Nuclear factor κB (NF-κB) suppresses food intake and energy expenditure in mice by directly activating the Pomc promoter View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-04

AUTHORS

X. Shi, X. Wang, Q. Li, M. Su, E. Chew, E. T. Wong, Z. Lacza, G. K. Radda, V. Tergaonkar, W. Han

ABSTRACT

AIMS/HYPOTHESIS: While chronic low-grade inflammation is associated with obesity, acute inflammation reduces food intake and leads to negative energy balance. Although both types of inflammation activate nuclear factor κB (NF-κB) signalling, it remains unclear how NF-κB activation results in opposite physiological responses in the two types of inflammation. The goal of this study was to address this question, and to understand the link between inflammation and leptin signalling. METHODS: We studied the ability of NF-κB to modulate Pomc transcription, and how it impinges on signal transducer and activator of transcription 3 (STAT3)-mediated leptin signalling by using a combination of animal models, biochemical assays and molecular biology. RESULTS: We report that suppression of food intake and physical movement with acute inflammation is not dependent on STAT3 activation in pro-opiomelanocortin (POMC) neurons. Under these conditions, activated NF-κB independently leads to increased Pomc transcription. Electrophoretic mobility shift assay and chromatin immunoprecipitation (ChIP) experiments reveal that NF-κB v-rel reticuloendotheliosis viral oncogene homologue A (avian) (RELA [also known as p65]) binds to the Pomc promoter region between -138 and -88 bp, which also harbours the trans-acting transcription factor 1 (SP1) binding site. We found significant changes in the methylation pattern at this region and reduced Pomc activation under chronic inflammation induced by a high-fat diet. Furthermore, RELA is unable to bind and activate transcription when the Pomc promoter is methylated. Finally, RELA binds to STAT3 and inhibits STAT3-mediated promoter activity, suggesting that RELA, possibly together with forkhead box-containing protein 1 (FOXO1), may prevent STAT3-mediated leptin activation of the Pomc promoter. CONCLUSIONS/INTERPRETATION: Our study provides a mechanism for the involvement of RELA in the divergent regulation of energy homeostasis in acute and chronic inflammation. More... »

PAGES

925-936

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00125-013-2831-2

DOI

http://dx.doi.org/10.1007/s00125-013-2831-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045570110

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23370526


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Behavior, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Eating", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Feeding Behavior", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Inflammation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leptin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "NF-kappa B", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pro-Opiomelanocortin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Promoter Regions, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "STAT3 Transcription Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Singapore Bioimaging Consortium", 
          "id": "https://www.grid.ac/institutes/grid.452254.0", 
          "name": [
            "Singapore Bioimaging Consortium, Agency for Science, Technology and Research (A*STAR), #02-02 Helios, 11 Biopolis Way, 138667, Singapore, Republic of Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shi", 
        "givenName": "X.", 
        "id": "sg:person.01006623757.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006623757.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Singapore Bioimaging Consortium", 
          "id": "https://www.grid.ac/institutes/grid.452254.0", 
          "name": [
            "Singapore Bioimaging Consortium, Agency for Science, Technology and Research (A*STAR), #02-02 Helios, 11 Biopolis Way, 138667, Singapore, Republic of Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "X.", 
        "id": "sg:person.01214445501.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214445501.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Singapore Bioimaging Consortium", 
          "id": "https://www.grid.ac/institutes/grid.452254.0", 
          "name": [
            "Singapore Bioimaging Consortium, Agency for Science, Technology and Research (A*STAR), #02-02 Helios, 11 Biopolis Way, 138667, Singapore, Republic of Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Q.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Singapore Bioimaging Consortium", 
          "id": "https://www.grid.ac/institutes/grid.452254.0", 
          "name": [
            "Singapore Bioimaging Consortium, Agency for Science, Technology and Research (A*STAR), #02-02 Helios, 11 Biopolis Way, 138667, Singapore, Republic of Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Su", 
        "givenName": "M.", 
        "id": "sg:person.0617725252.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617725252.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Singapore Bioimaging Consortium", 
          "id": "https://www.grid.ac/institutes/grid.452254.0", 
          "name": [
            "Singapore Bioimaging Consortium, Agency for Science, Technology and Research (A*STAR), #02-02 Helios, 11 Biopolis Way, 138667, Singapore, Republic of Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chew", 
        "givenName": "E.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Molecular and Cell Biology", 
          "id": "https://www.grid.ac/institutes/grid.418812.6", 
          "name": [
            "Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, #3-17 Proteos, 61 Biopolis Drive, 138673, Singapore, Republic of Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wong", 
        "givenName": "E. T.", 
        "id": "sg:person.01135735430.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01135735430.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Semmelweis University", 
          "id": "https://www.grid.ac/institutes/grid.11804.3c", 
          "name": [
            "Department of Human Physiology and Clinical Experimental Research, Semmelweis University, Budapest, Hungary"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lacza", 
        "givenName": "Z.", 
        "id": "sg:person.01227143717.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227143717.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Singapore Bioimaging Consortium", 
          "id": "https://www.grid.ac/institutes/grid.452254.0", 
          "name": [
            "Singapore Bioimaging Consortium, Agency for Science, Technology and Research (A*STAR), #02-02 Helios, 11 Biopolis Way, 138667, Singapore, Republic of Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Radda", 
        "givenName": "G. K.", 
        "id": "sg:person.0745527057.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745527057.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National University of Singapore", 
          "id": "https://www.grid.ac/institutes/grid.4280.e", 
          "name": [
            "Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, #3-17 Proteos, 61 Biopolis Drive, 138673, Singapore, Republic of Singapore", 
            "Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tergaonkar", 
        "givenName": "V.", 
        "id": "sg:person.01053632230.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053632230.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke NUS Graduate Medical School", 
          "id": "https://www.grid.ac/institutes/grid.428397.3", 
          "name": [
            "Singapore Bioimaging Consortium, Agency for Science, Technology and Research (A*STAR), #02-02 Helios, 11 Biopolis Way, 138667, Singapore, Republic of Singapore", 
            "Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, #3-17 Proteos, 61 Biopolis Drive, 138673, Singapore, Republic of Singapore", 
            "Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore", 
            "Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Graduate Medical School, Singapore, Republic of Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Han", 
        "givenName": "W.", 
        "id": "sg:person.01061755457.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061755457.18"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)64967-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000100065"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20011885", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000490084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1743-7075-4-18", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000942906", 
          "https://doi.org/10.1186/1743-7075-4-18"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m007577200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004180651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci59816", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005772614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn1731", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006320546", 
          "https://doi.org/10.1038/nn1731"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn1731", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006320546", 
          "https://doi.org/10.1038/nn1731"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci59660", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006963732"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1279", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009116910", 
          "https://doi.org/10.1038/nrc1279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1279", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009116910", 
          "https://doi.org/10.1038/nrc1279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2008.01.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009453492"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1958410", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009690435"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tem.2010.08.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013952518"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1089", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015302967", 
          "https://doi.org/10.1038/ng1089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1089", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015302967", 
          "https://doi.org/10.1038/ng1089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2008.07.043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015488411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0026671", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017166507"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05913", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017539696", 
          "https://doi.org/10.1038/nature05913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.96.17.9677", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018606776"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.96.6.2994", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019677021"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m205825200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019975386"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.185.5.953", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020621884"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/db09-1024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020887650"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci9842", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021408712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2010.09.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022813509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.2009.176156", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023921215"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1435", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027745942", 
          "https://doi.org/10.1038/nm1435"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1435", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027745942", 
          "https://doi.org/10.1038/nm1435"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(00)80062-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029461343"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0011669", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029700296"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.2007.58", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030400859", 
          "https://doi.org/10.1038/ng.2007.58"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/376167a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032619133", 
          "https://doi.org/10.1038/376167a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35007534", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036745532", 
          "https://doi.org/10.1038/35007534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35007534", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036745532", 
          "https://doi.org/10.1038/35007534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m804965200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038836600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m109.070706", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039448453"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1553707", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044910828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045364560", 
          "https://doi.org/10.1038/nature05026"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045364560", 
          "https://doi.org/10.1038/nature05026"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045364560", 
          "https://doi.org/10.1038/nature05026"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2009.02.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045384677"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1677/joe.1.05963", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046287497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1185", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046586789", 
          "https://doi.org/10.1038/nm1185"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1185", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046586789", 
          "https://doi.org/10.1038/nm1185"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/27376", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048314480", 
          "https://doi.org/10.1038/27376"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/27376", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048314480", 
          "https://doi.org/10.1038/27376"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1392", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048416303", 
          "https://doi.org/10.1038/nm1392"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1392", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048416303", 
          "https://doi.org/10.1038/nm1392"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb2080", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050949002", 
          "https://doi.org/10.1038/ncb2080"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb2080", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050949002", 
          "https://doi.org/10.1038/ncb2080"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20020588", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053186991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20020588", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053186991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.physbeh.2010.03.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053639328"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.asn.0000114556.19556.f9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060319519"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.asn.0000114556.19556.f9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060319519"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.asn.0000114556.19556.f9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060319519"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1061620", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062445120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.274.5288.782", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062554671"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.283.5407.1544", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062564408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2003-0669", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064246250"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2004-1520", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064247230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2006-1119", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064248279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2010-0094", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064250442"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/mend.15.2.0599", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064332133"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-04", 
    "datePublishedReg": "2013-04-01", 
    "description": "AIMS/HYPOTHESIS: While chronic low-grade inflammation is associated with obesity, acute inflammation reduces food intake and leads to negative energy balance. Although both types of inflammation activate nuclear factor \u03baB (NF-\u03baB) signalling, it remains unclear how NF-\u03baB activation results in opposite physiological responses in the two types of inflammation. The goal of this study was to address this question, and to understand the link between inflammation and leptin signalling.\nMETHODS: We studied the ability of NF-\u03baB to modulate Pomc transcription, and how it impinges on signal transducer and activator of transcription 3 (STAT3)-mediated leptin signalling by using a combination of animal models, biochemical assays and molecular biology.\nRESULTS: We report that suppression of food intake and physical movement with acute inflammation is not dependent on STAT3 activation in pro-opiomelanocortin (POMC) neurons. Under these conditions, activated NF-\u03baB independently leads to increased Pomc transcription. Electrophoretic mobility shift assay and chromatin immunoprecipitation (ChIP) experiments reveal that NF-\u03baB v-rel reticuloendotheliosis viral oncogene homologue A (avian) (RELA [also known as p65]) binds to the Pomc promoter region between -138 and -88 bp, which also harbours the trans-acting transcription factor 1 (SP1) binding site. We found significant changes in the methylation pattern at this region and reduced Pomc activation under chronic inflammation induced by a high-fat diet. Furthermore, RELA is unable to bind and activate transcription when the Pomc promoter is methylated. Finally, RELA binds to STAT3 and inhibits STAT3-mediated promoter activity, suggesting that RELA, possibly together with forkhead box-containing protein 1 (FOXO1), may prevent STAT3-mediated leptin activation of the Pomc promoter.\nCONCLUSIONS/INTERPRETATION: Our study provides a mechanism for the involvement of RELA in the divergent regulation of energy homeostasis in acute and chronic inflammation.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00125-013-2831-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1001482", 
        "issn": [
          "0012-186X", 
          "1432-0428"
        ], 
        "name": "Diabetologia", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "56"
      }
    ], 
    "name": "Nuclear factor \u03baB (NF-\u03baB) suppresses food intake and energy expenditure in mice by directly activating the Pomc promoter", 
    "pagination": "925-936", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "d912429aca6f3fdfefaa5f148080dedc88e5d0834b69ff453a1b7a0fe0a6adcd"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23370526"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0006777"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00125-013-2831-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1045570110"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00125-013-2831-2", 
      "https://app.dimensions.ai/details/publication/pub.1045570110"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:34", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000349_0000000349/records_113664_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs00125-013-2831-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00125-013-2831-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00125-013-2831-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00125-013-2831-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00125-013-2831-2'


 

This table displays all metadata directly associated to this object as RDF triples.

378 TRIPLES      21 PREDICATES      96 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00125-013-2831-2 schema:about N01936a13235d4085a0a6d4fe073018e3
2 N13ca45d31d11439ea8038b2a6f7a2194
3 N1703bbb1e8cc4877b164c2dcddc81bd3
4 N177d114845124ee1ad6a153656a3dad6
5 N4e04afb8d4904f558155cab54e763394
6 N557a17a17b624e31ae89c4b52fbadede
7 N5910ffc7bd754317b4b698d56686aeb0
8 N5b2ba58c742f419ea01a5c128b88f2c2
9 N5cb08546b44148a9852a8fd80e4497cf
10 N7366ce7e3dde4b3d9158e116f96a59ba
11 N81cb31ff26e849fb8190c3999d245137
12 Nad81d77fd66e47e49c055a3f2ff6c24d
13 Nae05dab2f1e644b384527a65f78ed22b
14 Nd3a3b9ddbb32431f89261b76c2867a18
15 Ndf5284f308224f59a620c8164330a8bf
16 Necf0ef747a1d4492b4ae0ad18604f92c
17 Nefe2e21e591a4641a938dfa62bb88cf4
18 anzsrc-for:06
19 anzsrc-for:0601
20 schema:author N2b8638f17f4149a18ce47aee3ddbbde3
21 schema:citation sg:pub.10.1038/27376
22 sg:pub.10.1038/35007534
23 sg:pub.10.1038/376167a0
24 sg:pub.10.1038/nature05026
25 sg:pub.10.1038/nature05913
26 sg:pub.10.1038/ncb2080
27 sg:pub.10.1038/ng.2007.58
28 sg:pub.10.1038/ng1089
29 sg:pub.10.1038/nm1185
30 sg:pub.10.1038/nm1392
31 sg:pub.10.1038/nm1435
32 sg:pub.10.1038/nn1731
33 sg:pub.10.1038/nrc1279
34 sg:pub.10.1186/1743-7075-4-18
35 https://doi.org/10.1016/j.ccr.2009.02.015
36 https://doi.org/10.1016/j.cell.2008.01.020
37 https://doi.org/10.1016/j.cell.2008.07.043
38 https://doi.org/10.1016/j.molcel.2010.09.010
39 https://doi.org/10.1016/j.physbeh.2010.03.011
40 https://doi.org/10.1016/j.tem.2010.08.002
41 https://doi.org/10.1016/s0002-9440(10)64967-x
42 https://doi.org/10.1016/s1097-2765(00)80062-3
43 https://doi.org/10.1042/bj20020588
44 https://doi.org/10.1073/pnas.96.17.9677
45 https://doi.org/10.1073/pnas.96.6.2994
46 https://doi.org/10.1074/jbc.m007577200
47 https://doi.org/10.1074/jbc.m109.070706
48 https://doi.org/10.1074/jbc.m205825200
49 https://doi.org/10.1074/jbc.m804965200
50 https://doi.org/10.1084/jem.185.5.953
51 https://doi.org/10.1084/jem.20011885
52 https://doi.org/10.1097/01.asn.0000114556.19556.f9
53 https://doi.org/10.1101/gad.1553707
54 https://doi.org/10.1101/gad.1958410
55 https://doi.org/10.1113/jphysiol.2009.176156
56 https://doi.org/10.1126/science.1061620
57 https://doi.org/10.1126/science.274.5288.782
58 https://doi.org/10.1126/science.283.5407.1544
59 https://doi.org/10.1172/jci59660
60 https://doi.org/10.1172/jci59816
61 https://doi.org/10.1172/jci9842
62 https://doi.org/10.1210/en.2003-0669
63 https://doi.org/10.1210/en.2004-1520
64 https://doi.org/10.1210/en.2006-1119
65 https://doi.org/10.1210/en.2010-0094
66 https://doi.org/10.1210/mend.15.2.0599
67 https://doi.org/10.1371/journal.pone.0011669
68 https://doi.org/10.1371/journal.pone.0026671
69 https://doi.org/10.1677/joe.1.05963
70 https://doi.org/10.2337/db09-1024
71 schema:datePublished 2013-04
72 schema:datePublishedReg 2013-04-01
73 schema:description AIMS/HYPOTHESIS: While chronic low-grade inflammation is associated with obesity, acute inflammation reduces food intake and leads to negative energy balance. Although both types of inflammation activate nuclear factor κB (NF-κB) signalling, it remains unclear how NF-κB activation results in opposite physiological responses in the two types of inflammation. The goal of this study was to address this question, and to understand the link between inflammation and leptin signalling. METHODS: We studied the ability of NF-κB to modulate Pomc transcription, and how it impinges on signal transducer and activator of transcription 3 (STAT3)-mediated leptin signalling by using a combination of animal models, biochemical assays and molecular biology. RESULTS: We report that suppression of food intake and physical movement with acute inflammation is not dependent on STAT3 activation in pro-opiomelanocortin (POMC) neurons. Under these conditions, activated NF-κB independently leads to increased Pomc transcription. Electrophoretic mobility shift assay and chromatin immunoprecipitation (ChIP) experiments reveal that NF-κB v-rel reticuloendotheliosis viral oncogene homologue A (avian) (RELA [also known as p65]) binds to the Pomc promoter region between -138 and -88 bp, which also harbours the trans-acting transcription factor 1 (SP1) binding site. We found significant changes in the methylation pattern at this region and reduced Pomc activation under chronic inflammation induced by a high-fat diet. Furthermore, RELA is unable to bind and activate transcription when the Pomc promoter is methylated. Finally, RELA binds to STAT3 and inhibits STAT3-mediated promoter activity, suggesting that RELA, possibly together with forkhead box-containing protein 1 (FOXO1), may prevent STAT3-mediated leptin activation of the Pomc promoter. CONCLUSIONS/INTERPRETATION: Our study provides a mechanism for the involvement of RELA in the divergent regulation of energy homeostasis in acute and chronic inflammation.
74 schema:genre research_article
75 schema:inLanguage en
76 schema:isAccessibleForFree true
77 schema:isPartOf N2c327a86633a495794070e3acd3fd46c
78 N6ded70c7c1804515826add3097bd2c63
79 sg:journal.1001482
80 schema:name Nuclear factor κB (NF-κB) suppresses food intake and energy expenditure in mice by directly activating the Pomc promoter
81 schema:pagination 925-936
82 schema:productId N0431d1a44d2149c7b64fd8e8c9c6163a
83 N29b93e4e69da42379dfc40e8d5de71c5
84 N4bd29c80b7a74b24ab781ce127a9feef
85 Ne8c42e3883474795a003d702c328d338
86 Nec346317b79f486886e83fb100470d18
87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045570110
88 https://doi.org/10.1007/s00125-013-2831-2
89 schema:sdDatePublished 2019-04-11T10:34
90 schema:sdLicense https://scigraph.springernature.com/explorer/license/
91 schema:sdPublisher Nfc435d979f6348a6a6208cc6914b1644
92 schema:url https://link.springer.com/10.1007%2Fs00125-013-2831-2
93 sgo:license sg:explorer/license/
94 sgo:sdDataset articles
95 rdf:type schema:ScholarlyArticle
96 N01936a13235d4085a0a6d4fe073018e3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Animals
98 rdf:type schema:DefinedTerm
99 N0431d1a44d2149c7b64fd8e8c9c6163a schema:name pubmed_id
100 schema:value 23370526
101 rdf:type schema:PropertyValue
102 N0fcb689e62e34fde80cb2017ad450c6e rdf:first sg:person.0617725252.06
103 rdf:rest N8c397ee77aed4b0895805c9bba175d73
104 N13ca45d31d11439ea8038b2a6f7a2194 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Behavior, Animal
106 rdf:type schema:DefinedTerm
107 N1703bbb1e8cc4877b164c2dcddc81bd3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Pro-Opiomelanocortin
109 rdf:type schema:DefinedTerm
110 N177d114845124ee1ad6a153656a3dad6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Feeding Behavior
112 rdf:type schema:DefinedTerm
113 N29b93e4e69da42379dfc40e8d5de71c5 schema:name readcube_id
114 schema:value d912429aca6f3fdfefaa5f148080dedc88e5d0834b69ff453a1b7a0fe0a6adcd
115 rdf:type schema:PropertyValue
116 N2b8638f17f4149a18ce47aee3ddbbde3 rdf:first sg:person.01006623757.23
117 rdf:rest N367c777497564504949885d2486c9b6a
118 N2c327a86633a495794070e3acd3fd46c schema:volumeNumber 56
119 rdf:type schema:PublicationVolume
120 N367c777497564504949885d2486c9b6a rdf:first sg:person.01214445501.55
121 rdf:rest N64a3665330e7453fbda690fbf91b70b5
122 N414f8bc463fa413c8cd1a8a10f386f56 rdf:first sg:person.0745527057.55
123 rdf:rest Ne19e9bbb32784eb0b61ce14b6a488882
124 N4bd29c80b7a74b24ab781ce127a9feef schema:name dimensions_id
125 schema:value pub.1045570110
126 rdf:type schema:PropertyValue
127 N4e04afb8d4904f558155cab54e763394 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Gene Expression Regulation
129 rdf:type schema:DefinedTerm
130 N557a17a17b624e31ae89c4b52fbadede schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Molecular Sequence Data
132 rdf:type schema:DefinedTerm
133 N5910ffc7bd754317b4b698d56686aeb0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name NF-kappa B
135 rdf:type schema:DefinedTerm
136 N5b2ba58c742f419ea01a5c128b88f2c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Eating
138 rdf:type schema:DefinedTerm
139 N5cb08546b44148a9852a8fd80e4497cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Inflammation
141 rdf:type schema:DefinedTerm
142 N606b6cfeaff547df94b854e408c3943b rdf:first sg:person.01227143717.25
143 rdf:rest N414f8bc463fa413c8cd1a8a10f386f56
144 N64a3665330e7453fbda690fbf91b70b5 rdf:first Nc98278de4e6f453e9e05ae6d13284948
145 rdf:rest N0fcb689e62e34fde80cb2017ad450c6e
146 N68575f30d4c44aa7aa6bbe5a3a6191fb schema:affiliation https://www.grid.ac/institutes/grid.452254.0
147 schema:familyName Chew
148 schema:givenName E.
149 rdf:type schema:Person
150 N6ded70c7c1804515826add3097bd2c63 schema:issueNumber 4
151 rdf:type schema:PublicationIssue
152 N7366ce7e3dde4b3d9158e116f96a59ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name STAT3 Transcription Factor
154 rdf:type schema:DefinedTerm
155 N81cb31ff26e849fb8190c3999d245137 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Promoter Regions, Genetic
157 rdf:type schema:DefinedTerm
158 N8c397ee77aed4b0895805c9bba175d73 rdf:first N68575f30d4c44aa7aa6bbe5a3a6191fb
159 rdf:rest Na5560677f0b24db28fe597d2b8b8ed0c
160 Na5560677f0b24db28fe597d2b8b8ed0c rdf:first sg:person.01135735430.50
161 rdf:rest N606b6cfeaff547df94b854e408c3943b
162 Nad81d77fd66e47e49c055a3f2ff6c24d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Signal Transduction
164 rdf:type schema:DefinedTerm
165 Nae05dab2f1e644b384527a65f78ed22b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Male
167 rdf:type schema:DefinedTerm
168 Nc98278de4e6f453e9e05ae6d13284948 schema:affiliation https://www.grid.ac/institutes/grid.452254.0
169 schema:familyName Li
170 schema:givenName Q.
171 rdf:type schema:Person
172 Nd3a3b9ddbb32431f89261b76c2867a18 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Mice
174 rdf:type schema:DefinedTerm
175 Ndf5284f308224f59a620c8164330a8bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Base Sequence
177 rdf:type schema:DefinedTerm
178 Ne19e9bbb32784eb0b61ce14b6a488882 rdf:first sg:person.01053632230.60
179 rdf:rest Nf445ac0834a544c99a65162210c57f0f
180 Ne8c42e3883474795a003d702c328d338 schema:name nlm_unique_id
181 schema:value 0006777
182 rdf:type schema:PropertyValue
183 Nec346317b79f486886e83fb100470d18 schema:name doi
184 schema:value 10.1007/s00125-013-2831-2
185 rdf:type schema:PropertyValue
186 Necf0ef747a1d4492b4ae0ad18604f92c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Mice, Inbred C57BL
188 rdf:type schema:DefinedTerm
189 Nefe2e21e591a4641a938dfa62bb88cf4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Leptin
191 rdf:type schema:DefinedTerm
192 Nf445ac0834a544c99a65162210c57f0f rdf:first sg:person.01061755457.18
193 rdf:rest rdf:nil
194 Nfc435d979f6348a6a6208cc6914b1644 schema:name Springer Nature - SN SciGraph project
195 rdf:type schema:Organization
196 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
197 schema:name Biological Sciences
198 rdf:type schema:DefinedTerm
199 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
200 schema:name Biochemistry and Cell Biology
201 rdf:type schema:DefinedTerm
202 sg:journal.1001482 schema:issn 0012-186X
203 1432-0428
204 schema:name Diabetologia
205 rdf:type schema:Periodical
206 sg:person.01006623757.23 schema:affiliation https://www.grid.ac/institutes/grid.452254.0
207 schema:familyName Shi
208 schema:givenName X.
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006623757.23
210 rdf:type schema:Person
211 sg:person.01053632230.60 schema:affiliation https://www.grid.ac/institutes/grid.4280.e
212 schema:familyName Tergaonkar
213 schema:givenName V.
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053632230.60
215 rdf:type schema:Person
216 sg:person.01061755457.18 schema:affiliation https://www.grid.ac/institutes/grid.428397.3
217 schema:familyName Han
218 schema:givenName W.
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061755457.18
220 rdf:type schema:Person
221 sg:person.01135735430.50 schema:affiliation https://www.grid.ac/institutes/grid.418812.6
222 schema:familyName Wong
223 schema:givenName E. T.
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01135735430.50
225 rdf:type schema:Person
226 sg:person.01214445501.55 schema:affiliation https://www.grid.ac/institutes/grid.452254.0
227 schema:familyName Wang
228 schema:givenName X.
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214445501.55
230 rdf:type schema:Person
231 sg:person.01227143717.25 schema:affiliation https://www.grid.ac/institutes/grid.11804.3c
232 schema:familyName Lacza
233 schema:givenName Z.
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227143717.25
235 rdf:type schema:Person
236 sg:person.0617725252.06 schema:affiliation https://www.grid.ac/institutes/grid.452254.0
237 schema:familyName Su
238 schema:givenName M.
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617725252.06
240 rdf:type schema:Person
241 sg:person.0745527057.55 schema:affiliation https://www.grid.ac/institutes/grid.452254.0
242 schema:familyName Radda
243 schema:givenName G. K.
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745527057.55
245 rdf:type schema:Person
246 sg:pub.10.1038/27376 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048314480
247 https://doi.org/10.1038/27376
248 rdf:type schema:CreativeWork
249 sg:pub.10.1038/35007534 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036745532
250 https://doi.org/10.1038/35007534
251 rdf:type schema:CreativeWork
252 sg:pub.10.1038/376167a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032619133
253 https://doi.org/10.1038/376167a0
254 rdf:type schema:CreativeWork
255 sg:pub.10.1038/nature05026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045364560
256 https://doi.org/10.1038/nature05026
257 rdf:type schema:CreativeWork
258 sg:pub.10.1038/nature05913 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017539696
259 https://doi.org/10.1038/nature05913
260 rdf:type schema:CreativeWork
261 sg:pub.10.1038/ncb2080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050949002
262 https://doi.org/10.1038/ncb2080
263 rdf:type schema:CreativeWork
264 sg:pub.10.1038/ng.2007.58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030400859
265 https://doi.org/10.1038/ng.2007.58
266 rdf:type schema:CreativeWork
267 sg:pub.10.1038/ng1089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015302967
268 https://doi.org/10.1038/ng1089
269 rdf:type schema:CreativeWork
270 sg:pub.10.1038/nm1185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046586789
271 https://doi.org/10.1038/nm1185
272 rdf:type schema:CreativeWork
273 sg:pub.10.1038/nm1392 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048416303
274 https://doi.org/10.1038/nm1392
275 rdf:type schema:CreativeWork
276 sg:pub.10.1038/nm1435 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027745942
277 https://doi.org/10.1038/nm1435
278 rdf:type schema:CreativeWork
279 sg:pub.10.1038/nn1731 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006320546
280 https://doi.org/10.1038/nn1731
281 rdf:type schema:CreativeWork
282 sg:pub.10.1038/nrc1279 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009116910
283 https://doi.org/10.1038/nrc1279
284 rdf:type schema:CreativeWork
285 sg:pub.10.1186/1743-7075-4-18 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000942906
286 https://doi.org/10.1186/1743-7075-4-18
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1016/j.ccr.2009.02.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045384677
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1016/j.cell.2008.01.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009453492
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1016/j.cell.2008.07.043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015488411
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1016/j.molcel.2010.09.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022813509
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1016/j.physbeh.2010.03.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053639328
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1016/j.tem.2010.08.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013952518
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1016/s0002-9440(10)64967-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000100065
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1016/s1097-2765(00)80062-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029461343
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1042/bj20020588 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053186991
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1073/pnas.96.17.9677 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018606776
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1073/pnas.96.6.2994 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019677021
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1074/jbc.m007577200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004180651
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1074/jbc.m109.070706 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039448453
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1074/jbc.m205825200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019975386
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1074/jbc.m804965200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038836600
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1084/jem.185.5.953 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020621884
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1084/jem.20011885 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000490084
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1097/01.asn.0000114556.19556.f9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060319519
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1101/gad.1553707 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044910828
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1101/gad.1958410 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009690435
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1113/jphysiol.2009.176156 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023921215
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1126/science.1061620 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062445120
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1126/science.274.5288.782 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062554671
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1126/science.283.5407.1544 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062564408
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1172/jci59660 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006963732
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1172/jci59816 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005772614
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1172/jci9842 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021408712
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1210/en.2003-0669 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064246250
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1210/en.2004-1520 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064247230
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1210/en.2006-1119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064248279
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1210/en.2010-0094 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064250442
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1210/mend.15.2.0599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064332133
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1371/journal.pone.0011669 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029700296
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1371/journal.pone.0026671 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017166507
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1677/joe.1.05963 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046287497
357 rdf:type schema:CreativeWork
358 https://doi.org/10.2337/db09-1024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020887650
359 rdf:type schema:CreativeWork
360 https://www.grid.ac/institutes/grid.11804.3c schema:alternateName Semmelweis University
361 schema:name Department of Human Physiology and Clinical Experimental Research, Semmelweis University, Budapest, Hungary
362 rdf:type schema:Organization
363 https://www.grid.ac/institutes/grid.418812.6 schema:alternateName Institute of Molecular and Cell Biology
364 schema:name Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, #3-17 Proteos, 61 Biopolis Drive, 138673, Singapore, Republic of Singapore
365 rdf:type schema:Organization
366 https://www.grid.ac/institutes/grid.4280.e schema:alternateName National University of Singapore
367 schema:name Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore
368 Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, #3-17 Proteos, 61 Biopolis Drive, 138673, Singapore, Republic of Singapore
369 rdf:type schema:Organization
370 https://www.grid.ac/institutes/grid.428397.3 schema:alternateName Duke NUS Graduate Medical School
371 schema:name Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Graduate Medical School, Singapore, Republic of Singapore
372 Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore
373 Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, #3-17 Proteos, 61 Biopolis Drive, 138673, Singapore, Republic of Singapore
374 Singapore Bioimaging Consortium, Agency for Science, Technology and Research (A*STAR), #02-02 Helios, 11 Biopolis Way, 138667, Singapore, Republic of Singapore
375 rdf:type schema:Organization
376 https://www.grid.ac/institutes/grid.452254.0 schema:alternateName Singapore Bioimaging Consortium
377 schema:name Singapore Bioimaging Consortium, Agency for Science, Technology and Research (A*STAR), #02-02 Helios, 11 Biopolis Way, 138667, Singapore, Republic of Singapore
378 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...