Ceramide stearic to palmitic acid ratio predicts incident diabetes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-03-15

AUTHORS

Mika Hilvo, Tuire Salonurmi, Aki S. Havulinna, Dimple Kauhanen, Eva Ringdal Pedersen, Grethe S. Tell, Klaus Meyer, Anna-Maria Teeriniemi, Tiina Laatikainen, Pekka Jousilahti, Markku J. Savolainen, Ottar Nygård, Veikko Salomaa, Reijo Laaksonen

ABSTRACT

Aims/hypothesisCeramide lipids have a role in the development of insulin resistance, diabetes and risk of cardiovascular disease. Here we investigated four ceramides and their ratios to find the best predictors of incident diabetes.MethodsA validated mass-spectrometric method was applied to measure Cer(d18:1/16:0), Cer(d18:1/18:0), Cer(d18:1/24:0) and Cer(d18:1/24:1) from serum or plasma samples. These ceramides were analysed in a population-based risk factor study (FINRISK 2002, n = 8045), in a cohort of participants undergoing elective coronary angiography for suspected stable angina pectoris (Western Norway Coronary Angiography Cohort [WECAC], n = 3344) and in an intervention trial investigating improved methods of lifestyle modification for individuals at high risk of the metabolic syndrome (Prevent Metabolic Syndrome [PrevMetSyn], n = 371). Diabetes risk score models were developed to estimate the 10 year risk of incident diabetes.ResultsAnalysis in FINRISK 2002 showed that the Cer(d18:1/18:0)/Cer(d18:1/16:0) ceramide ratio was predictive of incident diabetes (HR per SD 2.23, 95% CI 2.05, 2.42), and remained significant after adjustment for several risk factors, including BMI, fasting glucose and HbA1c (HR 1.34, 95% CI 1.14, 1.57). The finding was validated in the WECAC study (unadjusted HR 1.81, 95% CI 1.53, 2.14; adjusted HR 1.39, 95% CI 1.16, 1.66). In the intervention trial, the ceramide ratio and diabetes risk scores significantly decreased in individuals who had 5% or more weight loss.Conclusions/interpretationThe Cer(d18:1/18:0)/Cer(d18:1/16:0) ratio is an independent predictive biomarker for incident diabetes, and may be modulated by lifestyle intervention. More... »

PAGES

1424-1434

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00125-018-4590-6

DOI

http://dx.doi.org/10.1007/s00125-018-4590-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1101554382

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29546476


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30 schema:description Aims/hypothesisCeramide lipids have a role in the development of insulin resistance, diabetes and risk of cardiovascular disease. Here we investigated four ceramides and their ratios to find the best predictors of incident diabetes.MethodsA validated mass-spectrometric method was applied to measure Cer(d18:1/16:0), Cer(d18:1/18:0), Cer(d18:1/24:0) and Cer(d18:1/24:1) from serum or plasma samples. These ceramides were analysed in a population-based risk factor study (FINRISK 2002, n = 8045), in a cohort of participants undergoing elective coronary angiography for suspected stable angina pectoris (Western Norway Coronary Angiography Cohort [WECAC], n = 3344) and in an intervention trial investigating improved methods of lifestyle modification for individuals at high risk of the metabolic syndrome (Prevent Metabolic Syndrome [PrevMetSyn], n = 371). Diabetes risk score models were developed to estimate the 10 year risk of incident diabetes.ResultsAnalysis in FINRISK 2002 showed that the Cer(d18:1/18:0)/Cer(d18:1/16:0) ceramide ratio was predictive of incident diabetes (HR per SD 2.23, 95% CI 2.05, 2.42), and remained significant after adjustment for several risk factors, including BMI, fasting glucose and HbA1c (HR 1.34, 95% CI 1.14, 1.57). The finding was validated in the WECAC study (unadjusted HR 1.81, 95% CI 1.53, 2.14; adjusted HR 1.39, 95% CI 1.16, 1.66). In the intervention trial, the ceramide ratio and diabetes risk scores significantly decreased in individuals who had 5% or more weight loss.Conclusions/interpretationThe Cer(d18:1/18:0)/Cer(d18:1/16:0) ratio is an independent predictive biomarker for incident diabetes, and may be modulated by lifestyle intervention.
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36 schema:keywords BMI
37 Conclusions/interpretationThe
38 HbA1c
39 MethodsA
40 ResultsAnalysis
41 Risk Factor Study
42 acid ratio
43 adjustment
44 angina pectoris
45 angiography
46 best predictor
47 biomarkers
48 cardiovascular disease
49 ceramide
50 ceramide ratio
51 cohort
52 cohort of participants
53 coronary angiography
54 development
55 diabetes
56 disease
57 elective coronary angiography
58 factor studies
59 factors
60 findings
61 glucose
62 high risk
63 incident diabetes
64 independent predictive biomarker
65 individuals
66 insulin resistance
67 intervention
68 intervention trials
69 lifestyle intervention
70 lifestyle modification
71 lipids
72 loss
73 mass spectrometric method
74 metabolic syndrome
75 method
76 model
77 modification
78 more weight loss
79 palmitic acid ratio
80 participants
81 pectoris
82 plasma samples
83 predictive biomarkers
84 predictors
85 ratio
86 resistance
87 risk
88 risk factors
89 risk score
90 risk score model
91 role
92 samples
93 score model
94 scores
95 serum
96 stable angina pectoris
97 study
98 syndrome
99 trials
100 weight loss
101 year risk
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