Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1999-01

AUTHORS

M. Krssak, K. Falk Petersen, A. Dresner, L. DiPietro, S. M. Vogel, D. L. Rothman, G. I. Shulman, M. Roden

ABSTRACT

Recent muscle biopsy studies have shown a relation between intramuscular lipid content and insulin resistance. The aim of this study was to test this relation in humans by using a novel proton nuclear magnetic resonance (1H NMR) spectroscopy technique, which enables non-invasive and rapid (approximately 45 min) determination of intramyocellular lipid (IMCL) content. Normal weight non-diabetic adults (n = 23, age 29+/-2 years. BMI = 24.1+/-0.5 kg/m2) were studied using cross-sectional analysis. Insulin sensitivity was assessed by a 2-h hyperinsulinaemic (approximately 450 pmol/l)-euglycaemic (approximately 5 mmol/l) clamp test. Intramyocellular lipid concentrations were determined by using localized 1H NMR spectroscopy of soleus muscle. Simple linear regression analysis showed an inverse correlation (r = -0.579, p = 0.0037) [corrected] between intramyocellular lipid content and M-value (100-120 min of clamp) as well as between fasting plasma non-esterified fatty acid concentration and M-value (r = -0.54, p = 0.0267). Intramyocellular lipid content was not related to BMI, age and fasting plasma concentrations of triglycerides, non-esterified fatty acids, glucose or insulin. These results show that intramyocellular lipid concentration, as assessed non invasively by localized 1H NMR spectroscopy, is a good indicator of whole body insulin sensitivity in non-diabetic, non-obese humans. More... »

PAGES

113-116

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s001250051123

DOI

http://dx.doi.org/10.1007/s001250051123

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039281035

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10027589


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Glucose", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fasting", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fatty Acids, Nonesterified", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glucose Clamp Technique", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hydrogen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Infusions, Intravenous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lipid Metabolism", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnetic Resonance Spectroscopy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Muscle, Skeletal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Regression Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Triglycerides", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Internal Medicine Yale University School of Medicine, New Haven, Connecticut, USA, US"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Krssak", 
        "givenName": "M.", 
        "id": "sg:person.01011364431.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011364431.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Internal Medicine Yale University School of Medicine, New Haven, Connecticut, USA, US"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Falk Petersen", 
        "givenName": "K.", 
        "id": "sg:person.014300404317.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014300404317.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Internal Medicine Yale University School of Medicine, New Haven, Connecticut, USA, US"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dresner", 
        "givenName": "A.", 
        "id": "sg:person.01020564236.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020564236.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "John B. Pierce Laboratory", 
          "id": "https://www.grid.ac/institutes/grid.280777.d", 
          "name": [
            "The John B. Pierce Laboratory and Department of Epidemiology & Public Health Yale University School of Medicine,  New Haven, Connecticut, USA, US"
          ], 
          "type": "Organization"
        }, 
        "familyName": "DiPietro", 
        "givenName": "L.", 
        "id": "sg:person.0735454303.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735454303.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Internal Medicine Yale University School of Medicine, New Haven, Connecticut, USA, US"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vogel", 
        "givenName": "S. M.", 
        "id": "sg:person.01227743355.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227743355.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Internal Medicine Yale University School of Medicine, New Haven, Connecticut, USA, US"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rothman", 
        "givenName": "D. L.", 
        "id": "sg:person.0660132734.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660132734.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, USA, US"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shulman", 
        "givenName": "G. I.", 
        "id": "sg:person.01340446106.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340446106.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Vienna", 
          "id": "https://www.grid.ac/institutes/grid.10420.37", 
          "name": [
            "Division of Endocrinology and Metabolism, Department of Internal Medicine III, University of Vienna, Vienna, Austria, AT"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roden", 
        "givenName": "M.", 
        "id": "sg:person.01142642655.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142642655.13"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/mrm.1910370403", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000198846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0026-0495(96)90260-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005319077"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci118742", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011856185"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001250050875", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012434962", 
          "https://doi.org/10.1007/s001250050875"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001250050875", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012434962", 
          "https://doi.org/10.1007/s001250050875"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mrm.1910090110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029038731"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci108486", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038647407"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mrm.1910290203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041908620"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diab.40.2.280", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070736437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diab.46.6.983", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070738221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.37.12.1595", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070741229"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1999-01", 
    "datePublishedReg": "1999-01-01", 
    "description": "Recent muscle biopsy studies have shown a relation between intramuscular lipid content and insulin resistance. The aim of this study was to test this relation in humans by using a novel proton nuclear magnetic resonance (1H NMR) spectroscopy technique, which enables non-invasive and rapid (approximately 45 min) determination of intramyocellular lipid (IMCL) content. Normal weight non-diabetic adults (n = 23, age 29+/-2 years. BMI = 24.1+/-0.5 kg/m2) were studied using cross-sectional analysis. Insulin sensitivity was assessed by a 2-h hyperinsulinaemic (approximately 450 pmol/l)-euglycaemic (approximately 5 mmol/l) clamp test. Intramyocellular lipid concentrations were determined by using localized 1H NMR spectroscopy of soleus muscle. Simple linear regression analysis showed an inverse correlation (r = -0.579, p = 0.0037) [corrected] between intramyocellular lipid content and M-value (100-120 min of clamp) as well as between fasting plasma non-esterified fatty acid concentration and M-value (r = -0.54, p = 0.0267). Intramyocellular lipid content was not related to BMI, age and fasting plasma concentrations of triglycerides, non-esterified fatty acids, glucose or insulin. These results show that intramyocellular lipid concentration, as assessed non invasively by localized 1H NMR spectroscopy, is a good indicator of whole body insulin sensitivity in non-diabetic, non-obese humans.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s001250051123", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2495379", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2441153", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2439003", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1001482", 
        "issn": [
          "0012-186X", 
          "1432-0428"
        ], 
        "name": "Diabetologia", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "42"
      }
    ], 
    "name": "Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study", 
    "pagination": "113-116", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "bb1d34aa6dfb1d1a24f8ae8bca3fb1b29d1b3d442e11705732c433641a47f000"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "10027589"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0006777"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s001250051123"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1039281035"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s001250051123", 
      "https://app.dimensions.ai/details/publication/pub.1039281035"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:37", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000349_0000000349/records_113676_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs001250051123"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s001250051123'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s001250051123'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s001250051123'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s001250051123'


 

This table displays all metadata directly associated to this object as RDF triples.

226 TRIPLES      21 PREDICATES      55 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s001250051123 schema:about N017f4b5f323e41319cd8d607137a3056
2 N20389e25766d43658f1ff04a85c9a038
3 N33b58595bdbb4fcfab21bae6daeec304
4 N3d7dfd47d80b4c2593c749b78fc48c2a
5 N6c5ba84f265e476a87df2d0fabd845b6
6 N7567d547e395445c994658f7d7a3a539
7 N76cfd45430fb4c148771b2afade865da
8 N89d8812b06d7461b8528be8079719433
9 Na49b197c084444baa33d9daa73e8c109
10 Na90976ef80884c128b8cfda7296c0e08
11 Ncb632e2539fe42acb444257cffb7f57c
12 Nd36776ac9f52432899133f175ebd8025
13 Ne51fa2c9add447e0955d8d4f100fec60
14 Ne6cfb9e2487041cc8f9335a4303044bc
15 Nf480a5a0433f4efd99157d15fbfb6999
16 Nfa52fec9aaa0446f97c6fde75dc48d09
17 anzsrc-for:11
18 anzsrc-for:1103
19 schema:author Neeb0dad1b4514050a0a8dcd52417c223
20 schema:citation sg:pub.10.1007/s001250050875
21 https://doi.org/10.1002/mrm.1910090110
22 https://doi.org/10.1002/mrm.1910290203
23 https://doi.org/10.1002/mrm.1910370403
24 https://doi.org/10.1016/s0026-0495(96)90260-7
25 https://doi.org/10.1172/jci108486
26 https://doi.org/10.1172/jci118742
27 https://doi.org/10.2337/diab.40.2.280
28 https://doi.org/10.2337/diab.46.6.983
29 https://doi.org/10.2337/diabetes.37.12.1595
30 schema:datePublished 1999-01
31 schema:datePublishedReg 1999-01-01
32 schema:description Recent muscle biopsy studies have shown a relation between intramuscular lipid content and insulin resistance. The aim of this study was to test this relation in humans by using a novel proton nuclear magnetic resonance (1H NMR) spectroscopy technique, which enables non-invasive and rapid (approximately 45 min) determination of intramyocellular lipid (IMCL) content. Normal weight non-diabetic adults (n = 23, age 29+/-2 years. BMI = 24.1+/-0.5 kg/m2) were studied using cross-sectional analysis. Insulin sensitivity was assessed by a 2-h hyperinsulinaemic (approximately 450 pmol/l)-euglycaemic (approximately 5 mmol/l) clamp test. Intramyocellular lipid concentrations were determined by using localized 1H NMR spectroscopy of soleus muscle. Simple linear regression analysis showed an inverse correlation (r = -0.579, p = 0.0037) [corrected] between intramyocellular lipid content and M-value (100-120 min of clamp) as well as between fasting plasma non-esterified fatty acid concentration and M-value (r = -0.54, p = 0.0267). Intramyocellular lipid content was not related to BMI, age and fasting plasma concentrations of triglycerides, non-esterified fatty acids, glucose or insulin. These results show that intramyocellular lipid concentration, as assessed non invasively by localized 1H NMR spectroscopy, is a good indicator of whole body insulin sensitivity in non-diabetic, non-obese humans.
33 schema:genre research_article
34 schema:inLanguage en
35 schema:isAccessibleForFree true
36 schema:isPartOf N7e5405a72f664ccc933924c2a35570a0
37 Nbff35c251eb44c70ac5b96c0f012cc1d
38 sg:journal.1001482
39 schema:name Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study
40 schema:pagination 113-116
41 schema:productId N453bc8d382ba406a8dadd4a2c8008d3a
42 N78899110ef41475e8bb156e4ebaf8dfb
43 N86b983f1a4e44d23a9e12d161ed18516
44 N88ba7322c1d141319793a90d0b040ffe
45 Nea70fba1b71d400aa8909294e9dfd521
46 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039281035
47 https://doi.org/10.1007/s001250051123
48 schema:sdDatePublished 2019-04-11T10:37
49 schema:sdLicense https://scigraph.springernature.com/explorer/license/
50 schema:sdPublisher N81a2921e8aa3482f839eb14ac13e861f
51 schema:url https://link.springer.com/10.1007%2Fs001250051123
52 sgo:license sg:explorer/license/
53 sgo:sdDataset articles
54 rdf:type schema:ScholarlyArticle
55 N017f4b5f323e41319cd8d607137a3056 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
56 schema:name Lipid Metabolism
57 rdf:type schema:DefinedTerm
58 N1004da184a8f402fadc285b9fd0dca1f rdf:first sg:person.014300404317.81
59 rdf:rest Ncb8569d842294dc1ad3c8493414e5060
60 N20389e25766d43658f1ff04a85c9a038 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
61 schema:name Infusions, Intravenous
62 rdf:type schema:DefinedTerm
63 N33b58595bdbb4fcfab21bae6daeec304 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
64 schema:name Hydrogen
65 rdf:type schema:DefinedTerm
66 N3d7dfd47d80b4c2593c749b78fc48c2a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
67 schema:name Magnetic Resonance Spectroscopy
68 rdf:type schema:DefinedTerm
69 N453bc8d382ba406a8dadd4a2c8008d3a schema:name doi
70 schema:value 10.1007/s001250051123
71 rdf:type schema:PropertyValue
72 N59b6e5bc408b45b18f70d69f935c18a7 rdf:first sg:person.01340446106.39
73 rdf:rest Nadeaf88f588240d1b326e4060664f74e
74 N6c5ba84f265e476a87df2d0fabd845b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Humans
76 rdf:type schema:DefinedTerm
77 N7567d547e395445c994658f7d7a3a539 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Fasting
79 rdf:type schema:DefinedTerm
80 N76cfd45430fb4c148771b2afade865da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Regression Analysis
82 rdf:type schema:DefinedTerm
83 N78899110ef41475e8bb156e4ebaf8dfb schema:name dimensions_id
84 schema:value pub.1039281035
85 rdf:type schema:PropertyValue
86 N7e5405a72f664ccc933924c2a35570a0 schema:volumeNumber 42
87 rdf:type schema:PublicationVolume
88 N81a2921e8aa3482f839eb14ac13e861f schema:name Springer Nature - SN SciGraph project
89 rdf:type schema:Organization
90 N86b983f1a4e44d23a9e12d161ed18516 schema:name nlm_unique_id
91 schema:value 0006777
92 rdf:type schema:PropertyValue
93 N883037f2854544e0a9424c1654f0dc55 rdf:first sg:person.0735454303.95
94 rdf:rest Nd806b1166cdb452e99d058b04eac90b1
95 N88ba7322c1d141319793a90d0b040ffe schema:name readcube_id
96 schema:value bb1d34aa6dfb1d1a24f8ae8bca3fb1b29d1b3d442e11705732c433641a47f000
97 rdf:type schema:PropertyValue
98 N89d8812b06d7461b8528be8079719433 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Insulin
100 rdf:type schema:DefinedTerm
101 Na49b197c084444baa33d9daa73e8c109 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Fatty Acids, Nonesterified
103 rdf:type schema:DefinedTerm
104 Na90976ef80884c128b8cfda7296c0e08 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Triglycerides
106 rdf:type schema:DefinedTerm
107 Nadeaf88f588240d1b326e4060664f74e rdf:first sg:person.01142642655.13
108 rdf:rest rdf:nil
109 Nbff35c251eb44c70ac5b96c0f012cc1d schema:issueNumber 1
110 rdf:type schema:PublicationIssue
111 Ncb632e2539fe42acb444257cffb7f57c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Glucose Clamp Technique
113 rdf:type schema:DefinedTerm
114 Ncb8569d842294dc1ad3c8493414e5060 rdf:first sg:person.01020564236.97
115 rdf:rest N883037f2854544e0a9424c1654f0dc55
116 Nd36776ac9f52432899133f175ebd8025 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Male
118 rdf:type schema:DefinedTerm
119 Nd806b1166cdb452e99d058b04eac90b1 rdf:first sg:person.01227743355.42
120 rdf:rest Nf3a6d9d51ed748a3b07f9fe945bae6e8
121 Ne51fa2c9add447e0955d8d4f100fec60 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Female
123 rdf:type schema:DefinedTerm
124 Ne6cfb9e2487041cc8f9335a4303044bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Muscle, Skeletal
126 rdf:type schema:DefinedTerm
127 Nea70fba1b71d400aa8909294e9dfd521 schema:name pubmed_id
128 schema:value 10027589
129 rdf:type schema:PropertyValue
130 Neeb0dad1b4514050a0a8dcd52417c223 rdf:first sg:person.01011364431.62
131 rdf:rest N1004da184a8f402fadc285b9fd0dca1f
132 Nf3a6d9d51ed748a3b07f9fe945bae6e8 rdf:first sg:person.0660132734.54
133 rdf:rest N59b6e5bc408b45b18f70d69f935c18a7
134 Nf480a5a0433f4efd99157d15fbfb6999 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Blood Glucose
136 rdf:type schema:DefinedTerm
137 Nfa52fec9aaa0446f97c6fde75dc48d09 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Adult
139 rdf:type schema:DefinedTerm
140 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
141 schema:name Medical and Health Sciences
142 rdf:type schema:DefinedTerm
143 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
144 schema:name Clinical Sciences
145 rdf:type schema:DefinedTerm
146 sg:grant.2439003 http://pending.schema.org/fundedItem sg:pub.10.1007/s001250051123
147 rdf:type schema:MonetaryGrant
148 sg:grant.2441153 http://pending.schema.org/fundedItem sg:pub.10.1007/s001250051123
149 rdf:type schema:MonetaryGrant
150 sg:grant.2495379 http://pending.schema.org/fundedItem sg:pub.10.1007/s001250051123
151 rdf:type schema:MonetaryGrant
152 sg:journal.1001482 schema:issn 0012-186X
153 1432-0428
154 schema:name Diabetologia
155 rdf:type schema:Periodical
156 sg:person.01011364431.62 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
157 schema:familyName Krssak
158 schema:givenName M.
159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011364431.62
160 rdf:type schema:Person
161 sg:person.01020564236.97 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
162 schema:familyName Dresner
163 schema:givenName A.
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020564236.97
165 rdf:type schema:Person
166 sg:person.01142642655.13 schema:affiliation https://www.grid.ac/institutes/grid.10420.37
167 schema:familyName Roden
168 schema:givenName M.
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142642655.13
170 rdf:type schema:Person
171 sg:person.01227743355.42 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
172 schema:familyName Vogel
173 schema:givenName S. M.
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227743355.42
175 rdf:type schema:Person
176 sg:person.01340446106.39 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
177 schema:familyName Shulman
178 schema:givenName G. I.
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340446106.39
180 rdf:type schema:Person
181 sg:person.014300404317.81 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
182 schema:familyName Falk Petersen
183 schema:givenName K.
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014300404317.81
185 rdf:type schema:Person
186 sg:person.0660132734.54 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
187 schema:familyName Rothman
188 schema:givenName D. L.
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660132734.54
190 rdf:type schema:Person
191 sg:person.0735454303.95 schema:affiliation https://www.grid.ac/institutes/grid.280777.d
192 schema:familyName DiPietro
193 schema:givenName L.
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735454303.95
195 rdf:type schema:Person
196 sg:pub.10.1007/s001250050875 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012434962
197 https://doi.org/10.1007/s001250050875
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1002/mrm.1910090110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029038731
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1002/mrm.1910290203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041908620
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1002/mrm.1910370403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000198846
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1016/s0026-0495(96)90260-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005319077
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1172/jci108486 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038647407
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1172/jci118742 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011856185
210 rdf:type schema:CreativeWork
211 https://doi.org/10.2337/diab.40.2.280 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070736437
212 rdf:type schema:CreativeWork
213 https://doi.org/10.2337/diab.46.6.983 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070738221
214 rdf:type schema:CreativeWork
215 https://doi.org/10.2337/diabetes.37.12.1595 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070741229
216 rdf:type schema:CreativeWork
217 https://www.grid.ac/institutes/grid.10420.37 schema:alternateName University of Vienna
218 schema:name Division of Endocrinology and Metabolism, Department of Internal Medicine III, University of Vienna, Vienna, Austria, AT
219 rdf:type schema:Organization
220 https://www.grid.ac/institutes/grid.280777.d schema:alternateName John B. Pierce Laboratory
221 schema:name The John B. Pierce Laboratory and Department of Epidemiology & Public Health Yale University School of Medicine, New Haven, Connecticut, USA, US
222 rdf:type schema:Organization
223 https://www.grid.ac/institutes/grid.47100.32 schema:alternateName Yale University
224 schema:name Department of Internal Medicine Yale University School of Medicine, New Haven, Connecticut, USA, US
225 Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, USA, US
226 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...