Similar patterns of myocardial metabolism and perfusion in patients with type 2 diabetes and heart disease of ischaemic and non-ischaemic ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-07-01

AUTHORS

S. Masi, R. Lautamäki, L. Guiducci, P. Di Cecco, C. Porciello, S. Pardini, M. A. Morales, V. Chubuchny, P. A. Salvadori, M. Emdin, A. M. Sironi, J. Knuuti, D. Neglia, P. Nuutila, E. Ferrannini, P. Iozzo

ABSTRACT

Aims/hypothesisType 2 diabetes and insulin resistance are often associated with the co-occurrence of coronary atherosclerosis and cardiac dysfunction. The aim of this study was to define the independent relationships between left ventricular dysfunction or ischaemia and patterns of myocardial perfusion and metabolism in type 2 diabetes.MethodsTwenty-four type 2 diabetic patients—12 with coronary artery disease (CAD) and preserved left ventricular function and 12 with non-ischaemic heart failure (HF)—were enrolled in a cross-sectional study. Positron emission tomography (PET) was used to assess myocardial blood flow (MBF) at rest, after pharmacological stress and under euglycaemic hyperinsulinaemia. Insulin-mediated myocardial glucose disposal was determined with 2-deoxy-2-[18F]fluoroglucose PET.ResultsThere was no difference in myocardial glucose uptake (MGU) between the healthy myocardium of CAD patients and the dysfunctional myocardium of HF patients. MGU was strongly influenced by levels of systemic insulin resistance in both groups (CAD, r = 0.85, p = 0.005; HF, r = 0.77, p = 0.01). In HF patients, there was an inverse association between MGU and the coronary flow reserve (r = −0.434, p = 0.0115). A similar relationship was observed in non-ischaemic segments of CAD patients. Hyperinsulinaemia increased MBF to a similar extent in the non-ischaemic myocardial of CAD and HF patients.Conclusions/interpretationIn type 2 diabetes, similar metabolic and perfusion patterns can be detected in the non-ischaemic regions of CAD patients with normal cardiac function and in the dysfunctional non-ischaemic myocardium of HF patients. This suggests that insulin resistance, rather than diagnosis of ischaemia or left ventricular dysfunction, affects the metabolism and perfusion features of patients with type 2 diabetes. More... »

PAGES

2494-2500

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00125-012-2631-0

DOI

http://dx.doi.org/10.1007/s00125-012-2631-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014730579

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22752026


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Coronary Artery Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Coronary Circulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cross-Sectional Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diabetes Mellitus, Type 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diabetic Angiopathies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorodeoxyglucose F18", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glucose", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glucose Clamp Technique", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin Resistance", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myocardial Ischemia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Positron-Emission Tomography", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiopharmaceuticals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ventricular Dysfunction, Left", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Institute of Clinical Physiology, National Research Council, Via Moruzzi, 1 56124, Pisa, Italy", 
          "id": "http://www.grid.ac/institutes/grid.418529.3", 
          "name": [
            "Department of Internal Medicine, University of Pisa, Pisa, Italy", 
            "Institute of Clinical Physiology, National Research Council, Via Moruzzi, 1 56124, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Masi", 
        "givenName": "S.", 
        "id": "sg:person.0665004305.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665004305.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland", 
          "id": "http://www.grid.ac/institutes/grid.410552.7", 
          "name": [
            "Turku PET Centre, University of Turku, Turku, Finland", 
            "Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lautam\u00e4ki", 
        "givenName": "R.", 
        "id": "sg:person.0617216003.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617216003.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Clinical Physiology, National Research Council, Via Moruzzi, 1 56124, Pisa, Italy", 
          "id": "http://www.grid.ac/institutes/grid.418529.3", 
          "name": [
            "Institute of Clinical Physiology, National Research Council, Via Moruzzi, 1 56124, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guiducci", 
        "givenName": "L.", 
        "id": "sg:person.01341223752.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341223752.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gabriele Monasterio Foundation, Pisa, Italy", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Gabriele Monasterio Foundation, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Di Cecco", 
        "givenName": "P.", 
        "id": "sg:person.01161707341.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161707341.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gabriele Monasterio Foundation, Pisa, Italy", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Gabriele Monasterio Foundation, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Porciello", 
        "givenName": "C.", 
        "id": "sg:person.0713172325.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713172325.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Clinical Physiology, National Research Council, Via Moruzzi, 1 56124, Pisa, Italy", 
          "id": "http://www.grid.ac/institutes/grid.418529.3", 
          "name": [
            "Institute of Clinical Physiology, National Research Council, Via Moruzzi, 1 56124, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pardini", 
        "givenName": "S.", 
        "id": "sg:person.01114410052.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114410052.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Clinical Physiology, National Research Council, Via Moruzzi, 1 56124, Pisa, Italy", 
          "id": "http://www.grid.ac/institutes/grid.418529.3", 
          "name": [
            "Institute of Clinical Physiology, National Research Council, Via Moruzzi, 1 56124, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morales", 
        "givenName": "M. A.", 
        "id": "sg:person.01167046254.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167046254.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gabriele Monasterio Foundation, Pisa, Italy", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Gabriele Monasterio Foundation, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chubuchny", 
        "givenName": "V.", 
        "id": "sg:person.0663733052.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663733052.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Clinical Physiology, National Research Council, Via Moruzzi, 1 56124, Pisa, Italy", 
          "id": "http://www.grid.ac/institutes/grid.418529.3", 
          "name": [
            "Institute of Clinical Physiology, National Research Council, Via Moruzzi, 1 56124, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Salvadori", 
        "givenName": "P. A.", 
        "id": "sg:person.01243004261.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243004261.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gabriele Monasterio Foundation, Pisa, Italy", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Gabriele Monasterio Foundation, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Emdin", 
        "givenName": "M.", 
        "id": "sg:person.0721171576.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721171576.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Clinical Physiology, National Research Council, Via Moruzzi, 1 56124, Pisa, Italy", 
          "id": "http://www.grid.ac/institutes/grid.418529.3", 
          "name": [
            "Institute of Clinical Physiology, National Research Council, Via Moruzzi, 1 56124, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sironi", 
        "givenName": "A. M.", 
        "id": "sg:person.0667053567.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667053567.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland", 
          "id": "http://www.grid.ac/institutes/grid.410552.7", 
          "name": [
            "Turku PET Centre, University of Turku, Turku, Finland", 
            "Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Knuuti", 
        "givenName": "J.", 
        "id": "sg:person.01163336756.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163336756.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gabriele Monasterio Foundation, Pisa, Italy", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Institute of Clinical Physiology, National Research Council, Via Moruzzi, 1 56124, Pisa, Italy", 
            "Gabriele Monasterio Foundation, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Neglia", 
        "givenName": "D.", 
        "id": "sg:person.01343641641.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343641641.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland", 
          "id": "http://www.grid.ac/institutes/grid.410552.7", 
          "name": [
            "Turku PET Centre, University of Turku, Turku, Finland", 
            "Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nuutila", 
        "givenName": "P.", 
        "id": "sg:person.0763376117.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763376117.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Clinical Physiology, National Research Council, Via Moruzzi, 1 56124, Pisa, Italy", 
          "id": "http://www.grid.ac/institutes/grid.418529.3", 
          "name": [
            "Department of Internal Medicine, University of Pisa, Pisa, Italy", 
            "Institute of Clinical Physiology, National Research Council, Via Moruzzi, 1 56124, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ferrannini", 
        "givenName": "E.", 
        "id": "sg:person.014646544462.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014646544462.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Turku PET Centre, University of Turku, Turku, Finland", 
          "id": "http://www.grid.ac/institutes/grid.470895.7", 
          "name": [
            "Institute of Clinical Physiology, National Research Council, Via Moruzzi, 1 56124, Pisa, Italy", 
            "Turku PET Centre, University of Turku, Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iozzo", 
        "givenName": "P.", 
        "id": "sg:person.01225611056.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225611056.51"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1016/s1071-3581(97)90061-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023219716", 
          "https://doi.org/10.1016/s1071-3581(97)90061-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-002-0917-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010807995", 
          "https://doi.org/10.1007/s00125-002-0917-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1067/mnc.2000.102678", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043922019", 
          "https://doi.org/10.1067/mnc.2000.102678"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-07-01", 
    "datePublishedReg": "2012-07-01", 
    "description": "Aims/hypothesisType 2 diabetes and insulin resistance are often associated with the co-occurrence of coronary atherosclerosis and cardiac dysfunction. The aim of this study was to define the independent relationships between left ventricular dysfunction or ischaemia and patterns of myocardial perfusion and metabolism in type 2 diabetes.MethodsTwenty-four type 2 diabetic patients\u201412 with coronary artery disease (CAD) and preserved left ventricular function and 12 with non-ischaemic heart failure (HF)\u2014were enrolled in a cross-sectional study. Positron emission tomography (PET) was used to assess myocardial blood flow (MBF) at rest, after pharmacological stress and under euglycaemic hyperinsulinaemia. Insulin-mediated myocardial glucose disposal was determined with 2-deoxy-2-[18F]fluoroglucose PET.ResultsThere was no difference in myocardial glucose uptake (MGU) between the healthy myocardium of CAD patients and the dysfunctional myocardium of HF patients. MGU was strongly influenced by levels of systemic insulin resistance in both groups (CAD, r\u2009=\u20090.85, p\u2009=\u20090.005; HF, r\u2009=\u20090.77, p\u2009=\u20090.01). In HF patients, there was an inverse association between MGU and the coronary flow reserve (r\u2009=\u2009\u22120.434, p\u2009=\u20090.0115). A similar relationship was observed in non-ischaemic segments of CAD patients. Hyperinsulinaemia increased MBF to a similar extent in the non-ischaemic myocardial of CAD and HF patients.Conclusions/interpretationIn type 2 diabetes, similar metabolic and perfusion patterns can be detected in the non-ischaemic regions of CAD patients with normal cardiac function and in the dysfunctional non-ischaemic myocardium of HF patients. This suggests that insulin resistance, rather than diagnosis of ischaemia or left ventricular dysfunction, affects the metabolism and perfusion features of patients with type 2 diabetes.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00125-012-2631-0", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1001482", 
        "issn": [
          "0012-186X", 
          "1432-0428"
        ], 
        "name": "Diabetologia", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "9", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "55"
      }
    ], 
    "keywords": [
      "myocardial glucose uptake", 
      "coronary artery disease", 
      "type 2 diabetes", 
      "myocardial blood flow", 
      "positron emission tomography", 
      "HF patients", 
      "CAD patients", 
      "insulin resistance", 
      "ventricular dysfunction", 
      "non-ischemic heart failure", 
      "Aims/hypothesisType 2 diabetes", 
      "non-ischemic origin", 
      "left ventricular dysfunction", 
      "left ventricular function", 
      "systemic insulin resistance", 
      "coronary flow reserve", 
      "cross-sectional study", 
      "normal cardiac function", 
      "non-ischemic myocardium", 
      "non-ischemic regions", 
      "non-ischemic segments", 
      "diagnosis of ischaemia", 
      "patients 12", 
      "coronary atherosclerosis", 
      "artery disease", 
      "heart failure", 
      "ventricular function", 
      "cardiac dysfunction", 
      "pharmacological stress", 
      "dysfunctional myocardium", 
      "perfusion patterns", 
      "euglycaemic hyperinsulinaemia", 
      "glucose disposal", 
      "inverse association", 
      "cardiac function", 
      "heart disease", 
      "flow reserve", 
      "myocardial metabolism", 
      "blood flow", 
      "myocardial perfusion", 
      "patients", 
      "type 2", 
      "diabetes", 
      "emission tomography", 
      "independent relationship", 
      "healthy myocardium", 
      "dysfunction", 
      "glucose uptake", 
      "myocardium", 
      "perfusion features", 
      "similar extent", 
      "hyperinsulinaemia", 
      "ischaemia", 
      "perfusion", 
      "disease", 
      "metabolism", 
      "similar pattern", 
      "atherosclerosis", 
      "ResultsThere", 
      "Myocardial", 
      "insulin", 
      "diagnosis", 
      "similar relationship", 
      "tomography", 
      "study", 
      "resistance", 
      "association", 
      "failure", 
      "group", 
      "patterns", 
      "aim", 
      "uptake", 
      "function", 
      "rest", 
      "levels", 
      "differences", 
      "relationship", 
      "segments", 
      "extent", 
      "stress", 
      "reserves", 
      "origin", 
      "features", 
      "region", 
      "flow", 
      "disposal", 
      "hypothesisType 2 diabetes", 
      "MethodsTwenty-four type 2 diabetic patients\u201412", 
      "type 2 diabetic patients\u201412", 
      "diabetic patients\u201412", 
      "myocardial glucose disposal", 
      "non-ischaemic myocardial", 
      "Conclusions/interpretationIn type 2 diabetes", 
      "interpretationIn type 2 diabetes", 
      "dysfunctional non-ischaemic myocardium"
    ], 
    "name": "Similar patterns of myocardial metabolism and perfusion in patients with type 2 diabetes and heart disease of ischaemic and non-ischaemic origin", 
    "pagination": "2494-2500", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1014730579"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00125-012-2631-0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22752026"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00125-012-2631-0", 
      "https://app.dimensions.ai/details/publication/pub.1014730579"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:27", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_574.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00125-012-2631-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00125-012-2631-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00125-012-2631-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00125-012-2631-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00125-012-2631-0'


 

This table displays all metadata directly associated to this object as RDF triples.

359 TRIPLES      22 PREDICATES      142 URIs      130 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00125-012-2631-0 schema:about N00dea7935f58426daeb7f1907c220e47
2 N162eb69d83f343829107fb9e6024037c
3 N164da702a1364c4bbf7bc25692900ede
4 N2c3b3a078785417db0a2992e60257455
5 N4284b6ad573e415fa6880afc71d88cc4
6 N4c59bc9644934500a11e912424c0d496
7 N588ba29795c040deb3fc4c5bbbc96b67
8 N8fc20c4e7ecf422484bdf64ca27068ef
9 N918a6665bb1d47f6a45c81dafd06d025
10 Nad7763574ac649d697c7e04a81da56dc
11 Nc192b1acfb6a4b2fb58ff96f8e70b63d
12 Nd572c2f8339746c9a47a15cb5a0f92ca
13 Ndf06d13661974bf5bf715744eba311e7
14 Ne0d02a7c1e6843f5bba4fa57a32a1fc2
15 Ne20ddd560913466085735cf71bfb36f1
16 Ne256de82230146a5af14506fb078fd05
17 Nf9ffe90f5e604388846da126a84fc673
18 anzsrc-for:11
19 anzsrc-for:1102
20 anzsrc-for:1103
21 schema:author N1b427f1a78b643c19d20dc521ecab37c
22 schema:citation sg:pub.10.1007/s00125-002-0917-3
23 sg:pub.10.1016/s1071-3581(97)90061-1
24 sg:pub.10.1067/mnc.2000.102678
25 schema:datePublished 2012-07-01
26 schema:datePublishedReg 2012-07-01
27 schema:description Aims/hypothesisType 2 diabetes and insulin resistance are often associated with the co-occurrence of coronary atherosclerosis and cardiac dysfunction. The aim of this study was to define the independent relationships between left ventricular dysfunction or ischaemia and patterns of myocardial perfusion and metabolism in type 2 diabetes.MethodsTwenty-four type 2 diabetic patients—12 with coronary artery disease (CAD) and preserved left ventricular function and 12 with non-ischaemic heart failure (HF)—were enrolled in a cross-sectional study. Positron emission tomography (PET) was used to assess myocardial blood flow (MBF) at rest, after pharmacological stress and under euglycaemic hyperinsulinaemia. Insulin-mediated myocardial glucose disposal was determined with 2-deoxy-2-[18F]fluoroglucose PET.ResultsThere was no difference in myocardial glucose uptake (MGU) between the healthy myocardium of CAD patients and the dysfunctional myocardium of HF patients. MGU was strongly influenced by levels of systemic insulin resistance in both groups (CAD, r = 0.85, p = 0.005; HF, r = 0.77, p = 0.01). In HF patients, there was an inverse association between MGU and the coronary flow reserve (r = −0.434, p = 0.0115). A similar relationship was observed in non-ischaemic segments of CAD patients. Hyperinsulinaemia increased MBF to a similar extent in the non-ischaemic myocardial of CAD and HF patients.Conclusions/interpretationIn type 2 diabetes, similar metabolic and perfusion patterns can be detected in the non-ischaemic regions of CAD patients with normal cardiac function and in the dysfunctional non-ischaemic myocardium of HF patients. This suggests that insulin resistance, rather than diagnosis of ischaemia or left ventricular dysfunction, affects the metabolism and perfusion features of patients with type 2 diabetes.
28 schema:genre article
29 schema:inLanguage en
30 schema:isAccessibleForFree true
31 schema:isPartOf N3e1e2a026ee44ab588e1d0b2e7a45f67
32 Nd990ee5710894cdcb2711692936f1d6c
33 sg:journal.1001482
34 schema:keywords Aims/hypothesisType 2 diabetes
35 CAD patients
36 Conclusions/interpretationIn type 2 diabetes
37 HF patients
38 MethodsTwenty-four type 2 diabetic patients—12
39 Myocardial
40 ResultsThere
41 aim
42 artery disease
43 association
44 atherosclerosis
45 blood flow
46 cardiac dysfunction
47 cardiac function
48 coronary artery disease
49 coronary atherosclerosis
50 coronary flow reserve
51 cross-sectional study
52 diabetes
53 diabetic patients—12
54 diagnosis
55 diagnosis of ischaemia
56 differences
57 disease
58 disposal
59 dysfunction
60 dysfunctional myocardium
61 dysfunctional non-ischaemic myocardium
62 emission tomography
63 euglycaemic hyperinsulinaemia
64 extent
65 failure
66 features
67 flow
68 flow reserve
69 function
70 glucose disposal
71 glucose uptake
72 group
73 healthy myocardium
74 heart disease
75 heart failure
76 hyperinsulinaemia
77 hypothesisType 2 diabetes
78 independent relationship
79 insulin
80 insulin resistance
81 interpretationIn type 2 diabetes
82 inverse association
83 ischaemia
84 left ventricular dysfunction
85 left ventricular function
86 levels
87 metabolism
88 myocardial blood flow
89 myocardial glucose disposal
90 myocardial glucose uptake
91 myocardial metabolism
92 myocardial perfusion
93 myocardium
94 non-ischaemic myocardial
95 non-ischemic heart failure
96 non-ischemic myocardium
97 non-ischemic origin
98 non-ischemic regions
99 non-ischemic segments
100 normal cardiac function
101 origin
102 patients
103 patients 12
104 patterns
105 perfusion
106 perfusion features
107 perfusion patterns
108 pharmacological stress
109 positron emission tomography
110 region
111 relationship
112 reserves
113 resistance
114 rest
115 segments
116 similar extent
117 similar pattern
118 similar relationship
119 stress
120 study
121 systemic insulin resistance
122 tomography
123 type 2
124 type 2 diabetes
125 type 2 diabetic patients—12
126 uptake
127 ventricular dysfunction
128 ventricular function
129 schema:name Similar patterns of myocardial metabolism and perfusion in patients with type 2 diabetes and heart disease of ischaemic and non-ischaemic origin
130 schema:pagination 2494-2500
131 schema:productId N033b19b36d614dde893468d3e697e5e8
132 N90a15ee5c6714dba9c2e8d9bf35ad8b9
133 Nfa2446998fc941fe9cb20d193fcb8b2d
134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014730579
135 https://doi.org/10.1007/s00125-012-2631-0
136 schema:sdDatePublished 2021-12-01T19:27
137 schema:sdLicense https://scigraph.springernature.com/explorer/license/
138 schema:sdPublisher N9fb2d2741dd74a5a868b396293be046e
139 schema:url https://doi.org/10.1007/s00125-012-2631-0
140 sgo:license sg:explorer/license/
141 sgo:sdDataset articles
142 rdf:type schema:ScholarlyArticle
143 N00dea7935f58426daeb7f1907c220e47 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Diabetic Angiopathies
145 rdf:type schema:DefinedTerm
146 N033b19b36d614dde893468d3e697e5e8 schema:name doi
147 schema:value 10.1007/s00125-012-2631-0
148 rdf:type schema:PropertyValue
149 N0a46ad7e2427410785b07d66dcc63a92 rdf:first sg:person.01161707341.44
150 rdf:rest Ncce24880656b43e7b0f73faf203e3712
151 N162eb69d83f343829107fb9e6024037c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Radiopharmaceuticals
153 rdf:type schema:DefinedTerm
154 N164da702a1364c4bbf7bc25692900ede schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Insulin Resistance
156 rdf:type schema:DefinedTerm
157 N1b427f1a78b643c19d20dc521ecab37c rdf:first sg:person.0665004305.36
158 rdf:rest N6095ce480793403ba2ae949c486f638c
159 N23a615bfdd784b709877ecef5a3b02bc rdf:first sg:person.01114410052.42
160 rdf:rest N3d87e9cf9b74444b98122c068e6d952d
161 N28b6895e139f4e048b8c4bb56c37fe68 rdf:first sg:person.01243004261.81
162 rdf:rest N53ee5b1f70a24132a86112f12c85ce01
163 N2c3b3a078785417db0a2992e60257455 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Male
165 rdf:type schema:DefinedTerm
166 N2c9114daecb240a3bfdb490e7fbc6146 rdf:first sg:person.014646544462.45
167 rdf:rest Ndf9e9ed133594ec4b4f197d63d3e1993
168 N30600233da8b46909d22e7bf82dac2d2 rdf:first sg:person.0763376117.17
169 rdf:rest N2c9114daecb240a3bfdb490e7fbc6146
170 N3c925c6394cd47d1b325271a15ec2ba6 rdf:first sg:person.0667053567.52
171 rdf:rest Nbae5c890e8244b759ff925944474241a
172 N3d87e9cf9b74444b98122c068e6d952d rdf:first sg:person.01167046254.16
173 rdf:rest N7c33772e34574c2586ad5d1dbdfb191e
174 N3e1e2a026ee44ab588e1d0b2e7a45f67 schema:volumeNumber 55
175 rdf:type schema:PublicationVolume
176 N4284b6ad573e415fa6880afc71d88cc4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Aged
178 rdf:type schema:DefinedTerm
179 N4c59bc9644934500a11e912424c0d496 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Humans
181 rdf:type schema:DefinedTerm
182 N53ee5b1f70a24132a86112f12c85ce01 rdf:first sg:person.0721171576.02
183 rdf:rest N3c925c6394cd47d1b325271a15ec2ba6
184 N588ba29795c040deb3fc4c5bbbc96b67 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Coronary Artery Disease
186 rdf:type schema:DefinedTerm
187 N6095ce480793403ba2ae949c486f638c rdf:first sg:person.0617216003.83
188 rdf:rest Nd8790b5a1ac8441d8eeb227d8fa9f96c
189 N7814734659264bf89b010c6f06a763f0 rdf:first sg:person.01343641641.38
190 rdf:rest N30600233da8b46909d22e7bf82dac2d2
191 N7c33772e34574c2586ad5d1dbdfb191e rdf:first sg:person.0663733052.18
192 rdf:rest N28b6895e139f4e048b8c4bb56c37fe68
193 N8fc20c4e7ecf422484bdf64ca27068ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Glucose Clamp Technique
195 rdf:type schema:DefinedTerm
196 N90a15ee5c6714dba9c2e8d9bf35ad8b9 schema:name pubmed_id
197 schema:value 22752026
198 rdf:type schema:PropertyValue
199 N918a6665bb1d47f6a45c81dafd06d025 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Diabetes Mellitus, Type 2
201 rdf:type schema:DefinedTerm
202 N9fb2d2741dd74a5a868b396293be046e schema:name Springer Nature - SN SciGraph project
203 rdf:type schema:Organization
204 Nad7763574ac649d697c7e04a81da56dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name Female
206 rdf:type schema:DefinedTerm
207 Nbae5c890e8244b759ff925944474241a rdf:first sg:person.01163336756.79
208 rdf:rest N7814734659264bf89b010c6f06a763f0
209 Nc192b1acfb6a4b2fb58ff96f8e70b63d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
210 schema:name Fluorodeoxyglucose F18
211 rdf:type schema:DefinedTerm
212 Ncce24880656b43e7b0f73faf203e3712 rdf:first sg:person.0713172325.20
213 rdf:rest N23a615bfdd784b709877ecef5a3b02bc
214 Nd572c2f8339746c9a47a15cb5a0f92ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
215 schema:name Myocardial Ischemia
216 rdf:type schema:DefinedTerm
217 Nd8790b5a1ac8441d8eeb227d8fa9f96c rdf:first sg:person.01341223752.45
218 rdf:rest N0a46ad7e2427410785b07d66dcc63a92
219 Nd990ee5710894cdcb2711692936f1d6c schema:issueNumber 9
220 rdf:type schema:PublicationIssue
221 Ndf06d13661974bf5bf715744eba311e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
222 schema:name Positron-Emission Tomography
223 rdf:type schema:DefinedTerm
224 Ndf9e9ed133594ec4b4f197d63d3e1993 rdf:first sg:person.01225611056.51
225 rdf:rest rdf:nil
226 Ne0d02a7c1e6843f5bba4fa57a32a1fc2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
227 schema:name Glucose
228 rdf:type schema:DefinedTerm
229 Ne20ddd560913466085735cf71bfb36f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
230 schema:name Coronary Circulation
231 rdf:type schema:DefinedTerm
232 Ne256de82230146a5af14506fb078fd05 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
233 schema:name Cross-Sectional Studies
234 rdf:type schema:DefinedTerm
235 Nf9ffe90f5e604388846da126a84fc673 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
236 schema:name Ventricular Dysfunction, Left
237 rdf:type schema:DefinedTerm
238 Nfa2446998fc941fe9cb20d193fcb8b2d schema:name dimensions_id
239 schema:value pub.1014730579
240 rdf:type schema:PropertyValue
241 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
242 schema:name Medical and Health Sciences
243 rdf:type schema:DefinedTerm
244 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
245 schema:name Cardiorespiratory Medicine and Haematology
246 rdf:type schema:DefinedTerm
247 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
248 schema:name Clinical Sciences
249 rdf:type schema:DefinedTerm
250 sg:journal.1001482 schema:issn 0012-186X
251 1432-0428
252 schema:name Diabetologia
253 schema:publisher Springer Nature
254 rdf:type schema:Periodical
255 sg:person.01114410052.42 schema:affiliation grid-institutes:grid.418529.3
256 schema:familyName Pardini
257 schema:givenName S.
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114410052.42
259 rdf:type schema:Person
260 sg:person.01161707341.44 schema:affiliation grid-institutes:None
261 schema:familyName Di Cecco
262 schema:givenName P.
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161707341.44
264 rdf:type schema:Person
265 sg:person.01163336756.79 schema:affiliation grid-institutes:grid.410552.7
266 schema:familyName Knuuti
267 schema:givenName J.
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163336756.79
269 rdf:type schema:Person
270 sg:person.01167046254.16 schema:affiliation grid-institutes:grid.418529.3
271 schema:familyName Morales
272 schema:givenName M. A.
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167046254.16
274 rdf:type schema:Person
275 sg:person.01225611056.51 schema:affiliation grid-institutes:grid.470895.7
276 schema:familyName Iozzo
277 schema:givenName P.
278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225611056.51
279 rdf:type schema:Person
280 sg:person.01243004261.81 schema:affiliation grid-institutes:grid.418529.3
281 schema:familyName Salvadori
282 schema:givenName P. A.
283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243004261.81
284 rdf:type schema:Person
285 sg:person.01341223752.45 schema:affiliation grid-institutes:grid.418529.3
286 schema:familyName Guiducci
287 schema:givenName L.
288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341223752.45
289 rdf:type schema:Person
290 sg:person.01343641641.38 schema:affiliation grid-institutes:None
291 schema:familyName Neglia
292 schema:givenName D.
293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343641641.38
294 rdf:type schema:Person
295 sg:person.014646544462.45 schema:affiliation grid-institutes:grid.418529.3
296 schema:familyName Ferrannini
297 schema:givenName E.
298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014646544462.45
299 rdf:type schema:Person
300 sg:person.0617216003.83 schema:affiliation grid-institutes:grid.410552.7
301 schema:familyName Lautamäki
302 schema:givenName R.
303 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617216003.83
304 rdf:type schema:Person
305 sg:person.0663733052.18 schema:affiliation grid-institutes:None
306 schema:familyName Chubuchny
307 schema:givenName V.
308 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663733052.18
309 rdf:type schema:Person
310 sg:person.0665004305.36 schema:affiliation grid-institutes:grid.418529.3
311 schema:familyName Masi
312 schema:givenName S.
313 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665004305.36
314 rdf:type schema:Person
315 sg:person.0667053567.52 schema:affiliation grid-institutes:grid.418529.3
316 schema:familyName Sironi
317 schema:givenName A. M.
318 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667053567.52
319 rdf:type schema:Person
320 sg:person.0713172325.20 schema:affiliation grid-institutes:None
321 schema:familyName Porciello
322 schema:givenName C.
323 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713172325.20
324 rdf:type schema:Person
325 sg:person.0721171576.02 schema:affiliation grid-institutes:None
326 schema:familyName Emdin
327 schema:givenName M.
328 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721171576.02
329 rdf:type schema:Person
330 sg:person.0763376117.17 schema:affiliation grid-institutes:grid.410552.7
331 schema:familyName Nuutila
332 schema:givenName P.
333 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763376117.17
334 rdf:type schema:Person
335 sg:pub.10.1007/s00125-002-0917-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010807995
336 https://doi.org/10.1007/s00125-002-0917-3
337 rdf:type schema:CreativeWork
338 sg:pub.10.1016/s1071-3581(97)90061-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023219716
339 https://doi.org/10.1016/s1071-3581(97)90061-1
340 rdf:type schema:CreativeWork
341 sg:pub.10.1067/mnc.2000.102678 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043922019
342 https://doi.org/10.1067/mnc.2000.102678
343 rdf:type schema:CreativeWork
344 grid-institutes:None schema:alternateName Gabriele Monasterio Foundation, Pisa, Italy
345 schema:name Gabriele Monasterio Foundation, Pisa, Italy
346 Institute of Clinical Physiology, National Research Council, Via Moruzzi, 1 56124, Pisa, Italy
347 rdf:type schema:Organization
348 grid-institutes:grid.410552.7 schema:alternateName Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland
349 schema:name Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland
350 Turku PET Centre, University of Turku, Turku, Finland
351 rdf:type schema:Organization
352 grid-institutes:grid.418529.3 schema:alternateName Institute of Clinical Physiology, National Research Council, Via Moruzzi, 1 56124, Pisa, Italy
353 schema:name Department of Internal Medicine, University of Pisa, Pisa, Italy
354 Institute of Clinical Physiology, National Research Council, Via Moruzzi, 1 56124, Pisa, Italy
355 rdf:type schema:Organization
356 grid-institutes:grid.470895.7 schema:alternateName Turku PET Centre, University of Turku, Turku, Finland
357 schema:name Institute of Clinical Physiology, National Research Council, Via Moruzzi, 1 56124, Pisa, Italy
358 Turku PET Centre, University of Turku, Turku, Finland
359 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...