Overweight, obesity and the risk of LADA: results from a Swedish case–control study and the Norwegian HUNT Study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-06

AUTHORS

Rebecka Hjort, Emma Ahlqvist, Per-Ola Carlsson, Valdemar Grill, Leif Groop, Mats Martinell, Bahareh Rasouli, Anders Rosengren, Tiinamaija Tuomi, Bjørn Olav Åsvold, Sofia Carlsson

ABSTRACT

AIMS/HYPOTHESIS: Excessive weight is a risk factor for type 2 diabetes, but its role in the promotion of autoimmune diabetes is not clear. We investigated the risk of latent autoimmune diabetes in adults (LADA) in relation to overweight/obesity in two large population-based studies. METHODS: Analyses were based on incident cases of LADA (n = 425) and type 2 diabetes (n = 1420), and 1704 randomly selected control participants from a Swedish case-control study and prospective data from the Norwegian HUNT Study including 147 people with LADA and 1,012,957 person-years of follow-up (1984-2008). We present adjusted ORs and HRs with 95% CI. RESULTS: In the Swedish data, obesity was associated with an increased risk of LADA (OR 2.93, 95% CI 2.17, 3.97), which was even stronger for type 2 diabetes (OR 18.88, 95% CI 14.29, 24.94). The association was stronger in LADA with low GAD antibody (GADA; More... »

PAGES

1333-1343

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00125-018-4596-0

DOI

http://dx.doi.org/10.1007/s00125-018-4596-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1101785725

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29589073


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