Ontology type: schema:ScholarlyArticle Open Access: True
2011-08
AUTHORSJ. E. Below, E. R. Gamazon, J. V. Morrison, A. Konkashbaev, A. Pluzhnikov, P. M. McKeigue, E. J. Parra, S. C. Elbein, D. M. Hallman, D. L. Nicolae, G. I. Bell, M. Cruz, N. J. Cox, C. L. Hanis
ABSTRACTAIMS/HYPOTHESIS: We conducted genome-wide association studies (GWASs) and expression quantitative trait loci (eQTL) analyses to identify and characterise risk loci for type 2 diabetes in Mexican-Americans from Starr County, TX, USA. METHOD: Using 1.8 million directly interrogated and imputed genotypes in 837 unrelated type 2 diabetes cases and 436 normoglycaemic controls, we conducted Armitage trend tests. To improve power in this population with high disease rates, we also performed ordinal regression including an intermediate class with impaired fasting glucose and/or glucose tolerance. These analyses were followed by meta-analysis with a study of 967 type 2 diabetes cases and 343 normoglycaemic controls from Mexico City, Mexico. RESULT: The top signals (unadjusted p value <1 × 10(-5)) included 49 single nucleotide polymorphisms (SNPs) in eight gene regions (PER3, PARD3B, EPHA4, TOMM7, PTPRD, HNT [also known as RREB1], LOC729993 and IL34) and six intergenic regions. Among these was a missense polymorphism (rs10462020; Gly639Val) in the clock gene PER3, a system recently implicated in diabetes. We also report a second signal (minimum p value 1.52 × 10(-6)) within PTPRD, independent of the previously implicated SNP, in a population of Han Chinese. Top meta-analysis signals included known regions HNF1A and KCNQ1. Annotation of top association signals in both studies revealed a marked excess of trans-acting eQTL in both adipose and muscle tissues. CONCLUSIONS/INTERPRETATION: In the largest study of type 2 diabetes in Mexican populations to date, we identified modest associations of novel and previously reported SNPs. In addition, in our top signals we report significant excess of SNPs that predict transcript levels in muscle and adipose tissues. More... »
PAGES2047-2055
http://scigraph.springernature.com/pub.10.1007/s00125-011-2188-3
DOIhttp://dx.doi.org/10.1007/s00125-011-2188-3
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1032399316
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/21647700
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"type": "PropertyValue",
"value": [
"9a58514ad888765dd456dda8fa906b14678900db5d0d488b4da6a9e2e784c5ac"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"21647700"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"0006777"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s00125-011-2188-3"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1032399316"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s00125-011-2188-3",
"https://app.dimensions.ai/details/publication/pub.1032399316"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T10:30",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000349_0000000349/records_113647_00000001.jsonl",
"type": "ScholarlyArticle",
"url": "https://link.springer.com/10.1007%2Fs00125-011-2188-3"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00125-011-2188-3'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00125-011-2188-3'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00125-011-2188-3'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00125-011-2188-3'
This table displays all metadata directly associated to this object as RDF triples.
343 TRIPLES
21 PREDICATES
70 URIs
32 LITERALS
20 BLANK NODES