NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1997-11

AUTHORS

J. C. Pickup, M. B. Mattock, G. D. Chusney, D. Burt

ABSTRACT

Non-insulin-dependent diabetes mellitus (NIDDM) is commonly associated with hypertriglyceridaemia, low serum HDL-cholesterol concentrations, hypertension, obesity and accelerated atherosclerosis (metabolic syndrome X). Since a similar dyslipidaemia occurs with the acute-phase response, we investigated whether elevated acute-phase/stress reactants (the innate immune system's response to environmental stress) and their major cytokine mediator (interleukin-6, IL-6) are associated with NIDDM and syndrome X, and may thus provide a unifying pathophysiological mechanism for these conditions. Two groups of Caucasian subjects with NIDDM were studied. Those with any 4 or 5 features of syndrome X (n = 19) were compared with a group with 0 or 1 feature of syndrome X (n = 25) but similar age, sex distribution, diabetes duration, glycaemic control and diabetes treatment. Healthy non-diabetic subjects of comparable age and sex acted as controls. Overnight urinary albumin excretion rate, a risk factor for cardiovascular disease, was also assayed in subjects to assess its relationship to the acute-phase response. Serum sialic acid was confirmed as a marker of the acute-phase response since serum concentrations were significantly related to established acute-phase proteins such as alpha-1 acid glycoprotein (r = 0.82, p < 0.0001). There was a significant graded increase of serum sialic acid, alpha-1 acid glycoprotein, IL-6 and urinary albumin excretion rate amongst the three groups, with the lowest levels in non-diabetic subjects, intermediate levels in NIDDM patients without syndrome X and highest levels in NIDDM patients with syndrome X. C-reactive protein and cortisol levels were also higher in syndrome X-positive compared to X-negative patients and serum amyloid A was higher in both diabetic groups than in the control group. We conclude that NIDDM is associated with an elevated acute-phase response, particularly in those with features of syndrome X. Abnormalities of the innate immune system may be a contributor to the hypertriglyceridaemia, low HDL cholesterol, hypertension, glucose intolerance, insulin resistance and accelerated atherosclerosis of NIDDM. Microalbuminuria may be a component of the acute-phase response. More... »

PAGES

1286

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s001250050822

DOI

http://dx.doi.org/10.1007/s001250050822

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046557332

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9389420


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Acute-Phase Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Albuminuria", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "C-Reactive Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diabetes Mellitus, Type 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hydrocortisone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin Resistance", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-6", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "N-Acetylneuraminic Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Orosomucoid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Serum Amyloid A Protein", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Guy's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.239826.4", 
          "name": [
            "Division of Chemical Pathology UMDS, Guy\u2019s Hospital, SE1 9RT, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pickup", 
        "givenName": "J. C.", 
        "id": "sg:person.01276470361.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276470361.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Guy's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.239826.4", 
          "name": [
            "Division of Chemical Pathology UMDS, Guy\u2019s Hospital, SE1 9RT, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mattock", 
        "givenName": "M. B.", 
        "id": "sg:person.01066334211.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066334211.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Guy's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.239826.4", 
          "name": [
            "Division of Chemical Pathology UMDS, Guy\u2019s Hospital, SE1 9RT, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chusney", 
        "givenName": "G. D.", 
        "id": "sg:person.0765350302.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765350302.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Guy's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.239826.4", 
          "name": [
            "Unit for Metabolic Medicine, UMDS, Guy\u2019s Hospital, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Burt", 
        "givenName": "D.", 
        "id": "sg:person.01231152350.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231152350.00"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1084/jem.178.6.2165", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000973784"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archinte.1989.00390070054005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003262971"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(63)90620-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004647887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0009-8981(93)90204-h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006424301"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0009-8981(93)90204-h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006424301"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0002-9343(82)90543-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007180554"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00395552", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013397893", 
          "https://doi.org/10.1007/bf00395552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00395552", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013397893", 
          "https://doi.org/10.1007/bf00395552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00395552", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013397893", 
          "https://doi.org/10.1007/bf00395552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dmr.5610100103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015281661"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dmr.5610100103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015281661"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00422091", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015531035", 
          "https://doi.org/10.1007/bf00422091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00422091", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015531035", 
          "https://doi.org/10.1007/bf00422091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2796.1995.tb00895.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019890030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2796.1995.tb00895.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019890030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/1043-4666(91)90489-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020086030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2796.1995.tb01229.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020269517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2796.1995.tb01229.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020269517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci103182", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022688685"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0026-0495(89)90038-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026152682"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0167-5699(94)90138-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028438524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0167-5699(94)90138-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028438524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm198402093100605", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029263631"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00399095", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030059890", 
          "https://doi.org/10.1007/bf00399095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00399095", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030059890", 
          "https://doi.org/10.1007/bf00399095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00399095", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030059890", 
          "https://doi.org/10.1007/bf00399095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1464-5491.1984.tb01915.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031542570"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1464-5491.1984.tb01915.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031542570"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00041433-199106000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032119004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00041433-199106000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032119004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-642-74856-1_7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032316513", 
          "https://doi.org/10.1007/978-3-642-74856-1_7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.12.4.1789", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032729192"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm198903163201105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034071791"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jcp.34.5.464", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034085754"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0167-5699(94)90137-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035808470"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0167-5699(94)90137-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035808470"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0024-3205(95)02096-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041979034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00404074", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042245933", 
          "https://doi.org/10.1007/bf00404074"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00404074", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042245933", 
          "https://doi.org/10.1007/bf00404074"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00404074", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042245933", 
          "https://doi.org/10.1007/bf00404074"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0306-9877(91)90280-c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046026870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0065-2776(08)60532-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046724142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.1830230950", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047019134"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2796.1993.tb00674.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047559036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2796.1993.tb00674.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047559036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4684-2226-9_9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048132175", 
          "https://doi.org/10.1007/978-1-4684-2226-9_9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00400592", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053636854", 
          "https://doi.org/10.1007/bf00400592"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00400592", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053636854", 
          "https://doi.org/10.1007/bf00400592"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00400592", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053636854", 
          "https://doi.org/10.1007/bf00400592"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archinte.149.7.1514", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054112550"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.3259727", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062601782"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.312.7038.1061", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062775599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.312.7038.1061", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062775599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/endo-114-3-914", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064257849"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diab.37.12.1595", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070735404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diab.41.2.s97", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070736757"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diab.43.11.1271", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070737207"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diab.43.5.613", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070737314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.37.12.1595", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070741229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.43.11.1271", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070742700"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.43.5.613", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070742794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.15.10.1245", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070745512"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.16.1.57", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070745860"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.16.2.445", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070745940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.18.8.1100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070746804"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-117-10-807", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073696575"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075688837", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076655607", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077186336", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078927667", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079208087", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082105850", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082466878", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082707565", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1997-11", 
    "datePublishedReg": "1997-11-01", 
    "description": "Non-insulin-dependent diabetes mellitus (NIDDM) is commonly associated with hypertriglyceridaemia, low serum HDL-cholesterol concentrations, hypertension, obesity and accelerated atherosclerosis (metabolic syndrome X). Since a similar dyslipidaemia occurs with the acute-phase response, we investigated whether elevated acute-phase/stress reactants (the innate immune system's response to environmental stress) and their major cytokine mediator (interleukin-6, IL-6) are associated with NIDDM and syndrome X, and may thus provide a unifying pathophysiological mechanism for these conditions. Two groups of Caucasian subjects with NIDDM were studied. Those with any 4 or 5 features of syndrome X (n = 19) were compared with a group with 0 or 1 feature of syndrome X (n = 25) but similar age, sex distribution, diabetes duration, glycaemic control and diabetes treatment. Healthy non-diabetic subjects of comparable age and sex acted as controls. Overnight urinary albumin excretion rate, a risk factor for cardiovascular disease, was also assayed in subjects to assess its relationship to the acute-phase response. Serum sialic acid was confirmed as a marker of the acute-phase response since serum concentrations were significantly related to established acute-phase proteins such as alpha-1 acid glycoprotein (r = 0.82, p < 0.0001). There was a significant graded increase of serum sialic acid, alpha-1 acid glycoprotein, IL-6 and urinary albumin excretion rate amongst the three groups, with the lowest levels in non-diabetic subjects, intermediate levels in NIDDM patients without syndrome X and highest levels in NIDDM patients with syndrome X. C-reactive protein and cortisol levels were also higher in syndrome X-positive compared to X-negative patients and serum amyloid A was higher in both diabetic groups than in the control group. We conclude that NIDDM is associated with an elevated acute-phase response, particularly in those with features of syndrome X. Abnormalities of the innate immune system may be a contributor to the hypertriglyceridaemia, low HDL cholesterol, hypertension, glucose intolerance, insulin resistance and accelerated atherosclerosis of NIDDM. Microalbuminuria may be a component of the acute-phase response.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s001250050822", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1001482", 
        "issn": [
          "0012-186X", 
          "1432-0428"
        ], 
        "name": "Diabetologia", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "11", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "40"
      }
    ], 
    "name": "NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X", 
    "pagination": "1286", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "ddc7f41c08157153bbf9b377d4987f124400a4f8f5c2e65bd5f66b9fc70252c5"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "9389420"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0006777"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s001250050822"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1046557332"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s001250050822", 
      "https://app.dimensions.ai/details/publication/pub.1046557332"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:39", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000349_0000000349/records_113679_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs001250050822"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s001250050822'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s001250050822'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s001250050822'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s001250050822'


 

This table displays all metadata directly associated to this object as RDF triples.

315 TRIPLES      21 PREDICATES      99 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s001250050822 schema:about N019a1f48a01a4f7b8a4fa6708f49eaca
2 N072b71bf1a414257926c60aa2ad8c11c
3 N0e90dbab960b41c7b95e728cd1407035
4 N27ceafc0e5694886bb29ca7340fb3eb2
5 N4531de561e024d86b8bd09cd6e270d02
6 N568b7e5d3a384b469c8b4e2f28bcab84
7 N60c1585e57c04a50bfa73c7f1e9dae88
8 N640e79201848433da8625c57d1bc9991
9 N85a7c309699f44198c26b1a8cfefaeac
10 N8a5a20938326441a9f8fd4274c074142
11 Na63b128acf2c4ed5b1f4144ded20272a
12 Ndd41f3f955184a73b5b16fb77de1c274
13 Nfc057512440f410286cd9f391066828e
14 Nfe11a2d7c5674ea78ef882549d2df197
15 Nff77142fd7264a1ba14a831f937a95de
16 anzsrc-for:11
17 anzsrc-for:1103
18 schema:author Ne677234d61964c8cb523f8555cc703f8
19 schema:citation sg:pub.10.1007/978-1-4684-2226-9_9
20 sg:pub.10.1007/978-3-642-74856-1_7
21 sg:pub.10.1007/bf00395552
22 sg:pub.10.1007/bf00399095
23 sg:pub.10.1007/bf00400592
24 sg:pub.10.1007/bf00404074
25 sg:pub.10.1007/bf00422091
26 https://app.dimensions.ai/details/publication/pub.1075688837
27 https://app.dimensions.ai/details/publication/pub.1076655607
28 https://app.dimensions.ai/details/publication/pub.1077186336
29 https://app.dimensions.ai/details/publication/pub.1078927667
30 https://app.dimensions.ai/details/publication/pub.1079208087
31 https://app.dimensions.ai/details/publication/pub.1082105850
32 https://app.dimensions.ai/details/publication/pub.1082466878
33 https://app.dimensions.ai/details/publication/pub.1082707565
34 https://doi.org/10.1001/archinte.149.7.1514
35 https://doi.org/10.1001/archinte.1989.00390070054005
36 https://doi.org/10.1002/dmr.5610100103
37 https://doi.org/10.1002/eji.1830230950
38 https://doi.org/10.1016/0002-9343(82)90543-5
39 https://doi.org/10.1016/0009-8981(93)90204-h
40 https://doi.org/10.1016/0024-3205(95)02096-2
41 https://doi.org/10.1016/0026-0495(89)90038-3
42 https://doi.org/10.1016/0167-5699(94)90137-6
43 https://doi.org/10.1016/0167-5699(94)90138-4
44 https://doi.org/10.1016/0306-9877(91)90280-c
45 https://doi.org/10.1016/1043-4666(91)90489-z
46 https://doi.org/10.1016/s0065-2776(08)60532-5
47 https://doi.org/10.1016/s0140-6736(63)90620-2
48 https://doi.org/10.1056/nejm198402093100605
49 https://doi.org/10.1056/nejm198903163201105
50 https://doi.org/10.1084/jem.178.6.2165
51 https://doi.org/10.1097/00041433-199106000-00009
52 https://doi.org/10.1111/j.1365-2796.1993.tb00674.x
53 https://doi.org/10.1111/j.1365-2796.1995.tb00895.x
54 https://doi.org/10.1111/j.1365-2796.1995.tb01229.x
55 https://doi.org/10.1111/j.1464-5491.1984.tb01915.x
56 https://doi.org/10.1126/science.3259727
57 https://doi.org/10.1128/mcb.12.4.1789
58 https://doi.org/10.1136/bmj.312.7038.1061
59 https://doi.org/10.1136/jcp.34.5.464
60 https://doi.org/10.1172/jci103182
61 https://doi.org/10.1210/endo-114-3-914
62 https://doi.org/10.2337/diab.37.12.1595
63 https://doi.org/10.2337/diab.41.2.s97
64 https://doi.org/10.2337/diab.43.11.1271
65 https://doi.org/10.2337/diab.43.5.613
66 https://doi.org/10.2337/diabetes.37.12.1595
67 https://doi.org/10.2337/diabetes.43.11.1271
68 https://doi.org/10.2337/diabetes.43.5.613
69 https://doi.org/10.2337/diacare.15.10.1245
70 https://doi.org/10.2337/diacare.16.1.57
71 https://doi.org/10.2337/diacare.16.2.445
72 https://doi.org/10.2337/diacare.18.8.1100
73 https://doi.org/10.7326/0003-4819-117-10-807
74 schema:datePublished 1997-11
75 schema:datePublishedReg 1997-11-01
76 schema:description Non-insulin-dependent diabetes mellitus (NIDDM) is commonly associated with hypertriglyceridaemia, low serum HDL-cholesterol concentrations, hypertension, obesity and accelerated atherosclerosis (metabolic syndrome X). Since a similar dyslipidaemia occurs with the acute-phase response, we investigated whether elevated acute-phase/stress reactants (the innate immune system's response to environmental stress) and their major cytokine mediator (interleukin-6, IL-6) are associated with NIDDM and syndrome X, and may thus provide a unifying pathophysiological mechanism for these conditions. Two groups of Caucasian subjects with NIDDM were studied. Those with any 4 or 5 features of syndrome X (n = 19) were compared with a group with 0 or 1 feature of syndrome X (n = 25) but similar age, sex distribution, diabetes duration, glycaemic control and diabetes treatment. Healthy non-diabetic subjects of comparable age and sex acted as controls. Overnight urinary albumin excretion rate, a risk factor for cardiovascular disease, was also assayed in subjects to assess its relationship to the acute-phase response. Serum sialic acid was confirmed as a marker of the acute-phase response since serum concentrations were significantly related to established acute-phase proteins such as alpha-1 acid glycoprotein (r = 0.82, p < 0.0001). There was a significant graded increase of serum sialic acid, alpha-1 acid glycoprotein, IL-6 and urinary albumin excretion rate amongst the three groups, with the lowest levels in non-diabetic subjects, intermediate levels in NIDDM patients without syndrome X and highest levels in NIDDM patients with syndrome X. C-reactive protein and cortisol levels were also higher in syndrome X-positive compared to X-negative patients and serum amyloid A was higher in both diabetic groups than in the control group. We conclude that NIDDM is associated with an elevated acute-phase response, particularly in those with features of syndrome X. Abnormalities of the innate immune system may be a contributor to the hypertriglyceridaemia, low HDL cholesterol, hypertension, glucose intolerance, insulin resistance and accelerated atherosclerosis of NIDDM. Microalbuminuria may be a component of the acute-phase response.
77 schema:genre research_article
78 schema:inLanguage en
79 schema:isAccessibleForFree true
80 schema:isPartOf N2b6cd5cf168a47be981a21d97b0c0d1c
81 N6fa8db3645774faebaccb3263eab45c7
82 sg:journal.1001482
83 schema:name NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X
84 schema:pagination 1286
85 schema:productId N20c4f84aa4f0490ca879c94bcb82c5b6
86 N526fbf8df6654d6fb1948ef00f2f4386
87 N666b4853b8364d20b40c77fe9cc69200
88 N8843360a487244daaf6199ad20a6df1b
89 N9414d9ab29ac45f5a2193d16c9fe2f22
90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046557332
91 https://doi.org/10.1007/s001250050822
92 schema:sdDatePublished 2019-04-11T10:39
93 schema:sdLicense https://scigraph.springernature.com/explorer/license/
94 schema:sdPublisher Nd1401f974e964fc5885568c4a615143a
95 schema:url https://link.springer.com/10.1007%2Fs001250050822
96 sgo:license sg:explorer/license/
97 sgo:sdDataset articles
98 rdf:type schema:ScholarlyArticle
99 N019a1f48a01a4f7b8a4fa6708f49eaca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Male
101 rdf:type schema:DefinedTerm
102 N072b71bf1a414257926c60aa2ad8c11c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Humans
104 rdf:type schema:DefinedTerm
105 N0e90dbab960b41c7b95e728cd1407035 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Interleukin-6
107 rdf:type schema:DefinedTerm
108 N20c4f84aa4f0490ca879c94bcb82c5b6 schema:name nlm_unique_id
109 schema:value 0006777
110 rdf:type schema:PropertyValue
111 N27ceafc0e5694886bb29ca7340fb3eb2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Hydrocortisone
113 rdf:type schema:DefinedTerm
114 N2b6cd5cf168a47be981a21d97b0c0d1c schema:issueNumber 11
115 rdf:type schema:PublicationIssue
116 N4531de561e024d86b8bd09cd6e270d02 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Acute-Phase Proteins
118 rdf:type schema:DefinedTerm
119 N526fbf8df6654d6fb1948ef00f2f4386 schema:name dimensions_id
120 schema:value pub.1046557332
121 rdf:type schema:PropertyValue
122 N568b7e5d3a384b469c8b4e2f28bcab84 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Adult
124 rdf:type schema:DefinedTerm
125 N60c1585e57c04a50bfa73c7f1e9dae88 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Female
127 rdf:type schema:DefinedTerm
128 N640e79201848433da8625c57d1bc9991 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Serum Amyloid A Protein
130 rdf:type schema:DefinedTerm
131 N666b4853b8364d20b40c77fe9cc69200 schema:name doi
132 schema:value 10.1007/s001250050822
133 rdf:type schema:PropertyValue
134 N6fa8db3645774faebaccb3263eab45c7 schema:volumeNumber 40
135 rdf:type schema:PublicationVolume
136 N85a7c309699f44198c26b1a8cfefaeac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name C-Reactive Protein
138 rdf:type schema:DefinedTerm
139 N8843360a487244daaf6199ad20a6df1b schema:name readcube_id
140 schema:value ddc7f41c08157153bbf9b377d4987f124400a4f8f5c2e65bd5f66b9fc70252c5
141 rdf:type schema:PropertyValue
142 N8a5a20938326441a9f8fd4274c074142 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Insulin Resistance
144 rdf:type schema:DefinedTerm
145 N9414d9ab29ac45f5a2193d16c9fe2f22 schema:name pubmed_id
146 schema:value 9389420
147 rdf:type schema:PropertyValue
148 Na63b128acf2c4ed5b1f4144ded20272a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Albuminuria
150 rdf:type schema:DefinedTerm
151 Nb54d6c94e0404434a065ee11b1d00489 rdf:first sg:person.01066334211.72
152 rdf:rest Nd126c626417348e495332fb70e018c35
153 Nd126c626417348e495332fb70e018c35 rdf:first sg:person.0765350302.20
154 rdf:rest Nf0860b72923246bfb985d309d344e26c
155 Nd1401f974e964fc5885568c4a615143a schema:name Springer Nature - SN SciGraph project
156 rdf:type schema:Organization
157 Ndd41f3f955184a73b5b16fb77de1c274 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Middle Aged
159 rdf:type schema:DefinedTerm
160 Ne677234d61964c8cb523f8555cc703f8 rdf:first sg:person.01276470361.10
161 rdf:rest Nb54d6c94e0404434a065ee11b1d00489
162 Nf0860b72923246bfb985d309d344e26c rdf:first sg:person.01231152350.00
163 rdf:rest rdf:nil
164 Nfc057512440f410286cd9f391066828e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Diabetes Mellitus, Type 2
166 rdf:type schema:DefinedTerm
167 Nfe11a2d7c5674ea78ef882549d2df197 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Orosomucoid
169 rdf:type schema:DefinedTerm
170 Nff77142fd7264a1ba14a831f937a95de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name N-Acetylneuraminic Acid
172 rdf:type schema:DefinedTerm
173 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
174 schema:name Medical and Health Sciences
175 rdf:type schema:DefinedTerm
176 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
177 schema:name Clinical Sciences
178 rdf:type schema:DefinedTerm
179 sg:journal.1001482 schema:issn 0012-186X
180 1432-0428
181 schema:name Diabetologia
182 rdf:type schema:Periodical
183 sg:person.01066334211.72 schema:affiliation https://www.grid.ac/institutes/grid.239826.4
184 schema:familyName Mattock
185 schema:givenName M. B.
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066334211.72
187 rdf:type schema:Person
188 sg:person.01231152350.00 schema:affiliation https://www.grid.ac/institutes/grid.239826.4
189 schema:familyName Burt
190 schema:givenName D.
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231152350.00
192 rdf:type schema:Person
193 sg:person.01276470361.10 schema:affiliation https://www.grid.ac/institutes/grid.239826.4
194 schema:familyName Pickup
195 schema:givenName J. C.
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276470361.10
197 rdf:type schema:Person
198 sg:person.0765350302.20 schema:affiliation https://www.grid.ac/institutes/grid.239826.4
199 schema:familyName Chusney
200 schema:givenName G. D.
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765350302.20
202 rdf:type schema:Person
203 sg:pub.10.1007/978-1-4684-2226-9_9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048132175
204 https://doi.org/10.1007/978-1-4684-2226-9_9
205 rdf:type schema:CreativeWork
206 sg:pub.10.1007/978-3-642-74856-1_7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032316513
207 https://doi.org/10.1007/978-3-642-74856-1_7
208 rdf:type schema:CreativeWork
209 sg:pub.10.1007/bf00395552 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013397893
210 https://doi.org/10.1007/bf00395552
211 rdf:type schema:CreativeWork
212 sg:pub.10.1007/bf00399095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030059890
213 https://doi.org/10.1007/bf00399095
214 rdf:type schema:CreativeWork
215 sg:pub.10.1007/bf00400592 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053636854
216 https://doi.org/10.1007/bf00400592
217 rdf:type schema:CreativeWork
218 sg:pub.10.1007/bf00404074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042245933
219 https://doi.org/10.1007/bf00404074
220 rdf:type schema:CreativeWork
221 sg:pub.10.1007/bf00422091 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015531035
222 https://doi.org/10.1007/bf00422091
223 rdf:type schema:CreativeWork
224 https://app.dimensions.ai/details/publication/pub.1075688837 schema:CreativeWork
225 https://app.dimensions.ai/details/publication/pub.1076655607 schema:CreativeWork
226 https://app.dimensions.ai/details/publication/pub.1077186336 schema:CreativeWork
227 https://app.dimensions.ai/details/publication/pub.1078927667 schema:CreativeWork
228 https://app.dimensions.ai/details/publication/pub.1079208087 schema:CreativeWork
229 https://app.dimensions.ai/details/publication/pub.1082105850 schema:CreativeWork
230 https://app.dimensions.ai/details/publication/pub.1082466878 schema:CreativeWork
231 https://app.dimensions.ai/details/publication/pub.1082707565 schema:CreativeWork
232 https://doi.org/10.1001/archinte.149.7.1514 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054112550
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1001/archinte.1989.00390070054005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003262971
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1002/dmr.5610100103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015281661
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1002/eji.1830230950 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047019134
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/0002-9343(82)90543-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007180554
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1016/0009-8981(93)90204-h schema:sameAs https://app.dimensions.ai/details/publication/pub.1006424301
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1016/0024-3205(95)02096-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041979034
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1016/0026-0495(89)90038-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026152682
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1016/0167-5699(94)90137-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035808470
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/0167-5699(94)90138-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028438524
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/0306-9877(91)90280-c schema:sameAs https://app.dimensions.ai/details/publication/pub.1046026870
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/1043-4666(91)90489-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1020086030
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1016/s0065-2776(08)60532-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046724142
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/s0140-6736(63)90620-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004647887
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1056/nejm198402093100605 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029263631
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1056/nejm198903163201105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034071791
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1084/jem.178.6.2165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000973784
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1097/00041433-199106000-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032119004
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1111/j.1365-2796.1993.tb00674.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047559036
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1111/j.1365-2796.1995.tb00895.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019890030
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1111/j.1365-2796.1995.tb01229.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1020269517
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1111/j.1464-5491.1984.tb01915.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031542570
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1126/science.3259727 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062601782
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1128/mcb.12.4.1789 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032729192
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1136/bmj.312.7038.1061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062775599
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1136/jcp.34.5.464 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034085754
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1172/jci103182 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022688685
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1210/endo-114-3-914 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064257849
287 rdf:type schema:CreativeWork
288 https://doi.org/10.2337/diab.37.12.1595 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070735404
289 rdf:type schema:CreativeWork
290 https://doi.org/10.2337/diab.41.2.s97 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070736757
291 rdf:type schema:CreativeWork
292 https://doi.org/10.2337/diab.43.11.1271 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070737207
293 rdf:type schema:CreativeWork
294 https://doi.org/10.2337/diab.43.5.613 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070737314
295 rdf:type schema:CreativeWork
296 https://doi.org/10.2337/diabetes.37.12.1595 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070741229
297 rdf:type schema:CreativeWork
298 https://doi.org/10.2337/diabetes.43.11.1271 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070742700
299 rdf:type schema:CreativeWork
300 https://doi.org/10.2337/diabetes.43.5.613 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070742794
301 rdf:type schema:CreativeWork
302 https://doi.org/10.2337/diacare.15.10.1245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070745512
303 rdf:type schema:CreativeWork
304 https://doi.org/10.2337/diacare.16.1.57 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070745860
305 rdf:type schema:CreativeWork
306 https://doi.org/10.2337/diacare.16.2.445 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070745940
307 rdf:type schema:CreativeWork
308 https://doi.org/10.2337/diacare.18.8.1100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070746804
309 rdf:type schema:CreativeWork
310 https://doi.org/10.7326/0003-4819-117-10-807 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073696575
311 rdf:type schema:CreativeWork
312 https://www.grid.ac/institutes/grid.239826.4 schema:alternateName Guy's Hospital
313 schema:name Division of Chemical Pathology UMDS, Guy’s Hospital, SE1 9RT, London, UK
314 Unit for Metabolic Medicine, UMDS, Guy’s Hospital, London, UK
315 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...