Plasma branched chain/aromatic amino acids, enriched Mediterranean diet and risk of type 2 diabetes: case-cohort study within the PREDIMED Trial View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-07

AUTHORS

Miguel Ruiz-Canela, Marta Guasch-Ferré, Estefanía Toledo, Clary B. Clish, Cristina Razquin, Liming Liang, Dong D. Wang, Dolores Corella, Ramón Estruch, Álvaro Hernáez, Edward Yu, Enrique Gómez-Gracia, Yan Zheng, Fernando Arós, Dora Romaguera, Courtney Dennis, Emilio Ros, José Lapetra, Lluis Serra-Majem, Christopher Papandreou, Olga Portoles, Montserrat Fitó, Jordi Salas-Salvadó, Frank B. Hu, Miguel A. Martínez-González

ABSTRACT

AIMS/HYPOTHESIS: Branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs) are associated with type 2 diabetes. However, repeated measurements of BCAA/AAA and their interactions with dietary interventions have not been evaluated. We investigated the associations between baseline and changes at 1 year in BCAA/AAA with type 2 diabetes in the context of a Mediterranean diet (MedDiet) trial. METHODS: We included 251 participants with incident type 2 diabetes and a random sample of 694 participants (641 participants without type 2 diabetes and 53 overlapping cases) in a case-cohort study nested within the PREvención con DIeta MEDiterránea (PREDIMED) trial. Participants were randomised to a MedDiet+extra-virgin olive oil (n = 273), a MedDiet+nuts (n = 324) or a control diet (n = 295). We used LC-MS/MS to measure plasma levels of amino acids. Type 2 diabetes was a pre-specified secondary outcome of the PREDIMED trial. RESULTS: Elevated plasma levels of individual BCAAs/AAAs were associated with higher type 2 diabetes risk after a median follow-up of 3.8 years: multivariable HR for the highest vs lowest quartile ranged from 1.32 for phenylalanine ([95% CI 0.90, 1.92], p for trend = 0.015) to 3.29 for leucine ([95% CI 2.03, 5.34], p for trend<0.001). Increases in BCAA score at 1 year were associated with higher type 2 diabetes risk in the control group with HR per SD = 1.61 (95% CI 1.02, 2.54), but not in the MedDiet groups (p for interaction <0.001). The MedDiet+extra-virgin olive oil significantly reduced BCAA levels after 1 year of intervention (p = 0.005 vs the control group). CONCLUSIONS/INTERPRETATION: Our results support that higher baseline BCAAs and their increases at 1 year were associated with higher type 2 diabetes risk. A Mediterranean diet rich in extra-virgin olive oil significantly reduced the levels of BCAA and attenuated the positive association between plasma BCAA levels and type 2 diabetes incidence. Clinical trial number: SRCTN35739639 ( www.controlled-trials.com ). More... »

PAGES

1560-1571

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00125-018-4611-5

DOI

http://dx.doi.org/10.1007/s00125-018-4611-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1103270100

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29663011


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432 Department of Cardiology, University Hospital, University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain
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436 Cardiovascular and Nutrition Research Group (Regicor Study Group), Hospital del Mar Research Institute (IMIM), Barcelona, Spain
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440 Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA
441 Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA
442 Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA
443 Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA
444 Department of Preventive Medicine and Public Health, Facultad de Medicina, Universidad de Navarra, Irunlarrea 1, 31008, Pamplona, Spain
445 IdiSNA, Navarra Institute for Health Research, Pamplona, Spain
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449 Human Nutrition Unit, Faculty of Medicine and Health Sciences, Pere Virgili Health Research Institute, Rovira i Virgili University, Reus, Spain
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453 Department of Family Medicine, Research Unit, Primary Care Division of Sevilla, Sevilla, Spain
454 Department of Internal Medicine, Biomedical Research Institute August Pi Sunyer (IDI- BAPS), Hospital Clinic, University of Barcelona, Barcelona, Spain
455 Department of Preventive Medicine and Public Health, Facultad de Medicina, Universidad de Navarra, Irunlarrea 1, 31008, Pamplona, Spain
456 Health Research Institute of the Balearic Islands (IdISBa), University Hospital Son Espases, Mallorca, Spain
457 IdiSNA, Navarra Institute for Health Research, Pamplona, Spain
458 Lipid Clinic, Department of Endocrinology and Nutrition Biomedical Research Institute August Pi Sunyer (IDIBAPS), Hospital Clinic, University of Barcelona, Barcelona, Spain
459 Research Institute of Biomedical and Health Sciences and Medical School University of Las Palmas de Gran Canarias, Las Palmas de Gran Canaria, Spain
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463 Department of Preventive Medicine, University of Valencia, Valencia, Spain
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466 schema:name CIBER Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain
467 Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA
468 Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA
469 Human Nutrition Unit, Faculty of Medicine and Health Sciences, Pere Virgili Health Research Institute, Rovira i Virgili University, Reus, Spain
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