Reassessment of the putative role of BLK-p.A71T loss-of-function mutation in MODY and type 2 diabetes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-03

AUTHORS

A. Bonnefond, L. Yengo, J. Philippe, A. Dechaume, I. Ezzidi, E. Vaillant, A. P. Gjesing, E. A. Andersson, S. Czernichow, S. Hercberg, S. Hadjadj, G. Charpentier, O. Lantieri, B. Balkau, M. Marre, O. Pedersen, T. Hansen, P. Froguel, M. Vaxillaire

ABSTRACT

AIMS/HYPOTHESIS: MODY is believed to be caused by at least 13 different genes. Five rare mutations at the BLK locus, including only one non-synonymous p.A71T variant, were reported to segregate with diabetes in three MODY families. The p.A71T mutation was shown to abolish the enhancing effect of BLK on insulin content and secretion from pancreatic beta cell lines. Here, we reassessed the contribution of BLK to MODY and tested the effect of BLK-p.A71T on type 2 diabetes risk and variations in related traits. METHODS: BLK was sequenced in 64 unelucidated MODY samples. The BLK-p.A71T variant was genotyped in a French type 2 diabetes case-control study including 4,901 cases and 4,280 controls, and in the DESIR (Data from an Epidemiological Study on the Insulin Resistance Syndrome) and SUVIMAX (Supplementation en Vitamines et Mineraux Antioxydants) population-based cohorts (n = 6,905). The variant effects were assessed by logistic and linear regression models. RESULTS: No rare non-synonymous BLK mutations were found in the MODY patients. The BLK p.A71T mutation was present in 52 normoglycaemic individuals, making it very unlikely that this loss-of-function mutation causes highly penetrant MODY. We found a nominal association between this variant and increased type 2 diabetes risk, with an enrichment of the mutation in the obese diabetic patients, although no significant association with BMI was identified. CONCLUSIONS/INTERPRETATION: No mutation in BLK was found in our MODY cohort. From our findings, the BLK-p.A71T mutation may weakly influence type 2 diabetes risk in the context of obesity; however, this will require further validation. More... »

PAGES

492-496

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00125-012-2794-8

DOI

http://dx.doi.org/10.1007/s00125-012-2794-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034783008

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23224494


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diabetes Mellitus, Type 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Predisposition to Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "src-Family Kinases", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "CNRS-UMR-8199, Lille Pasteur Institute, 1 rue du Professeur Calmette, 59019, Lille Cedex, France", 
            "Lille Nord de France University, Lille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bonnefond", 
        "givenName": "A.", 
        "id": "sg:person.0630161707.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630161707.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "CNRS-UMR-8199, Lille Pasteur Institute, 1 rue du Professeur Calmette, 59019, Lille Cedex, France", 
            "Lille Nord de France University, Lille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yengo", 
        "givenName": "L.", 
        "id": "sg:person.01222435227.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222435227.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "CNRS-UMR-8199, Lille Pasteur Institute, 1 rue du Professeur Calmette, 59019, Lille Cedex, France", 
            "Lille Nord de France University, Lille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Philippe", 
        "givenName": "J.", 
        "id": "sg:person.01265120455.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265120455.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "CNRS-UMR-8199, Lille Pasteur Institute, 1 rue du Professeur Calmette, 59019, Lille Cedex, France", 
            "Lille Nord de France University, Lille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dechaume", 
        "givenName": "A.", 
        "id": "sg:person.01251020621.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251020621.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Monastir", 
          "id": "https://www.grid.ac/institutes/grid.411838.7", 
          "name": [
            "Research Unit of Biology and Genetics of Hematological and Auto-immune Diseases, Faculty of Pharmacy of Monastir, University of Monastir, Monastir, Tunisia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ezzidi", 
        "givenName": "I.", 
        "id": "sg:person.01230360602.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230360602.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "CNRS-UMR-8199, Lille Pasteur Institute, 1 rue du Professeur Calmette, 59019, Lille Cedex, France", 
            "Lille Nord de France University, Lille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vaillant", 
        "givenName": "E.", 
        "id": "sg:person.01031111754.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031111754.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Copenhagen", 
          "id": "https://www.grid.ac/institutes/grid.5254.6", 
          "name": [
            "The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gjesing", 
        "givenName": "A. P.", 
        "id": "sg:person.0753626413.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753626413.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Copenhagen", 
          "id": "https://www.grid.ac/institutes/grid.5254.6", 
          "name": [
            "The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Andersson", 
        "givenName": "E. A.", 
        "id": "sg:person.01004203750.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004203750.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre for research in epidemiology and population health", 
          "id": "https://www.grid.ac/institutes/grid.463845.8", 
          "name": [
            "University Versailles St-Quentin and Department of Nutrition, Ambroise Par\u00e9 Hospital, Boulogne-Billancourt, France", 
            "Inserm-U1018, Centre for Research in Epidemiology and Population Health, Villejuif, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Czernichow", 
        "givenName": "S.", 
        "id": "sg:person.0630750367.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630750367.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Avicenne", 
          "id": "https://www.grid.ac/institutes/grid.413780.9", 
          "name": [
            "Inserm-U557, Institut National de la Recherche Agronomique-1125 Unit, Conservatoire National des Arts et M\u00e9tiers, Centre de Recherches en Nutrition Humaine, Paris 13 University, Bobigny, France", 
            "Department of Public Health, Avicenne Hospital, AP-HP, Bobigny, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hercberg", 
        "givenName": "S.", 
        "id": "sg:person.01042142266.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042142266.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Universitaire de Poitiers", 
          "id": "https://www.grid.ac/institutes/grid.411162.1", 
          "name": [
            "Centre Hospitalier Universitaire Poitiers, Department of Endocrinology and Diabetology, Poitiers, France", 
            "Inserm-U927 and Biotheque of the Clinical Investigation Centre of Poitiers (CIC0802), Poitiers, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hadjadj", 
        "givenName": "S.", 
        "id": "sg:person.0607263311.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607263311.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Endocrinology and Diabetology, Corbeil-Essonnes Hospital, Corbeil-Essonnes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Charpentier", 
        "givenName": "G.", 
        "id": "sg:person.01122664436.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122664436.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Institut Inter-R\u00e9gional pour la Sant\u00e9 (IRSA), La Riche, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lantieri", 
        "givenName": "O.", 
        "id": "sg:person.01233251736.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233251736.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre for research in epidemiology and population health", 
          "id": "https://www.grid.ac/institutes/grid.463845.8", 
          "name": [
            "Inserm-U780, Centre for Research in Epidemiology and Population Health, Villejuif, France", 
            "Paris-Sud 11 University, Orsay, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Balkau", 
        "givenName": "B.", 
        "id": "sg:person.016601014304.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016601014304.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paris Diderot University", 
          "id": "https://www.grid.ac/institutes/grid.7452.4", 
          "name": [
            "Department of Endocrinology, Diabetology and Nutrition, Bichat-Claude Bernard University Hospital, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), Paris, France", 
            "Inserm-U695, Paris 7 University, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marre", 
        "givenName": "M.", 
        "id": "sg:person.01200505026.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200505026.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Aarhus University", 
          "id": "https://www.grid.ac/institutes/grid.7048.b", 
          "name": [
            "The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark", 
            "Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Denmark", 
            "Faculty of Health Sciences, University of Aarhus, Aarhus, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pedersen", 
        "givenName": "O.", 
        "id": "sg:person.0765447455.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765447455.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Southern Denmark", 
          "id": "https://www.grid.ac/institutes/grid.10825.3e", 
          "name": [
            "The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark", 
            "Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Denmark", 
            "Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hansen", 
        "givenName": "T.", 
        "id": "sg:person.016350427407.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016350427407.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Imperial College London", 
          "id": "https://www.grid.ac/institutes/grid.7445.2", 
          "name": [
            "CNRS-UMR-8199, Lille Pasteur Institute, 1 rue du Professeur Calmette, 59019, Lille Cedex, France", 
            "Lille Nord de France University, Lille, France", 
            "Department of Genomic Medicine, School Of Public Health, Hammersmith Hospital, Imperial College London, Room E303, Burlington-Danes Building, Du Cane Road, W12 0NN, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Froguel", 
        "givenName": "P.", 
        "id": "sg:person.011675646602.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011675646602.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "CNRS-UMR-8199, Lille Pasteur Institute, 1 rue du Professeur Calmette, 59019, Lille Cedex, France", 
            "Lille Nord de France University, Lille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vaxillaire", 
        "givenName": "M.", 
        "id": "sg:person.011616734614.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011616734614.30"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.2337/db08-0906", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000524276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-007-0787-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001867567", 
          "https://doi.org/10.1007/s00125-007-0787-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-007-0787-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001867567", 
          "https://doi.org/10.1007/s00125-007-0787-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-007-0787-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001867567", 
          "https://doi.org/10.1007/s00125-007-0787-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.beem.2011.12.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002170600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-010-1799-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005493236", 
          "https://doi.org/10.1007/s00125-010-1799-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-010-1799-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005493236", 
          "https://doi.org/10.1007/s00125-010-1799-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-010-1799-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005493236", 
          "https://doi.org/10.1007/s00125-010-1799-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2350-11-42", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028562489", 
          "https://doi.org/10.1186/1471-2350-11-42"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0906474106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029676333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2350-9-45", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029731010", 
          "https://doi.org/10.1186/1471-2350-9-45"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/dc11-0035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042123844"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/db09-0652", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042129422"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-011-2418-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046868199", 
          "https://doi.org/10.1007/s00125-011-2418-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-011-2418-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046868199", 
          "https://doi.org/10.1007/s00125-011-2418-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/db06-0191", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047529095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0037423", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048848905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.1053", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051356278", 
          "https://doi.org/10.1038/ng.1053"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001250051025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053160066", 
          "https://doi.org/10.1007/s001250051025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001250051025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053160066", 
          "https://doi.org/10.1007/s001250051025"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-03", 
    "datePublishedReg": "2013-03-01", 
    "description": "AIMS/HYPOTHESIS: MODY is believed to be caused by at least 13 different genes. Five rare mutations at the BLK locus, including only one non-synonymous p.A71T variant, were reported to segregate with diabetes in three MODY families. The p.A71T mutation was shown to abolish the enhancing effect of BLK on insulin content and secretion from pancreatic beta cell lines. Here, we reassessed the contribution of BLK to MODY and tested the effect of BLK-p.A71T on type 2 diabetes risk and variations in related traits.\nMETHODS: BLK was sequenced in 64 unelucidated MODY samples. The BLK-p.A71T variant was genotyped in a French type 2 diabetes case-control study including 4,901 cases and 4,280 controls, and in the DESIR (Data from an Epidemiological Study on the Insulin Resistance Syndrome) and SUVIMAX (Supplementation en Vitamines et Mineraux Antioxydants) population-based cohorts (n = 6,905). The variant effects were assessed by logistic and linear regression models.\nRESULTS: No rare non-synonymous BLK mutations were found in the MODY patients. The BLK p.A71T mutation was present in 52 normoglycaemic individuals, making it very unlikely that this loss-of-function mutation causes highly penetrant MODY. We found a nominal association between this variant and increased type 2 diabetes risk, with an enrichment of the mutation in the obese diabetic patients, although no significant association with BMI was identified.\nCONCLUSIONS/INTERPRETATION: No mutation in BLK was found in our MODY cohort. From our findings, the BLK-p.A71T mutation may weakly influence type 2 diabetes risk in the context of obesity; however, this will require further validation.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00125-012-2794-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2773325", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1001482", 
        "issn": [
          "0012-186X", 
          "1432-0428"
        ], 
        "name": "Diabetologia", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "56"
      }
    ], 
    "name": "Reassessment of the putative role of BLK-p.A71T loss-of-function mutation in MODY and type 2 diabetes", 
    "pagination": "492-496", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a5b15fc52f508d7298902bcbe5503d414f3a1e3b877e44d7e6b2f9906fde70fe"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23224494"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0006777"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00125-012-2794-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1034783008"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00125-012-2794-8", 
      "https://app.dimensions.ai/details/publication/pub.1034783008"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:16", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000348_0000000348/records_54307_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs00125-012-2794-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00125-012-2794-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00125-012-2794-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00125-012-2794-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00125-012-2794-8'


 

This table displays all metadata directly associated to this object as RDF triples.

348 TRIPLES      21 PREDICATES      54 URIs      32 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00125-012-2794-8 schema:about N0270dab25f3b48bd911b899b48fd12cc
2 N119779eabcfb48388bc54f9b64afd318
3 N1c249468349843c29ffae30630ded7ac
4 N4b5346c27ef244fba13bb65b00232e3c
5 N51fa74d424334628812893dfd23b4139
6 N5281ec689089464a994eb0700254c97c
7 N70d4208a8cd945e3ad6078946ab7672c
8 N9524a6671a914bfcb473392aaad88326
9 Nbd868d6583a6491887b92878f919bf1a
10 Ncb0e01baaf0f46c0a30a73399d274b42
11 Ncbabe7da897241f1a8a8a3a3febf80ff
12 anzsrc-for:11
13 anzsrc-for:1103
14 schema:author N9668de9b4d874076a14e709c0513c321
15 schema:citation sg:pub.10.1007/s00125-007-0787-9
16 sg:pub.10.1007/s00125-010-1799-4
17 sg:pub.10.1007/s00125-011-2418-8
18 sg:pub.10.1007/s001250051025
19 sg:pub.10.1038/ng.1053
20 sg:pub.10.1186/1471-2350-11-42
21 sg:pub.10.1186/1471-2350-9-45
22 https://doi.org/10.1016/j.beem.2011.12.001
23 https://doi.org/10.1073/pnas.0906474106
24 https://doi.org/10.1371/journal.pone.0037423
25 https://doi.org/10.2337/db06-0191
26 https://doi.org/10.2337/db08-0906
27 https://doi.org/10.2337/db09-0652
28 https://doi.org/10.2337/dc11-0035
29 schema:datePublished 2013-03
30 schema:datePublishedReg 2013-03-01
31 schema:description AIMS/HYPOTHESIS: MODY is believed to be caused by at least 13 different genes. Five rare mutations at the BLK locus, including only one non-synonymous p.A71T variant, were reported to segregate with diabetes in three MODY families. The p.A71T mutation was shown to abolish the enhancing effect of BLK on insulin content and secretion from pancreatic beta cell lines. Here, we reassessed the contribution of BLK to MODY and tested the effect of BLK-p.A71T on type 2 diabetes risk and variations in related traits. METHODS: BLK was sequenced in 64 unelucidated MODY samples. The BLK-p.A71T variant was genotyped in a French type 2 diabetes case-control study including 4,901 cases and 4,280 controls, and in the DESIR (Data from an Epidemiological Study on the Insulin Resistance Syndrome) and SUVIMAX (Supplementation en Vitamines et Mineraux Antioxydants) population-based cohorts (n = 6,905). The variant effects were assessed by logistic and linear regression models. RESULTS: No rare non-synonymous BLK mutations were found in the MODY patients. The BLK p.A71T mutation was present in 52 normoglycaemic individuals, making it very unlikely that this loss-of-function mutation causes highly penetrant MODY. We found a nominal association between this variant and increased type 2 diabetes risk, with an enrichment of the mutation in the obese diabetic patients, although no significant association with BMI was identified. CONCLUSIONS/INTERPRETATION: No mutation in BLK was found in our MODY cohort. From our findings, the BLK-p.A71T mutation may weakly influence type 2 diabetes risk in the context of obesity; however, this will require further validation.
32 schema:genre research_article
33 schema:inLanguage en
34 schema:isAccessibleForFree true
35 schema:isPartOf N22567519b0714e05b785141a3de9218a
36 Na2d09fe704b34f8b9870abc14b82eb70
37 sg:journal.1001482
38 schema:name Reassessment of the putative role of BLK-p.A71T loss-of-function mutation in MODY and type 2 diabetes
39 schema:pagination 492-496
40 schema:productId N82243e90f20f46a683363e40c5267d48
41 N9f720169fc1a4eff81a23abc89b7ecab
42 Nb099b4347c3746978efe9ea1cb4b809b
43 Ne489f212faac413fba66f902eba1e85a
44 Ne51e13f640d846d7a06995094c1938aa
45 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034783008
46 https://doi.org/10.1007/s00125-012-2794-8
47 schema:sdDatePublished 2019-04-11T10:16
48 schema:sdLicense https://scigraph.springernature.com/explorer/license/
49 schema:sdPublisher N9086d194ae6845768034396b6e2584f8
50 schema:url https://link.springer.com/10.1007%2Fs00125-012-2794-8
51 sgo:license sg:explorer/license/
52 sgo:sdDataset articles
53 rdf:type schema:ScholarlyArticle
54 N0270dab25f3b48bd911b899b48fd12cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
55 schema:name Young Adult
56 rdf:type schema:DefinedTerm
57 N03ff9376702043c4b661616e9396545a rdf:first sg:person.01042142266.65
58 rdf:rest N04343042275d4717899261d250a9f813
59 N04343042275d4717899261d250a9f813 rdf:first sg:person.0607263311.54
60 rdf:rest N4dd1e50725464dfabefafd06e6c3b0f0
61 N0f32411e64984791a07f3887a4ca46da schema:name Institut Inter-Régional pour la Santé (IRSA), La Riche, France
62 rdf:type schema:Organization
63 N119779eabcfb48388bc54f9b64afd318 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
64 schema:name src-Family Kinases
65 rdf:type schema:DefinedTerm
66 N1c249468349843c29ffae30630ded7ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
67 schema:name Male
68 rdf:type schema:DefinedTerm
69 N22567519b0714e05b785141a3de9218a schema:issueNumber 3
70 rdf:type schema:PublicationIssue
71 N2335ab261558425093771e295d0147d2 schema:name CNRS-UMR-8199, Lille Pasteur Institute, 1 rue du Professeur Calmette, 59019, Lille Cedex, France
72 Lille Nord de France University, Lille, France
73 rdf:type schema:Organization
74 N298108396ec7456b8987996366745c6a schema:name CNRS-UMR-8199, Lille Pasteur Institute, 1 rue du Professeur Calmette, 59019, Lille Cedex, France
75 Lille Nord de France University, Lille, France
76 rdf:type schema:Organization
77 N3264b37213064409b98dd957357908b5 rdf:first sg:person.01251020621.24
78 rdf:rest N6ed4ba5be38d4fa7a90c8000d670f38e
79 N36e3f4747d4045fe85f27a082e470798 schema:name CNRS-UMR-8199, Lille Pasteur Institute, 1 rue du Professeur Calmette, 59019, Lille Cedex, France
80 Lille Nord de France University, Lille, France
81 rdf:type schema:Organization
82 N3fabe5e5c5934f398bf016e3b71a30b9 schema:name CNRS-UMR-8199, Lille Pasteur Institute, 1 rue du Professeur Calmette, 59019, Lille Cedex, France
83 Lille Nord de France University, Lille, France
84 rdf:type schema:Organization
85 N3fc03732627941f3b8137f5193485803 rdf:first sg:person.0753626413.90
86 rdf:rest N9a629a0e2f204753bac1c7675e4c7730
87 N4b5346c27ef244fba13bb65b00232e3c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Mutation
89 rdf:type schema:DefinedTerm
90 N4dd1e50725464dfabefafd06e6c3b0f0 rdf:first sg:person.01122664436.36
91 rdf:rest N9ee1fcf228644f51834d510194a6b48b
92 N4e0565239b3c46f2b19a07451b6303ea rdf:first sg:person.0630750367.35
93 rdf:rest N03ff9376702043c4b661616e9396545a
94 N51fa74d424334628812893dfd23b4139 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Child
96 rdf:type schema:DefinedTerm
97 N5281ec689089464a994eb0700254c97c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Genetic Predisposition to Disease
99 rdf:type schema:DefinedTerm
100 N5caa53e539a94c2fb74e143410d06c27 rdf:first sg:person.016350427407.47
101 rdf:rest Nbb2812585a714da5a9bbfcc13bcb0c05
102 N6bc34378bcf94f6aa0c62926b307951c rdf:first sg:person.01200505026.40
103 rdf:rest Nfcc2bff66cfa4fa1af82bef912f6f64d
104 N6ed4ba5be38d4fa7a90c8000d670f38e rdf:first sg:person.01230360602.84
105 rdf:rest Naa496754244f4cbf97c987789e583b09
106 N70d4208a8cd945e3ad6078946ab7672c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Humans
108 rdf:type schema:DefinedTerm
109 N82243e90f20f46a683363e40c5267d48 schema:name pubmed_id
110 schema:value 23224494
111 rdf:type schema:PropertyValue
112 N9086d194ae6845768034396b6e2584f8 schema:name Springer Nature - SN SciGraph project
113 rdf:type schema:Organization
114 N9524a6671a914bfcb473392aaad88326 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Female
116 rdf:type schema:DefinedTerm
117 N9668de9b4d874076a14e709c0513c321 rdf:first sg:person.0630161707.73
118 rdf:rest Na3517446e9f946519e1d5512924009d0
119 N9a629a0e2f204753bac1c7675e4c7730 rdf:first sg:person.01004203750.27
120 rdf:rest N4e0565239b3c46f2b19a07451b6303ea
121 N9c6ac7ad04384838a0dce3b43e28b2b4 schema:name CNRS-UMR-8199, Lille Pasteur Institute, 1 rue du Professeur Calmette, 59019, Lille Cedex, France
122 Lille Nord de France University, Lille, France
123 rdf:type schema:Organization
124 N9ee1fcf228644f51834d510194a6b48b rdf:first sg:person.01233251736.53
125 rdf:rest Nf308b85d36e1422aaa80f3951d042321
126 N9f720169fc1a4eff81a23abc89b7ecab schema:name readcube_id
127 schema:value a5b15fc52f508d7298902bcbe5503d414f3a1e3b877e44d7e6b2f9906fde70fe
128 rdf:type schema:PropertyValue
129 Na2d09fe704b34f8b9870abc14b82eb70 schema:volumeNumber 56
130 rdf:type schema:PublicationVolume
131 Na3517446e9f946519e1d5512924009d0 rdf:first sg:person.01222435227.61
132 rdf:rest Nd872474e8ef6468f889aca7ba17021a6
133 Na50e5ddf9fb1465496f83ed7082bdc6d schema:name CNRS-UMR-8199, Lille Pasteur Institute, 1 rue du Professeur Calmette, 59019, Lille Cedex, France
134 Lille Nord de France University, Lille, France
135 rdf:type schema:Organization
136 Naa496754244f4cbf97c987789e583b09 rdf:first sg:person.01031111754.45
137 rdf:rest N3fc03732627941f3b8137f5193485803
138 Nb099b4347c3746978efe9ea1cb4b809b schema:name doi
139 schema:value 10.1007/s00125-012-2794-8
140 rdf:type schema:PropertyValue
141 Nbb2812585a714da5a9bbfcc13bcb0c05 rdf:first sg:person.011675646602.80
142 rdf:rest Nc56a2c9a8f234cec8677b41f33bf54a9
143 Nbd868d6583a6491887b92878f919bf1a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Adolescent
145 rdf:type schema:DefinedTerm
146 Nc56a2c9a8f234cec8677b41f33bf54a9 rdf:first sg:person.011616734614.30
147 rdf:rest rdf:nil
148 Ncb0e01baaf0f46c0a30a73399d274b42 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Diabetes Mellitus, Type 2
150 rdf:type schema:DefinedTerm
151 Ncbabe7da897241f1a8a8a3a3febf80ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Adult
153 rdf:type schema:DefinedTerm
154 Nd872474e8ef6468f889aca7ba17021a6 rdf:first sg:person.01265120455.18
155 rdf:rest N3264b37213064409b98dd957357908b5
156 Ne489f212faac413fba66f902eba1e85a schema:name dimensions_id
157 schema:value pub.1034783008
158 rdf:type schema:PropertyValue
159 Ne51e13f640d846d7a06995094c1938aa schema:name nlm_unique_id
160 schema:value 0006777
161 rdf:type schema:PropertyValue
162 Nee4c5a87e45c4bfbb892566588578148 schema:name Department of Endocrinology and Diabetology, Corbeil-Essonnes Hospital, Corbeil-Essonnes, France
163 rdf:type schema:Organization
164 Nf308b85d36e1422aaa80f3951d042321 rdf:first sg:person.016601014304.03
165 rdf:rest N6bc34378bcf94f6aa0c62926b307951c
166 Nfcc2bff66cfa4fa1af82bef912f6f64d rdf:first sg:person.0765447455.52
167 rdf:rest N5caa53e539a94c2fb74e143410d06c27
168 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
169 schema:name Medical and Health Sciences
170 rdf:type schema:DefinedTerm
171 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
172 schema:name Clinical Sciences
173 rdf:type schema:DefinedTerm
174 sg:grant.2773325 http://pending.schema.org/fundedItem sg:pub.10.1007/s00125-012-2794-8
175 rdf:type schema:MonetaryGrant
176 sg:journal.1001482 schema:issn 0012-186X
177 1432-0428
178 schema:name Diabetologia
179 rdf:type schema:Periodical
180 sg:person.01004203750.27 schema:affiliation https://www.grid.ac/institutes/grid.5254.6
181 schema:familyName Andersson
182 schema:givenName E. A.
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004203750.27
184 rdf:type schema:Person
185 sg:person.01031111754.45 schema:affiliation N2335ab261558425093771e295d0147d2
186 schema:familyName Vaillant
187 schema:givenName E.
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031111754.45
189 rdf:type schema:Person
190 sg:person.01042142266.65 schema:affiliation https://www.grid.ac/institutes/grid.413780.9
191 schema:familyName Hercberg
192 schema:givenName S.
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042142266.65
194 rdf:type schema:Person
195 sg:person.01122664436.36 schema:affiliation Nee4c5a87e45c4bfbb892566588578148
196 schema:familyName Charpentier
197 schema:givenName G.
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122664436.36
199 rdf:type schema:Person
200 sg:person.011616734614.30 schema:affiliation N36e3f4747d4045fe85f27a082e470798
201 schema:familyName Vaxillaire
202 schema:givenName M.
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011616734614.30
204 rdf:type schema:Person
205 sg:person.011675646602.80 schema:affiliation https://www.grid.ac/institutes/grid.7445.2
206 schema:familyName Froguel
207 schema:givenName P.
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011675646602.80
209 rdf:type schema:Person
210 sg:person.01200505026.40 schema:affiliation https://www.grid.ac/institutes/grid.7452.4
211 schema:familyName Marre
212 schema:givenName M.
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200505026.40
214 rdf:type schema:Person
215 sg:person.01222435227.61 schema:affiliation N9c6ac7ad04384838a0dce3b43e28b2b4
216 schema:familyName Yengo
217 schema:givenName L.
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222435227.61
219 rdf:type schema:Person
220 sg:person.01230360602.84 schema:affiliation https://www.grid.ac/institutes/grid.411838.7
221 schema:familyName Ezzidi
222 schema:givenName I.
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230360602.84
224 rdf:type schema:Person
225 sg:person.01233251736.53 schema:affiliation N0f32411e64984791a07f3887a4ca46da
226 schema:familyName Lantieri
227 schema:givenName O.
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233251736.53
229 rdf:type schema:Person
230 sg:person.01251020621.24 schema:affiliation N298108396ec7456b8987996366745c6a
231 schema:familyName Dechaume
232 schema:givenName A.
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251020621.24
234 rdf:type schema:Person
235 sg:person.01265120455.18 schema:affiliation N3fabe5e5c5934f398bf016e3b71a30b9
236 schema:familyName Philippe
237 schema:givenName J.
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265120455.18
239 rdf:type schema:Person
240 sg:person.016350427407.47 schema:affiliation https://www.grid.ac/institutes/grid.10825.3e
241 schema:familyName Hansen
242 schema:givenName T.
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016350427407.47
244 rdf:type schema:Person
245 sg:person.016601014304.03 schema:affiliation https://www.grid.ac/institutes/grid.463845.8
246 schema:familyName Balkau
247 schema:givenName B.
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016601014304.03
249 rdf:type schema:Person
250 sg:person.0607263311.54 schema:affiliation https://www.grid.ac/institutes/grid.411162.1
251 schema:familyName Hadjadj
252 schema:givenName S.
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607263311.54
254 rdf:type schema:Person
255 sg:person.0630161707.73 schema:affiliation Na50e5ddf9fb1465496f83ed7082bdc6d
256 schema:familyName Bonnefond
257 schema:givenName A.
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630161707.73
259 rdf:type schema:Person
260 sg:person.0630750367.35 schema:affiliation https://www.grid.ac/institutes/grid.463845.8
261 schema:familyName Czernichow
262 schema:givenName S.
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630750367.35
264 rdf:type schema:Person
265 sg:person.0753626413.90 schema:affiliation https://www.grid.ac/institutes/grid.5254.6
266 schema:familyName Gjesing
267 schema:givenName A. P.
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753626413.90
269 rdf:type schema:Person
270 sg:person.0765447455.52 schema:affiliation https://www.grid.ac/institutes/grid.7048.b
271 schema:familyName Pedersen
272 schema:givenName O.
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765447455.52
274 rdf:type schema:Person
275 sg:pub.10.1007/s00125-007-0787-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001867567
276 https://doi.org/10.1007/s00125-007-0787-9
277 rdf:type schema:CreativeWork
278 sg:pub.10.1007/s00125-010-1799-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005493236
279 https://doi.org/10.1007/s00125-010-1799-4
280 rdf:type schema:CreativeWork
281 sg:pub.10.1007/s00125-011-2418-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046868199
282 https://doi.org/10.1007/s00125-011-2418-8
283 rdf:type schema:CreativeWork
284 sg:pub.10.1007/s001250051025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053160066
285 https://doi.org/10.1007/s001250051025
286 rdf:type schema:CreativeWork
287 sg:pub.10.1038/ng.1053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051356278
288 https://doi.org/10.1038/ng.1053
289 rdf:type schema:CreativeWork
290 sg:pub.10.1186/1471-2350-11-42 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028562489
291 https://doi.org/10.1186/1471-2350-11-42
292 rdf:type schema:CreativeWork
293 sg:pub.10.1186/1471-2350-9-45 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029731010
294 https://doi.org/10.1186/1471-2350-9-45
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1016/j.beem.2011.12.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002170600
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1073/pnas.0906474106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029676333
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1371/journal.pone.0037423 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048848905
301 rdf:type schema:CreativeWork
302 https://doi.org/10.2337/db06-0191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047529095
303 rdf:type schema:CreativeWork
304 https://doi.org/10.2337/db08-0906 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000524276
305 rdf:type schema:CreativeWork
306 https://doi.org/10.2337/db09-0652 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042129422
307 rdf:type schema:CreativeWork
308 https://doi.org/10.2337/dc11-0035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042123844
309 rdf:type schema:CreativeWork
310 https://www.grid.ac/institutes/grid.10825.3e schema:alternateName University of Southern Denmark
311 schema:name Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark
312 Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Denmark
313 The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
314 rdf:type schema:Organization
315 https://www.grid.ac/institutes/grid.411162.1 schema:alternateName Centre Hospitalier Universitaire de Poitiers
316 schema:name Centre Hospitalier Universitaire Poitiers, Department of Endocrinology and Diabetology, Poitiers, France
317 Inserm-U927 and Biotheque of the Clinical Investigation Centre of Poitiers (CIC0802), Poitiers, France
318 rdf:type schema:Organization
319 https://www.grid.ac/institutes/grid.411838.7 schema:alternateName University of Monastir
320 schema:name Research Unit of Biology and Genetics of Hematological and Auto-immune Diseases, Faculty of Pharmacy of Monastir, University of Monastir, Monastir, Tunisia
321 rdf:type schema:Organization
322 https://www.grid.ac/institutes/grid.413780.9 schema:alternateName Hôpital Avicenne
323 schema:name Department of Public Health, Avicenne Hospital, AP-HP, Bobigny, France
324 Inserm-U557, Institut National de la Recherche Agronomique-1125 Unit, Conservatoire National des Arts et Métiers, Centre de Recherches en Nutrition Humaine, Paris 13 University, Bobigny, France
325 rdf:type schema:Organization
326 https://www.grid.ac/institutes/grid.463845.8 schema:alternateName Centre for research in epidemiology and population health
327 schema:name Inserm-U1018, Centre for Research in Epidemiology and Population Health, Villejuif, France
328 Inserm-U780, Centre for Research in Epidemiology and Population Health, Villejuif, France
329 Paris-Sud 11 University, Orsay, France
330 University Versailles St-Quentin and Department of Nutrition, Ambroise Paré Hospital, Boulogne-Billancourt, France
331 rdf:type schema:Organization
332 https://www.grid.ac/institutes/grid.5254.6 schema:alternateName University of Copenhagen
333 schema:name The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
334 rdf:type schema:Organization
335 https://www.grid.ac/institutes/grid.7048.b schema:alternateName Aarhus University
336 schema:name Faculty of Health Sciences, University of Aarhus, Aarhus, Denmark
337 Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Denmark
338 The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
339 rdf:type schema:Organization
340 https://www.grid.ac/institutes/grid.7445.2 schema:alternateName Imperial College London
341 schema:name CNRS-UMR-8199, Lille Pasteur Institute, 1 rue du Professeur Calmette, 59019, Lille Cedex, France
342 Department of Genomic Medicine, School Of Public Health, Hammersmith Hospital, Imperial College London, Room E303, Burlington-Danes Building, Du Cane Road, W12 0NN, London, UK
343 Lille Nord de France University, Lille, France
344 rdf:type schema:Organization
345 https://www.grid.ac/institutes/grid.7452.4 schema:alternateName Paris Diderot University
346 schema:name Department of Endocrinology, Diabetology and Nutrition, Bichat-Claude Bernard University Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France
347 Inserm-U695, Paris 7 University, Paris, France
348 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...