Favourable effects of fenofibrate on lipids and cardiovascular disease in women with type 2 diabetes: results from the Fenofibrate Intervention ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-11

AUTHORS

Michael C. d’Emden, Alicia J. Jenkins, Liping Li, Diana Zannino, Kristy P. Mann, James D. Best, Bronwyn G. A. Stuckey, Kris Park, Juha Saltevo, Anthony C. Keech, on behalf of the FIELD Study Investigators

ABSTRACT

AIMS/HYPOTHESIS: In the double-blind placebo-controlled Fenofibrate Intervention and Event Lowering in Diabetes trial (n = 9,795), fenofibrate reduced major cardiovascular events in type 2 diabetes. Sex-related differences in fenofibrate response could be clinically relevant and were pre-specified analyses. METHODS: Women (n = 3,657) and men (n = 6,138) with type 2 diabetes not using statins were assigned fenofibrate (200 mg/day) or placebo for 5 years. Effects on lipoproteins and total cardiovascular events were evaluated by sex. RESULTS: Baseline total, LDL-, HDL- and non-HDL cholesterol and apolipoproteins A-I and B differed between sexes, and these and triacylglycerol levels improved with fenofibrate in both sexes (all p < 0.001). Fenofibrate reduced total, LDL- and non-HDL cholesterol and apolipoprotein B more in women (all p < 0.001), independent of menopausal status and statin uptake. Adjusted for covariates, fenofibrate reduced total cardiovascular outcomes (cardiovascular death, fatal and non-fatal stroke and carotid and coronary revascularisation) by 30% in women (95% CI 8%, 46%; p = 0.008) and 13% in men (95% CI -1%, 24%; p = 0.07) with no treatment-by-sex interaction (p > 0.1). In patients with high triacylglycerol levels and low HDL-cholesterol, fenofibrate reduced total cardiovascular outcomes by 30% (95% CI -7%, 54%) in women and 24% (95% CI 2%, 42%) in men, with no treatment-by-sex interaction (p > 0.1). CONCLUSIONS/INTERPRETATION: Fenofibrate improved the lipoprotein profile more in women than men. Cardiovascular event reductions with fenofibrate were consistently similar in women and men, both overall and among those with low HDL-cholesterol and high triacylglycerol levels. These data provide reassurance about fenofibrate efficacy in women and men. Both sexes with type 2 diabetes should be considered for fenofibrate therapy for cardioprotection. More... »

PAGES

2296-2303

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00125-014-3344-3

DOI

http://dx.doi.org/10.1007/s00125-014-3344-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049919699

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25149070


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apolipoproteins B", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cardiovascular Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cholesterol, HDL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cholesterol, LDL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diabetes Mellitus, Type 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Double-Blind Method", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fenofibrate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypolipidemic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Triglycerides", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Queensland", 
          "id": "https://www.grid.ac/institutes/grid.1003.2", 
          "name": [
            "Endocrine Research Unit, Royal Brisbane Hospital, Brisbane, QLD, Australia", 
            "Department of Medicine, University of Queensland, Brisbane, QLD, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "d\u2019Emden", 
        "givenName": "Michael C.", 
        "id": "sg:person.01072344723.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072344723.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Camperdown, Locked Bag 77, 1450, Sydney, NSW, Australia", 
            "Department of Medicine, University of Melbourne, Melbourne, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jenkins", 
        "givenName": "Alicia J.", 
        "id": "sg:person.0752754263.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752754263.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sydney", 
          "id": "https://www.grid.ac/institutes/grid.1013.3", 
          "name": [
            "National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Camperdown, Locked Bag 77, 1450, Sydney, NSW, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Liping", 
        "id": "sg:person.0776344035.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776344035.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sydney", 
          "id": "https://www.grid.ac/institutes/grid.1013.3", 
          "name": [
            "National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Camperdown, Locked Bag 77, 1450, Sydney, NSW, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zannino", 
        "givenName": "Diana", 
        "id": "sg:person.01360566006.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360566006.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sydney", 
          "id": "https://www.grid.ac/institutes/grid.1013.3", 
          "name": [
            "National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Camperdown, Locked Bag 77, 1450, Sydney, NSW, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mann", 
        "givenName": "Kristy P.", 
        "id": "sg:person.0616007502.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616007502.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Department of Medicine, University of Melbourne, Melbourne, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Best", 
        "givenName": "James D.", 
        "id": "sg:person.01113011537.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113011537.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Keogh Institute for Medical Research", 
          "id": "https://www.grid.ac/institutes/grid.489043.2", 
          "name": [
            "Keogh Institute for Medical Research and Sir Charles Gairdner Hospital, Perth, WA, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stuckey", 
        "givenName": "Bronwyn G. A.", 
        "id": "sg:person.01123267045.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123267045.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nepean Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413243.3", 
          "name": [
            "Nepean Hospital, Sydney, NSW, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Park", 
        "givenName": "Kris", 
        "id": "sg:person.0672667704.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672667704.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Central Finland Health Care District", 
          "id": "https://www.grid.ac/institutes/grid.460356.2", 
          "name": [
            "Department of Medicine, Central Finland Central Hospital, Jyv\u00e4skyl\u00e4, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saltevo", 
        "givenName": "Juha", 
        "id": "sg:person.01063043575.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063043575.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sydney", 
          "id": "https://www.grid.ac/institutes/grid.1013.3", 
          "name": [
            "National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Camperdown, Locked Bag 77, 1450, Sydney, NSW, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Keech", 
        "givenName": "Anthony C.", 
        "id": "sg:person.0725556462.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725556462.42"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "on behalf of the FIELD Study Investigators", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1056/nejme1002498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000776166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02533579", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000794512", 
          "https://doi.org/10.1007/bf02533579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199907223410401", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003973101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2796.2004.01328.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006026146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm198711123172001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018904003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1001282", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023090275"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(05)67667-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029064920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/dc08-1543", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031197397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.285.19.2486", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033739611"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.102.1.21", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036775756"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199908053410604", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043703645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0008580", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052051554"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2010-2061", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064292441"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.82.12.3955", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064299387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080284174", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-11", 
    "datePublishedReg": "2014-11-01", 
    "description": "AIMS/HYPOTHESIS: In the double-blind placebo-controlled Fenofibrate Intervention and Event Lowering in Diabetes trial (n\u2009=\u20099,795), fenofibrate reduced major cardiovascular events in type 2 diabetes. Sex-related differences in fenofibrate response could be clinically relevant and were pre-specified analyses.\nMETHODS: Women (n\u2009=\u20093,657) and men (n\u2009=\u20096,138) with type 2 diabetes not using statins were assigned fenofibrate (200\u00a0mg/day) or placebo for 5\u00a0years. Effects on lipoproteins and total cardiovascular events were evaluated by sex.\nRESULTS: Baseline total, LDL-, HDL- and non-HDL cholesterol and apolipoproteins A-I and B differed between sexes, and these and triacylglycerol levels improved with fenofibrate in both sexes (all p\u2009<\u20090.001). Fenofibrate reduced total, LDL- and non-HDL cholesterol and apolipoprotein B more in women (all p\u2009<\u20090.001), independent of menopausal status and statin uptake. Adjusted for covariates, fenofibrate reduced total cardiovascular outcomes (cardiovascular death, fatal and non-fatal stroke and carotid and coronary revascularisation) by 30% in women (95% CI 8%, 46%; p\u2009=\u20090.008) and 13% in men (95% CI -1%, 24%; p\u2009=\u20090.07) with no treatment-by-sex interaction (p\u2009>\u20090.1). In patients with high triacylglycerol levels and low HDL-cholesterol, fenofibrate reduced total cardiovascular outcomes by 30% (95% CI -7%, 54%) in women and 24% (95% CI 2%, 42%) in men, with no treatment-by-sex interaction (p\u2009>\u20090.1).\nCONCLUSIONS/INTERPRETATION: Fenofibrate improved the lipoprotein profile more in women than men. Cardiovascular event reductions with fenofibrate were consistently similar in women and men, both overall and among those with low HDL-cholesterol and high triacylglycerol levels. These data provide reassurance about fenofibrate efficacy in women and men. Both sexes with type 2 diabetes should be considered for fenofibrate therapy for cardioprotection.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00125-014-3344-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1001482", 
        "issn": [
          "0012-186X", 
          "1432-0428"
        ], 
        "name": "Diabetologia", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "11", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "57"
      }
    ], 
    "name": "Favourable effects of fenofibrate on lipids and cardiovascular disease in women with type 2 diabetes: results from the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study", 
    "pagination": "2296-2303", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "edcd174fd09c5e7bcad5ed877e3fbf74f05236b0964b850235e8e2050b51aef8"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25149070"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0006777"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00125-014-3344-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1049919699"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00125-014-3344-3", 
      "https://app.dimensions.ai/details/publication/pub.1049919699"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:32", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000349_0000000349/records_113655_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs00125-014-3344-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00125-014-3344-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00125-014-3344-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00125-014-3344-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00125-014-3344-3'


 

This table displays all metadata directly associated to this object as RDF triples.

254 TRIPLES      21 PREDICATES      58 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00125-014-3344-3 schema:about N00fd9e527c254fb6b3cd3cd2e654ff48
2 N2592bdaebcb640bdb09e3ff137d99e58
3 N2e87619d3b4a4312b949226be1b48a49
4 N4a8deba28b8b418cbd197d833168cb1c
5 N5ab5c59dc08b4cb4b94423c691a55b28
6 N6451485eebfa43cfaf5b62942d87b8ec
7 N74b4298d9ac5429b9f8734dc6dd128e0
8 N7e927674e24f4ad79e75d9d63c8dd15d
9 N9c678b07ac85483dbf95d71e4bb29be2
10 Na2c46c7d347b4a74a8782a4a8a397be6
11 Nc8ec54f491984fd0bcfdc7fa32c7c872
12 Nca9db286a1044ed7b4a0430ecb6cb31b
13 Ncaed4dddb2f64496be7716bf68a04027
14 Nf769fbaef63b4417b16dedc9fdc283aa
15 anzsrc-for:11
16 anzsrc-for:1103
17 schema:author Ncaaa44cc676a4d78b0f367aacc4dcfde
18 schema:citation sg:pub.10.1007/bf02533579
19 https://app.dimensions.ai/details/publication/pub.1080284174
20 https://doi.org/10.1001/jama.285.19.2486
21 https://doi.org/10.1016/s0140-6736(05)67667-2
22 https://doi.org/10.1056/nejm198711123172001
23 https://doi.org/10.1056/nejm199907223410401
24 https://doi.org/10.1056/nejm199908053410604
25 https://doi.org/10.1056/nejme1002498
26 https://doi.org/10.1056/nejmoa1001282
27 https://doi.org/10.1111/j.1365-2796.2004.01328.x
28 https://doi.org/10.1161/01.cir.102.1.21
29 https://doi.org/10.1210/jc.2010-2061
30 https://doi.org/10.1210/jc.82.12.3955
31 https://doi.org/10.1371/journal.pone.0008580
32 https://doi.org/10.2337/dc08-1543
33 schema:datePublished 2014-11
34 schema:datePublishedReg 2014-11-01
35 schema:description AIMS/HYPOTHESIS: In the double-blind placebo-controlled Fenofibrate Intervention and Event Lowering in Diabetes trial (n = 9,795), fenofibrate reduced major cardiovascular events in type 2 diabetes. Sex-related differences in fenofibrate response could be clinically relevant and were pre-specified analyses. METHODS: Women (n = 3,657) and men (n = 6,138) with type 2 diabetes not using statins were assigned fenofibrate (200 mg/day) or placebo for 5 years. Effects on lipoproteins and total cardiovascular events were evaluated by sex. RESULTS: Baseline total, LDL-, HDL- and non-HDL cholesterol and apolipoproteins A-I and B differed between sexes, and these and triacylglycerol levels improved with fenofibrate in both sexes (all p < 0.001). Fenofibrate reduced total, LDL- and non-HDL cholesterol and apolipoprotein B more in women (all p < 0.001), independent of menopausal status and statin uptake. Adjusted for covariates, fenofibrate reduced total cardiovascular outcomes (cardiovascular death, fatal and non-fatal stroke and carotid and coronary revascularisation) by 30% in women (95% CI 8%, 46%; p = 0.008) and 13% in men (95% CI -1%, 24%; p = 0.07) with no treatment-by-sex interaction (p > 0.1). In patients with high triacylglycerol levels and low HDL-cholesterol, fenofibrate reduced total cardiovascular outcomes by 30% (95% CI -7%, 54%) in women and 24% (95% CI 2%, 42%) in men, with no treatment-by-sex interaction (p > 0.1). CONCLUSIONS/INTERPRETATION: Fenofibrate improved the lipoprotein profile more in women than men. Cardiovascular event reductions with fenofibrate were consistently similar in women and men, both overall and among those with low HDL-cholesterol and high triacylglycerol levels. These data provide reassurance about fenofibrate efficacy in women and men. Both sexes with type 2 diabetes should be considered for fenofibrate therapy for cardioprotection.
36 schema:genre research_article
37 schema:inLanguage en
38 schema:isAccessibleForFree true
39 schema:isPartOf N7483fb4ebff749408cdc63bddc2eac61
40 N8ee21b98eb8548698a36dc8a39358eb1
41 sg:journal.1001482
42 schema:name Favourable effects of fenofibrate on lipids and cardiovascular disease in women with type 2 diabetes: results from the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study
43 schema:pagination 2296-2303
44 schema:productId N663f49006b5045cc90fb3be649ca1cbd
45 Nd3b895f7efa84f5a804857e30c456e2b
46 Nd79f14ef6c0f4cc1aaea2839bd0eae30
47 Nd8380ae6080c4dfba87264863a7adcfc
48 Nfaa2daea1b60485fa87d66d69666a232
49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049919699
50 https://doi.org/10.1007/s00125-014-3344-3
51 schema:sdDatePublished 2019-04-11T10:32
52 schema:sdLicense https://scigraph.springernature.com/explorer/license/
53 schema:sdPublisher N307b641ee9164a478b7e9ff7263cfe63
54 schema:url https://link.springer.com/10.1007%2Fs00125-014-3344-3
55 sgo:license sg:explorer/license/
56 sgo:sdDataset articles
57 rdf:type schema:ScholarlyArticle
58 N00fd9e527c254fb6b3cd3cd2e654ff48 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
59 schema:name Female
60 rdf:type schema:DefinedTerm
61 N03818cc13ed348508a0c574ab90a3dbd rdf:first Nf712c7247beb4b50be946177a86a3439
62 rdf:rest rdf:nil
63 N1ed5446db1874875b532d401a93046f8 rdf:first sg:person.01123267045.93
64 rdf:rest Nb81f60c001c247aa95636c1b4a0f8de8
65 N2592bdaebcb640bdb09e3ff137d99e58 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
66 schema:name Cholesterol, LDL
67 rdf:type schema:DefinedTerm
68 N2e87619d3b4a4312b949226be1b48a49 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
69 schema:name Middle Aged
70 rdf:type schema:DefinedTerm
71 N307b641ee9164a478b7e9ff7263cfe63 schema:name Springer Nature - SN SciGraph project
72 rdf:type schema:Organization
73 N363c509e518847e4aa0a036d94a5c31d rdf:first sg:person.01063043575.68
74 rdf:rest N5de2885a57f049179777c38bf8d44fa0
75 N48fa0bcbfa534c5896d49bafcfbb8952 rdf:first sg:person.0616007502.36
76 rdf:rest N64c2a6b8cb7b4f598e9699853ee2123e
77 N4a8deba28b8b418cbd197d833168cb1c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Fenofibrate
79 rdf:type schema:DefinedTerm
80 N5ab5c59dc08b4cb4b94423c691a55b28 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Apolipoproteins B
82 rdf:type schema:DefinedTerm
83 N5de2885a57f049179777c38bf8d44fa0 rdf:first sg:person.0725556462.42
84 rdf:rest N03818cc13ed348508a0c574ab90a3dbd
85 N6451485eebfa43cfaf5b62942d87b8ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Triglycerides
87 rdf:type schema:DefinedTerm
88 N64c2a6b8cb7b4f598e9699853ee2123e rdf:first sg:person.01113011537.16
89 rdf:rest N1ed5446db1874875b532d401a93046f8
90 N663f49006b5045cc90fb3be649ca1cbd schema:name readcube_id
91 schema:value edcd174fd09c5e7bcad5ed877e3fbf74f05236b0964b850235e8e2050b51aef8
92 rdf:type schema:PropertyValue
93 N7483fb4ebff749408cdc63bddc2eac61 schema:volumeNumber 57
94 rdf:type schema:PublicationVolume
95 N74b4298d9ac5429b9f8734dc6dd128e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Aged
97 rdf:type schema:DefinedTerm
98 N7e927674e24f4ad79e75d9d63c8dd15d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Diabetes Mellitus, Type 2
100 rdf:type schema:DefinedTerm
101 N8ee21b98eb8548698a36dc8a39358eb1 schema:issueNumber 11
102 rdf:type schema:PublicationIssue
103 N9c678b07ac85483dbf95d71e4bb29be2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Humans
105 rdf:type schema:DefinedTerm
106 Na2c46c7d347b4a74a8782a4a8a397be6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Cardiovascular Diseases
108 rdf:type schema:DefinedTerm
109 Nb81f60c001c247aa95636c1b4a0f8de8 rdf:first sg:person.0672667704.61
110 rdf:rest N363c509e518847e4aa0a036d94a5c31d
111 Nc15079ab8faf47c29e24bed50ed021ed rdf:first sg:person.0776344035.61
112 rdf:rest Ndd8506ce6fd14f06b3e5b185d0953121
113 Nc8ec54f491984fd0bcfdc7fa32c7c872 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Male
115 rdf:type schema:DefinedTerm
116 Nca9db286a1044ed7b4a0430ecb6cb31b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Cholesterol, HDL
118 rdf:type schema:DefinedTerm
119 Ncaaa44cc676a4d78b0f367aacc4dcfde rdf:first sg:person.01072344723.52
120 rdf:rest Ne702736869354367a9cdafee7f93b051
121 Ncaed4dddb2f64496be7716bf68a04027 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Hypolipidemic Agents
123 rdf:type schema:DefinedTerm
124 Nd3b895f7efa84f5a804857e30c456e2b schema:name pubmed_id
125 schema:value 25149070
126 rdf:type schema:PropertyValue
127 Nd79f14ef6c0f4cc1aaea2839bd0eae30 schema:name doi
128 schema:value 10.1007/s00125-014-3344-3
129 rdf:type schema:PropertyValue
130 Nd8380ae6080c4dfba87264863a7adcfc schema:name nlm_unique_id
131 schema:value 0006777
132 rdf:type schema:PropertyValue
133 Ndd8506ce6fd14f06b3e5b185d0953121 rdf:first sg:person.01360566006.57
134 rdf:rest N48fa0bcbfa534c5896d49bafcfbb8952
135 Ne702736869354367a9cdafee7f93b051 rdf:first sg:person.0752754263.53
136 rdf:rest Nc15079ab8faf47c29e24bed50ed021ed
137 Nf712c7247beb4b50be946177a86a3439 schema:familyName on behalf of the FIELD Study Investigators
138 rdf:type schema:Person
139 Nf769fbaef63b4417b16dedc9fdc283aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Double-Blind Method
141 rdf:type schema:DefinedTerm
142 Nfaa2daea1b60485fa87d66d69666a232 schema:name dimensions_id
143 schema:value pub.1049919699
144 rdf:type schema:PropertyValue
145 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
146 schema:name Medical and Health Sciences
147 rdf:type schema:DefinedTerm
148 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
149 schema:name Clinical Sciences
150 rdf:type schema:DefinedTerm
151 sg:journal.1001482 schema:issn 0012-186X
152 1432-0428
153 schema:name Diabetologia
154 rdf:type schema:Periodical
155 sg:person.01063043575.68 schema:affiliation https://www.grid.ac/institutes/grid.460356.2
156 schema:familyName Saltevo
157 schema:givenName Juha
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063043575.68
159 rdf:type schema:Person
160 sg:person.01072344723.52 schema:affiliation https://www.grid.ac/institutes/grid.1003.2
161 schema:familyName d’Emden
162 schema:givenName Michael C.
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072344723.52
164 rdf:type schema:Person
165 sg:person.01113011537.16 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
166 schema:familyName Best
167 schema:givenName James D.
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113011537.16
169 rdf:type schema:Person
170 sg:person.01123267045.93 schema:affiliation https://www.grid.ac/institutes/grid.489043.2
171 schema:familyName Stuckey
172 schema:givenName Bronwyn G. A.
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123267045.93
174 rdf:type schema:Person
175 sg:person.01360566006.57 schema:affiliation https://www.grid.ac/institutes/grid.1013.3
176 schema:familyName Zannino
177 schema:givenName Diana
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360566006.57
179 rdf:type schema:Person
180 sg:person.0616007502.36 schema:affiliation https://www.grid.ac/institutes/grid.1013.3
181 schema:familyName Mann
182 schema:givenName Kristy P.
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616007502.36
184 rdf:type schema:Person
185 sg:person.0672667704.61 schema:affiliation https://www.grid.ac/institutes/grid.413243.3
186 schema:familyName Park
187 schema:givenName Kris
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672667704.61
189 rdf:type schema:Person
190 sg:person.0725556462.42 schema:affiliation https://www.grid.ac/institutes/grid.1013.3
191 schema:familyName Keech
192 schema:givenName Anthony C.
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725556462.42
194 rdf:type schema:Person
195 sg:person.0752754263.53 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
196 schema:familyName Jenkins
197 schema:givenName Alicia J.
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752754263.53
199 rdf:type schema:Person
200 sg:person.0776344035.61 schema:affiliation https://www.grid.ac/institutes/grid.1013.3
201 schema:familyName Li
202 schema:givenName Liping
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776344035.61
204 rdf:type schema:Person
205 sg:pub.10.1007/bf02533579 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000794512
206 https://doi.org/10.1007/bf02533579
207 rdf:type schema:CreativeWork
208 https://app.dimensions.ai/details/publication/pub.1080284174 schema:CreativeWork
209 https://doi.org/10.1001/jama.285.19.2486 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033739611
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/s0140-6736(05)67667-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029064920
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1056/nejm198711123172001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018904003
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1056/nejm199907223410401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003973101
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1056/nejm199908053410604 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043703645
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1056/nejme1002498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000776166
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1056/nejmoa1001282 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023090275
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1111/j.1365-2796.2004.01328.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006026146
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1161/01.cir.102.1.21 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036775756
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1210/jc.2010-2061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064292441
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1210/jc.82.12.3955 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064299387
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1371/journal.pone.0008580 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052051554
232 rdf:type schema:CreativeWork
233 https://doi.org/10.2337/dc08-1543 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031197397
234 rdf:type schema:CreativeWork
235 https://www.grid.ac/institutes/grid.1003.2 schema:alternateName University of Queensland
236 schema:name Department of Medicine, University of Queensland, Brisbane, QLD, Australia
237 Endocrine Research Unit, Royal Brisbane Hospital, Brisbane, QLD, Australia
238 rdf:type schema:Organization
239 https://www.grid.ac/institutes/grid.1008.9 schema:alternateName University of Melbourne
240 schema:name Department of Medicine, University of Melbourne, Melbourne, VIC, Australia
241 National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Camperdown, Locked Bag 77, 1450, Sydney, NSW, Australia
242 rdf:type schema:Organization
243 https://www.grid.ac/institutes/grid.1013.3 schema:alternateName University of Sydney
244 schema:name National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Camperdown, Locked Bag 77, 1450, Sydney, NSW, Australia
245 rdf:type schema:Organization
246 https://www.grid.ac/institutes/grid.413243.3 schema:alternateName Nepean Hospital
247 schema:name Nepean Hospital, Sydney, NSW, Australia
248 rdf:type schema:Organization
249 https://www.grid.ac/institutes/grid.460356.2 schema:alternateName Central Finland Health Care District
250 schema:name Department of Medicine, Central Finland Central Hospital, Jyväskylä, Finland
251 rdf:type schema:Organization
252 https://www.grid.ac/institutes/grid.489043.2 schema:alternateName Keogh Institute for Medical Research
253 schema:name Keogh Institute for Medical Research and Sir Charles Gairdner Hospital, Perth, WA, Australia
254 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...