Lower limb events in individuals with type 2 diabetes: evidence for an increased risk associated with diuretic use View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-02-26

AUTHORS

Louis Potier, Ronan Roussel, Gilberto Velho, Pierre-Jean Saulnier, Anisoara Bumbu, Odette Matar, Fabrice Schneider, Stéphanie Ragot, Michel Marre, Kamel Mohammedi, Samy Hadjadj

ABSTRACT

AIMS/HYPOTHESIS: Recently, safety data signalled an increased risk of amputations in people taking canagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor. If this side effect is due to drug-induced hypovolaemia, diuretics should also increase that risk. The aim of this study was to analyse the association between diuretic use and the risk of lower limb events (LLEs) in people with type 2 diabetes. METHODS: SURDIAGENE (SUivi Rénal, DIAbète de type 2 et GENEtique) is a prospective observational cohort that includes people with type 2 diabetes enrolled from 2002 to 2012 and followed-up until onset of LLE, death or 31 December 2015, whichever came first. Primary outcome was the first occurrence of LLE, a composite of lower limb amputation (LLA) and lower limb revascularisation (LLR). The rates of primary outcome were compared between participants taking and not taking diuretics at baseline in a Cox-adjusted model. RESULTS: At baseline, of the 1459 participants included, 670 were taking diuretics. In participants with and without diuretics, the mean ages were 67.1 and 62.9 years and 55.8% and 59.8% were men, respectively. During a median follow-up of 7.1 years, the incidence of LLE was 1.80 per 100 patient-years in diuretic users vs 1.00 in non-users (p < 0.001). The HR for LLE in users vs non-users was 2.08 (95% CI 1.49, 2.93), p < 0.001. This association remained significant in a multivariable-adjusted model (1.49 [1.01, 2.19]; p = 0.04) and similar after considering death as a competing risk (subhazard ratio 1.89 [1.35, 2.64]; p < 0.001). When separated, LLA but not LLR, was associated with the use of diuretics: 2.01 (1.14, 3.54), p = 0.02 and 1.05 (0.67, 1.64), p = 0.84, respectively, in the multivariable-adjusted model. CONCLUSIONS/INTERPRETATION: Among people with type 2 diabetes treated with diuretics, there was a significant increase in the risk of LLE, predominantly in the risk of LLA. More... »

PAGES

1-9

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00125-019-4835-z

DOI

http://dx.doi.org/10.1007/s00125-019-4835-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112394539

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30809716


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Public Health and Health Services", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Paris Diderot University", 
          "id": "https://www.grid.ac/institutes/grid.7452.4", 
          "name": [
            "Department of Diabetology, Endocrinology and Nutrition, Bichat Hospital, Assistance Publique \u2013 H\u00f4pitaux de Paris, DHU FIRE, 46 rue Henri Huchard 75877, Paris Cedex 18, France", 
            "UFR de M\u00e9decine, Paris Diderot University, Sorbonne Paris Cit\u00e9, Paris, France", 
            "Centre de Recherche des Cordeliers, INSERM, Sorbonne Universit\u00e9, USPC, Universit\u00e9 Paris Descartes, Universit\u00e9 Paris Diderot, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Potier", 
        "givenName": "Louis", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paris Diderot University", 
          "id": "https://www.grid.ac/institutes/grid.7452.4", 
          "name": [
            "Department of Diabetology, Endocrinology and Nutrition, Bichat Hospital, Assistance Publique \u2013 H\u00f4pitaux de Paris, DHU FIRE, 46 rue Henri Huchard 75877, Paris Cedex 18, France", 
            "UFR de M\u00e9decine, Paris Diderot University, Sorbonne Paris Cit\u00e9, Paris, France", 
            "Centre de Recherche des Cordeliers, INSERM, Sorbonne Universit\u00e9, USPC, Universit\u00e9 Paris Descartes, Universit\u00e9 Paris Diderot, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roussel", 
        "givenName": "Ronan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Centre de Recherche des Cordeliers, INSERM, Sorbonne Universit\u00e9, USPC, Universit\u00e9 Paris Descartes, Universit\u00e9 Paris Diderot, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Velho", 
        "givenName": "Gilberto", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Universitaire de Poitiers", 
          "id": "https://www.grid.ac/institutes/grid.411162.1", 
          "name": [
            "CIC1402, INSERM, Poitiers, France", 
            "UFR de M\u00e9decine et Pharmacie, Poitiers University, Poitiers, France", 
            "Clinical Investigation Centre, CHU de Poitiers, Poitiers, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saulnier", 
        "givenName": "Pierre-Jean", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Diabetology, Endocrinology and Nutrition, Bichat Hospital, Assistance Publique \u2013 H\u00f4pitaux de Paris, DHU FIRE, 46 rue Henri Huchard 75877, Paris Cedex 18, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bumbu", 
        "givenName": "Anisoara", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Diabetology, Endocrinology and Nutrition, Bichat Hospital, Assistance Publique \u2013 H\u00f4pitaux de Paris, DHU FIRE, 46 rue Henri Huchard 75877, Paris Cedex 18, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matar", 
        "givenName": "Odette", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Universitaire de Poitiers", 
          "id": "https://www.grid.ac/institutes/grid.411162.1", 
          "name": [
            "CIC1402, INSERM, Poitiers, France", 
            "UFR de M\u00e9decine et Pharmacie, Poitiers University, Poitiers, France", 
            "Clinical Investigation Centre, CHU de Poitiers, Poitiers, France", 
            "Department of Vascular Surgery, Centre Hospitalier Universitaire de Poitiers, Poitiers, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schneider", 
        "givenName": "Fabrice", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Universitaire de Poitiers", 
          "id": "https://www.grid.ac/institutes/grid.411162.1", 
          "name": [
            "CIC1402, INSERM, Poitiers, France", 
            "UFR de M\u00e9decine et Pharmacie, Poitiers University, Poitiers, France", 
            "Clinical Investigation Centre, CHU de Poitiers, Poitiers, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ragot", 
        "givenName": "St\u00e9phanie", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fondation Ophtalmologique Adolphe de Rothschild", 
          "id": "https://www.grid.ac/institutes/grid.417888.a", 
          "name": [
            "Department of Diabetology, Endocrinology and Nutrition, Bichat Hospital, Assistance Publique \u2013 H\u00f4pitaux de Paris, DHU FIRE, 46 rue Henri Huchard 75877, Paris Cedex 18, France", 
            "UFR de M\u00e9decine, Paris Diderot University, Sorbonne Paris Cit\u00e9, Paris, France", 
            "Centre de Recherche des Cordeliers, INSERM, Sorbonne Universit\u00e9, USPC, Universit\u00e9 Paris Descartes, Universit\u00e9 Paris Diderot, Paris, France", 
            "Fondation Ophtalmologique Adolphe de Rothschild, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marre", 
        "givenName": "Michel", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bordeaux", 
          "id": "https://www.grid.ac/institutes/grid.412041.2", 
          "name": [
            "Department of Diabetology, Endocrinology and Nutrition, H\u00f4pital Haut-L\u00e9v\u00eaque, Bordeaux, France", 
            "Bordeaux University, Bordeaux, France", 
            "Inserm U1219 \u2018Bordeaux Population Health\u2019, Bordeaux, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mohammedi", 
        "givenName": "Kamel", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Universitaire de Nantes", 
          "id": "https://www.grid.ac/institutes/grid.277151.7", 
          "name": [
            "Institut du Thorax, Inserm, CNRS, CHU Nantes, Nantes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hadjadj", 
        "givenName": "Samy", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/pds.932", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000483199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(00)02527-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000631578"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.1.6120.1114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009116973"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.288.23.2981", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016077891"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/00273171.2011.568786", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026060254"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/biostatistics/2.1.85", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030176140"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.1974.03230490039020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030384277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/1056-8727(95)00088-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030865276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/dc07-2079", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038571693"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1534734610371594", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042906552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1534734610371594", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042906552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/eurheartj/ehl441", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043168707"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/md.0000000000001054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043279404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/md.0000000000001054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043279404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.48.3.455", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047100864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-006-0431-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051864625", 
          "https://doi.org/10.1007/s00125-006-0431-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-006-0431-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051864625", 
          "https://doi.org/10.1007/s00125-006-0431-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-006-0431-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051864625", 
          "https://doi.org/10.1007/s00125-006-0431-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.atv.0000149377.90852.d8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053681998"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.atv.0000149377.90852.d8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053681998"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-150-9-200905050-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073710774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1611925", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085993372"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s2213-8587(17)30257-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090779906"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/dom.13115", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091567969"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.117.031227", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092675327"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.117.031227", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092675327"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.117.031227", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092675327"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/dc17-1551", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092681358"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/dom.13255", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100975552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.diabres.2018.03.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101823255"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.diabres.2018.03.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101823255"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/dom.13424", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1105102700"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/dom.13424", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1105102700"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/dom.13424", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1105102700"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/dom.13459", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1105294322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/dom.13477", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1105775429"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/dom.13477", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1105775429"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jamainternmed.2018.3034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106130173"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.k4365", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1109904450"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.k4365", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1109904450"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.k4365", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1109904450"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.k4365", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1109904450"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.k4365", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1109904450"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.k4365", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1109904450"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-02-26", 
    "datePublishedReg": "2019-02-26", 
    "description": "AIMS/HYPOTHESIS: Recently, safety data signalled an increased risk of amputations in people taking canagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor. If this side effect is due to drug-induced hypovolaemia, diuretics should also increase that risk. The aim of this study was to analyse the association between diuretic use and the risk of lower limb events (LLEs) in people with type 2 diabetes.\nMETHODS: SURDIAGENE (SUivi R\u00e9nal, DIAb\u00e8te de type 2 et GENEtique) is a prospective observational cohort that includes people with type 2 diabetes enrolled from 2002 to 2012 and followed-up until onset of LLE, death or 31 December 2015, whichever came first. Primary outcome was the first occurrence of LLE, a composite of lower limb amputation (LLA) and lower limb revascularisation (LLR). The rates of primary outcome were compared between participants taking and not taking diuretics at baseline in a Cox-adjusted model.\nRESULTS: At baseline, of the 1459 participants included, 670 were taking diuretics. In participants with and without diuretics, the mean ages were 67.1 and 62.9\u00a0years and 55.8% and 59.8% were men, respectively. During a median follow-up of 7.1\u00a0years, the incidence of LLE was 1.80 per 100 patient-years in diuretic users vs 1.00 in non-users (p\u2009<\u20090.001). The HR for LLE in users vs non-users was 2.08 (95% CI 1.49, 2.93), p\u00a0<\u20090.001. This association remained significant in a multivariable-adjusted model (1.49 [1.01, 2.19]; p\u2009=\u20090.04) and similar after considering death as a competing risk (subhazard ratio 1.89 [1.35, 2.64]; p\u2009<\u20090.001). When separated, LLA but not LLR, was associated with the use of diuretics: 2.01 (1.14, 3.54), p\u2009=\u20090.02 and 1.05 (0.67, 1.64), p\u2009=\u20090.84, respectively, in the multivariable-adjusted model.\nCONCLUSIONS/INTERPRETATION: Among people with type 2 diabetes treated with diuretics, there was a significant increase in the risk of LLE, predominantly in the risk of LLA.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00125-019-4835-z", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1001482", 
        "issn": [
          "0012-186X", 
          "1432-0428"
        ], 
        "name": "Diabetologia", 
        "type": "Periodical"
      }
    ], 
    "name": "Lower limb events in individuals with type 2 diabetes: evidence for an increased risk associated with diuretic use", 
    "pagination": "1-9", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a0576ab53c142465e1f0c5f3c164928710f4db3bdbf2763a329ac240f47d2194"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30809716"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0006777"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00125-019-4835-z"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112394539"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00125-019-4835-z", 
      "https://app.dimensions.ai/details/publication/pub.1112394539"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:17", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000348_0000000348/records_54307_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs00125-019-4835-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00125-019-4835-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00125-019-4835-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00125-019-4835-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00125-019-4835-z'


 

This table displays all metadata directly associated to this object as RDF triples.

235 TRIPLES      21 PREDICATES      54 URIs      18 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00125-019-4835-z schema:about anzsrc-for:11
2 anzsrc-for:1117
3 schema:author N9e7bf7a79d514173a9d9273d28b79902
4 schema:citation sg:pub.10.1007/s00125-006-0431-0
5 https://doi.org/10.1001/jama.1974.03230490039020
6 https://doi.org/10.1001/jama.288.23.2981
7 https://doi.org/10.1001/jamainternmed.2018.3034
8 https://doi.org/10.1002/pds.932
9 https://doi.org/10.1016/1056-8727(95)00088-7
10 https://doi.org/10.1016/j.diabres.2018.03.027
11 https://doi.org/10.1016/s0140-6736(00)02527-7
12 https://doi.org/10.1016/s2213-8587(17)30257-7
13 https://doi.org/10.1056/nejmoa1611925
14 https://doi.org/10.1080/00273171.2011.568786
15 https://doi.org/10.1093/biostatistics/2.1.85
16 https://doi.org/10.1093/eurheartj/ehl441
17 https://doi.org/10.1097/md.0000000000001054
18 https://doi.org/10.1111/dom.13115
19 https://doi.org/10.1111/dom.13255
20 https://doi.org/10.1111/dom.13424
21 https://doi.org/10.1111/dom.13459
22 https://doi.org/10.1111/dom.13477
23 https://doi.org/10.1136/bmj.1.6120.1114
24 https://doi.org/10.1136/bmj.k4365
25 https://doi.org/10.1161/01.atv.0000149377.90852.d8
26 https://doi.org/10.1161/01.cir.48.3.455
27 https://doi.org/10.1161/circulationaha.117.031227
28 https://doi.org/10.1177/1534734610371594
29 https://doi.org/10.2337/dc07-2079
30 https://doi.org/10.2337/dc17-1551
31 https://doi.org/10.7326/0003-4819-150-9-200905050-00006
32 schema:datePublished 2019-02-26
33 schema:datePublishedReg 2019-02-26
34 schema:description AIMS/HYPOTHESIS: Recently, safety data signalled an increased risk of amputations in people taking canagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor. If this side effect is due to drug-induced hypovolaemia, diuretics should also increase that risk. The aim of this study was to analyse the association between diuretic use and the risk of lower limb events (LLEs) in people with type 2 diabetes. METHODS: SURDIAGENE (SUivi Rénal, DIAbète de type 2 et GENEtique) is a prospective observational cohort that includes people with type 2 diabetes enrolled from 2002 to 2012 and followed-up until onset of LLE, death or 31 December 2015, whichever came first. Primary outcome was the first occurrence of LLE, a composite of lower limb amputation (LLA) and lower limb revascularisation (LLR). The rates of primary outcome were compared between participants taking and not taking diuretics at baseline in a Cox-adjusted model. RESULTS: At baseline, of the 1459 participants included, 670 were taking diuretics. In participants with and without diuretics, the mean ages were 67.1 and 62.9 years and 55.8% and 59.8% were men, respectively. During a median follow-up of 7.1 years, the incidence of LLE was 1.80 per 100 patient-years in diuretic users vs 1.00 in non-users (p < 0.001). The HR for LLE in users vs non-users was 2.08 (95% CI 1.49, 2.93), p < 0.001. This association remained significant in a multivariable-adjusted model (1.49 [1.01, 2.19]; p = 0.04) and similar after considering death as a competing risk (subhazard ratio 1.89 [1.35, 2.64]; p < 0.001). When separated, LLA but not LLR, was associated with the use of diuretics: 2.01 (1.14, 3.54), p = 0.02 and 1.05 (0.67, 1.64), p = 0.84, respectively, in the multivariable-adjusted model. CONCLUSIONS/INTERPRETATION: Among people with type 2 diabetes treated with diuretics, there was a significant increase in the risk of LLE, predominantly in the risk of LLA.
35 schema:genre research_article
36 schema:inLanguage en
37 schema:isAccessibleForFree false
38 schema:isPartOf sg:journal.1001482
39 schema:name Lower limb events in individuals with type 2 diabetes: evidence for an increased risk associated with diuretic use
40 schema:pagination 1-9
41 schema:productId N418e1f95dd324ccabcb75115213caf1a
42 N67dd73348cd4488290efe54d9325f84e
43 Ndc37d69dbb5348b8bc27748399ab2356
44 Ndcc51354121c443bb8b6ecf640e96c2d
45 Nf4708758339648c8ba34f515f8fe4900
46 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112394539
47 https://doi.org/10.1007/s00125-019-4835-z
48 schema:sdDatePublished 2019-04-11T10:17
49 schema:sdLicense https://scigraph.springernature.com/explorer/license/
50 schema:sdPublisher N35cef4e45907443ab57ab9802775e54c
51 schema:url https://link.springer.com/10.1007%2Fs00125-019-4835-z
52 sgo:license sg:explorer/license/
53 sgo:sdDataset articles
54 rdf:type schema:ScholarlyArticle
55 N16c53f1dd49b4c9681d5e457138fdbe1 schema:affiliation https://www.grid.ac/institutes/grid.411162.1
56 schema:familyName Schneider
57 schema:givenName Fabrice
58 rdf:type schema:Person
59 N1d902af3695b48c4ab2ffa15e097726b rdf:first Ne53ff064b6c34a7889702cce806fa41c
60 rdf:rest N2e163d6343c641d68e495736b711723b
61 N256cea5bef2b472bac24c11a7e831091 rdf:first N57e669a3658a495d8f020f7c9d1b678b
62 rdf:rest Na2ffaa14e76e4bd88ff6ab787bab1c48
63 N2e163d6343c641d68e495736b711723b rdf:first Nc2c134fa79974b2f9655e54bf27fea31
64 rdf:rest N7b92bbb840bc43458acc382c8b6c7c14
65 N35cef4e45907443ab57ab9802775e54c schema:name Springer Nature - SN SciGraph project
66 rdf:type schema:Organization
67 N418e1f95dd324ccabcb75115213caf1a schema:name nlm_unique_id
68 schema:value 0006777
69 rdf:type schema:PropertyValue
70 N45129d1636c74cab9bab14cd08981822 rdf:first N87a370d63c8c4fa7bb512fa89a9c7be9
71 rdf:rest Ned9c3f7915024790ba084cda0e204fb8
72 N4cb3cb70a442424a89bf986a0f3f6169 schema:affiliation https://www.grid.ac/institutes/grid.411162.1
73 schema:familyName Ragot
74 schema:givenName Stéphanie
75 rdf:type schema:Person
76 N4ddc4314245040caa90735328f21f875 schema:affiliation https://www.grid.ac/institutes/grid.7452.4
77 schema:familyName Roussel
78 schema:givenName Ronan
79 rdf:type schema:Person
80 N57e669a3658a495d8f020f7c9d1b678b schema:affiliation N7058d9fa7e6b46659fde6864703827d6
81 schema:familyName Matar
82 schema:givenName Odette
83 rdf:type schema:Person
84 N6602ca8e90d441d58cc21b0a8483dfcc schema:affiliation Nbb4c6243cb6d4d48ba4b56bfe5eefafc
85 schema:familyName Bumbu
86 schema:givenName Anisoara
87 rdf:type schema:Person
88 N67dd73348cd4488290efe54d9325f84e schema:name pubmed_id
89 schema:value 30809716
90 rdf:type schema:PropertyValue
91 N6dcbc1e18a1343be86378e5f3adcf306 rdf:first Nb5fbb27274834188ac6112e1cfce03a0
92 rdf:rest rdf:nil
93 N7058d9fa7e6b46659fde6864703827d6 schema:name Department of Diabetology, Endocrinology and Nutrition, Bichat Hospital, Assistance Publique – Hôpitaux de Paris, DHU FIRE, 46 rue Henri Huchard 75877, Paris Cedex 18, France
94 rdf:type schema:Organization
95 N7b92bbb840bc43458acc382c8b6c7c14 rdf:first N6602ca8e90d441d58cc21b0a8483dfcc
96 rdf:rest N256cea5bef2b472bac24c11a7e831091
97 N7c7bbd6aba5045d5a7b4f01d3a4faf75 schema:name Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, USPC, Université Paris Descartes, Université Paris Diderot, Paris, France
98 rdf:type schema:Organization
99 N87a370d63c8c4fa7bb512fa89a9c7be9 schema:affiliation https://www.grid.ac/institutes/grid.417888.a
100 schema:familyName Marre
101 schema:givenName Michel
102 rdf:type schema:Person
103 N9e7bf7a79d514173a9d9273d28b79902 rdf:first Na0c4ea7ec6984255ba55ca4836960736
104 rdf:rest Ne6548464edb64ba0b6c753f654b76ec7
105 Na0c4ea7ec6984255ba55ca4836960736 schema:affiliation https://www.grid.ac/institutes/grid.7452.4
106 schema:familyName Potier
107 schema:givenName Louis
108 rdf:type schema:Person
109 Na2ffaa14e76e4bd88ff6ab787bab1c48 rdf:first N16c53f1dd49b4c9681d5e457138fdbe1
110 rdf:rest Nf722085635f74013ae8372a7348efd65
111 Nb27cf8f76ec642b1958340b2bc0c43e6 schema:affiliation https://www.grid.ac/institutes/grid.412041.2
112 schema:familyName Mohammedi
113 schema:givenName Kamel
114 rdf:type schema:Person
115 Nb5fbb27274834188ac6112e1cfce03a0 schema:affiliation https://www.grid.ac/institutes/grid.277151.7
116 schema:familyName Hadjadj
117 schema:givenName Samy
118 rdf:type schema:Person
119 Nbb4c6243cb6d4d48ba4b56bfe5eefafc schema:name Department of Diabetology, Endocrinology and Nutrition, Bichat Hospital, Assistance Publique – Hôpitaux de Paris, DHU FIRE, 46 rue Henri Huchard 75877, Paris Cedex 18, France
120 rdf:type schema:Organization
121 Nc2c134fa79974b2f9655e54bf27fea31 schema:affiliation https://www.grid.ac/institutes/grid.411162.1
122 schema:familyName Saulnier
123 schema:givenName Pierre-Jean
124 rdf:type schema:Person
125 Ndc37d69dbb5348b8bc27748399ab2356 schema:name doi
126 schema:value 10.1007/s00125-019-4835-z
127 rdf:type schema:PropertyValue
128 Ndcc51354121c443bb8b6ecf640e96c2d schema:name dimensions_id
129 schema:value pub.1112394539
130 rdf:type schema:PropertyValue
131 Ne53ff064b6c34a7889702cce806fa41c schema:affiliation N7c7bbd6aba5045d5a7b4f01d3a4faf75
132 schema:familyName Velho
133 schema:givenName Gilberto
134 rdf:type schema:Person
135 Ne6548464edb64ba0b6c753f654b76ec7 rdf:first N4ddc4314245040caa90735328f21f875
136 rdf:rest N1d902af3695b48c4ab2ffa15e097726b
137 Ned9c3f7915024790ba084cda0e204fb8 rdf:first Nb27cf8f76ec642b1958340b2bc0c43e6
138 rdf:rest N6dcbc1e18a1343be86378e5f3adcf306
139 Nf4708758339648c8ba34f515f8fe4900 schema:name readcube_id
140 schema:value a0576ab53c142465e1f0c5f3c164928710f4db3bdbf2763a329ac240f47d2194
141 rdf:type schema:PropertyValue
142 Nf722085635f74013ae8372a7348efd65 rdf:first N4cb3cb70a442424a89bf986a0f3f6169
143 rdf:rest N45129d1636c74cab9bab14cd08981822
144 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
145 schema:name Medical and Health Sciences
146 rdf:type schema:DefinedTerm
147 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
148 schema:name Public Health and Health Services
149 rdf:type schema:DefinedTerm
150 sg:journal.1001482 schema:issn 0012-186X
151 1432-0428
152 schema:name Diabetologia
153 rdf:type schema:Periodical
154 sg:pub.10.1007/s00125-006-0431-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051864625
155 https://doi.org/10.1007/s00125-006-0431-0
156 rdf:type schema:CreativeWork
157 https://doi.org/10.1001/jama.1974.03230490039020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030384277
158 rdf:type schema:CreativeWork
159 https://doi.org/10.1001/jama.288.23.2981 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016077891
160 rdf:type schema:CreativeWork
161 https://doi.org/10.1001/jamainternmed.2018.3034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106130173
162 rdf:type schema:CreativeWork
163 https://doi.org/10.1002/pds.932 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000483199
164 rdf:type schema:CreativeWork
165 https://doi.org/10.1016/1056-8727(95)00088-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030865276
166 rdf:type schema:CreativeWork
167 https://doi.org/10.1016/j.diabres.2018.03.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101823255
168 rdf:type schema:CreativeWork
169 https://doi.org/10.1016/s0140-6736(00)02527-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000631578
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1016/s2213-8587(17)30257-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090779906
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1056/nejmoa1611925 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085993372
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1080/00273171.2011.568786 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026060254
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1093/biostatistics/2.1.85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030176140
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1093/eurheartj/ehl441 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043168707
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1097/md.0000000000001054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043279404
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1111/dom.13115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091567969
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1111/dom.13255 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100975552
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1111/dom.13424 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105102700
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1111/dom.13459 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105294322
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1111/dom.13477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105775429
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1136/bmj.1.6120.1114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009116973
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1136/bmj.k4365 schema:sameAs https://app.dimensions.ai/details/publication/pub.1109904450
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1161/01.atv.0000149377.90852.d8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053681998
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1161/01.cir.48.3.455 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047100864
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1161/circulationaha.117.031227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092675327
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1177/1534734610371594 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042906552
204 rdf:type schema:CreativeWork
205 https://doi.org/10.2337/dc07-2079 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038571693
206 rdf:type schema:CreativeWork
207 https://doi.org/10.2337/dc17-1551 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092681358
208 rdf:type schema:CreativeWork
209 https://doi.org/10.7326/0003-4819-150-9-200905050-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073710774
210 rdf:type schema:CreativeWork
211 https://www.grid.ac/institutes/grid.277151.7 schema:alternateName Centre Hospitalier Universitaire de Nantes
212 schema:name Institut du Thorax, Inserm, CNRS, CHU Nantes, Nantes, France
213 rdf:type schema:Organization
214 https://www.grid.ac/institutes/grid.411162.1 schema:alternateName Centre Hospitalier Universitaire de Poitiers
215 schema:name CIC1402, INSERM, Poitiers, France
216 Clinical Investigation Centre, CHU de Poitiers, Poitiers, France
217 Department of Vascular Surgery, Centre Hospitalier Universitaire de Poitiers, Poitiers, France
218 UFR de Médecine et Pharmacie, Poitiers University, Poitiers, France
219 rdf:type schema:Organization
220 https://www.grid.ac/institutes/grid.412041.2 schema:alternateName University of Bordeaux
221 schema:name Bordeaux University, Bordeaux, France
222 Department of Diabetology, Endocrinology and Nutrition, Hôpital Haut-Lévêque, Bordeaux, France
223 Inserm U1219 ‘Bordeaux Population Health’, Bordeaux, France
224 rdf:type schema:Organization
225 https://www.grid.ac/institutes/grid.417888.a schema:alternateName Fondation Ophtalmologique Adolphe de Rothschild
226 schema:name Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, USPC, Université Paris Descartes, Université Paris Diderot, Paris, France
227 Department of Diabetology, Endocrinology and Nutrition, Bichat Hospital, Assistance Publique – Hôpitaux de Paris, DHU FIRE, 46 rue Henri Huchard 75877, Paris Cedex 18, France
228 Fondation Ophtalmologique Adolphe de Rothschild, Paris, France
229 UFR de Médecine, Paris Diderot University, Sorbonne Paris Cité, Paris, France
230 rdf:type schema:Organization
231 https://www.grid.ac/institutes/grid.7452.4 schema:alternateName Paris Diderot University
232 schema:name Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, USPC, Université Paris Descartes, Université Paris Diderot, Paris, France
233 Department of Diabetology, Endocrinology and Nutrition, Bichat Hospital, Assistance Publique – Hôpitaux de Paris, DHU FIRE, 46 rue Henri Huchard 75877, Paris Cedex 18, France
234 UFR de Médecine, Paris Diderot University, Sorbonne Paris Cité, Paris, France
235 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...