Meal sequence and glucose excursion, gastric emptying and incretin secretion in type 2 diabetes: a randomised, controlled crossover, exploratory trial View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12-24

AUTHORS

Hitoshi Kuwata, Masahiro Iwasaki, Shinobu Shimizu, Kohtaro Minami, Haruyo Maeda, Susumu Seino, Koji Nakada, Chihiro Nosaka, Kenta Murotani, Takeshi Kurose, Yutaka Seino, Daisuke Yabe

ABSTRACT

AIMS/HYPOTHESIS: Investigation of dietary therapy for diabetes has focused on meal size and composition; examination of the effects of meal sequence on postprandial glucose management is limited. The effects of fish or meat before rice on postprandial glucose excursion, gastric emptying and incretin secretions were investigated. METHODS: The experiment was a single centre, randomised controlled crossover, exploratory trial conducted in an outpatient ward of a private hospital in Osaka, Japan. Patients with type 2 diabetes (n = 12) and healthy volunteers (n = 10), with age 30-75 years, HbA1c 9.0% (75 mmol/mol) or less, and BMI 35 kg/m(2) or less, were randomised evenly to two groups by use of stratified randomisation, and subjected to meal sequence tests on three separate mornings; days 1 and 2, rice before fish (RF) or fish before rice (FR) in a crossover fashion; and day 3, meat before rice (MR). Pre- and postprandial levels of glucose, insulin, C-peptide and glucagon as well as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide were evaluated. Gastric emptying rate was determined by (13)C-acetate breath test involving measurement of (13)CO2 in breath samples collected before and after ingestion of rice steamed with (13)C-labelled sodium acetate. Participants, people doing measurements or examinations, and people assessing the outcomes were not blinded to group assignment. RESULTS: FR and MR in comparison with RF ameliorated postprandial glucose excursion (AUC-15-240 min-glucose: type 2 diabetes, FR 2,326.6 ± 114.7 mmol/l × min, MR 2,257.0 ± 82.3 mmol/l × min, RF 2,475.6 ± 87.2 mmol/l × min [p < 0.05 for FR vs RF and MR vs RF]; healthy, FR 1,419.8 ± 72.3 mmol/l × min, MR 1,389.7 ± 69.4 mmol/l × min, RF 1,483.9 ± 72.8 mmol/l × min) and glucose variability (SD-15-240 min-glucose: type 2 diabetes, FR 1.94 ± 0.22 mmol/l, MR 1.68 ± 0.18 mmol/l, RF 2.77 ± 0.24 mmol/l [p < 0.05 for FR vs RF and MR vs RF]; healthy, FR 0.95 ± 0.21 mmol/l, MR 0.83 ± 0.16 mmol/l, RF 1.18 ± 0.27 mmol/l). FR and MR also enhanced GLP-1 secretion, MR more strongly than FR or RF (AUC-15-240 min-GLP-1: type 2 diabetes, FR 7,123.4 ± 376.3 pmol/l × min, MR 7,743.6 ± 801.4 pmol/l × min, RF 6,189.9 ± 581.3 pmol/l × min [p < 0.05 for FR vs RF and MR vs RF]; healthy, FR 3,977.3 ± 324.6 pmol/l × min, MR 4,897.7 ± 330.7 pmol/l × min, RF 3,747.5 ± 572.6 pmol/l × min [p < 0.05 for MR vs RF and MR vs FR]). FR and MR delayed gastric emptying (Time50%: type 2 diabetes, FR 83.2 ± 7.2 min, MR 82.3 ± 6.4 min, RF 29.8 ± 3.9 min [p < 0.05 for FR vs RF and MR vs RF]; healthy, FR 66.3 ± 5.5 min, MR 74.4 ± 7.6 min, RF 32.4 ± 4.5 min [p < 0.05 for FR vs RF and MR vs RF]), which is associated with amelioration of postprandial glucose excursion (AUC-15-120 min-glucose: type 2 diabetes, r = -0.746, p < 0.05; healthy, r = -0.433, p < 0.05) and glucose variability (SD-15-240 min-glucose: type 2 diabetes, r = -0.578, p < 0.05; healthy, r = -0.526, p < 0.05), as well as with increasing GLP-1 (AUC-15-120 min-GLP-1: type 2 diabetes, r = 0.437, p < 0.05; healthy, r = 0.300, p = 0.107) and glucagon (AUC-15-120 min-glucagon: type 2 diabetes, r = 0.399, p < 0.05; healthy, r = 0.471, p < 0.05). The measured outcomes were comparable between the two randomised groups. CONCLUSIONS/INTERPRETATION: Meal sequence can play a role in postprandial glucose control through both delayed gastric emptying and enhanced incretin secretion. Our findings provide clues for medical nutrition therapy to better prevent and manage type 2 diabetes. TRIAL REGISTRATION: UMIN Clinical Trials Registry UMIN000017434. FUNDING: Japan Society for Promotion of Science, Japan Association for Diabetes Education and Care, and Japan Vascular Disease Research Foundation. More... »

PAGES

453-461

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00125-015-3841-z

DOI

http://dx.doi.org/10.1007/s00125-015-3841-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026375330

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26704625


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "C-Peptide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cross-Over Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diabetes Mellitus, Type 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diet", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gastric Inhibitory Polypeptide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glucagon", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glucagon-Like Peptide 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glucose", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Incretins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Japan", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Meals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Postprandial Period", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Center for Diabetes, Endocrinology and Metabolism, Kansai Electric Power Hospital, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.414973.c", 
          "name": [
            "Yutaka Seino Distinguished Center for Diabetes Research, Kansai Electric Power Medical Research Institute, 1-5-6 Minatojimaminamimachi, Chuo-ku, Kobe, 650-0047 Japan", 
            "Center for Diabetes, Endocrinology and Metabolism, Kansai Electric Power Hospital, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kuwata", 
        "givenName": "Hitoshi", 
        "id": "sg:person.01030312656.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030312656.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan", 
          "id": "http://www.grid.ac/institutes/grid.31432.37", 
          "name": [
            "Yutaka Seino Distinguished Center for Diabetes Research, Kansai Electric Power Medical Research Institute, 1-5-6 Minatojimaminamimachi, Chuo-ku, Kobe, 650-0047 Japan", 
            "Center for Metabolism and Clinical Nutrition, Kansai Electric Power Hospital, Osaka, Japan", 
            "Division of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iwasaki", 
        "givenName": "Masahiro", 
        "id": "sg:person.0717725356.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717725356.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Clinical Laboratory, Kansai Electric Power Hospital, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.414973.c", 
          "name": [
            "Yutaka Seino Distinguished Center for Diabetes Research, Kansai Electric Power Medical Research Institute, 1-5-6 Minatojimaminamimachi, Chuo-ku, Kobe, 650-0047 Japan", 
            "Department of Clinical Laboratory, Kansai Electric Power Hospital, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shimizu", 
        "givenName": "Shinobu", 
        "id": "sg:person.01063260763.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063260763.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan", 
          "id": "http://www.grid.ac/institutes/grid.31432.37", 
          "name": [
            "Division of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Minami", 
        "givenName": "Kohtaro", 
        "id": "sg:person.01307326611.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307326611.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan", 
          "id": "http://www.grid.ac/institutes/grid.31432.37", 
          "name": [
            "Division of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maeda", 
        "givenName": "Haruyo", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan", 
          "id": "http://www.grid.ac/institutes/grid.31432.37", 
          "name": [
            "Division of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Seino", 
        "givenName": "Susumu", 
        "id": "sg:person.0767130147.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767130147.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Jikei University School of Medicine, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.411898.d", 
          "name": [
            "Department of Surgery, Jikei University School of Medicine, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakada", 
        "givenName": "Koji", 
        "id": "sg:person.0776544013.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776544013.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kyowa Hakko Kirin Co. Ltd, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.473316.4", 
          "name": [
            "Kyowa Hakko Kirin Co. Ltd, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nosaka", 
        "givenName": "Chihiro", 
        "id": "sg:person.0677032136.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677032136.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Biostatistics, Clinical Research Center, Aichi Medical University, Nagakute, Aichi Japan", 
          "id": "http://www.grid.ac/institutes/grid.411234.1", 
          "name": [
            "Division of Biostatistics, Clinical Research Center, Aichi Medical University, Nagakute, Aichi Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Murotani", 
        "givenName": "Kenta", 
        "id": "sg:person.01002652037.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002652037.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Center for Diabetes, Endocrinology and Metabolism, Kansai Electric Power Hospital, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.414973.c", 
          "name": [
            "Yutaka Seino Distinguished Center for Diabetes Research, Kansai Electric Power Medical Research Institute, 1-5-6 Minatojimaminamimachi, Chuo-ku, Kobe, 650-0047 Japan", 
            "Center for Diabetes, Endocrinology and Metabolism, Kansai Electric Power Hospital, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kurose", 
        "givenName": "Takeshi", 
        "id": "sg:person.01034153756.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034153756.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Center for Diabetes, Endocrinology and Metabolism, Kansai Electric Power Hospital, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.414973.c", 
          "name": [
            "Yutaka Seino Distinguished Center for Diabetes Research, Kansai Electric Power Medical Research Institute, 1-5-6 Minatojimaminamimachi, Chuo-ku, Kobe, 650-0047 Japan", 
            "Center for Diabetes, Endocrinology and Metabolism, Kansai Electric Power Hospital, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Seino", 
        "givenName": "Yutaka", 
        "id": "sg:person.0645706232.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645706232.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan", 
          "id": "http://www.grid.ac/institutes/grid.31432.37", 
          "name": [
            "Yutaka Seino Distinguished Center for Diabetes Research, Kansai Electric Power Medical Research Institute, 1-5-6 Minatojimaminamimachi, Chuo-ku, Kobe, 650-0047 Japan", 
            "Center for Diabetes, Endocrinology and Metabolism, Kansai Electric Power Hospital, Osaka, Japan", 
            "Center for Metabolism and Clinical Nutrition, Kansai Electric Power Hospital, Osaka, Japan", 
            "Division of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yabe", 
        "givenName": "Daisuke", 
        "id": "sg:person.01343065365.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343065365.86"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nrendo.2014.202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020313291", 
          "https://doi.org/10.1038/nrendo.2014.202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-013-2841-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017157768", 
          "https://doi.org/10.1007/s00125-013-2841-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11892-015-0602-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026921846", 
          "https://doi.org/10.1007/s11892-015-0602-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1168", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037198312", 
          "https://doi.org/10.1038/nm1168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-90-481-3271-3_18", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039940836", 
          "https://doi.org/10.1007/978-90-481-3271-3_18"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s13340-015-0206-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007451476", 
          "https://doi.org/10.1007/s13340-015-0206-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrendo.2012.140", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011731640", 
          "https://doi.org/10.1038/nrendo.2012.140"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11892-014-0555-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023952105", 
          "https://doi.org/10.1007/s11892-014-0555-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-013-2876-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007118291", 
          "https://doi.org/10.1007/s00125-013-2876-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-014-3305-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011812323", 
          "https://doi.org/10.1007/s00125-014-3305-x"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-12-24", 
    "datePublishedReg": "2015-12-24", 
    "description": "AIMS/HYPOTHESIS: Investigation of dietary therapy for diabetes has focused on meal size and composition; examination of the effects of meal sequence on postprandial glucose management is limited. The effects of fish or meat before rice on postprandial glucose excursion, gastric emptying and incretin secretions were investigated.\nMETHODS: The experiment was a single centre, randomised controlled crossover, exploratory trial conducted in an outpatient ward of a private hospital in Osaka, Japan. Patients with type 2 diabetes (n\u2009=\u200912) and healthy volunteers (n\u2009=\u200910), with age 30-75 years, HbA1c 9.0% (75 mmol/mol) or less, and BMI 35 kg/m(2) or less, were randomised evenly to two groups by use of stratified randomisation, and subjected to meal sequence tests on three separate mornings; days 1 and 2, rice before fish (RF) or fish before rice (FR) in a crossover fashion; and day 3, meat before rice (MR). Pre- and postprandial levels of glucose, insulin, C-peptide and glucagon as well as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide were evaluated. Gastric emptying rate was determined by (13)C-acetate breath test involving measurement of (13)CO2 in breath samples collected before and after ingestion of rice steamed with (13)C-labelled sodium acetate. Participants, people doing measurements or examinations, and people assessing the outcomes were not blinded to group assignment.\nRESULTS: FR and MR in comparison with RF ameliorated postprandial glucose excursion (AUC-15-240 min-glucose: type 2 diabetes, FR 2,326.6\u2009\u00b1\u2009114.7 mmol/l\u2009\u00d7\u2009min, MR 2,257.0\u2009\u00b1\u200982.3 mmol/l\u2009\u00d7\u2009min, RF 2,475.6\u2009\u00b1\u200987.2 mmol/l\u2009\u00d7\u2009min [p\u2009<\u20090.05 for FR vs RF and MR vs RF]; healthy, FR 1,419.8\u2009\u00b1\u200972.3 mmol/l\u2009\u00d7\u2009min, MR 1,389.7\u2009\u00b1\u200969.4 mmol/l\u2009\u00d7\u2009min, RF 1,483.9\u2009\u00b1\u200972.8 mmol/l\u2009\u00d7\u2009min) and glucose variability (SD-15-240 min-glucose: type 2 diabetes, FR 1.94\u2009\u00b1\u20090.22 mmol/l, MR 1.68\u2009\u00b1\u20090.18 mmol/l, RF 2.77\u2009\u00b1\u20090.24 mmol/l [p\u2009<\u20090.05 for FR vs RF and MR vs RF]; healthy, FR 0.95\u2009\u00b1\u20090.21 mmol/l, MR 0.83\u2009\u00b1\u20090.16 mmol/l, RF 1.18\u2009\u00b1\u20090.27 mmol/l). FR and MR also enhanced GLP-1 secretion, MR more strongly than FR or RF (AUC-15-240 min-GLP-1: type 2 diabetes, FR 7,123.4\u2009\u00b1\u2009376.3 pmol/l\u2009\u00d7\u2009min, MR 7,743.6\u2009\u00b1\u2009801.4 pmol/l\u2009\u00d7\u2009min, RF 6,189.9\u2009\u00b1\u2009581.3 pmol/l\u2009\u00d7\u2009min [p\u2009<\u20090.05 for FR vs RF and MR vs RF]; healthy, FR 3,977.3\u2009\u00b1\u2009324.6 pmol/l\u2009\u00d7\u2009min, MR 4,897.7\u2009\u00b1\u2009330.7 pmol/l\u2009\u00d7\u2009min, RF 3,747.5\u2009\u00b1\u2009572.6 pmol/l\u2009\u00d7\u2009min [p\u2009<\u20090.05 for MR vs RF and MR vs FR]). FR and MR delayed gastric emptying (Time50%: type 2 diabetes, FR 83.2\u2009\u00b1\u20097.2 min, MR 82.3\u2009\u00b1\u20096.4 min, RF 29.8\u2009\u00b1\u20093.9 min [p\u2009<\u20090.05 for FR vs RF and MR vs RF]; healthy, FR 66.3\u2009\u00b1\u20095.5 min, MR 74.4\u2009\u00b1\u20097.6 min, RF 32.4\u2009\u00b1\u20094.5 min [p\u2009<\u20090.05 for FR vs RF and MR vs RF]), which is associated with amelioration of postprandial glucose excursion (AUC-15-120 min-glucose: type 2 diabetes, r\u2009=\u2009-0.746, p\u2009<\u20090.05; healthy, r\u2009=\u2009-0.433, p\u2009<\u20090.05) and glucose variability (SD-15-240 min-glucose: type 2 diabetes, r\u2009=\u2009-0.578, p\u2009<\u20090.05; healthy, r\u2009=\u2009-0.526, p\u2009<\u20090.05), as well as with increasing GLP-1 (AUC-15-120 min-GLP-1: type 2 diabetes, r\u2009=\u20090.437, p\u2009<\u20090.05; healthy, r\u2009=\u20090.300, p\u2009=\u20090.107) and glucagon (AUC-15-120 min-glucagon: type 2 diabetes, r\u2009=\u20090.399, p\u2009<\u20090.05; healthy, r\u2009=\u20090.471, p\u2009<\u20090.05). The measured outcomes were comparable between the two randomised groups.\nCONCLUSIONS/INTERPRETATION: Meal sequence can play a role in postprandial glucose control through both delayed gastric emptying and enhanced incretin secretion. Our findings provide clues for medical nutrition therapy to better prevent and manage type 2 diabetes.\nTRIAL REGISTRATION: UMIN Clinical Trials Registry UMIN000017434.\nFUNDING: Japan Society for Promotion of Science, Japan Association for Diabetes Education and Care, and Japan Vascular Disease Research Foundation.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00125-015-3841-z", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6133260", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6084611", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1001482", 
        "issn": [
          "0012-186X", 
          "1432-0428"
        ], 
        "name": "Diabetologia", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "59"
      }
    ], 
    "keywords": [
      "glucagon-like peptide-1", 
      "postprandial glucose excursions", 
      "type 2 diabetes", 
      "glucose excursions", 
      "incretin secretion", 
      "gastric emptying", 
      "glucose variability", 
      "exploratory trial", 
      "meal sequence", 
      "postprandial glucose management", 
      "medical nutrition therapy", 
      "GLP-1 secretion", 
      "postprandial glucose control", 
      "acetate breath test", 
      "ingestion of rice", 
      "nutrition therapy", 
      "dietary therapy", 
      "crossover fashion", 
      "postprandial levels", 
      "single center", 
      "glucose control", 
      "glucose management", 
      "outpatient ward", 
      "healthy volunteers", 
      "breath test", 
      "stratified randomisation", 
      "separate mornings", 
      "peptide-1", 
      "day 1", 
      "diabetes education", 
      "day 3", 
      "type 2", 
      "age 30", 
      "diabetes", 
      "private hospitals", 
      "meal size", 
      "group assignment", 
      "secretion", 
      "therapy", 
      "emptying", 
      "breath samples", 
      "glucagon", 
      "trials", 
      "outcomes", 
      "Japan Society", 
      "MR", 
      "examination", 
      "sequence test", 
      "BMI", 
      "patients", 
      "group", 
      "randomisation", 
      "hospital", 
      "Japan Association", 
      "wards", 
      "insulin", 
      "volunteers", 
      "ingestion", 
      "care", 
      "amelioration", 
      "association", 
      "meat", 
      "excursion", 
      "glucose", 
      "test", 
      "effect", 
      "participants", 
      "Research Foundation", 
      "morning", 
      "people", 
      "FR", 
      "years", 
      "findings", 
      "peptides", 
      "effects of fish", 
      "management", 
      "levels", 
      "control", 
      "center", 
      "role", 
      "promotion", 
      "clues", 
      "rate", 
      "fish", 
      "variability", 
      "Promotion of Science", 
      "fashion", 
      "acetate", 
      "use", 
      "sodium acetate", 
      "samples", 
      "education", 
      "Osaka", 
      "investigation", 
      "comparison", 
      "Japan", 
      "measurements", 
      "sequence", 
      "crossover", 
      "size", 
      "society", 
      "RF", 
      "experiments", 
      "composition", 
      "science", 
      "foundation", 
      "rice", 
      "assignment", 
      "meal sequence tests", 
      "UMIN Clinical Trials Registry UMIN000017434", 
      "Clinical Trials Registry UMIN000017434", 
      "Trials Registry UMIN000017434", 
      "Registry UMIN000017434", 
      "UMIN000017434", 
      "Japan Vascular Disease Research Foundation", 
      "Vascular Disease Research Foundation", 
      "Disease Research Foundation"
    ], 
    "name": "Meal sequence and glucose excursion, gastric emptying and incretin secretion in type 2 diabetes: a randomised, controlled crossover, exploratory trial", 
    "pagination": "453-461", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1026375330"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00125-015-3841-z"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26704625"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00125-015-3841-z", 
      "https://app.dimensions.ai/details/publication/pub.1026375330"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-11-01T18:25", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211101/entities/gbq_results/article/article_676.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00125-015-3841-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00125-015-3841-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00125-015-3841-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00125-015-3841-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00125-015-3841-z'


 

This table displays all metadata directly associated to this object as RDF triples.

393 TRIPLES      22 PREDICATES      172 URIs      154 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00125-015-3841-z schema:about N1250e58d21fe45dd8f270956e3506a00
2 N384579bbdd954f86b3f8c26182d7ca58
3 N39e0a1429d544cd6bb284ad162db2c9a
4 N3eaa424c84d4402b99d662e161b1efa3
5 N481391fff4af434c95623f9cf5e6997b
6 N4e1ae4499dd544158e0c7ea08ac933b5
7 N5c4030802b02499bb0e22ffa819b9255
8 N61bfb946086f46caa8b3d6cb7af59715
9 N635f3f066ba246ec90925e3350e6fa29
10 N6e080770e2fe4ec7b81be5cdf2f1a7e2
11 N76c1f5d588104905a593d3fe0bd623c6
12 N9b0f2b395e1b4adf8fad975f54c22935
13 Na289d7187982412aa006e6dd4769fd82
14 Nb57bf19a1acc4edab0a6ea7cfacb5716
15 Nb5d4ef972d484fc99991daaefa2c3292
16 Nbcd8562a1b47461f8e84c0e74743efd3
17 Nc1da08a7545848a7bbcb4983c9dda27b
18 Ncb6a0565278b42bc8eb91784df80d74a
19 Nd34b06b8dee24aeebde6c5fbcd932dd7
20 anzsrc-for:11
21 anzsrc-for:1103
22 schema:author Naf9065572f0f4790be49e4886329c890
23 schema:citation sg:pub.10.1007/978-90-481-3271-3_18
24 sg:pub.10.1007/s00125-013-2841-0
25 sg:pub.10.1007/s00125-013-2876-2
26 sg:pub.10.1007/s00125-014-3305-x
27 sg:pub.10.1007/s11892-014-0555-4
28 sg:pub.10.1007/s11892-015-0602-9
29 sg:pub.10.1007/s13340-015-0206-2
30 sg:pub.10.1038/nm1168
31 sg:pub.10.1038/nrendo.2012.140
32 sg:pub.10.1038/nrendo.2014.202
33 schema:datePublished 2015-12-24
34 schema:datePublishedReg 2015-12-24
35 schema:description AIMS/HYPOTHESIS: Investigation of dietary therapy for diabetes has focused on meal size and composition; examination of the effects of meal sequence on postprandial glucose management is limited. The effects of fish or meat before rice on postprandial glucose excursion, gastric emptying and incretin secretions were investigated. METHODS: The experiment was a single centre, randomised controlled crossover, exploratory trial conducted in an outpatient ward of a private hospital in Osaka, Japan. Patients with type 2 diabetes (n = 12) and healthy volunteers (n = 10), with age 30-75 years, HbA1c 9.0% (75 mmol/mol) or less, and BMI 35 kg/m(2) or less, were randomised evenly to two groups by use of stratified randomisation, and subjected to meal sequence tests on three separate mornings; days 1 and 2, rice before fish (RF) or fish before rice (FR) in a crossover fashion; and day 3, meat before rice (MR). Pre- and postprandial levels of glucose, insulin, C-peptide and glucagon as well as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide were evaluated. Gastric emptying rate was determined by (13)C-acetate breath test involving measurement of (13)CO2 in breath samples collected before and after ingestion of rice steamed with (13)C-labelled sodium acetate. Participants, people doing measurements or examinations, and people assessing the outcomes were not blinded to group assignment. RESULTS: FR and MR in comparison with RF ameliorated postprandial glucose excursion (AUC-15-240 min-glucose: type 2 diabetes, FR 2,326.6 ± 114.7 mmol/l × min, MR 2,257.0 ± 82.3 mmol/l × min, RF 2,475.6 ± 87.2 mmol/l × min [p < 0.05 for FR vs RF and MR vs RF]; healthy, FR 1,419.8 ± 72.3 mmol/l × min, MR 1,389.7 ± 69.4 mmol/l × min, RF 1,483.9 ± 72.8 mmol/l × min) and glucose variability (SD-15-240 min-glucose: type 2 diabetes, FR 1.94 ± 0.22 mmol/l, MR 1.68 ± 0.18 mmol/l, RF 2.77 ± 0.24 mmol/l [p < 0.05 for FR vs RF and MR vs RF]; healthy, FR 0.95 ± 0.21 mmol/l, MR 0.83 ± 0.16 mmol/l, RF 1.18 ± 0.27 mmol/l). FR and MR also enhanced GLP-1 secretion, MR more strongly than FR or RF (AUC-15-240 min-GLP-1: type 2 diabetes, FR 7,123.4 ± 376.3 pmol/l × min, MR 7,743.6 ± 801.4 pmol/l × min, RF 6,189.9 ± 581.3 pmol/l × min [p < 0.05 for FR vs RF and MR vs RF]; healthy, FR 3,977.3 ± 324.6 pmol/l × min, MR 4,897.7 ± 330.7 pmol/l × min, RF 3,747.5 ± 572.6 pmol/l × min [p < 0.05 for MR vs RF and MR vs FR]). FR and MR delayed gastric emptying (Time50%: type 2 diabetes, FR 83.2 ± 7.2 min, MR 82.3 ± 6.4 min, RF 29.8 ± 3.9 min [p < 0.05 for FR vs RF and MR vs RF]; healthy, FR 66.3 ± 5.5 min, MR 74.4 ± 7.6 min, RF 32.4 ± 4.5 min [p < 0.05 for FR vs RF and MR vs RF]), which is associated with amelioration of postprandial glucose excursion (AUC-15-120 min-glucose: type 2 diabetes, r = -0.746, p < 0.05; healthy, r = -0.433, p < 0.05) and glucose variability (SD-15-240 min-glucose: type 2 diabetes, r = -0.578, p < 0.05; healthy, r = -0.526, p < 0.05), as well as with increasing GLP-1 (AUC-15-120 min-GLP-1: type 2 diabetes, r = 0.437, p < 0.05; healthy, r = 0.300, p = 0.107) and glucagon (AUC-15-120 min-glucagon: type 2 diabetes, r = 0.399, p < 0.05; healthy, r = 0.471, p < 0.05). The measured outcomes were comparable between the two randomised groups. CONCLUSIONS/INTERPRETATION: Meal sequence can play a role in postprandial glucose control through both delayed gastric emptying and enhanced incretin secretion. Our findings provide clues for medical nutrition therapy to better prevent and manage type 2 diabetes. TRIAL REGISTRATION: UMIN Clinical Trials Registry UMIN000017434. FUNDING: Japan Society for Promotion of Science, Japan Association for Diabetes Education and Care, and Japan Vascular Disease Research Foundation.
36 schema:genre article
37 schema:inLanguage en
38 schema:isAccessibleForFree true
39 schema:isPartOf N2d68528e3ed649bb8ad76cece0b49b45
40 N4c04036a409d478da098ba5e09413b06
41 sg:journal.1001482
42 schema:keywords BMI
43 Clinical Trials Registry UMIN000017434
44 Disease Research Foundation
45 FR
46 GLP-1 secretion
47 Japan
48 Japan Association
49 Japan Society
50 Japan Vascular Disease Research Foundation
51 MR
52 Osaka
53 Promotion of Science
54 RF
55 Registry UMIN000017434
56 Research Foundation
57 Trials Registry UMIN000017434
58 UMIN Clinical Trials Registry UMIN000017434
59 UMIN000017434
60 Vascular Disease Research Foundation
61 acetate
62 acetate breath test
63 age 30
64 amelioration
65 assignment
66 association
67 breath samples
68 breath test
69 care
70 center
71 clues
72 comparison
73 composition
74 control
75 crossover
76 crossover fashion
77 day 1
78 day 3
79 diabetes
80 diabetes education
81 dietary therapy
82 education
83 effect
84 effects of fish
85 emptying
86 examination
87 excursion
88 experiments
89 exploratory trial
90 fashion
91 findings
92 fish
93 foundation
94 gastric emptying
95 glucagon
96 glucagon-like peptide-1
97 glucose
98 glucose control
99 glucose excursions
100 glucose management
101 glucose variability
102 group
103 group assignment
104 healthy volunteers
105 hospital
106 incretin secretion
107 ingestion
108 ingestion of rice
109 insulin
110 investigation
111 levels
112 management
113 meal sequence
114 meal sequence tests
115 meal size
116 measurements
117 meat
118 medical nutrition therapy
119 morning
120 nutrition therapy
121 outcomes
122 outpatient ward
123 participants
124 patients
125 people
126 peptide-1
127 peptides
128 postprandial glucose control
129 postprandial glucose excursions
130 postprandial glucose management
131 postprandial levels
132 private hospitals
133 promotion
134 randomisation
135 rate
136 rice
137 role
138 samples
139 science
140 secretion
141 separate mornings
142 sequence
143 sequence test
144 single center
145 size
146 society
147 sodium acetate
148 stratified randomisation
149 test
150 therapy
151 trials
152 type 2
153 type 2 diabetes
154 use
155 variability
156 volunteers
157 wards
158 years
159 schema:name Meal sequence and glucose excursion, gastric emptying and incretin secretion in type 2 diabetes: a randomised, controlled crossover, exploratory trial
160 schema:pagination 453-461
161 schema:productId N193c91e1db9049978a651587597a2cb3
162 N1e68f3ebffe14779bc17acdc75348c3f
163 N2e441a72e33c487880f371ed4c085b15
164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026375330
165 https://doi.org/10.1007/s00125-015-3841-z
166 schema:sdDatePublished 2021-11-01T18:25
167 schema:sdLicense https://scigraph.springernature.com/explorer/license/
168 schema:sdPublisher N7db8dd8189984d2596da04aa627a2683
169 schema:url https://doi.org/10.1007/s00125-015-3841-z
170 sgo:license sg:explorer/license/
171 sgo:sdDataset articles
172 rdf:type schema:ScholarlyArticle
173 N0527c172940a455f877efc7e7540ca66 rdf:first sg:person.01002652037.58
174 rdf:rest N1b31e822665042c0b856088d78eb9f4e
175 N0696ec86b5c64484a1f3641a6f0942dd rdf:first sg:person.0767130147.33
176 rdf:rest N8b89bb4f88754b308aecb5747fc63839
177 N1250e58d21fe45dd8f270956e3506a00 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Glucagon-Like Peptide 1
179 rdf:type schema:DefinedTerm
180 N193c91e1db9049978a651587597a2cb3 schema:name dimensions_id
181 schema:value pub.1026375330
182 rdf:type schema:PropertyValue
183 N1b09095e645642fdb5d1a74c7189b7b6 rdf:first sg:person.01307326611.14
184 rdf:rest N8f8b812882ff4492b1b0f2a910082cb4
185 N1b31e822665042c0b856088d78eb9f4e rdf:first sg:person.01034153756.92
186 rdf:rest Nf39da346fbf84450a715e8bd58cc79c5
187 N1e68f3ebffe14779bc17acdc75348c3f schema:name doi
188 schema:value 10.1007/s00125-015-3841-z
189 rdf:type schema:PropertyValue
190 N25119ae8571449ba9c001bab053ff2e6 rdf:first sg:person.01063260763.29
191 rdf:rest N1b09095e645642fdb5d1a74c7189b7b6
192 N2d0eeed6c514453d86dce7baadf2bc47 rdf:first sg:person.01343065365.86
193 rdf:rest rdf:nil
194 N2d68528e3ed649bb8ad76cece0b49b45 schema:volumeNumber 59
195 rdf:type schema:PublicationVolume
196 N2e441a72e33c487880f371ed4c085b15 schema:name pubmed_id
197 schema:value 26704625
198 rdf:type schema:PropertyValue
199 N384579bbdd954f86b3f8c26182d7ca58 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Gastric Inhibitory Polypeptide
201 rdf:type schema:DefinedTerm
202 N39e0a1429d544cd6bb284ad162db2c9a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Aged
204 rdf:type schema:DefinedTerm
205 N3eaa424c84d4402b99d662e161b1efa3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Insulin
207 rdf:type schema:DefinedTerm
208 N481391fff4af434c95623f9cf5e6997b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
209 schema:name Adult
210 rdf:type schema:DefinedTerm
211 N4c04036a409d478da098ba5e09413b06 schema:issueNumber 3
212 rdf:type schema:PublicationIssue
213 N4e1ae4499dd544158e0c7ea08ac933b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
214 schema:name Meals
215 rdf:type schema:DefinedTerm
216 N5c4030802b02499bb0e22ffa819b9255 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
217 schema:name Japan
218 rdf:type schema:DefinedTerm
219 N6042a0e387354ee1a7b60818f0b441cf rdf:first sg:person.0717725356.24
220 rdf:rest N25119ae8571449ba9c001bab053ff2e6
221 N61bfb946086f46caa8b3d6cb7af59715 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
222 schema:name Male
223 rdf:type schema:DefinedTerm
224 N635f3f066ba246ec90925e3350e6fa29 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
225 schema:name Female
226 rdf:type schema:DefinedTerm
227 N6e080770e2fe4ec7b81be5cdf2f1a7e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
228 schema:name Glucose
229 rdf:type schema:DefinedTerm
230 N76c1f5d588104905a593d3fe0bd623c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
231 schema:name Diet
232 rdf:type schema:DefinedTerm
233 N7db8dd8189984d2596da04aa627a2683 schema:name Springer Nature - SN SciGraph project
234 rdf:type schema:Organization
235 N8b89bb4f88754b308aecb5747fc63839 rdf:first sg:person.0776544013.19
236 rdf:rest Nb0f6b6a5310d4be491359c29ae899b1a
237 N8f8b812882ff4492b1b0f2a910082cb4 rdf:first Nda14c929f03d4a46b58c85300e3d5aa1
238 rdf:rest N0696ec86b5c64484a1f3641a6f0942dd
239 N9b0f2b395e1b4adf8fad975f54c22935 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
240 schema:name Humans
241 rdf:type schema:DefinedTerm
242 Na289d7187982412aa006e6dd4769fd82 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
243 schema:name Postprandial Period
244 rdf:type schema:DefinedTerm
245 Naf9065572f0f4790be49e4886329c890 rdf:first sg:person.01030312656.20
246 rdf:rest N6042a0e387354ee1a7b60818f0b441cf
247 Nb0f6b6a5310d4be491359c29ae899b1a rdf:first sg:person.0677032136.42
248 rdf:rest N0527c172940a455f877efc7e7540ca66
249 Nb57bf19a1acc4edab0a6ea7cfacb5716 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
250 schema:name Diabetes Mellitus, Type 2
251 rdf:type schema:DefinedTerm
252 Nb5d4ef972d484fc99991daaefa2c3292 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
253 schema:name C-Peptide
254 rdf:type schema:DefinedTerm
255 Nbcd8562a1b47461f8e84c0e74743efd3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
256 schema:name Cross-Over Studies
257 rdf:type schema:DefinedTerm
258 Nc1da08a7545848a7bbcb4983c9dda27b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
259 schema:name Middle Aged
260 rdf:type schema:DefinedTerm
261 Ncb6a0565278b42bc8eb91784df80d74a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
262 schema:name Incretins
263 rdf:type schema:DefinedTerm
264 Nd34b06b8dee24aeebde6c5fbcd932dd7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
265 schema:name Glucagon
266 rdf:type schema:DefinedTerm
267 Nda14c929f03d4a46b58c85300e3d5aa1 schema:affiliation grid-institutes:grid.31432.37
268 schema:familyName Maeda
269 schema:givenName Haruyo
270 rdf:type schema:Person
271 Nf39da346fbf84450a715e8bd58cc79c5 rdf:first sg:person.0645706232.36
272 rdf:rest N2d0eeed6c514453d86dce7baadf2bc47
273 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
274 schema:name Medical and Health Sciences
275 rdf:type schema:DefinedTerm
276 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
277 schema:name Clinical Sciences
278 rdf:type schema:DefinedTerm
279 sg:grant.6084611 http://pending.schema.org/fundedItem sg:pub.10.1007/s00125-015-3841-z
280 rdf:type schema:MonetaryGrant
281 sg:grant.6133260 http://pending.schema.org/fundedItem sg:pub.10.1007/s00125-015-3841-z
282 rdf:type schema:MonetaryGrant
283 sg:journal.1001482 schema:issn 0012-186X
284 1432-0428
285 schema:name Diabetologia
286 schema:publisher Springer Nature
287 rdf:type schema:Periodical
288 sg:person.01002652037.58 schema:affiliation grid-institutes:grid.411234.1
289 schema:familyName Murotani
290 schema:givenName Kenta
291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002652037.58
292 rdf:type schema:Person
293 sg:person.01030312656.20 schema:affiliation grid-institutes:grid.414973.c
294 schema:familyName Kuwata
295 schema:givenName Hitoshi
296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030312656.20
297 rdf:type schema:Person
298 sg:person.01034153756.92 schema:affiliation grid-institutes:grid.414973.c
299 schema:familyName Kurose
300 schema:givenName Takeshi
301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034153756.92
302 rdf:type schema:Person
303 sg:person.01063260763.29 schema:affiliation grid-institutes:grid.414973.c
304 schema:familyName Shimizu
305 schema:givenName Shinobu
306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063260763.29
307 rdf:type schema:Person
308 sg:person.01307326611.14 schema:affiliation grid-institutes:grid.31432.37
309 schema:familyName Minami
310 schema:givenName Kohtaro
311 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307326611.14
312 rdf:type schema:Person
313 sg:person.01343065365.86 schema:affiliation grid-institutes:grid.31432.37
314 schema:familyName Yabe
315 schema:givenName Daisuke
316 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343065365.86
317 rdf:type schema:Person
318 sg:person.0645706232.36 schema:affiliation grid-institutes:grid.414973.c
319 schema:familyName Seino
320 schema:givenName Yutaka
321 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645706232.36
322 rdf:type schema:Person
323 sg:person.0677032136.42 schema:affiliation grid-institutes:grid.473316.4
324 schema:familyName Nosaka
325 schema:givenName Chihiro
326 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677032136.42
327 rdf:type schema:Person
328 sg:person.0717725356.24 schema:affiliation grid-institutes:grid.31432.37
329 schema:familyName Iwasaki
330 schema:givenName Masahiro
331 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717725356.24
332 rdf:type schema:Person
333 sg:person.0767130147.33 schema:affiliation grid-institutes:grid.31432.37
334 schema:familyName Seino
335 schema:givenName Susumu
336 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767130147.33
337 rdf:type schema:Person
338 sg:person.0776544013.19 schema:affiliation grid-institutes:grid.411898.d
339 schema:familyName Nakada
340 schema:givenName Koji
341 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776544013.19
342 rdf:type schema:Person
343 sg:pub.10.1007/978-90-481-3271-3_18 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039940836
344 https://doi.org/10.1007/978-90-481-3271-3_18
345 rdf:type schema:CreativeWork
346 sg:pub.10.1007/s00125-013-2841-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017157768
347 https://doi.org/10.1007/s00125-013-2841-0
348 rdf:type schema:CreativeWork
349 sg:pub.10.1007/s00125-013-2876-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007118291
350 https://doi.org/10.1007/s00125-013-2876-2
351 rdf:type schema:CreativeWork
352 sg:pub.10.1007/s00125-014-3305-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011812323
353 https://doi.org/10.1007/s00125-014-3305-x
354 rdf:type schema:CreativeWork
355 sg:pub.10.1007/s11892-014-0555-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023952105
356 https://doi.org/10.1007/s11892-014-0555-4
357 rdf:type schema:CreativeWork
358 sg:pub.10.1007/s11892-015-0602-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026921846
359 https://doi.org/10.1007/s11892-015-0602-9
360 rdf:type schema:CreativeWork
361 sg:pub.10.1007/s13340-015-0206-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007451476
362 https://doi.org/10.1007/s13340-015-0206-2
363 rdf:type schema:CreativeWork
364 sg:pub.10.1038/nm1168 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037198312
365 https://doi.org/10.1038/nm1168
366 rdf:type schema:CreativeWork
367 sg:pub.10.1038/nrendo.2012.140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011731640
368 https://doi.org/10.1038/nrendo.2012.140
369 rdf:type schema:CreativeWork
370 sg:pub.10.1038/nrendo.2014.202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020313291
371 https://doi.org/10.1038/nrendo.2014.202
372 rdf:type schema:CreativeWork
373 grid-institutes:grid.31432.37 schema:alternateName Division of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan
374 schema:name Center for Diabetes, Endocrinology and Metabolism, Kansai Electric Power Hospital, Osaka, Japan
375 Center for Metabolism and Clinical Nutrition, Kansai Electric Power Hospital, Osaka, Japan
376 Division of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan
377 Yutaka Seino Distinguished Center for Diabetes Research, Kansai Electric Power Medical Research Institute, 1-5-6 Minatojimaminamimachi, Chuo-ku, Kobe, 650-0047 Japan
378 rdf:type schema:Organization
379 grid-institutes:grid.411234.1 schema:alternateName Division of Biostatistics, Clinical Research Center, Aichi Medical University, Nagakute, Aichi Japan
380 schema:name Division of Biostatistics, Clinical Research Center, Aichi Medical University, Nagakute, Aichi Japan
381 rdf:type schema:Organization
382 grid-institutes:grid.411898.d schema:alternateName Department of Surgery, Jikei University School of Medicine, Tokyo, Japan
383 schema:name Department of Surgery, Jikei University School of Medicine, Tokyo, Japan
384 rdf:type schema:Organization
385 grid-institutes:grid.414973.c schema:alternateName Center for Diabetes, Endocrinology and Metabolism, Kansai Electric Power Hospital, Osaka, Japan
386 Department of Clinical Laboratory, Kansai Electric Power Hospital, Osaka, Japan
387 schema:name Center for Diabetes, Endocrinology and Metabolism, Kansai Electric Power Hospital, Osaka, Japan
388 Department of Clinical Laboratory, Kansai Electric Power Hospital, Osaka, Japan
389 Yutaka Seino Distinguished Center for Diabetes Research, Kansai Electric Power Medical Research Institute, 1-5-6 Minatojimaminamimachi, Chuo-ku, Kobe, 650-0047 Japan
390 rdf:type schema:Organization
391 grid-institutes:grid.473316.4 schema:alternateName Kyowa Hakko Kirin Co. Ltd, Tokyo, Japan
392 schema:name Kyowa Hakko Kirin Co. Ltd, Tokyo, Japan
393 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...