Soy protein isoflavones differentially regulate liver X receptor isoforms to modulate lipid metabolism and cholesterol transport in the liver and ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-06-29

AUTHORS

M. González-Granillo, K. R. Steffensen, O. Granados, N. Torres, M. Korach-André, V. Ortíz, C. Aguilar-Salinas, T. Jakobsson, A. Díaz-Villaseñor, A. Loza-Valdes, R. Hernandez-Pando, J.-Å. Gustafsson, A. R. Tovar

ABSTRACT

Aims/hypothesisLiver X receptor (LXR)α regulates the genes involved in cholesterol, fatty acid and glucose metabolism. Soy protein (SP) consumption reduces the hepatic accumulation of cholesterol and triacylglycerol, and improves insulin sensitivity. However, it is not known whether these effects are mediated via LXRα. We therefore investigated whether the consumption of SP regulates metabolic changes in cholesterol metabolism and insulin sensitivity via LXRα.MethodsWild-type (WT) and Lxrα−/− (Lxrα, also known as Nr1h3) mice were fed an SP diet with or without cholesterol for 28 days. The expression of LXRα target genes was measured in liver and intestine, as were hepatic lipid content and faecal bile acid concentration. Oral glucose and insulin tolerance tests were also performed. Hepatocytes were used to study the effect of isoflavones on LXR activity.ResultsThe livers of WT and Lxrα−/− mice fed an SP high-cholesterol diet showed less steatosis than those fed casein. The SP diet increased the expression of the ATP-binding cassette (ABC) sub-family genes Abca1, Abcg5 and Abcg8 in the liver and intestine, as well as increasing total faecal bile acid excretion and insulin sensitivity in WT mice compared with mice fed a casein diet. However, these effects of SP were not observed in Lxrα−/− mice. The SP isoflavone, genistein, repressed the activation of LXRα target genes by T0901317, whereas it stimulated the activation of LXRβ target genes. The AMP-activated protein kinase inhibitor, compound C, had the opposite effects to those of genistein.Conclusions/interpretationOur results suggest that SP isoflavones stimulate the phosphorylation of LXRα or LXRβ, resulting in different biological effects for each LXR isoform. More... »

PAGES

2469-2478

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00125-012-2599-9

DOI

http://dx.doi.org/10.1007/s00125-012-2599-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000205138

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22739758


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1114", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Paediatrics and Reproductive Medicine", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Public Health and Health Services", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bile Acids and Salts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biological Transport", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diet, High-Fat", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hepatocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin Resistance", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intestinal Mucosa", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Isoflavones", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lipid Metabolism", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver X Receptors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Transgenic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Orphan Nuclear Receptors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Isoforms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Soybean Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Departamento Fisiolog\u00eda de la Nutrici\u00f3n, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n, Vasco de Quiroga No 15, Tlalpan, 14000, M\u00e9xico D.F., M\u00e9xico", 
          "id": "http://www.grid.ac/institutes/grid.416850.e", 
          "name": [
            "Departamento Fisiolog\u00eda de la Nutrici\u00f3n, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n, Vasco de Quiroga No 15, Tlalpan, 14000, M\u00e9xico D.F., M\u00e9xico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gonz\u00e1lez-Granillo", 
        "givenName": "M.", 
        "id": "sg:person.01171206375.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171206375.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden", 
          "id": "http://www.grid.ac/institutes/grid.4714.6", 
          "name": [
            "Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Steffensen", 
        "givenName": "K. R.", 
        "id": "sg:person.01023216447.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023216447.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Departamento Fisiolog\u00eda de la Nutrici\u00f3n, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n, Vasco de Quiroga No 15, Tlalpan, 14000, M\u00e9xico D.F., M\u00e9xico", 
          "id": "http://www.grid.ac/institutes/grid.416850.e", 
          "name": [
            "Departamento Fisiolog\u00eda de la Nutrici\u00f3n, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n, Vasco de Quiroga No 15, Tlalpan, 14000, M\u00e9xico D.F., M\u00e9xico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Granados", 
        "givenName": "O.", 
        "id": "sg:person.0764507546.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764507546.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Departamento Fisiolog\u00eda de la Nutrici\u00f3n, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n, Vasco de Quiroga No 15, Tlalpan, 14000, M\u00e9xico D.F., M\u00e9xico", 
          "id": "http://www.grid.ac/institutes/grid.416850.e", 
          "name": [
            "Departamento Fisiolog\u00eda de la Nutrici\u00f3n, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n, Vasco de Quiroga No 15, Tlalpan, 14000, M\u00e9xico D.F., M\u00e9xico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Torres", 
        "givenName": "N.", 
        "id": "sg:person.01030204005.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030204005.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden", 
          "id": "http://www.grid.ac/institutes/grid.4714.6", 
          "name": [
            "Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Korach-Andr\u00e9", 
        "givenName": "M.", 
        "id": "sg:person.01111750304.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111750304.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Departamento Fisiolog\u00eda de la Nutrici\u00f3n, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n, Vasco de Quiroga No 15, Tlalpan, 14000, M\u00e9xico D.F., M\u00e9xico", 
          "id": "http://www.grid.ac/institutes/grid.416850.e", 
          "name": [
            "Departamento Fisiolog\u00eda de la Nutrici\u00f3n, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n, Vasco de Quiroga No 15, Tlalpan, 14000, M\u00e9xico D.F., M\u00e9xico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ort\u00edz", 
        "givenName": "V.", 
        "id": "sg:person.01175215510.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175215510.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico", 
          "id": "http://www.grid.ac/institutes/grid.416850.e", 
          "name": [
            "Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aguilar-Salinas", 
        "givenName": "C.", 
        "id": "sg:person.0757112137.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757112137.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden", 
          "id": "http://www.grid.ac/institutes/grid.4714.6", 
          "name": [
            "Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jakobsson", 
        "givenName": "T.", 
        "id": "sg:person.0602273316.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602273316.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Departamento Fisiolog\u00eda de la Nutrici\u00f3n, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n, Vasco de Quiroga No 15, Tlalpan, 14000, M\u00e9xico D.F., M\u00e9xico", 
          "id": "http://www.grid.ac/institutes/grid.416850.e", 
          "name": [
            "Departamento Fisiolog\u00eda de la Nutrici\u00f3n, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n, Vasco de Quiroga No 15, Tlalpan, 14000, M\u00e9xico D.F., M\u00e9xico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "D\u00edaz-Villase\u00f1or", 
        "givenName": "A.", 
        "id": "sg:person.0602145746.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602145746.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Departamento Fisiolog\u00eda de la Nutrici\u00f3n, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n, Vasco de Quiroga No 15, Tlalpan, 14000, M\u00e9xico D.F., M\u00e9xico", 
          "id": "http://www.grid.ac/institutes/grid.416850.e", 
          "name": [
            "Departamento Fisiolog\u00eda de la Nutrici\u00f3n, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n, Vasco de Quiroga No 15, Tlalpan, 14000, M\u00e9xico D.F., M\u00e9xico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Loza-Valdes", 
        "givenName": "A.", 
        "id": "sg:person.012203705203.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012203705203.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Experimental Pathology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico", 
          "id": "http://www.grid.ac/institutes/grid.416850.e", 
          "name": [
            "Department of Experimental Pathology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hernandez-Pando", 
        "givenName": "R.", 
        "id": "sg:person.01176732673.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176732673.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, TX, USA", 
          "id": "http://www.grid.ac/institutes/grid.266436.3", 
          "name": [
            "Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden", 
            "Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gustafsson", 
        "givenName": "J.-\u00c5.", 
        "id": "sg:person.0671057475.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671057475.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Departamento Fisiolog\u00eda de la Nutrici\u00f3n, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n, Vasco de Quiroga No 15, Tlalpan, 14000, M\u00e9xico D.F., M\u00e9xico", 
          "id": "http://www.grid.ac/institutes/grid.416850.e", 
          "name": [
            "Departamento Fisiolog\u00eda de la Nutrici\u00f3n, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n, Vasco de Quiroga No 15, Tlalpan, 14000, M\u00e9xico D.F., M\u00e9xico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tovar", 
        "givenName": "A. R.", 
        "id": "sg:person.01163022605.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163022605.39"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nature05488", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006317191", 
          "https://doi.org/10.1038/nature05488"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02533049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014512637", 
          "https://doi.org/10.1007/bf02533049"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-06-29", 
    "datePublishedReg": "2012-06-29", 
    "description": "Aims/hypothesisLiver X receptor (LXR)\u03b1 regulates the genes involved in cholesterol, fatty acid and glucose metabolism. Soy protein (SP) consumption reduces the hepatic accumulation of cholesterol and triacylglycerol, and improves insulin sensitivity. However, it is not known whether these effects are mediated via LXR\u03b1. We therefore investigated whether the consumption of SP regulates metabolic changes in cholesterol metabolism and insulin sensitivity via LXR\u03b1.MethodsWild-type (WT) and Lxr\u03b1\u2212/\u2212 (Lxr\u03b1, also known as Nr1h3) mice were fed an SP diet with or without cholesterol for 28\u00a0days. The expression of LXR\u03b1 target genes was measured in liver and intestine, as were hepatic lipid content and faecal bile acid concentration. Oral glucose and insulin tolerance tests were also performed. Hepatocytes were used to study the effect of isoflavones on LXR activity.ResultsThe livers of WT and Lxr\u03b1\u2212/\u2212 mice fed an SP high-cholesterol diet showed less steatosis than those fed casein. The SP diet increased the expression of the ATP-binding cassette (ABC) sub-family genes Abca1, Abcg5 and Abcg8 in the liver and intestine, as well as increasing total faecal bile acid excretion and insulin sensitivity in WT mice compared with mice fed a casein diet. However, these effects of SP were not observed in Lxr\u03b1\u2212/\u2212 mice. The SP isoflavone, genistein, repressed the activation of LXR\u03b1 target genes by T0901317, whereas it stimulated the activation of LXR\u03b2 target genes. The AMP-activated protein kinase inhibitor, compound C, had the opposite effects to those of genistein.Conclusions/interpretationOur results suggest that SP isoflavones stimulate the phosphorylation of LXR\u03b1 or LXR\u03b2, resulting in different biological effects for each LXR isoform.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00125-012-2599-9", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1001482", 
        "issn": [
          "0012-186X", 
          "1432-0428"
        ], 
        "name": "Diabetologia", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "9", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "55"
      }
    ], 
    "keywords": [
      "insulin sensitivity", 
      "LXR\u03b1 target genes", 
      "fecal bile acid concentration", 
      "total fecal bile acid excretion", 
      "fecal bile acid excretion", 
      "soy protein isoflavones", 
      "soy protein consumption", 
      "bile acid excretion", 
      "insulin tolerance test", 
      "high-cholesterol diet", 
      "hepatic lipid content", 
      "bile acid concentrations", 
      "Conclusions/interpretationOur results", 
      "SP diet", 
      "effects of isoflavones", 
      "livers of WT", 
      "consumption of sP", 
      "less steatosis", 
      "oral glucose", 
      "WT mice", 
      "tolerance test", 
      "target genes", 
      "hepatic accumulation", 
      "MethodsWild-type", 
      "acid excretion", 
      "glucose metabolism", 
      "cholesterol metabolism", 
      "LXR activity", 
      "casein diet", 
      "interpretationOur results", 
      "lipid metabolism", 
      "different biological effects", 
      "mice", 
      "receptor isoforms", 
      "cholesterol transport", 
      "metabolic changes", 
      "genes ABCA1", 
      "liver", 
      "kinase inhibitors", 
      "fed casein", 
      "LXR\u03b1", 
      "effect of SP", 
      "cholesterol", 
      "intestine", 
      "diet", 
      "protein consumption", 
      "compound C", 
      "biological effects", 
      "isoflavones", 
      "fatty acids", 
      "metabolism", 
      "protein kinase inhibitors", 
      "genistein", 
      "opposite effect", 
      "activation", 
      "lipid content", 
      "steatosis", 
      "T0901317", 
      "expression", 
      "acid concentration", 
      "excretion", 
      "ABCA1", 
      "LXR", 
      "LXR\u03b2", 
      "ABCG5", 
      "genes", 
      "receptors", 
      "sensitivity", 
      "effect", 
      "AMP", 
      "hepatocytes", 
      "inhibitors", 
      "days", 
      "glucose", 
      "triacylglycerols", 
      "isoforms", 
      "phosphorylation", 
      "ATP", 
      "activity", 
      "consumption", 
      "accumulation", 
      "test", 
      "casein", 
      "acid", 
      "changes", 
      "concentration", 
      "results", 
      "wt", 
      "sp", 
      "content", 
      "transport", 
      "Aims/hypothesisLiver X receptor", 
      "hypothesisLiver X receptor", 
      "X receptor", 
      "SP high-cholesterol diet", 
      "cassette (ABC) sub-family genes Abca1", 
      "sub-family genes Abca1", 
      "SP isoflavone", 
      "LXR\u03b2 target genes", 
      "phosphorylation of LXR\u03b1", 
      "protein isoflavones", 
      "liver X receptor isoforms", 
      "X receptor isoforms"
    ], 
    "name": "Soy protein isoflavones differentially regulate liver X receptor isoforms to modulate lipid metabolism and cholesterol transport in the liver and intestine in mice", 
    "pagination": "2469-2478", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1000205138"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00125-012-2599-9"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22739758"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00125-012-2599-9", 
      "https://app.dimensions.ai/details/publication/pub.1000205138"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-11-01T18:17", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211101/entities/gbq_results/article/article_559.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00125-012-2599-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00125-012-2599-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00125-012-2599-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00125-012-2599-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00125-012-2599-9'


 

This table displays all metadata directly associated to this object as RDF triples.

348 TRIPLES      22 PREDICATES      151 URIs      139 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00125-012-2599-9 schema:about N0645f343dc004225bc641fee79c0a8ca
2 N101a9256653549239c74479bde9f4140
3 N1a78594961f144e99c2edac1c4cc1353
4 N1ac6ccc3ff7c4155aa65b636111efc88
5 N38a87f093b3b4180beff93670151476c
6 N3b798e4faca94618836163b8452d6c6b
7 N425f08fb2aae4d71a5178d724ecf4ad8
8 N5da13ce664904263b0b066052ad007b2
9 N66781fde9c4c485b8767e2808b7d06c4
10 N695397fb5b4e40178361e233f9889a48
11 N6f20b6bc4dee4d5ba39031673d88e196
12 N8438a9c5ba9d475ea1aac604903d8eb4
13 N86c47be09c764a899ea37266312715ec
14 Nc3a6c042ffa14e539917f75f302b0dcb
15 Nc56960ab917f44c4b40ab112314b0dfc
16 Nca74b33592f04d3ea2ecbd8094260856
17 Nd40e49af1f3c4b5dad75a31db1764ad3
18 Ne7f91b7c3f2c444581cb467f7cce1a11
19 anzsrc-for:11
20 anzsrc-for:1103
21 anzsrc-for:1114
22 anzsrc-for:1117
23 schema:author N947d16be88c14bbda811edd25c75d831
24 schema:citation sg:pub.10.1007/bf02533049
25 sg:pub.10.1038/nature05488
26 schema:datePublished 2012-06-29
27 schema:datePublishedReg 2012-06-29
28 schema:description Aims/hypothesisLiver X receptor (LXR)α regulates the genes involved in cholesterol, fatty acid and glucose metabolism. Soy protein (SP) consumption reduces the hepatic accumulation of cholesterol and triacylglycerol, and improves insulin sensitivity. However, it is not known whether these effects are mediated via LXRα. We therefore investigated whether the consumption of SP regulates metabolic changes in cholesterol metabolism and insulin sensitivity via LXRα.MethodsWild-type (WT) and Lxrα−/− (Lxrα, also known as Nr1h3) mice were fed an SP diet with or without cholesterol for 28 days. The expression of LXRα target genes was measured in liver and intestine, as were hepatic lipid content and faecal bile acid concentration. Oral glucose and insulin tolerance tests were also performed. Hepatocytes were used to study the effect of isoflavones on LXR activity.ResultsThe livers of WT and Lxrα−/− mice fed an SP high-cholesterol diet showed less steatosis than those fed casein. The SP diet increased the expression of the ATP-binding cassette (ABC) sub-family genes Abca1, Abcg5 and Abcg8 in the liver and intestine, as well as increasing total faecal bile acid excretion and insulin sensitivity in WT mice compared with mice fed a casein diet. However, these effects of SP were not observed in Lxrα−/− mice. The SP isoflavone, genistein, repressed the activation of LXRα target genes by T0901317, whereas it stimulated the activation of LXRβ target genes. The AMP-activated protein kinase inhibitor, compound C, had the opposite effects to those of genistein.Conclusions/interpretationOur results suggest that SP isoflavones stimulate the phosphorylation of LXRα or LXRβ, resulting in different biological effects for each LXR isoform.
29 schema:genre article
30 schema:inLanguage en
31 schema:isAccessibleForFree true
32 schema:isPartOf N11e53b4f732144f7bb7aa3bfdaae01cb
33 Na26d25c2a7944c37a98893dbbb980c32
34 sg:journal.1001482
35 schema:keywords ABCA1
36 ABCG5
37 AMP
38 ATP
39 Aims/hypothesisLiver X receptor
40 Conclusions/interpretationOur results
41 LXR
42 LXR activity
43 LXRα
44 LXRα target genes
45 LXRβ
46 LXRβ target genes
47 MethodsWild-type
48 SP diet
49 SP high-cholesterol diet
50 SP isoflavone
51 T0901317
52 WT mice
53 X receptor
54 X receptor isoforms
55 accumulation
56 acid
57 acid concentration
58 acid excretion
59 activation
60 activity
61 bile acid concentrations
62 bile acid excretion
63 biological effects
64 casein
65 casein diet
66 cassette (ABC) sub-family genes Abca1
67 changes
68 cholesterol
69 cholesterol metabolism
70 cholesterol transport
71 compound C
72 concentration
73 consumption
74 consumption of sP
75 content
76 days
77 diet
78 different biological effects
79 effect
80 effect of SP
81 effects of isoflavones
82 excretion
83 expression
84 fatty acids
85 fecal bile acid concentration
86 fecal bile acid excretion
87 fed casein
88 genes
89 genes ABCA1
90 genistein
91 glucose
92 glucose metabolism
93 hepatic accumulation
94 hepatic lipid content
95 hepatocytes
96 high-cholesterol diet
97 hypothesisLiver X receptor
98 inhibitors
99 insulin sensitivity
100 insulin tolerance test
101 interpretationOur results
102 intestine
103 isoflavones
104 isoforms
105 kinase inhibitors
106 less steatosis
107 lipid content
108 lipid metabolism
109 liver
110 liver X receptor isoforms
111 livers of WT
112 metabolic changes
113 metabolism
114 mice
115 opposite effect
116 oral glucose
117 phosphorylation
118 phosphorylation of LXRα
119 protein consumption
120 protein isoflavones
121 protein kinase inhibitors
122 receptor isoforms
123 receptors
124 results
125 sensitivity
126 soy protein consumption
127 soy protein isoflavones
128 sp
129 steatosis
130 sub-family genes Abca1
131 target genes
132 test
133 tolerance test
134 total fecal bile acid excretion
135 transport
136 triacylglycerols
137 wt
138 schema:name Soy protein isoflavones differentially regulate liver X receptor isoforms to modulate lipid metabolism and cholesterol transport in the liver and intestine in mice
139 schema:pagination 2469-2478
140 schema:productId N12dc55f5732145428b5089c31f4048af
141 N60c7629a941442cdbba44fe7073800bd
142 Ndc2027e8edbd42148a1a02493ef17b17
143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000205138
144 https://doi.org/10.1007/s00125-012-2599-9
145 schema:sdDatePublished 2021-11-01T18:17
146 schema:sdLicense https://scigraph.springernature.com/explorer/license/
147 schema:sdPublisher Naec55fea47eb42d182e09e08c8e56c72
148 schema:url https://doi.org/10.1007/s00125-012-2599-9
149 sgo:license sg:explorer/license/
150 sgo:sdDataset articles
151 rdf:type schema:ScholarlyArticle
152 N0645f343dc004225bc641fee79c0a8ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Orphan Nuclear Receptors
154 rdf:type schema:DefinedTerm
155 N101a9256653549239c74479bde9f4140 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Liver
157 rdf:type schema:DefinedTerm
158 N11e53b4f732144f7bb7aa3bfdaae01cb schema:issueNumber 9
159 rdf:type schema:PublicationIssue
160 N12dc55f5732145428b5089c31f4048af schema:name dimensions_id
161 schema:value pub.1000205138
162 rdf:type schema:PropertyValue
163 N1a78594961f144e99c2edac1c4cc1353 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Animals
165 rdf:type schema:DefinedTerm
166 N1ac6ccc3ff7c4155aa65b636111efc88 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Lipid Metabolism
168 rdf:type schema:DefinedTerm
169 N2167a70952954843b07063dc9f422b24 rdf:first sg:person.0764507546.70
170 rdf:rest Nee5a5485e2e54523a0ca1e2e977fdf42
171 N38a87f093b3b4180beff93670151476c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Male
173 rdf:type schema:DefinedTerm
174 N3b798e4faca94618836163b8452d6c6b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Intestinal Mucosa
176 rdf:type schema:DefinedTerm
177 N419f97fd18c74aa2b61663cae3b97020 rdf:first sg:person.01111750304.27
178 rdf:rest N41dc3f5b439e4dd6b0d1a162391cbfbe
179 N41dc3f5b439e4dd6b0d1a162391cbfbe rdf:first sg:person.01175215510.74
180 rdf:rest N798ea4dce43444868e2beef2a245af6f
181 N425f08fb2aae4d71a5178d724ecf4ad8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Liver X Receptors
183 rdf:type schema:DefinedTerm
184 N539d1e84d55a4cf78339a0cda2c78204 rdf:first sg:person.01163022605.39
185 rdf:rest rdf:nil
186 N5da13ce664904263b0b066052ad007b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Isoflavones
188 rdf:type schema:DefinedTerm
189 N60c7629a941442cdbba44fe7073800bd schema:name doi
190 schema:value 10.1007/s00125-012-2599-9
191 rdf:type schema:PropertyValue
192 N66781fde9c4c485b8767e2808b7d06c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Soybean Proteins
194 rdf:type schema:DefinedTerm
195 N695397fb5b4e40178361e233f9889a48 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name Gene Expression Regulation
197 rdf:type schema:DefinedTerm
198 N6f20b6bc4dee4d5ba39031673d88e196 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Protein Isoforms
200 rdf:type schema:DefinedTerm
201 N770b5743da964de185aa2ece546ae534 rdf:first sg:person.0602273316.32
202 rdf:rest N981e43291c37482fbc86b36b3f348b69
203 N798ea4dce43444868e2beef2a245af6f rdf:first sg:person.0757112137.57
204 rdf:rest N770b5743da964de185aa2ece546ae534
205 N8438a9c5ba9d475ea1aac604903d8eb4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Bile Acids and Salts
207 rdf:type schema:DefinedTerm
208 N86c47be09c764a899ea37266312715ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
209 schema:name Hepatocytes
210 rdf:type schema:DefinedTerm
211 N898ecec696784c09a1bb203f2580fbc1 rdf:first sg:person.0671057475.03
212 rdf:rest N539d1e84d55a4cf78339a0cda2c78204
213 N947d16be88c14bbda811edd25c75d831 rdf:first sg:person.01171206375.76
214 rdf:rest Nf2f65fce6ad241daa09934dc36ce8e21
215 N9530bfabcd6d449fbf709c279d25f055 rdf:first sg:person.01176732673.47
216 rdf:rest N898ecec696784c09a1bb203f2580fbc1
217 N981e43291c37482fbc86b36b3f348b69 rdf:first sg:person.0602145746.72
218 rdf:rest Ne9e53bc956ac46d28299ee02c4ac2cae
219 Na26d25c2a7944c37a98893dbbb980c32 schema:volumeNumber 55
220 rdf:type schema:PublicationVolume
221 Naec55fea47eb42d182e09e08c8e56c72 schema:name Springer Nature - SN SciGraph project
222 rdf:type schema:Organization
223 Nc3a6c042ffa14e539917f75f302b0dcb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
224 schema:name Mice
225 rdf:type schema:DefinedTerm
226 Nc56960ab917f44c4b40ab112314b0dfc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
227 schema:name Mice, Transgenic
228 rdf:type schema:DefinedTerm
229 Nca74b33592f04d3ea2ecbd8094260856 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
230 schema:name Biological Transport
231 rdf:type schema:DefinedTerm
232 Nd40e49af1f3c4b5dad75a31db1764ad3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
233 schema:name Insulin Resistance
234 rdf:type schema:DefinedTerm
235 Ndc2027e8edbd42148a1a02493ef17b17 schema:name pubmed_id
236 schema:value 22739758
237 rdf:type schema:PropertyValue
238 Ne7f91b7c3f2c444581cb467f7cce1a11 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
239 schema:name Diet, High-Fat
240 rdf:type schema:DefinedTerm
241 Ne9e53bc956ac46d28299ee02c4ac2cae rdf:first sg:person.012203705203.83
242 rdf:rest N9530bfabcd6d449fbf709c279d25f055
243 Nee5a5485e2e54523a0ca1e2e977fdf42 rdf:first sg:person.01030204005.15
244 rdf:rest N419f97fd18c74aa2b61663cae3b97020
245 Nf2f65fce6ad241daa09934dc36ce8e21 rdf:first sg:person.01023216447.12
246 rdf:rest N2167a70952954843b07063dc9f422b24
247 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
248 schema:name Medical and Health Sciences
249 rdf:type schema:DefinedTerm
250 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
251 schema:name Clinical Sciences
252 rdf:type schema:DefinedTerm
253 anzsrc-for:1114 schema:inDefinedTermSet anzsrc-for:
254 schema:name Paediatrics and Reproductive Medicine
255 rdf:type schema:DefinedTerm
256 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
257 schema:name Public Health and Health Services
258 rdf:type schema:DefinedTerm
259 sg:journal.1001482 schema:issn 0012-186X
260 1432-0428
261 schema:name Diabetologia
262 schema:publisher Springer Nature
263 rdf:type schema:Periodical
264 sg:person.01023216447.12 schema:affiliation grid-institutes:grid.4714.6
265 schema:familyName Steffensen
266 schema:givenName K. R.
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023216447.12
268 rdf:type schema:Person
269 sg:person.01030204005.15 schema:affiliation grid-institutes:grid.416850.e
270 schema:familyName Torres
271 schema:givenName N.
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030204005.15
273 rdf:type schema:Person
274 sg:person.01111750304.27 schema:affiliation grid-institutes:grid.4714.6
275 schema:familyName Korach-André
276 schema:givenName M.
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111750304.27
278 rdf:type schema:Person
279 sg:person.01163022605.39 schema:affiliation grid-institutes:grid.416850.e
280 schema:familyName Tovar
281 schema:givenName A. R.
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163022605.39
283 rdf:type schema:Person
284 sg:person.01171206375.76 schema:affiliation grid-institutes:grid.416850.e
285 schema:familyName González-Granillo
286 schema:givenName M.
287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171206375.76
288 rdf:type schema:Person
289 sg:person.01175215510.74 schema:affiliation grid-institutes:grid.416850.e
290 schema:familyName Ortíz
291 schema:givenName V.
292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175215510.74
293 rdf:type schema:Person
294 sg:person.01176732673.47 schema:affiliation grid-institutes:grid.416850.e
295 schema:familyName Hernandez-Pando
296 schema:givenName R.
297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176732673.47
298 rdf:type schema:Person
299 sg:person.012203705203.83 schema:affiliation grid-institutes:grid.416850.e
300 schema:familyName Loza-Valdes
301 schema:givenName A.
302 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012203705203.83
303 rdf:type schema:Person
304 sg:person.0602145746.72 schema:affiliation grid-institutes:grid.416850.e
305 schema:familyName Díaz-Villaseñor
306 schema:givenName A.
307 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602145746.72
308 rdf:type schema:Person
309 sg:person.0602273316.32 schema:affiliation grid-institutes:grid.4714.6
310 schema:familyName Jakobsson
311 schema:givenName T.
312 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602273316.32
313 rdf:type schema:Person
314 sg:person.0671057475.03 schema:affiliation grid-institutes:grid.266436.3
315 schema:familyName Gustafsson
316 schema:givenName J.-Å.
317 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671057475.03
318 rdf:type schema:Person
319 sg:person.0757112137.57 schema:affiliation grid-institutes:grid.416850.e
320 schema:familyName Aguilar-Salinas
321 schema:givenName C.
322 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757112137.57
323 rdf:type schema:Person
324 sg:person.0764507546.70 schema:affiliation grid-institutes:grid.416850.e
325 schema:familyName Granados
326 schema:givenName O.
327 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764507546.70
328 rdf:type schema:Person
329 sg:pub.10.1007/bf02533049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014512637
330 https://doi.org/10.1007/bf02533049
331 rdf:type schema:CreativeWork
332 sg:pub.10.1038/nature05488 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006317191
333 https://doi.org/10.1038/nature05488
334 rdf:type schema:CreativeWork
335 grid-institutes:grid.266436.3 schema:alternateName Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, TX, USA
336 schema:name Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, TX, USA
337 Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden
338 rdf:type schema:Organization
339 grid-institutes:grid.416850.e schema:alternateName Departamento Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición, Vasco de Quiroga No 15, Tlalpan, 14000, México D.F., México
340 Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
341 Department of Experimental Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
342 schema:name Departamento Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición, Vasco de Quiroga No 15, Tlalpan, 14000, México D.F., México
343 Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
344 Department of Experimental Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
345 rdf:type schema:Organization
346 grid-institutes:grid.4714.6 schema:alternateName Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden
347 schema:name Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden
348 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...