Plasma branched chain/aromatic amino acids, enriched Mediterranean diet and risk of type 2 diabetes: case-cohort study within the PREDIMED Trial View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-04-16

AUTHORS

Miguel Ruiz-Canela, Marta Guasch-Ferré, Estefanía Toledo, Clary B. Clish, Cristina Razquin, Liming Liang, Dong D. Wang, Dolores Corella, Ramón Estruch, Álvaro Hernáez, Edward Yu, Enrique Gómez-Gracia, Yan Zheng, Fernando Arós, Dora Romaguera, Courtney Dennis, Emilio Ros, José Lapetra, Lluis Serra-Majem, Christopher Papandreou, Olga Portoles, Montserrat Fitó, Jordi Salas-Salvadó, Frank B. Hu, Miguel A. Martínez-González

ABSTRACT

Aims/hypothesisBranched-chain amino acids (BCAAs) and aromatic amino acids (AAAs) are associated with type 2 diabetes. However, repeated measurements of BCAA/AAA and their interactions with dietary interventions have not been evaluated. We investigated the associations between baseline and changes at 1 year in BCAA/AAA with type 2 diabetes in the context of a Mediterranean diet (MedDiet) trial.MethodsWe included 251 participants with incident type 2 diabetes and a random sample of 694 participants (641 participants without type 2 diabetes and 53 overlapping cases) in a case-cohort study nested within the PREvención con DIeta MEDiterránea (PREDIMED) trial. Participants were randomised to a MedDiet+extra-virgin olive oil (n = 273), a MedDiet+nuts (n = 324) or a control diet (n = 295). We used LC-MS/MS to measure plasma levels of amino acids. Type 2 diabetes was a pre-specified secondary outcome of the PREDIMED trial.ResultsElevated plasma levels of individual BCAAs/AAAs were associated with higher type 2 diabetes risk after a median follow-up of 3.8 years: multivariable HR for the highest vs lowest quartile ranged from 1.32 for phenylalanine ([95% CI 0.90, 1.92], p for trend = 0.015) to 3.29 for leucine ([95% CI 2.03, 5.34], p for trend<0.001). Increases in BCAA score at 1 year were associated with higher type 2 diabetes risk in the control group with HR per SD = 1.61 (95% CI 1.02, 2.54), but not in the MedDiet groups (p for interaction <0.001). The MedDiet+extra-virgin olive oil significantly reduced BCAA levels after 1 year of intervention (p = 0.005 vs the control group).Conclusions/interpretationOur results support that higher baseline BCAAs and their increases at 1 year were associated with higher type 2 diabetes risk. A Mediterranean diet rich in extra-virgin olive oil significantly reduced the levels of BCAA and attenuated the positive association between plasma BCAA levels and type 2 diabetes incidence.Clinical trial number: SRCTN35739639 (www.controlled-trials.com) More... »

PAGES

1560-1571

Journal

TITLE

Diabetologia

ISSUE

7

VOLUME

61

Author Affiliations

  • CIBER Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain
  • Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA
  • Broad Institute of MIT and Harvard University, Cambridge, MA, USA
  • Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA
  • Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA
  • Department of Preventive Medicine, University of Valencia, Valencia, Spain
  • Department of Internal Medicine, Biomedical Research Institute August Pi Sunyer (IDI- BAPS), Hospital Clinic, University of Barcelona, Barcelona, Spain
  • Cardiovascular and Nutrition Research Group (Regicor Study Group), Hospital del Mar Research Institute (IMIM), Barcelona, Spain
  • Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA
  • Department of Preventive Medicine, University of Malaga, Malaga, Spain
  • Department of Cardiology, University Hospital, University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain
  • Health Research Institute of the Balearic Islands (IdISBa), University Hospital Son Espases, Mallorca, Spain
  • Lipid Clinic, Department of Endocrinology and Nutrition Biomedical Research Institute August Pi Sunyer (IDIBAPS), Hospital Clinic, University of Barcelona, Barcelona, Spain
  • Department of Family Medicine, Research Unit, Primary Care Division of Sevilla, Sevilla, Spain
  • Research Institute of Biomedical and Health Sciences and Medical School University of Las Palmas de Gran Canarias, Las Palmas de Gran Canaria, Spain
  • Human Nutrition Unit, Faculty of Medicine and Health Sciences, Pere Virgili Health Research Institute, Rovira i Virgili University, Reus, Spain
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00125-018-4611-5

    DOI

    http://dx.doi.org/10.1007/s00125-018-4611-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1103270100

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29663011


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