285 schema:name Department of Internal Medicine, Keimyung University School of Medicine, Taegu, Korea, KR
286 Institute for Medical Science, Keimyung University School of Medicine, Taegu, Korea, KR
287 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...