Ontology type: schema:ScholarlyArticle Open Access: True
2000-02
AUTHORSM. Carraro, W. Mancini, M. Artero, C. Zennaro, L. Faccini, R. Candido, L. Armini, M. Calci, R. Carretta, B. Fabris
ABSTRACTAims/hypothesis. The pre-clinical phase of diabetic nephropathy is characterised by increased glomerular filtration rate and episodes of microalbuminuria. The cause of the microalbuminuria has been variably ascribed to alterations of the size or charge selective barriers of the glomerulus or both or as a consequence of the haemodynamic changes. Our aim was to investigate very early albumin permeability alterations in isolated glomeruli which were not subject to perfusion pressure.¶Methods. Isolated glomeruli were studied from 120 male Wistar rats, divided into three groups: streptozotocin-treated, streptozotocin-treated with insulin pellet implants, and controls. From each group ten animals were killed at 7, 14, 28, and 56 days after induction. Study variables included blood pressure, proteinuria, iopamidol clearance, albumin permeability and glomerular area. Subsequently, albumin permeability, proteinuria, and iopamidol clearance were determined in an additional group of 40 diabetic animals studied at 24, 72, 96, and 120 h after induction.¶Results. Albumin permeability increased steadily from induction in streptozotocin-treated animals, reaching a plateau at approximately 120 h. Glomerular filtration rate was shown to increase significantly at approximately 7 days and proteinuria correlated with it. Glomerular hypertrophy was observed both in streptozotocin-treated animals and in streptozotocin-treated rats with insulin pellet implants. Strict blood glucose control delayed the appearance of the permeability defect in isolated glomeruli and inhibited the increase in glomerular filtration in intact animals. It did not prevent glomerular hypertrophy.¶Conclusion/interpretation. An albumin permeability defect exists early in isolated non-perfused glomeruli from streptozotocin-treated rats and seems to be independent of glomerular filtration rate alterations. [Diabetologia (2000) 43: 235–241] More... »
PAGES235-241
http://scigraph.springernature.com/pub.10.1007/s001250050035
DOIhttp://dx.doi.org/10.1007/s001250050035
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1032492081
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/10753047
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Blood Glucose",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Blood Pressure",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Diabetes Mellitus, Experimental",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Glomerular Filtration Rate",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Hyperglycemia",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "In Vitro Techniques",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Insulin",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Iopamidol",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Kidney Glomerulus",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Permeability",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Proteinuria",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Rats",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Rats, Inbred WKY",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Rats, Wistar",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Reference Values",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Serum Albumin, Bovine",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Institute of Clinical Medicine, University of Trieste, Trieste, Italy, IT",
"id": "http://www.grid.ac/institutes/grid.5133.4",
"name": [
"Institute of Clinical Medicine, University of Trieste, Trieste, Italy, IT"
],
"type": "Organization"
},
"familyName": "Carraro",
"givenName": "M.",
"id": "sg:person.0577543120.81",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577543120.81"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institute of Clinical Medicine, University of Trieste, Trieste, Italy, IT",
"id": "http://www.grid.ac/institutes/grid.5133.4",
"name": [
"Institute of Clinical Medicine, University of Trieste, Trieste, Italy, IT"
],
"type": "Organization"
},
"familyName": "Mancini",
"givenName": "W.",
"id": "sg:person.0645656320.18",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645656320.18"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institute of Clinical Medicine, University of Trieste, Trieste, Italy, IT",
"id": "http://www.grid.ac/institutes/grid.5133.4",
"name": [
"Institute of Clinical Medicine, University of Trieste, Trieste, Italy, IT"
],
"type": "Organization"
},
"familyName": "Artero",
"givenName": "M.",
"id": "sg:person.01327254434.18",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327254434.18"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institute of Clinical Medicine, University of Trieste, Trieste, Italy, IT",
"id": "http://www.grid.ac/institutes/grid.5133.4",
"name": [
"Institute of Clinical Medicine, University of Trieste, Trieste, Italy, IT"
],
"type": "Organization"
},
"familyName": "Zennaro",
"givenName": "C.",
"id": "sg:person.0604721205.50",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604721205.50"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institute of Clinical Medicine, University of Trieste, Trieste, Italy, IT",
"id": "http://www.grid.ac/institutes/grid.5133.4",
"name": [
"Institute of Clinical Medicine, University of Trieste, Trieste, Italy, IT"
],
"type": "Organization"
},
"familyName": "Faccini",
"givenName": "L.",
"id": "sg:person.0745532061.06",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745532061.06"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institute of Clinical Medicine, University of Trieste, Trieste, Italy, IT",
"id": "http://www.grid.ac/institutes/grid.5133.4",
"name": [
"Institute of Clinical Medicine, University of Trieste, Trieste, Italy, IT"
],
"type": "Organization"
},
"familyName": "Candido",
"givenName": "R.",
"id": "sg:person.01026702544.26",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026702544.26"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institute of Clinical Medicine, University of Trieste, Trieste, Italy, IT",
"id": "http://www.grid.ac/institutes/grid.5133.4",
"name": [
"Institute of Clinical Medicine, University of Trieste, Trieste, Italy, IT"
],
"type": "Organization"
},
"familyName": "Armini",
"givenName": "L.",
"id": "sg:person.0642117660.54",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642117660.54"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institute of Clinical Medicine, University of Trieste, Trieste, Italy, IT",
"id": "http://www.grid.ac/institutes/grid.5133.4",
"name": [
"Institute of Clinical Medicine, University of Trieste, Trieste, Italy, IT"
],
"type": "Organization"
},
"familyName": "Calci",
"givenName": "M.",
"id": "sg:person.01317410560.95",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317410560.95"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institute of Clinical Medicine, University of Trieste, Trieste, Italy, IT",
"id": "http://www.grid.ac/institutes/grid.5133.4",
"name": [
"Institute of Clinical Medicine, University of Trieste, Trieste, Italy, IT"
],
"type": "Organization"
},
"familyName": "Carretta",
"givenName": "R.",
"id": "sg:person.01265120523.66",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265120523.66"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institute of Clinical Medicine, University of Trieste, Trieste, Italy, IT",
"id": "http://www.grid.ac/institutes/grid.5133.4",
"name": [
"Institute of Clinical Medicine, University of Trieste, Trieste, Italy, IT"
],
"type": "Organization"
},
"familyName": "Fabris",
"givenName": "B.",
"id": "sg:person.0607436476.87",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607436476.87"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1007/bf00252632",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023129991",
"https://doi.org/10.1007/bf00252632"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf01219701",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052874218",
"https://doi.org/10.1007/bf01219701"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00399958",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017376600",
"https://doi.org/10.1007/bf00399958"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s001250050752",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038796617",
"https://doi.org/10.1007/s001250050752"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00454877",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029054633",
"https://doi.org/10.1007/bf00454877"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00280880",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035506327",
"https://doi.org/10.1007/bf00280880"
],
"type": "CreativeWork"
}
],
"datePublished": "2000-02",
"datePublishedReg": "2000-02-01",
"description": "Aims/hypothesis. The pre-clinical phase of diabetic nephropathy is characterised by increased glomerular filtration rate and episodes of microalbuminuria. The cause of the microalbuminuria has been variably ascribed to alterations of the size or charge selective barriers of the glomerulus or both or as a consequence of the haemodynamic changes. Our aim was to investigate very early albumin permeability alterations in isolated glomeruli which were not subject to perfusion pressure.\u00b6Methods. Isolated glomeruli were studied from 120 male Wistar rats, divided into three groups: streptozotocin-treated, streptozotocin-treated with insulin pellet implants, and controls. From each group ten animals were killed at 7, 14, 28, and 56 days after induction. Study variables included blood pressure, proteinuria, iopamidol clearance, albumin permeability and glomerular area. Subsequently, albumin permeability, proteinuria, and iopamidol clearance were determined in an additional group of 40 diabetic animals studied at 24, 72, 96, and 120 h after induction.\u00b6Results. Albumin permeability increased steadily from induction in streptozotocin-treated animals, reaching a plateau at approximately 120 h. Glomerular filtration rate was shown to increase significantly at approximately 7 days and proteinuria correlated with it. Glomerular hypertrophy was observed both in streptozotocin-treated animals and in streptozotocin-treated rats with insulin pellet implants. Strict blood glucose control delayed the appearance of the permeability defect in isolated glomeruli and inhibited the increase in glomerular filtration in intact animals. It did not prevent glomerular hypertrophy.\u00b6Conclusion/interpretation. An albumin permeability defect exists early in isolated non-perfused glomeruli from streptozotocin-treated rats and seems to be independent of glomerular filtration rate alterations. [Diabetologia (2000) 43: 235\u2013241]",
"genre": "article",
"id": "sg:pub.10.1007/s001250050035",
"inLanguage": "en",
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1001482",
"issn": [
"0012-186X",
"1432-0428"
],
"name": "Diabetologia",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "2",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "43"
}
],
"keywords": [
"glomerular filtration rate",
"albumin permeability",
"glomerular hypertrophy",
"pellet implants",
"filtration rate",
"strict blood glucose control",
"experimental diabetes mellitus",
"blood glucose control",
"male Wistar rats",
"pre-clinical phase",
"diabetic nephropathy",
"diabetes mellitus",
"haemodynamic changes",
"perfusion pressure",
"blood pressure",
"glomerular area",
"diabetic animals",
"glucose control",
"Wistar rats",
"glomerular filtration",
"streptozotocin",
"isolated glomeruli",
"glomeruli",
"proteinuria",
"intact animals",
"additional group",
"rats",
"microalbuminuria",
"permeability defect",
"hypertrophy",
"animals",
"clearance",
"study variables",
"alterations",
"induction",
"permeability alterations",
"rate alterations",
"implants",
"days",
"nephropathy",
"mellitus",
"group",
"episodes",
"control",
"cause",
"selective barrier",
"rate",
"pressure",
"aim",
"permeability",
"appearance",
"increase",
"defects",
"barriers",
"changes",
"consequences",
"variables",
"area",
"filtration",
"size",
"plateau",
"phase",
"interpretation"
],
"name": "Albumin permeability in isolated glomeruli in incipient experimental diabetes mellitus",
"pagination": "235-241",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1032492081"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s001250050035"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"10753047"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s001250050035",
"https://app.dimensions.ai/details/publication/pub.1032492081"
],
"sdDataset": "articles",
"sdDatePublished": "2022-05-20T07:21",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_321.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1007/s001250050035"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s001250050035'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s001250050035'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s001250050035'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s001250050035'
This table displays all metadata directly associated to this object as RDF triples.
284 TRIPLES
22 PREDICATES
114 URIs
100 LITERALS
25 BLANK NODES