Molecular screening of the human melanocortin-4 receptor gene: identification of a missense variant showing no association with obesity, plasma glucose, ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1997-07

AUTHORS

T. Gotoda, J. Scott, T. J. Aitman

ABSTRACT

Disruption of the melanocortin-4 (MC-4) receptor gene in mice results in maturity-onset obesity, hyperinsulinaemia and hyperglycaemia. These phenotypes are characteristic of human obesity that frequently accompanies non-insulin-dependent diabetes. It is therefore possible that human MC-4 receptor gene mutations contribute to human obesity. To test this possibility, we examined by DNA sequencing the entire coding region of the human MC-4 receptor gene in 40 morbidly obese (BMI > 35 kg/m2) white British males and examined the 5'- and 3'-flanking regions in 20 out of these obese subjects. We also sequenced all these regions in 10 lean (BMI < 18 kg/m2) white British males for a reference. We identified a single nucleotide substitution that replaces valine with isoleucine at codon 103, in two obese subjects in the heterozygous state. No other nucleotide alterations were found. The prevalence of this missense variant was studied in 322 white British males (190 with BMI > 28 kg/m2 and 132 with BMI < 22 kg/m2) selected from a population-based epidemiological survey. In these subjects, no homozygotes for the isoleucine allele were found. The frequency of heterozygotes was similar (4.2 vs 4.5%) in the two groups and there was no significant difference in BMI, total skinfold thickness, plasma insulin and glucose levels between heterozygotes and codon-103 valine homozygotes in either group. These results suggest that coding sequence mutations in the MC-4 receptor gene are unlikely to be a major cause of human obesity, at least in white British males. More... »

PAGES

976-979

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s001250050777

DOI

http://dx.doi.org/10.1007/s001250050777

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043846277

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9267995


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Glucose", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cohort Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "European Continental Ancestry Group", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Variation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Obesity, Morbid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phenotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Restriction Fragment Length", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptor, Melanocortin, Type 4", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Peptide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sequence Analysis, DNA", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Imperial College London", 
          "id": "https://www.grid.ac/institutes/grid.7445.2", 
          "name": [
            "Molecular Medicine Group, MRC Clinical Sciences Centre, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK, GB"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gotoda", 
        "givenName": "T.", 
        "id": "sg:person.0747355457.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747355457.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Imperial College London", 
          "id": "https://www.grid.ac/institutes/grid.7445.2", 
          "name": [
            "Molecular Medicine Group, MRC Clinical Sciences Centre, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK, GB"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Scott", 
        "givenName": "J.", 
        "id": "sg:person.0762127452.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762127452.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Imperial College London", 
          "id": "https://www.grid.ac/institutes/grid.7445.2", 
          "name": [
            "Molecular Medicine Group, MRC Clinical Sciences Centre, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK, GB"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aitman", 
        "givenName": "T. J.", 
        "id": "sg:person.015537525157.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015537525157.40"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/385119a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002755467", 
          "https://doi.org/10.1038/385119a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(91)91164-p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005869018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(91)91164-p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005869018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/6.6.869", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014763842"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/385165a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028016940", 
          "https://doi.org/10.1038/385165a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001250050610", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031074423", 
          "https://doi.org/10.1007/s001250050610"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001250050610", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031074423", 
          "https://doi.org/10.1007/s001250050610"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81865-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044272952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/371799a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045929899", 
          "https://doi.org/10.1038/371799a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/mend.8.10.7854347", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064333316"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diab.45.11.1455", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070737716"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1997-07", 
    "datePublishedReg": "1997-07-01", 
    "description": "Disruption of the melanocortin-4 (MC-4) receptor gene in mice results in maturity-onset obesity, hyperinsulinaemia and hyperglycaemia. These phenotypes are characteristic of human obesity that frequently accompanies non-insulin-dependent diabetes. It is therefore possible that human MC-4 receptor gene mutations contribute to human obesity. To test this possibility, we examined by DNA sequencing the entire coding region of the human MC-4 receptor gene in 40 morbidly obese (BMI > 35 kg/m2) white British males and examined the 5'- and 3'-flanking regions in 20 out of these obese subjects. We also sequenced all these regions in 10 lean (BMI < 18 kg/m2) white British males for a reference. We identified a single nucleotide substitution that replaces valine with isoleucine at codon 103, in two obese subjects in the heterozygous state. No other nucleotide alterations were found. The prevalence of this missense variant was studied in 322 white British males (190 with BMI > 28 kg/m2 and 132 with BMI < 22 kg/m2) selected from a population-based epidemiological survey. In these subjects, no homozygotes for the isoleucine allele were found. The frequency of heterozygotes was similar (4.2 vs 4.5%) in the two groups and there was no significant difference in BMI, total skinfold thickness, plasma insulin and glucose levels between heterozygotes and codon-103 valine homozygotes in either group. These results suggest that coding sequence mutations in the MC-4 receptor gene are unlikely to be a major cause of human obesity, at least in white British males.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s001250050777", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1001482", 
        "issn": [
          "0012-186X", 
          "1432-0428"
        ], 
        "name": "Diabetologia", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "8", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "40"
      }
    ], 
    "name": "Molecular screening of the human melanocortin-4 receptor gene: identification of a missense variant showing no association with obesity, plasma glucose, or insulin", 
    "pagination": "976-979", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "d0db7543dd7ebde0c3b3b487c18783a4c96299e1281d614079579c17960744b0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "9267995"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0006777"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s001250050777"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1043846277"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s001250050777", 
      "https://app.dimensions.ai/details/publication/pub.1043846277"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:15", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000348_0000000348/records_54298_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs001250050777"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s001250050777'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s001250050777'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s001250050777'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s001250050777'


 

This table displays all metadata directly associated to this object as RDF triples.

194 TRIPLES      21 PREDICATES      58 URIs      41 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s001250050777 schema:about N00df4978c7f64f5593b3fa06934ff542
2 N024db4ca98884cbd8c505a92062c93ab
3 N02515b42e7f840a8b2e6c8c938e7f2dc
4 N0921662bbee246dba884671acb8f1219
5 N51c16a3d2c1544b894bf9a544619575d
6 N5a1bcf600b124d46abb20802e81d9c1c
7 N61498f7c11e141fe9da42fa45aa997f6
8 N6c471dd1952a4268ab2fbd8da0af9ba4
9 N76b5a42c41ad41e1b3cc737fb8986896
10 N9705abe0e80d4f9f89f9552224e3d16b
11 Na1415d5beae244b1b785c6318fe44c88
12 Nacca76e2f27b482690268d0c27097fa4
13 Nc6b1bc7b8cdf452c99036aff537cd080
14 Nc7333c32b0b345b1b31b71b74339671a
15 Nccc2af950ab64bbe94537ea5e58b8f69
16 Nd5f85e987de14094a38fcd5ba956367e
17 Nde46fb2a300641cf8c97b32b64bfee75
18 Ne0e1ea18d4994fefbeed492f03dcca36
19 Ne8a696523f414f2e81f4357c7279c1d6
20 Ned2f3bd139ee43be87d0d3b07d244f59
21 anzsrc-for:11
22 anzsrc-for:1103
23 schema:author Nccc86292119e4d4e8e6d249c54907b52
24 schema:citation sg:pub.10.1007/s001250050610
25 sg:pub.10.1038/371799a0
26 sg:pub.10.1038/385119a0
27 sg:pub.10.1038/385165a0
28 https://doi.org/10.1016/0140-6736(91)91164-p
29 https://doi.org/10.1016/s0092-8674(00)81865-6
30 https://doi.org/10.1093/hmg/6.6.869
31 https://doi.org/10.1210/mend.8.10.7854347
32 https://doi.org/10.2337/diab.45.11.1455
33 schema:datePublished 1997-07
34 schema:datePublishedReg 1997-07-01
35 schema:description Disruption of the melanocortin-4 (MC-4) receptor gene in mice results in maturity-onset obesity, hyperinsulinaemia and hyperglycaemia. These phenotypes are characteristic of human obesity that frequently accompanies non-insulin-dependent diabetes. It is therefore possible that human MC-4 receptor gene mutations contribute to human obesity. To test this possibility, we examined by DNA sequencing the entire coding region of the human MC-4 receptor gene in 40 morbidly obese (BMI > 35 kg/m2) white British males and examined the 5'- and 3'-flanking regions in 20 out of these obese subjects. We also sequenced all these regions in 10 lean (BMI < 18 kg/m2) white British males for a reference. We identified a single nucleotide substitution that replaces valine with isoleucine at codon 103, in two obese subjects in the heterozygous state. No other nucleotide alterations were found. The prevalence of this missense variant was studied in 322 white British males (190 with BMI > 28 kg/m2 and 132 with BMI < 22 kg/m2) selected from a population-based epidemiological survey. In these subjects, no homozygotes for the isoleucine allele were found. The frequency of heterozygotes was similar (4.2 vs 4.5%) in the two groups and there was no significant difference in BMI, total skinfold thickness, plasma insulin and glucose levels between heterozygotes and codon-103 valine homozygotes in either group. These results suggest that coding sequence mutations in the MC-4 receptor gene are unlikely to be a major cause of human obesity, at least in white British males.
36 schema:genre research_article
37 schema:inLanguage en
38 schema:isAccessibleForFree true
39 schema:isPartOf N06ab7670401543f4b6dfc3ed5801c2f2
40 N8d9e74d6957942ae8d21e5f93389fae1
41 sg:journal.1001482
42 schema:name Molecular screening of the human melanocortin-4 receptor gene: identification of a missense variant showing no association with obesity, plasma glucose, or insulin
43 schema:pagination 976-979
44 schema:productId N11f3436983c0491d89f31f23f62d87b7
45 N4593c634b83047628f156b2124e00962
46 N49775c2da9114a069fffcc89fa11f731
47 Na6a9757c75a94701839ba140cf1603bd
48 Nf7ee2eae90d9489886a494c8436745b1
49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043846277
50 https://doi.org/10.1007/s001250050777
51 schema:sdDatePublished 2019-04-11T10:15
52 schema:sdLicense https://scigraph.springernature.com/explorer/license/
53 schema:sdPublisher N088f605ef5e341429846e940bb4f9c1a
54 schema:url https://link.springer.com/10.1007%2Fs001250050777
55 sgo:license sg:explorer/license/
56 sgo:sdDataset articles
57 rdf:type schema:ScholarlyArticle
58 N00df4978c7f64f5593b3fa06934ff542 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
59 schema:name Male
60 rdf:type schema:DefinedTerm
61 N024db4ca98884cbd8c505a92062c93ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
62 schema:name Blood Glucose
63 rdf:type schema:DefinedTerm
64 N02515b42e7f840a8b2e6c8c938e7f2dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
65 schema:name Adult
66 rdf:type schema:DefinedTerm
67 N06ab7670401543f4b6dfc3ed5801c2f2 schema:volumeNumber 40
68 rdf:type schema:PublicationVolume
69 N088f605ef5e341429846e940bb4f9c1a schema:name Springer Nature - SN SciGraph project
70 rdf:type schema:Organization
71 N0921662bbee246dba884671acb8f1219 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
72 schema:name European Continental Ancestry Group
73 rdf:type schema:DefinedTerm
74 N11f3436983c0491d89f31f23f62d87b7 schema:name nlm_unique_id
75 schema:value 0006777
76 rdf:type schema:PropertyValue
77 N4593c634b83047628f156b2124e00962 schema:name dimensions_id
78 schema:value pub.1043846277
79 rdf:type schema:PropertyValue
80 N49775c2da9114a069fffcc89fa11f731 schema:name doi
81 schema:value 10.1007/s001250050777
82 rdf:type schema:PropertyValue
83 N51c16a3d2c1544b894bf9a544619575d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Receptors, Peptide
85 rdf:type schema:DefinedTerm
86 N5a1bcf600b124d46abb20802e81d9c1c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Polymerase Chain Reaction
88 rdf:type schema:DefinedTerm
89 N61498f7c11e141fe9da42fa45aa997f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Middle Aged
91 rdf:type schema:DefinedTerm
92 N6c471dd1952a4268ab2fbd8da0af9ba4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name DNA
94 rdf:type schema:DefinedTerm
95 N76b5a42c41ad41e1b3cc737fb8986896 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Sequence Analysis, DNA
97 rdf:type schema:DefinedTerm
98 N8d9e74d6957942ae8d21e5f93389fae1 schema:issueNumber 8
99 rdf:type schema:PublicationIssue
100 N9705abe0e80d4f9f89f9552224e3d16b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Insulin
102 rdf:type schema:DefinedTerm
103 Na1415d5beae244b1b785c6318fe44c88 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Humans
105 rdf:type schema:DefinedTerm
106 Na6a9757c75a94701839ba140cf1603bd schema:name pubmed_id
107 schema:value 9267995
108 rdf:type schema:PropertyValue
109 Nacca76e2f27b482690268d0c27097fa4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Genetic Variation
111 rdf:type schema:DefinedTerm
112 Nc6b1bc7b8cdf452c99036aff537cd080 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Base Sequence
114 rdf:type schema:DefinedTerm
115 Nc7333c32b0b345b1b31b71b74339671a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Obesity, Morbid
117 rdf:type schema:DefinedTerm
118 Nccc2af950ab64bbe94537ea5e58b8f69 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Receptor, Melanocortin, Type 4
120 rdf:type schema:DefinedTerm
121 Nccc86292119e4d4e8e6d249c54907b52 rdf:first sg:person.0747355457.61
122 rdf:rest Nf8a450eaa2fd4f98b5beab73fe77ced7
123 Nd5f85e987de14094a38fcd5ba956367e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Phenotype
125 rdf:type schema:DefinedTerm
126 Nde46fb2a300641cf8c97b32b64bfee75 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Genotype
128 rdf:type schema:DefinedTerm
129 Ne0e1ea18d4994fefbeed492f03dcca36 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Mutation
131 rdf:type schema:DefinedTerm
132 Ne8a696523f414f2e81f4357c7279c1d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Cohort Studies
134 rdf:type schema:DefinedTerm
135 Ned2f3bd139ee43be87d0d3b07d244f59 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Polymorphism, Restriction Fragment Length
137 rdf:type schema:DefinedTerm
138 Nee842475e1004e279965f0d9fa9c85d6 rdf:first sg:person.015537525157.40
139 rdf:rest rdf:nil
140 Nf7ee2eae90d9489886a494c8436745b1 schema:name readcube_id
141 schema:value d0db7543dd7ebde0c3b3b487c18783a4c96299e1281d614079579c17960744b0
142 rdf:type schema:PropertyValue
143 Nf8a450eaa2fd4f98b5beab73fe77ced7 rdf:first sg:person.0762127452.15
144 rdf:rest Nee842475e1004e279965f0d9fa9c85d6
145 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
146 schema:name Medical and Health Sciences
147 rdf:type schema:DefinedTerm
148 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
149 schema:name Clinical Sciences
150 rdf:type schema:DefinedTerm
151 sg:journal.1001482 schema:issn 0012-186X
152 1432-0428
153 schema:name Diabetologia
154 rdf:type schema:Periodical
155 sg:person.015537525157.40 schema:affiliation https://www.grid.ac/institutes/grid.7445.2
156 schema:familyName Aitman
157 schema:givenName T. J.
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015537525157.40
159 rdf:type schema:Person
160 sg:person.0747355457.61 schema:affiliation https://www.grid.ac/institutes/grid.7445.2
161 schema:familyName Gotoda
162 schema:givenName T.
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747355457.61
164 rdf:type schema:Person
165 sg:person.0762127452.15 schema:affiliation https://www.grid.ac/institutes/grid.7445.2
166 schema:familyName Scott
167 schema:givenName J.
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762127452.15
169 rdf:type schema:Person
170 sg:pub.10.1007/s001250050610 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031074423
171 https://doi.org/10.1007/s001250050610
172 rdf:type schema:CreativeWork
173 sg:pub.10.1038/371799a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045929899
174 https://doi.org/10.1038/371799a0
175 rdf:type schema:CreativeWork
176 sg:pub.10.1038/385119a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002755467
177 https://doi.org/10.1038/385119a0
178 rdf:type schema:CreativeWork
179 sg:pub.10.1038/385165a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028016940
180 https://doi.org/10.1038/385165a0
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1016/0140-6736(91)91164-p schema:sameAs https://app.dimensions.ai/details/publication/pub.1005869018
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1016/s0092-8674(00)81865-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044272952
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1093/hmg/6.6.869 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014763842
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1210/mend.8.10.7854347 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064333316
189 rdf:type schema:CreativeWork
190 https://doi.org/10.2337/diab.45.11.1455 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070737716
191 rdf:type schema:CreativeWork
192 https://www.grid.ac/institutes/grid.7445.2 schema:alternateName Imperial College London
193 schema:name Molecular Medicine Group, MRC Clinical Sciences Centre, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK, GB
194 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...