Dietary acid load, insulin sensitivity and risk of type 2 diabetes in community-dwelling older men View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-08

AUTHORS

Hong Xu, Ting Jia, Xiaoyan Huang, Ulf Risérus, Tommy Cederholm, Johan Ärnlöv, Per Sjögren, Bengt Lindholm, Juan-Jesús Carrero

ABSTRACT

AIMS/HYPOTHESIS: We tested the hypothesis that dietary acid load may increase the risk of type 2 diabetes, and studied the association between acid load and insulin sensitivity as a possible mechanism involved. METHODS: An observational survey with prospective follow-up including 911 non-diabetic Swedish men aged 70-71 years was carried out. The gold standard euglycaemic-hyperinsulinaemic clamp technique and the OGTT were used to determine insulin sensitivity and beta cell function, respectively. Diabetes incidence was assessed during 18 years of follow-up. Renal function was estimated from serum cystatin C concentrations. Dietary acid load was calculated as potential renal acid load (PRAL) and net endogenous acid production (NEAP) algorithms from 7 day food records. Adequate dietary reporters were identified by Goldberg cut-offs. RESULTS: PRAL and NEAP were not associated with insulin sensitivity or beta cell function. Underlying kidney function or consideration of dietary adequate reporters did not modify these null findings. During follow-up, 115 new cases of diabetes were validated. Neither PRAL nor NEAP was associated with diabetes incidence. CONCLUSIONS/INTERPRETATION: Our results do not support the hypothesis that dietary acid load influences insulin sensitivity, beta cell function or diabetes risk. Interventional studies modifying acid-base dietary intake are needed to further elucidate a possible role of acid load in the development of type 2 diabetes. More... »

PAGES

1561-1568

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00125-014-3275-z

DOI

http://dx.doi.org/10.1007/s00125-014-3275-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007370011

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24875749


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