Effects of short-term high-fat overfeeding on genome-wide DNA methylation in the skeletal muscle of healthy young men View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-12

AUTHORS

S. C. Jacobsen, C. Brøns, J. Bork-Jensen, R. Ribel-Madsen, B. Yang, E. Lara, E. Hall, V. Calvanese, E. Nilsson, S. W. Jørgensen, S. Mandrup, C. Ling, A. F. Fernandez, M. F. Fraga, P. Poulsen, A. Vaag

ABSTRACT

AIMS/HYPOTHESIS: Energy-dense diets that are high in fat are associated with a risk of metabolic diseases. The underlying molecular mechanisms could involve epigenetics, as recent data show altered DNA methylation of putative type 2 diabetes candidate genes in response to high-fat diets. We examined the effect of a short-term high-fat overfeeding (HFO) diet on genome-wide DNA methylation patterns in human skeletal muscle. METHODS: Skeletal muscle biopsies were obtained from 21 healthy young men after ingestion of a short-term HFO diet and a control diet, in a randomised crossover setting. DNA methylation was measured in 27,578 CpG sites/14,475 genes using Illumina's Infinium Bead Array. Candidate gene expression was determined by quantitative real-time PCR. RESULTS: HFO introduced widespread DNA methylation changes affecting 6,508 genes (45%), with a maximum methylation change of 13.0 percentage points. The HFO-induced methylation changes were only partly and non-significantly reversed after 6-8 weeks. Alterations in DNA methylation levels primarily affected genes involved in inflammation, the reproductive system and cancer. Few gene expression changes were observed and these had poor correlation to DNA methylation. CONCLUSIONS/INTERPRETATION: The genome-wide DNA methylation changes induced by the short-term HFO diet could have implications for our understanding of transient epigenetic regulation in humans and its contribution to the development of metabolic diseases. The slow reversibility suggests a methylation build-up with HFO, which over time may influence gene expression levels. More... »

PAGES

3341-3349

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00125-012-2717-8

DOI

http://dx.doi.org/10.1007/s00125-012-2717-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048429283

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22961225


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cation Transport Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CpG Islands", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cross-Over Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclin-Dependent Kinase Inhibitor p15", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclin-Dependent Kinase Inhibitor p16", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Methylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diet, High-Fat", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epigenesis, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heat-Shock Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Homeodomain Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin Resistance", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Muscle, Skeletal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Overnutrition", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-akt", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Real-Time Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Trans-Activators", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Zinc Transporter 8", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Rigshospitalet", 
          "id": "https://www.grid.ac/institutes/grid.475435.4", 
          "name": [
            "Steno Diabetes Center, Gentofte, Denmark", 
            "Department of Endocrinology, Rigshospitalet, Tagensvej 20, Sec. 7652, 2200, Copenhagen N, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jacobsen", 
        "givenName": "S. C.", 
        "id": "sg:person.0613100746.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613100746.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Rigshospitalet", 
          "id": "https://www.grid.ac/institutes/grid.475435.4", 
          "name": [
            "Steno Diabetes Center, Gentofte, Denmark", 
            "Department of Endocrinology, Rigshospitalet, Tagensvej 20, Sec. 7652, 2200, Copenhagen N, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Br\u00f8ns", 
        "givenName": "C.", 
        "id": "sg:person.01272030717.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272030717.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Rigshospitalet", 
          "id": "https://www.grid.ac/institutes/grid.475435.4", 
          "name": [
            "Steno Diabetes Center, Gentofte, Denmark", 
            "Department of Endocrinology, Rigshospitalet, Tagensvej 20, Sec. 7652, 2200, Copenhagen N, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bork-Jensen", 
        "givenName": "J.", 
        "id": "sg:person.0664633045.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664633045.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Steno Diabetes Center", 
          "id": "https://www.grid.ac/institutes/grid.419658.7", 
          "name": [
            "Steno Diabetes Center, Gentofte, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ribel-Madsen", 
        "givenName": "R.", 
        "id": "sg:person.0702666560.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702666560.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lund University", 
          "id": "https://www.grid.ac/institutes/grid.4514.4", 
          "name": [
            "Department of Clinical Sciences, Lund University, Malm\u00f6, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "B.", 
        "id": "sg:person.01173340517.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173340517.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Cancer Epigenetics Group, National Cancer Centre, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lara", 
        "givenName": "E.", 
        "id": "sg:person.0627032217.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627032217.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lund University", 
          "id": "https://www.grid.ac/institutes/grid.4514.4", 
          "name": [
            "Department of Clinical Sciences, Lund University, Malm\u00f6, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hall", 
        "givenName": "E.", 
        "id": "sg:person.01176503722.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176503722.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Cancer Epigenetics Group, National Cancer Centre, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Calvanese", 
        "givenName": "V.", 
        "id": "sg:person.01124254637.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124254637.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Steno Diabetes Center", 
          "id": "https://www.grid.ac/institutes/grid.419658.7", 
          "name": [
            "Steno Diabetes Center, Gentofte, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nilsson", 
        "givenName": "E.", 
        "id": "sg:person.0777101617.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777101617.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Rigshospitalet", 
          "id": "https://www.grid.ac/institutes/grid.475435.4", 
          "name": [
            "Steno Diabetes Center, Gentofte, Denmark", 
            "Department of Endocrinology, Rigshospitalet, Tagensvej 20, Sec. 7652, 2200, Copenhagen N, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "J\u00f8rgensen", 
        "givenName": "S. W.", 
        "id": "sg:person.01043363650.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043363650.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Southern Denmark", 
          "id": "https://www.grid.ac/institutes/grid.10825.3e", 
          "name": [
            "Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mandrup", 
        "givenName": "S.", 
        "id": "sg:person.0736676455.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736676455.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lund University", 
          "id": "https://www.grid.ac/institutes/grid.4514.4", 
          "name": [
            "Department of Clinical Sciences, Lund University, Malm\u00f6, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ling", 
        "givenName": "C.", 
        "id": "sg:person.01030343543.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030343543.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Cancer Epigenetics Group, National Cancer Centre, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fernandez", 
        "givenName": "A. F.", 
        "id": "sg:person.011265671100.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011265671100.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Cancer Epigenetics Group, National Cancer Centre, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fraga", 
        "givenName": "M. F.", 
        "id": "sg:person.01071503364.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071503364.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Steno Diabetes Center", 
          "id": "https://www.grid.ac/institutes/grid.419658.7", 
          "name": [
            "Steno Diabetes Center, Gentofte, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Poulsen", 
        "givenName": "P.", 
        "id": "sg:person.01156461353.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156461353.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Rigshospitalet", 
          "id": "https://www.grid.ac/institutes/grid.475435.4", 
          "name": [
            "Steno Diabetes Center, Gentofte, Denmark", 
            "Department of Endocrinology, Rigshospitalet, Tagensvej 20, Sec. 7652, 2200, Copenhagen N, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vaag", 
        "givenName": "A.", 
        "id": "sg:person.01040410202.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040410202.61"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81656-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000139913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.121164498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000700321"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1289/ehp.8700", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002161475"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddp353", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002439782"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cmet.2012.01.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004900499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11892-006-0031-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005854220", 
          "https://doi.org/10.1007/s11892-006-0031-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/301089a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007069955", 
          "https://doi.org/10.1038/301089a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.96.11.6107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007359638"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpendo.00729.2007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007411620"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0500398102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007497036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1909", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014231758", 
          "https://doi.org/10.1038/ng1909"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1909", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014231758", 
          "https://doi.org/10.1038/ng1909"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.50.7.1612", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014642406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/01635589609514457", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019926809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m403427200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020369341"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1000602", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020883389"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf03165964", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021943273", 
          "https://doi.org/10.1007/bf03165964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf03165964", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021943273", 
          "https://doi.org/10.1007/bf03165964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ogc.2009.03.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022792039"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0003294", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023146042"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2009.01.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024502694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/oby.2009.246", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024517052"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/oby.2009.246", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024517052"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0215(200002)9999:9999<::aid-ijc1053>3.0.co;2-t", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025467771"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/emboj.2011.503", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026023849"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.2009.169078", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029313556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0806560105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029731295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci30938", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032779998"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg2341", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036150552", 
          "https://doi.org/10.1038/nrg2341"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.286", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037289311", 
          "https://doi.org/10.1038/ng.286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/oby.2005.259", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041845434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cmet.2009.07.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044313576"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-007-0916-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046111705", 
          "https://doi.org/10.1007/s00125-007-0916-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-007-0916-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046111705", 
          "https://doi.org/10.1007/s00125-007-0916-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-007-0916-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046111705", 
          "https://doi.org/10.1007/s00125-007-0916-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0033290", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048620356"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1108190", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053161003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/11.12.2093", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059449337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1083557", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062448026"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2006-0640", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064248116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2009-2413", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064291832"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/me.2012-1004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064328790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082813891", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fasebj.12.11.949", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083306714"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-12", 
    "datePublishedReg": "2012-12-01", 
    "description": "AIMS/HYPOTHESIS: Energy-dense diets that are high in fat are associated with a risk of metabolic diseases. The underlying molecular mechanisms could involve epigenetics, as recent data show altered DNA methylation of putative type 2 diabetes candidate genes in response to high-fat diets. We examined the effect of a short-term high-fat overfeeding (HFO) diet on genome-wide DNA methylation patterns in human skeletal muscle.\nMETHODS: Skeletal muscle biopsies were obtained from 21 healthy young men after ingestion of a short-term HFO diet and a control diet, in a randomised crossover setting. DNA methylation was measured in 27,578 CpG sites/14,475 genes using Illumina's Infinium Bead Array. Candidate gene expression was determined by quantitative real-time PCR.\nRESULTS: HFO introduced widespread DNA methylation changes affecting 6,508 genes (45%), with a maximum methylation change of 13.0 percentage points. The HFO-induced methylation changes were only partly and non-significantly reversed after 6-8\u00a0weeks. Alterations in DNA methylation levels primarily affected genes involved in inflammation, the reproductive system and cancer. Few gene expression changes were observed and these had poor correlation to DNA methylation.\nCONCLUSIONS/INTERPRETATION: The genome-wide DNA methylation changes induced by the short-term HFO diet could have implications for our understanding of transient epigenetic regulation in humans and its contribution to the development of metabolic diseases. The slow reversibility suggests a methylation build-up with HFO, which over time may influence gene expression levels.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00125-012-2717-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1001482", 
        "issn": [
          "0012-186X", 
          "1432-0428"
        ], 
        "name": "Diabetologia", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "12", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "55"
      }
    ], 
    "name": "Effects of short-term high-fat overfeeding on genome-wide DNA methylation in the skeletal muscle of healthy young men", 
    "pagination": "3341-3349", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e6b5702e912094ed091d7a9f0ae14e6b772152e9071e316974c9536c81f13c3d"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22961225"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0006777"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00125-012-2717-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1048429283"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00125-012-2717-8", 
      "https://app.dimensions.ai/details/publication/pub.1048429283"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:16", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000348_0000000348/records_54301_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs00125-012-2717-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00125-012-2717-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00125-012-2717-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00125-012-2717-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00125-012-2717-8'


 

This table displays all metadata directly associated to this object as RDF triples.

407 TRIPLES      21 PREDICATES      91 URIs      44 LITERALS      32 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00125-012-2717-8 schema:about N014f3b3b25f84959bdc16446274f2472
2 N020e9a9bfe8641e69832f6f9359db875
3 N0a90fdfe32a6460d82f7c9c46a49e340
4 N0fb3015508724639a88b54da1874c189
5 N1ea5f40a4c204feab05c3e01a45cba1d
6 N21f537fd54154ad6b96eace55cf63a70
7 N3c24ea6c981b4955b5c0c2360ea78323
8 N3c6a51957a364b6fad95b21db7b905fa
9 N7a689744ecb34ad09984282aa259e642
10 N803675ed78d544f8b5eff80627ae4320
11 N8bcfbe4ec80a47d5991b4f1f04fb3eae
12 N8c2663fa3ebf4953ab5d2f46be5c2c8f
13 N9831533c6e2b4b8ea06b7e368f875e65
14 Na097599580a24a21b1d68c6d0667a424
15 Nabd07ff180504d48bb9069ee5820cccd
16 Nb730d973efa146fea8aa95e9f34a58cb
17 Nb99a5d7f4ca84fe2a1b3504f10893239
18 Nd2cec41add764e31a61ba0420d6b9fe8
19 Nd6acdfc6ee9248b5b39a9cd4cdfaccbd
20 Ne8184660c0a548289a030996d798f9ed
21 Nef7c11d71ea445c2aeb59b8cacd60f2c
22 Nf05a5f3421504c11a3603e0a33627a49
23 Nf81c0bacc9254b7b9503a36b02abd070
24 anzsrc-for:06
25 anzsrc-for:0604
26 schema:author N8d87da7f45de4553a02b545f99dbd7ba
27 schema:citation sg:pub.10.1007/bf03165964
28 sg:pub.10.1007/s00125-007-0916-5
29 sg:pub.10.1007/s11892-006-0031-x
30 sg:pub.10.1038/301089a0
31 sg:pub.10.1038/ng.286
32 sg:pub.10.1038/ng1909
33 sg:pub.10.1038/nrg2341
34 https://app.dimensions.ai/details/publication/pub.1082813891
35 https://doi.org/10.1002/1097-0215(200002)9999:9999<::aid-ijc1053>3.0.co;2-t
36 https://doi.org/10.1016/j.cmet.2009.07.011
37 https://doi.org/10.1016/j.cmet.2012.01.001
38 https://doi.org/10.1016/j.molcel.2009.01.015
39 https://doi.org/10.1016/j.ogc.2009.03.002
40 https://doi.org/10.1016/s0092-8674(00)81656-6
41 https://doi.org/10.1038/emboj.2011.503
42 https://doi.org/10.1038/oby.2005.259
43 https://doi.org/10.1038/oby.2009.246
44 https://doi.org/10.1073/pnas.0500398102
45 https://doi.org/10.1073/pnas.0806560105
46 https://doi.org/10.1073/pnas.121164498
47 https://doi.org/10.1073/pnas.96.11.6107
48 https://doi.org/10.1074/jbc.m403427200
49 https://doi.org/10.1080/01635589609514457
50 https://doi.org/10.1093/carcin/11.12.2093
51 https://doi.org/10.1093/hmg/ddp353
52 https://doi.org/10.1096/fasebj.12.11.949
53 https://doi.org/10.1113/jphysiol.2009.169078
54 https://doi.org/10.1126/science.1083557
55 https://doi.org/10.1126/science.1108190
56 https://doi.org/10.1152/ajpendo.00729.2007
57 https://doi.org/10.1172/jci30938
58 https://doi.org/10.1210/en.2006-0640
59 https://doi.org/10.1210/jc.2009-2413
60 https://doi.org/10.1210/me.2012-1004
61 https://doi.org/10.1289/ehp.8700
62 https://doi.org/10.1371/journal.pgen.1000602
63 https://doi.org/10.1371/journal.pone.0003294
64 https://doi.org/10.1371/journal.pone.0033290
65 https://doi.org/10.2337/diabetes.50.7.1612
66 schema:datePublished 2012-12
67 schema:datePublishedReg 2012-12-01
68 schema:description AIMS/HYPOTHESIS: Energy-dense diets that are high in fat are associated with a risk of metabolic diseases. The underlying molecular mechanisms could involve epigenetics, as recent data show altered DNA methylation of putative type 2 diabetes candidate genes in response to high-fat diets. We examined the effect of a short-term high-fat overfeeding (HFO) diet on genome-wide DNA methylation patterns in human skeletal muscle. METHODS: Skeletal muscle biopsies were obtained from 21 healthy young men after ingestion of a short-term HFO diet and a control diet, in a randomised crossover setting. DNA methylation was measured in 27,578 CpG sites/14,475 genes using Illumina's Infinium Bead Array. Candidate gene expression was determined by quantitative real-time PCR. RESULTS: HFO introduced widespread DNA methylation changes affecting 6,508 genes (45%), with a maximum methylation change of 13.0 percentage points. The HFO-induced methylation changes were only partly and non-significantly reversed after 6-8 weeks. Alterations in DNA methylation levels primarily affected genes involved in inflammation, the reproductive system and cancer. Few gene expression changes were observed and these had poor correlation to DNA methylation. CONCLUSIONS/INTERPRETATION: The genome-wide DNA methylation changes induced by the short-term HFO diet could have implications for our understanding of transient epigenetic regulation in humans and its contribution to the development of metabolic diseases. The slow reversibility suggests a methylation build-up with HFO, which over time may influence gene expression levels.
69 schema:genre research_article
70 schema:inLanguage en
71 schema:isAccessibleForFree true
72 schema:isPartOf N9a893d3fb8374c819409a80fdc04e5b8
73 Nc5cc294b0c344adab9824ea4f88339d1
74 sg:journal.1001482
75 schema:name Effects of short-term high-fat overfeeding on genome-wide DNA methylation in the skeletal muscle of healthy young men
76 schema:pagination 3341-3349
77 schema:productId N7f0457ec8ed04029a81ebee665b01407
78 N8673d560862347b8aace5e40b56ba5b9
79 Nb0ccc6a24927488bbdedd9e80cc8d169
80 Nc8f89c04ed3b4fd799a3b998f3fa53ac
81 Ne3ec1cd8963c41f5833c452713dc8948
82 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048429283
83 https://doi.org/10.1007/s00125-012-2717-8
84 schema:sdDatePublished 2019-04-11T10:16
85 schema:sdLicense https://scigraph.springernature.com/explorer/license/
86 schema:sdPublisher Nac389fd612884a2792025e2dd31b8941
87 schema:url https://link.springer.com/10.1007%2Fs00125-012-2717-8
88 sgo:license sg:explorer/license/
89 sgo:sdDataset articles
90 rdf:type schema:ScholarlyArticle
91 N014f3b3b25f84959bdc16446274f2472 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Insulin Resistance
93 rdf:type schema:DefinedTerm
94 N020e9a9bfe8641e69832f6f9359db875 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Proto-Oncogene Proteins c-akt
96 rdf:type schema:DefinedTerm
97 N0a90fdfe32a6460d82f7c9c46a49e340 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Humans
99 rdf:type schema:DefinedTerm
100 N0fb3015508724639a88b54da1874c189 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Epigenesis, Genetic
102 rdf:type schema:DefinedTerm
103 N1ea5f40a4c204feab05c3e01a45cba1d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Gene Expression
105 rdf:type schema:DefinedTerm
106 N21f537fd54154ad6b96eace55cf63a70 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Diet, High-Fat
108 rdf:type schema:DefinedTerm
109 N32eeb95e5c704ea4b51db71ac4f5db6c rdf:first sg:person.0702666560.07
110 rdf:rest Na26634bca2f447beb285702374c53b6a
111 N3921140c08a84f6cb8a72b14222a760b schema:name Cancer Epigenetics Group, National Cancer Centre, Madrid, Spain
112 rdf:type schema:Organization
113 N398920ed58a84679a4ceaf49d9ced0e8 rdf:first sg:person.0777101617.95
114 rdf:rest N5e93647245b646899af20ba10221aea6
115 N3c24ea6c981b4955b5c0c2360ea78323 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Trans-Activators
117 rdf:type schema:DefinedTerm
118 N3c6a51957a364b6fad95b21db7b905fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Cyclin-Dependent Kinase Inhibitor p16
120 rdf:type schema:DefinedTerm
121 N41fc951bc1a74839830718e116ec7fc5 schema:name Cancer Epigenetics Group, National Cancer Centre, Madrid, Spain
122 rdf:type schema:Organization
123 N5e93647245b646899af20ba10221aea6 rdf:first sg:person.01043363650.97
124 rdf:rest Nfa17d2e7c3be448c9322f5837be130a7
125 N60b158d57a2a4e39a7dd9a1887095da9 rdf:first sg:person.011265671100.75
126 rdf:rest Na0f08e2a9d324f2ca4366da7b4fd1ce0
127 N7a689744ecb34ad09984282aa259e642 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Male
129 rdf:type schema:DefinedTerm
130 N7f0457ec8ed04029a81ebee665b01407 schema:name pubmed_id
131 schema:value 22961225
132 rdf:type schema:PropertyValue
133 N803675ed78d544f8b5eff80627ae4320 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Homeodomain Proteins
135 rdf:type schema:DefinedTerm
136 N81b2eef096e34e89903d7cc0533b557f rdf:first sg:person.01176503722.47
137 rdf:rest Ne192fcda2c71448696f67283133da494
138 N8673d560862347b8aace5e40b56ba5b9 schema:name readcube_id
139 schema:value e6b5702e912094ed091d7a9f0ae14e6b772152e9071e316974c9536c81f13c3d
140 rdf:type schema:PropertyValue
141 N8bcfbe4ec80a47d5991b4f1f04fb3eae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name DNA Methylation
143 rdf:type schema:DefinedTerm
144 N8c2663fa3ebf4953ab5d2f46be5c2c8f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name CpG Islands
146 rdf:type schema:DefinedTerm
147 N8d87da7f45de4553a02b545f99dbd7ba rdf:first sg:person.0613100746.31
148 rdf:rest Nec7db250b5ee4b259b25ca21cabd7496
149 N920fb453dc6948eb847ce62223ba7b20 schema:name Cancer Epigenetics Group, National Cancer Centre, Madrid, Spain
150 rdf:type schema:Organization
151 N93c8cd5053f8473285c9d728c0196217 rdf:first sg:person.01030343543.98
152 rdf:rest N60b158d57a2a4e39a7dd9a1887095da9
153 N961e9602a1da4934adc688384516a7bb rdf:first sg:person.01156461353.18
154 rdf:rest Na4f98b0d65fd42c888408402be781acd
155 N9831533c6e2b4b8ea06b7e368f875e65 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Heat-Shock Proteins
157 rdf:type schema:DefinedTerm
158 N9a893d3fb8374c819409a80fdc04e5b8 schema:volumeNumber 55
159 rdf:type schema:PublicationVolume
160 Na097599580a24a21b1d68c6d0667a424 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Young Adult
162 rdf:type schema:DefinedTerm
163 Na0f08e2a9d324f2ca4366da7b4fd1ce0 rdf:first sg:person.01071503364.28
164 rdf:rest N961e9602a1da4934adc688384516a7bb
165 Na26634bca2f447beb285702374c53b6a rdf:first sg:person.01173340517.15
166 rdf:rest Nd1af747cdd9e48689dd99ccf01fe2e8b
167 Na4f98b0d65fd42c888408402be781acd rdf:first sg:person.01040410202.61
168 rdf:rest rdf:nil
169 Nabd07ff180504d48bb9069ee5820cccd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Muscle, Skeletal
171 rdf:type schema:DefinedTerm
172 Nac389fd612884a2792025e2dd31b8941 schema:name Springer Nature - SN SciGraph project
173 rdf:type schema:Organization
174 Nb0ccc6a24927488bbdedd9e80cc8d169 schema:name nlm_unique_id
175 schema:value 0006777
176 rdf:type schema:PropertyValue
177 Nb730d973efa146fea8aa95e9f34a58cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
179 rdf:type schema:DefinedTerm
180 Nb99a5d7f4ca84fe2a1b3504f10893239 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Transcription Factors
182 rdf:type schema:DefinedTerm
183 Nc5cc294b0c344adab9824ea4f88339d1 schema:issueNumber 12
184 rdf:type schema:PublicationIssue
185 Nc8f89c04ed3b4fd799a3b998f3fa53ac schema:name dimensions_id
186 schema:value pub.1048429283
187 rdf:type schema:PropertyValue
188 Nd1af747cdd9e48689dd99ccf01fe2e8b rdf:first sg:person.0627032217.37
189 rdf:rest N81b2eef096e34e89903d7cc0533b557f
190 Nd2cec41add764e31a61ba0420d6b9fe8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Cation Transport Proteins
192 rdf:type schema:DefinedTerm
193 Nd47c5bd84dc04c4ca6dd149a9f278a76 rdf:first sg:person.0664633045.78
194 rdf:rest N32eeb95e5c704ea4b51db71ac4f5db6c
195 Nd6acdfc6ee9248b5b39a9cd4cdfaccbd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name Cyclin-Dependent Kinase Inhibitor p15
197 rdf:type schema:DefinedTerm
198 Ne192fcda2c71448696f67283133da494 rdf:first sg:person.01124254637.10
199 rdf:rest N398920ed58a84679a4ceaf49d9ced0e8
200 Ne3ec1cd8963c41f5833c452713dc8948 schema:name doi
201 schema:value 10.1007/s00125-012-2717-8
202 rdf:type schema:PropertyValue
203 Ne6c3b44163af4c2fa7d6bddae8b164d3 schema:name Cancer Epigenetics Group, National Cancer Centre, Madrid, Spain
204 rdf:type schema:Organization
205 Ne8184660c0a548289a030996d798f9ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Real-Time Polymerase Chain Reaction
207 rdf:type schema:DefinedTerm
208 Nec7db250b5ee4b259b25ca21cabd7496 rdf:first sg:person.01272030717.02
209 rdf:rest Nd47c5bd84dc04c4ca6dd149a9f278a76
210 Nef7c11d71ea445c2aeb59b8cacd60f2c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
211 schema:name Zinc Transporter 8
212 rdf:type schema:DefinedTerm
213 Nf05a5f3421504c11a3603e0a33627a49 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
214 schema:name Cross-Over Studies
215 rdf:type schema:DefinedTerm
216 Nf81c0bacc9254b7b9503a36b02abd070 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
217 schema:name Overnutrition
218 rdf:type schema:DefinedTerm
219 Nfa17d2e7c3be448c9322f5837be130a7 rdf:first sg:person.0736676455.94
220 rdf:rest N93c8cd5053f8473285c9d728c0196217
221 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
222 schema:name Biological Sciences
223 rdf:type schema:DefinedTerm
224 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
225 schema:name Genetics
226 rdf:type schema:DefinedTerm
227 sg:journal.1001482 schema:issn 0012-186X
228 1432-0428
229 schema:name Diabetologia
230 rdf:type schema:Periodical
231 sg:person.01030343543.98 schema:affiliation https://www.grid.ac/institutes/grid.4514.4
232 schema:familyName Ling
233 schema:givenName C.
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030343543.98
235 rdf:type schema:Person
236 sg:person.01040410202.61 schema:affiliation https://www.grid.ac/institutes/grid.475435.4
237 schema:familyName Vaag
238 schema:givenName A.
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040410202.61
240 rdf:type schema:Person
241 sg:person.01043363650.97 schema:affiliation https://www.grid.ac/institutes/grid.475435.4
242 schema:familyName Jørgensen
243 schema:givenName S. W.
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043363650.97
245 rdf:type schema:Person
246 sg:person.01071503364.28 schema:affiliation N41fc951bc1a74839830718e116ec7fc5
247 schema:familyName Fraga
248 schema:givenName M. F.
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071503364.28
250 rdf:type schema:Person
251 sg:person.01124254637.10 schema:affiliation N3921140c08a84f6cb8a72b14222a760b
252 schema:familyName Calvanese
253 schema:givenName V.
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124254637.10
255 rdf:type schema:Person
256 sg:person.011265671100.75 schema:affiliation N920fb453dc6948eb847ce62223ba7b20
257 schema:familyName Fernandez
258 schema:givenName A. F.
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011265671100.75
260 rdf:type schema:Person
261 sg:person.01156461353.18 schema:affiliation https://www.grid.ac/institutes/grid.419658.7
262 schema:familyName Poulsen
263 schema:givenName P.
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156461353.18
265 rdf:type schema:Person
266 sg:person.01173340517.15 schema:affiliation https://www.grid.ac/institutes/grid.4514.4
267 schema:familyName Yang
268 schema:givenName B.
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173340517.15
270 rdf:type schema:Person
271 sg:person.01176503722.47 schema:affiliation https://www.grid.ac/institutes/grid.4514.4
272 schema:familyName Hall
273 schema:givenName E.
274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176503722.47
275 rdf:type schema:Person
276 sg:person.01272030717.02 schema:affiliation https://www.grid.ac/institutes/grid.475435.4
277 schema:familyName Brøns
278 schema:givenName C.
279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272030717.02
280 rdf:type schema:Person
281 sg:person.0613100746.31 schema:affiliation https://www.grid.ac/institutes/grid.475435.4
282 schema:familyName Jacobsen
283 schema:givenName S. C.
284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613100746.31
285 rdf:type schema:Person
286 sg:person.0627032217.37 schema:affiliation Ne6c3b44163af4c2fa7d6bddae8b164d3
287 schema:familyName Lara
288 schema:givenName E.
289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627032217.37
290 rdf:type schema:Person
291 sg:person.0664633045.78 schema:affiliation https://www.grid.ac/institutes/grid.475435.4
292 schema:familyName Bork-Jensen
293 schema:givenName J.
294 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664633045.78
295 rdf:type schema:Person
296 sg:person.0702666560.07 schema:affiliation https://www.grid.ac/institutes/grid.419658.7
297 schema:familyName Ribel-Madsen
298 schema:givenName R.
299 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702666560.07
300 rdf:type schema:Person
301 sg:person.0736676455.94 schema:affiliation https://www.grid.ac/institutes/grid.10825.3e
302 schema:familyName Mandrup
303 schema:givenName S.
304 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736676455.94
305 rdf:type schema:Person
306 sg:person.0777101617.95 schema:affiliation https://www.grid.ac/institutes/grid.419658.7
307 schema:familyName Nilsson
308 schema:givenName E.
309 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777101617.95
310 rdf:type schema:Person
311 sg:pub.10.1007/bf03165964 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021943273
312 https://doi.org/10.1007/bf03165964
313 rdf:type schema:CreativeWork
314 sg:pub.10.1007/s00125-007-0916-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046111705
315 https://doi.org/10.1007/s00125-007-0916-5
316 rdf:type schema:CreativeWork
317 sg:pub.10.1007/s11892-006-0031-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005854220
318 https://doi.org/10.1007/s11892-006-0031-x
319 rdf:type schema:CreativeWork
320 sg:pub.10.1038/301089a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007069955
321 https://doi.org/10.1038/301089a0
322 rdf:type schema:CreativeWork
323 sg:pub.10.1038/ng.286 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037289311
324 https://doi.org/10.1038/ng.286
325 rdf:type schema:CreativeWork
326 sg:pub.10.1038/ng1909 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014231758
327 https://doi.org/10.1038/ng1909
328 rdf:type schema:CreativeWork
329 sg:pub.10.1038/nrg2341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036150552
330 https://doi.org/10.1038/nrg2341
331 rdf:type schema:CreativeWork
332 https://app.dimensions.ai/details/publication/pub.1082813891 schema:CreativeWork
333 https://doi.org/10.1002/1097-0215(200002)9999:9999<::aid-ijc1053>3.0.co;2-t schema:sameAs https://app.dimensions.ai/details/publication/pub.1025467771
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1016/j.cmet.2009.07.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044313576
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1016/j.cmet.2012.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004900499
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1016/j.molcel.2009.01.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024502694
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1016/j.ogc.2009.03.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022792039
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1016/s0092-8674(00)81656-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000139913
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1038/emboj.2011.503 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026023849
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1038/oby.2005.259 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041845434
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1038/oby.2009.246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024517052
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1073/pnas.0500398102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007497036
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1073/pnas.0806560105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029731295
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1073/pnas.121164498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000700321
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1073/pnas.96.11.6107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007359638
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1074/jbc.m403427200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020369341
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1080/01635589609514457 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019926809
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1093/carcin/11.12.2093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059449337
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1093/hmg/ddp353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002439782
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1096/fasebj.12.11.949 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083306714
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1113/jphysiol.2009.169078 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029313556
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1126/science.1083557 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062448026
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1126/science.1108190 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053161003
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1152/ajpendo.00729.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007411620
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1172/jci30938 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032779998
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1210/en.2006-0640 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064248116
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1210/jc.2009-2413 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064291832
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1210/me.2012-1004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064328790
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1289/ehp.8700 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002161475
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1371/journal.pgen.1000602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020883389
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1371/journal.pone.0003294 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023146042
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1371/journal.pone.0033290 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048620356
392 rdf:type schema:CreativeWork
393 https://doi.org/10.2337/diabetes.50.7.1612 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014642406
394 rdf:type schema:CreativeWork
395 https://www.grid.ac/institutes/grid.10825.3e schema:alternateName University of Southern Denmark
396 schema:name Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark
397 rdf:type schema:Organization
398 https://www.grid.ac/institutes/grid.419658.7 schema:alternateName Steno Diabetes Center
399 schema:name Steno Diabetes Center, Gentofte, Denmark
400 rdf:type schema:Organization
401 https://www.grid.ac/institutes/grid.4514.4 schema:alternateName Lund University
402 schema:name Department of Clinical Sciences, Lund University, Malmö, Sweden
403 rdf:type schema:Organization
404 https://www.grid.ac/institutes/grid.475435.4 schema:alternateName Rigshospitalet
405 schema:name Department of Endocrinology, Rigshospitalet, Tagensvej 20, Sec. 7652, 2200, Copenhagen N, Denmark
406 Steno Diabetes Center, Gentofte, Denmark
407 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...