Adenylyl cyclase 8 is central to glucagon-like peptide 1 signalling and effects of chronically elevated glucose in rat and human ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-02

AUTHORS

B. Roger, J. Papin, P. Vacher, M. Raoux, A. Mulot, M. Dubois, J. Kerr-Conte, B. H. Voy, F. Pattou, G. Charpentier, J.-C. Jonas, N. Moustaïd-Moussa, J. Lang

ABSTRACT

AIMS/HYPOTHESIS: Glucose and incretins regulate beta cell function, gene expression and insulin exocytosis via calcium and cAMP. Prolonged exposure to elevated glucose (also termed glucotoxicity) disturbs calcium homeostasis, but little is known about cAMP signalling. We therefore investigated long-term effects of glucose on this pathway with special regard to the incretin glucagon-like peptide 1 (GLP-1). METHODS: We exposed INS-1E cells and rat or human islets to different levels of glucose for 3 days and determined functional responses in terms of second messengers (cAMP, Ca(2+)), transcription profiles, activation of cAMP-responsive element (CRE) and secretion by measuring membrane capacitance. Moreover, we modulated directly the abundance of a calcium-sensitive adenylyl cyclase (ADCY8) and GLP-1 receptor (GLP1R). RESULTS: GLP-1- or forskolin-mediated increases in cytosolic calcium, cAMP-levels or insulin secretion were largely reduced in INS-1E cells cultured at elevated glucose (>5.5 mmol/l). Statistical analysis of transcription profiles identified cAMP pathways as major targets regulated by glucose. Quantitative PCR confirmed these findings and unravelled marked downregulation of the calcium-sensitive adenylyl cyclase ADCY8 also in rat and in human islets. Re-expression of ADCY8, but not of the GLP1R, recovered GLP-1 signalling in glucotoxicity in INS-1E cells and in rat islets. Moreover, knockdown of this adenylyl cyclase showed that GLP-1-induced cAMP generation, calcium signalling, activation of the downstream target CRE and direct amplification of exocytosis by cAMP-raising agents (evaluated by capacitance measurement) proceeds via ADCY8. CONCLUSIONS/INTERPRETATION: cAMP-mediated pathways are modelled by glucose, and downregulation of the calcium-sensitive ADCY8 plays a central role herein, including signalling via the GLP1R. More... »

PAGES

390-402

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00125-010-1955-x

DOI

http://dx.doi.org/10.1007/s00125-010-1955-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004212228

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21046358


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenylyl Cyclases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colforsin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclic AMP", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytophotometry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Electrophysiology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glucagon-Like Peptide 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glucagon-Like Peptide-1 Receptor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glucose", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin-Secreting Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Biological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oligonucleotide Array Sequence Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Glucagon", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Bordeaux", 
          "id": "https://www.grid.ac/institutes/grid.412041.2", 
          "name": [
            "Universit\u00e9 de Bordeaux 1, Institut Europ\u00e9en de Chimie et Biologie, UMR CNRS 5248, 2 Av Robert Escarpit, 33607, Pessac, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roger", 
        "givenName": "B.", 
        "id": "sg:person.01152602715.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152602715.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bordeaux", 
          "id": "https://www.grid.ac/institutes/grid.412041.2", 
          "name": [
            "Universit\u00e9 de Bordeaux 1, Institut Europ\u00e9en de Chimie et Biologie, UMR CNRS 5248, 2 Av Robert Escarpit, 33607, Pessac, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Papin", 
        "givenName": "J.", 
        "id": "sg:person.01220716115.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220716115.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bordeaux", 
          "id": "https://www.grid.ac/institutes/grid.412041.2", 
          "name": [
            "Institut Bergoni\u00e9, Universit\u00e9 de Bordeaux 2, INSERM U916, Bordeaux, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vacher", 
        "givenName": "P.", 
        "id": "sg:person.01363421447.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363421447.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bordeaux", 
          "id": "https://www.grid.ac/institutes/grid.412041.2", 
          "name": [
            "Universit\u00e9 de Bordeaux 1, Institut Europ\u00e9en de Chimie et Biologie, UMR CNRS 5248, 2 Av Robert Escarpit, 33607, Pessac, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Raoux", 
        "givenName": "M.", 
        "id": "sg:person.0730003023.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730003023.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bordeaux", 
          "id": "https://www.grid.ac/institutes/grid.412041.2", 
          "name": [
            "Universit\u00e9 de Bordeaux 1, Institut Europ\u00e9en de Chimie et Biologie, UMR CNRS 5248, 2 Av Robert Escarpit, 33607, Pessac, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mulot", 
        "givenName": "A.", 
        "id": "sg:person.01136740250.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136740250.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bordeaux", 
          "id": "https://www.grid.ac/institutes/grid.412041.2", 
          "name": [
            "Universit\u00e9 de Bordeaux 1, Institut Europ\u00e9en de Chimie et Biologie, UMR CNRS 5248, 2 Av Robert Escarpit, 33607, Pessac, France", 
            "UFR de Pharmacie, Universit\u00e9 de Bordeaux 2, Bordeaux, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dubois", 
        "givenName": "M.", 
        "id": "sg:person.01213052213.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213052213.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Lille Nord de France", 
          "id": "https://www.grid.ac/institutes/grid.412304.0", 
          "name": [
            "Biotherapies for Diabetes, Universit\u00e9 Lille-Nord de France, INSERM U859, Lille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kerr-Conte", 
        "givenName": "J.", 
        "id": "sg:person.01257053263.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257053263.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tennessee at Knoxville", 
          "id": "https://www.grid.ac/institutes/grid.411461.7", 
          "name": [
            "Obesity Research Center and Department of Animal Science, University of Tennessee, Knoxville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Voy", 
        "givenName": "B. H.", 
        "id": "sg:person.01231042207.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231042207.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Lille Nord de France", 
          "id": "https://www.grid.ac/institutes/grid.412304.0", 
          "name": [
            "Biotherapies for Diabetes, Universit\u00e9 Lille-Nord de France, INSERM U859, Lille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pattou", 
        "givenName": "F.", 
        "id": "sg:person.01071152320.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071152320.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bordeaux", 
          "id": "https://www.grid.ac/institutes/grid.412041.2", 
          "name": [
            "Universit\u00e9 de Bordeaux 1, Institut Europ\u00e9en de Chimie et Biologie, UMR CNRS 5248, 2 Av Robert Escarpit, 33607, Pessac, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Charpentier", 
        "givenName": "G.", 
        "id": "sg:person.01122664436.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122664436.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e9 Catholique de Louvain", 
          "id": "https://www.grid.ac/institutes/grid.7942.8", 
          "name": [
            "Secteur des Sciences de la Sant\u00e9, Institut de Recherche Exp\u00e9rimentale et Clinique, P\u00f4le de Recherche en Endocrinologie, Diab\u00e8te et Nutrition, Universit\u00e9 Catholique de Louvain, Brussels, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jonas", 
        "givenName": "J.-C.", 
        "id": "sg:person.0773217120.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773217120.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tennessee at Knoxville", 
          "id": "https://www.grid.ac/institutes/grid.411461.7", 
          "name": [
            "Obesity Research Center and Department of Animal Science, University of Tennessee, Knoxville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mousta\u00efd-Moussa", 
        "givenName": "N.", 
        "id": "sg:person.012523726354.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012523726354.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bordeaux", 
          "id": "https://www.grid.ac/institutes/grid.412041.2", 
          "name": [
            "Universit\u00e9 de Bordeaux 1, Institut Europ\u00e9en de Chimie et Biologie, UMR CNRS 5248, 2 Av Robert Escarpit, 33607, Pessac, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lang", 
        "givenName": "J.", 
        "id": "sg:person.01014245022.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014245022.88"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/ng.520", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004642598", 
          "https://doi.org/10.1038/ng.520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.520", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004642598", 
          "https://doi.org/10.1038/ng.520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/db05-1618", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004930216"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-003-1203-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005326937", 
          "https://doi.org/10.1007/s00125-003-1203-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-003-1203-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005326937", 
          "https://doi.org/10.1007/s00125-003-1203-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physiol.00047.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005812197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/db06-1033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008695127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/db06-1150", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011384132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cmet.2008.06.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012252034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bcp.2008.07.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013102629"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0800796105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014480269"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci109665", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014786437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.24.7.2831-2841.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015290993"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1469-7793.1997.105bl.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016657133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m307612200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018434383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/db07-0100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019123707"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20021288", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019772533"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20021288", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019772533"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.272.5.3091", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020307541"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/db07-1414", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020753094"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpcell.00555.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021565112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ceca.2003.10.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021641646"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1176827", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022009282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1176827", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022009282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-009-1314-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022670888", 
          "https://doi.org/10.1007/s00125-009-1314-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-009-1314-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022670888", 
          "https://doi.org/10.1007/s00125-009-1314-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-009-1314-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022670888", 
          "https://doi.org/10.1007/s00125-009-1314-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-009-1314-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022670888", 
          "https://doi.org/10.1007/s00125-009-1314-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-004-1347-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024194969", 
          "https://doi.org/10.1007/s00125-004-1347-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-004-1347-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024194969", 
          "https://doi.org/10.1007/s00125-004-1347-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-004-1347-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024194969", 
          "https://doi.org/10.1007/s00125-004-1347-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpendo.00070.2007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024572717"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-008-1245-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025147179", 
          "https://doi.org/10.1007/s00125-008-1245-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-008-1245-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025147179", 
          "https://doi.org/10.1007/s00125-008-1245-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1432-1327.1999.00043.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026547327"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-008-1195-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027457320", 
          "https://doi.org/10.1007/s00125-008-1195-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-008-1195-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027457320", 
          "https://doi.org/10.1007/s00125-008-1195-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-008-1195-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027457320", 
          "https://doi.org/10.1007/s00125-008-1195-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.52.1.124", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027527210"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.emboj.7601008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028077569"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.emboj.7601008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028077569"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.521", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029752947", 
          "https://doi.org/10.1038/ng.521"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.521", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029752947", 
          "https://doi.org/10.1038/ng.521"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m807359200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032795220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biopsych.2009.06.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034166239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci24867", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036084765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physrev.00049.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036867550"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1755-8794-2-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037046290", 
          "https://doi.org/10.1186/1755-8794-2-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00281991", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037834209", 
          "https://doi.org/10.1007/bf00281991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00281991", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037834209", 
          "https://doi.org/10.1007/bf00281991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1085/jgp.200810044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037971592"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.52.4.974", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041152624"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00335-005-0130-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041946394", 
          "https://doi.org/10.1007/s00335-005-0130-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00335-005-0130-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041946394", 
          "https://doi.org/10.1007/s00335-005-0130-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpcell.00216.2008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043770966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.2006.119644", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044752330"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physrev.00034.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045521074"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m510528200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047791224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m510528200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047791224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.55.04.06.db05-1577", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049906164"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.00325-07", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050456894"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.5317-07.2008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050511038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpendo.00426.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050814397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci32994", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063417025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2006-1022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064248256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/er.2007-0023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064285903"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.44.7.767", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070743056"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00273856", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1080015905", 
          "https://doi.org/10.1007/bf00273856"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00273856", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1080015905", 
          "https://doi.org/10.1007/bf00273856"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-02", 
    "datePublishedReg": "2011-02-01", 
    "description": "AIMS/HYPOTHESIS: Glucose and incretins regulate beta cell function, gene expression and insulin exocytosis via calcium and cAMP. Prolonged exposure to elevated glucose (also termed glucotoxicity) disturbs calcium homeostasis, but little is known about cAMP signalling. We therefore investigated long-term effects of glucose on this pathway with special regard to the incretin glucagon-like peptide 1 (GLP-1).\nMETHODS: We exposed INS-1E cells and rat or human islets to different levels of glucose for 3 days and determined functional responses in terms of second messengers (cAMP, Ca(2+)), transcription profiles, activation of cAMP-responsive element (CRE) and secretion by measuring membrane capacitance. Moreover, we modulated directly the abundance of a calcium-sensitive adenylyl cyclase (ADCY8) and GLP-1 receptor (GLP1R).\nRESULTS: GLP-1- or forskolin-mediated increases in cytosolic calcium, cAMP-levels or insulin secretion were largely reduced in INS-1E cells cultured at elevated glucose (>5.5 mmol/l). Statistical analysis of transcription profiles identified cAMP pathways as major targets regulated by glucose. Quantitative PCR confirmed these findings and unravelled marked downregulation of the calcium-sensitive adenylyl cyclase ADCY8 also in rat and in human islets. Re-expression of ADCY8, but not of the GLP1R, recovered GLP-1 signalling in glucotoxicity in INS-1E cells and in rat islets. Moreover, knockdown of this adenylyl cyclase showed that GLP-1-induced cAMP generation, calcium signalling, activation of the downstream target CRE and direct amplification of exocytosis by cAMP-raising agents (evaluated by capacitance measurement) proceeds via ADCY8.\nCONCLUSIONS/INTERPRETATION: cAMP-mediated pathways are modelled by glucose, and downregulation of the calcium-sensitive ADCY8 plays a central role herein, including signalling via the GLP1R.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00125-010-1955-x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1001482", 
        "issn": [
          "0012-186X", 
          "1432-0428"
        ], 
        "name": "Diabetologia", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "54"
      }
    ], 
    "name": "Adenylyl cyclase 8 is central to glucagon-like peptide 1 signalling and effects of chronically elevated glucose in rat and human pancreatic beta cells", 
    "pagination": "390-402", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "14126054f444f1088ea36351e2397da68788b048d1f4e0859f0cca69d9a9a7d2"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21046358"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0006777"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00125-010-1955-x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1004212228"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00125-010-1955-x", 
      "https://app.dimensions.ai/details/publication/pub.1004212228"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:59", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000347_0000000347/records_89816_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs00125-010-1955-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00125-010-1955-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00125-010-1955-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00125-010-1955-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00125-010-1955-x'


 

This table displays all metadata directly associated to this object as RDF triples.

404 TRIPLES      21 PREDICATES      99 URIs      40 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00125-010-1955-x schema:about N05c8777c4ef14f52bd7eba3abad96be0
2 N09b90a6dbba74ce08edb32a89311e8e6
3 N0a10f7ebca6b4131adfd51a5439053d3
4 N0b4d5e0ff09045d9885bc9dbba146642
5 N0cace2a7c2b64830aaf2f4db4e0d99f1
6 N1153341a221043399a3058c8f78609d6
7 N31dfad7b27f6429a89730ce08a0e6675
8 N391466b8ca804c3a9a5191c261d819b3
9 N473a100abb0b48cc99dbbef1df6f9100
10 N5e21621a310d4b4fb09283fdb4bb48ed
11 N65f23c5daa154ad78ec1e2806391b4da
12 N6baea47b7f5b45b787bb36802c796126
13 N766a7a608a14457c9459aeea1d3334fa
14 N88681a0928f143ec975cfcbb8151d07c
15 Nbdeda832124e41028cf7a89994826a0b
16 Nc49c721024b54984a283636f6c2f875b
17 Nd7f30e606acc4023b760fce38c51263d
18 Nfa933abab1134c149aa9ecd877b3991c
19 Nfdde29d7e4dd494fb6fd75de6dfccb6b
20 anzsrc-for:06
21 anzsrc-for:0601
22 schema:author Nd8502721dc644a82ac88e7ca7ef760b5
23 schema:citation sg:pub.10.1007/bf00273856
24 sg:pub.10.1007/bf00281991
25 sg:pub.10.1007/s00125-003-1203-8
26 sg:pub.10.1007/s00125-004-1347-1
27 sg:pub.10.1007/s00125-008-1195-5
28 sg:pub.10.1007/s00125-008-1245-z
29 sg:pub.10.1007/s00125-009-1314-y
30 sg:pub.10.1007/s00335-005-0130-z
31 sg:pub.10.1038/ng.520
32 sg:pub.10.1038/ng.521
33 sg:pub.10.1186/1755-8794-2-3
34 https://doi.org/10.1016/j.bcp.2008.07.025
35 https://doi.org/10.1016/j.biopsych.2009.06.016
36 https://doi.org/10.1016/j.ceca.2003.10.006
37 https://doi.org/10.1016/j.cmet.2008.06.003
38 https://doi.org/10.1038/sj.emboj.7601008
39 https://doi.org/10.1042/bj20021288
40 https://doi.org/10.1046/j.1432-1327.1999.00043.x
41 https://doi.org/10.1073/pnas.0800796105
42 https://doi.org/10.1074/jbc.272.5.3091
43 https://doi.org/10.1074/jbc.m307612200
44 https://doi.org/10.1074/jbc.m510528200
45 https://doi.org/10.1074/jbc.m807359200
46 https://doi.org/10.1085/jgp.200810044
47 https://doi.org/10.1111/j.1469-7793.1997.105bl.x
48 https://doi.org/10.1113/jphysiol.2006.119644
49 https://doi.org/10.1126/science.1176827
50 https://doi.org/10.1128/mcb.00325-07
51 https://doi.org/10.1128/mcb.24.7.2831-2841.2004
52 https://doi.org/10.1152/ajpcell.00216.2008
53 https://doi.org/10.1152/ajpcell.00555.2006
54 https://doi.org/10.1152/ajpendo.00070.2007
55 https://doi.org/10.1152/ajpendo.00426.2003
56 https://doi.org/10.1152/physiol.00047.2006
57 https://doi.org/10.1152/physrev.00034.2006
58 https://doi.org/10.1152/physrev.00049.2006
59 https://doi.org/10.1172/jci109665
60 https://doi.org/10.1172/jci24867
61 https://doi.org/10.1172/jci32994
62 https://doi.org/10.1210/en.2006-1022
63 https://doi.org/10.1210/er.2007-0023
64 https://doi.org/10.1523/jneurosci.5317-07.2008
65 https://doi.org/10.2337/db05-1618
66 https://doi.org/10.2337/db06-1033
67 https://doi.org/10.2337/db06-1150
68 https://doi.org/10.2337/db07-0100
69 https://doi.org/10.2337/db07-1414
70 https://doi.org/10.2337/diabetes.44.7.767
71 https://doi.org/10.2337/diabetes.52.1.124
72 https://doi.org/10.2337/diabetes.52.4.974
73 https://doi.org/10.2337/diabetes.55.04.06.db05-1577
74 schema:datePublished 2011-02
75 schema:datePublishedReg 2011-02-01
76 schema:description AIMS/HYPOTHESIS: Glucose and incretins regulate beta cell function, gene expression and insulin exocytosis via calcium and cAMP. Prolonged exposure to elevated glucose (also termed glucotoxicity) disturbs calcium homeostasis, but little is known about cAMP signalling. We therefore investigated long-term effects of glucose on this pathway with special regard to the incretin glucagon-like peptide 1 (GLP-1). METHODS: We exposed INS-1E cells and rat or human islets to different levels of glucose for 3 days and determined functional responses in terms of second messengers (cAMP, Ca(2+)), transcription profiles, activation of cAMP-responsive element (CRE) and secretion by measuring membrane capacitance. Moreover, we modulated directly the abundance of a calcium-sensitive adenylyl cyclase (ADCY8) and GLP-1 receptor (GLP1R). RESULTS: GLP-1- or forskolin-mediated increases in cytosolic calcium, cAMP-levels or insulin secretion were largely reduced in INS-1E cells cultured at elevated glucose (>5.5 mmol/l). Statistical analysis of transcription profiles identified cAMP pathways as major targets regulated by glucose. Quantitative PCR confirmed these findings and unravelled marked downregulation of the calcium-sensitive adenylyl cyclase ADCY8 also in rat and in human islets. Re-expression of ADCY8, but not of the GLP1R, recovered GLP-1 signalling in glucotoxicity in INS-1E cells and in rat islets. Moreover, knockdown of this adenylyl cyclase showed that GLP-1-induced cAMP generation, calcium signalling, activation of the downstream target CRE and direct amplification of exocytosis by cAMP-raising agents (evaluated by capacitance measurement) proceeds via ADCY8. CONCLUSIONS/INTERPRETATION: cAMP-mediated pathways are modelled by glucose, and downregulation of the calcium-sensitive ADCY8 plays a central role herein, including signalling via the GLP1R.
77 schema:genre research_article
78 schema:inLanguage en
79 schema:isAccessibleForFree true
80 schema:isPartOf N11c465f887da4ba58a8a8f5a11d1737a
81 N46636f593b0844f8acbfd8591a440a1c
82 sg:journal.1001482
83 schema:name Adenylyl cyclase 8 is central to glucagon-like peptide 1 signalling and effects of chronically elevated glucose in rat and human pancreatic beta cells
84 schema:pagination 390-402
85 schema:productId N243a25212c5a42cfa6d2bc93d22b6853
86 N8d0af446067649aca4e8ae77e33b2b0f
87 Ndadbd6f786b04f779a59dbfd856032b4
88 Neb457de171c54ba183d223cafd444424
89 Nf1a2f17b333b4fe9bf27e435ccc5f904
90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004212228
91 https://doi.org/10.1007/s00125-010-1955-x
92 schema:sdDatePublished 2019-04-11T09:59
93 schema:sdLicense https://scigraph.springernature.com/explorer/license/
94 schema:sdPublisher Ndd2854b6bc8d4014b9fa78674c0e2f75
95 schema:url https://link.springer.com/10.1007%2Fs00125-010-1955-x
96 sgo:license sg:explorer/license/
97 sgo:sdDataset articles
98 rdf:type schema:ScholarlyArticle
99 N03f3b4ced83d43779df28a45c20d6c62 rdf:first sg:person.01122664436.36
100 rdf:rest N24eb337f9770481294f5f01d2599a0f0
101 N05c8777c4ef14f52bd7eba3abad96be0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Polymerase Chain Reaction
103 rdf:type schema:DefinedTerm
104 N09b90a6dbba74ce08edb32a89311e8e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Cell Line
106 rdf:type schema:DefinedTerm
107 N0a10f7ebca6b4131adfd51a5439053d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Glucose
109 rdf:type schema:DefinedTerm
110 N0b4d5e0ff09045d9885bc9dbba146642 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Receptors, Glucagon
112 rdf:type schema:DefinedTerm
113 N0cace2a7c2b64830aaf2f4db4e0d99f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Oligonucleotide Array Sequence Analysis
115 rdf:type schema:DefinedTerm
116 N1153341a221043399a3058c8f78609d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Cytophotometry
118 rdf:type schema:DefinedTerm
119 N11c465f887da4ba58a8a8f5a11d1737a schema:volumeNumber 54
120 rdf:type schema:PublicationVolume
121 N243a25212c5a42cfa6d2bc93d22b6853 schema:name pubmed_id
122 schema:value 21046358
123 rdf:type schema:PropertyValue
124 N24eb337f9770481294f5f01d2599a0f0 rdf:first sg:person.0773217120.07
125 rdf:rest N6ae11c3ee38348b6ae7384244fb58e8a
126 N296a5674028a4838bee01016e912df76 rdf:first sg:person.01220716115.02
127 rdf:rest Naf301de82eb54561bb7f39ed2c7d558d
128 N31dfad7b27f6429a89730ce08a0e6675 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Electrophysiology
130 rdf:type schema:DefinedTerm
131 N391466b8ca804c3a9a5191c261d819b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Cyclic AMP
133 rdf:type schema:DefinedTerm
134 N46636f593b0844f8acbfd8591a440a1c schema:issueNumber 2
135 rdf:type schema:PublicationIssue
136 N473a100abb0b48cc99dbbef1df6f9100 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Rats
138 rdf:type schema:DefinedTerm
139 N4b5f7e8d6bba4602b8286ed99d93ded6 rdf:first sg:person.01071152320.60
140 rdf:rest N03f3b4ced83d43779df28a45c20d6c62
141 N5e21621a310d4b4fb09283fdb4bb48ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Insulin-Secreting Cells
143 rdf:type schema:DefinedTerm
144 N65f23c5daa154ad78ec1e2806391b4da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Models, Biological
146 rdf:type schema:DefinedTerm
147 N6ae11c3ee38348b6ae7384244fb58e8a rdf:first sg:person.012523726354.80
148 rdf:rest Nf00647cb0d214639b69b6315932fcd09
149 N6baea47b7f5b45b787bb36802c796126 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Adenylyl Cyclases
151 rdf:type schema:DefinedTerm
152 N766a7a608a14457c9459aeea1d3334fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Colforsin
154 rdf:type schema:DefinedTerm
155 N7c2ee85be6c6479a958a711b241b7b1c rdf:first sg:person.01231042207.18
156 rdf:rest N4b5f7e8d6bba4602b8286ed99d93ded6
157 N835fb78398e341b999e75ae87ce0ca8a rdf:first sg:person.01257053263.38
158 rdf:rest N7c2ee85be6c6479a958a711b241b7b1c
159 N88681a0928f143ec975cfcbb8151d07c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Calcium
161 rdf:type schema:DefinedTerm
162 N8d0af446067649aca4e8ae77e33b2b0f schema:name nlm_unique_id
163 schema:value 0006777
164 rdf:type schema:PropertyValue
165 Naf301de82eb54561bb7f39ed2c7d558d rdf:first sg:person.01363421447.87
166 rdf:rest Ne738060946784adf95a6042185534675
167 Nbd64642e7bb44470886c99ba74640226 rdf:first sg:person.01213052213.69
168 rdf:rest N835fb78398e341b999e75ae87ce0ca8a
169 Nbdeda832124e41028cf7a89994826a0b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Glucagon-Like Peptide 1
171 rdf:type schema:DefinedTerm
172 Nc49c721024b54984a283636f6c2f875b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Cells, Cultured
174 rdf:type schema:DefinedTerm
175 Nd7f30e606acc4023b760fce38c51263d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Glucagon-Like Peptide-1 Receptor
177 rdf:type schema:DefinedTerm
178 Nd8502721dc644a82ac88e7ca7ef760b5 rdf:first sg:person.01152602715.12
179 rdf:rest N296a5674028a4838bee01016e912df76
180 Ndadbd6f786b04f779a59dbfd856032b4 schema:name readcube_id
181 schema:value 14126054f444f1088ea36351e2397da68788b048d1f4e0859f0cca69d9a9a7d2
182 rdf:type schema:PropertyValue
183 Ndd2854b6bc8d4014b9fa78674c0e2f75 schema:name Springer Nature - SN SciGraph project
184 rdf:type schema:Organization
185 Ne2091d1641d04a52b8bb6f65211a8060 rdf:first sg:person.01136740250.36
186 rdf:rest Nbd64642e7bb44470886c99ba74640226
187 Ne738060946784adf95a6042185534675 rdf:first sg:person.0730003023.17
188 rdf:rest Ne2091d1641d04a52b8bb6f65211a8060
189 Neb457de171c54ba183d223cafd444424 schema:name dimensions_id
190 schema:value pub.1004212228
191 rdf:type schema:PropertyValue
192 Nf00647cb0d214639b69b6315932fcd09 rdf:first sg:person.01014245022.88
193 rdf:rest rdf:nil
194 Nf1a2f17b333b4fe9bf27e435ccc5f904 schema:name doi
195 schema:value 10.1007/s00125-010-1955-x
196 rdf:type schema:PropertyValue
197 Nfa933abab1134c149aa9ecd877b3991c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Animals
199 rdf:type schema:DefinedTerm
200 Nfdde29d7e4dd494fb6fd75de6dfccb6b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Humans
202 rdf:type schema:DefinedTerm
203 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
204 schema:name Biological Sciences
205 rdf:type schema:DefinedTerm
206 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
207 schema:name Biochemistry and Cell Biology
208 rdf:type schema:DefinedTerm
209 sg:journal.1001482 schema:issn 0012-186X
210 1432-0428
211 schema:name Diabetologia
212 rdf:type schema:Periodical
213 sg:person.01014245022.88 schema:affiliation https://www.grid.ac/institutes/grid.412041.2
214 schema:familyName Lang
215 schema:givenName J.
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014245022.88
217 rdf:type schema:Person
218 sg:person.01071152320.60 schema:affiliation https://www.grid.ac/institutes/grid.412304.0
219 schema:familyName Pattou
220 schema:givenName F.
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071152320.60
222 rdf:type schema:Person
223 sg:person.01122664436.36 schema:affiliation https://www.grid.ac/institutes/grid.412041.2
224 schema:familyName Charpentier
225 schema:givenName G.
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122664436.36
227 rdf:type schema:Person
228 sg:person.01136740250.36 schema:affiliation https://www.grid.ac/institutes/grid.412041.2
229 schema:familyName Mulot
230 schema:givenName A.
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136740250.36
232 rdf:type schema:Person
233 sg:person.01152602715.12 schema:affiliation https://www.grid.ac/institutes/grid.412041.2
234 schema:familyName Roger
235 schema:givenName B.
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152602715.12
237 rdf:type schema:Person
238 sg:person.01213052213.69 schema:affiliation https://www.grid.ac/institutes/grid.412041.2
239 schema:familyName Dubois
240 schema:givenName M.
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213052213.69
242 rdf:type schema:Person
243 sg:person.01220716115.02 schema:affiliation https://www.grid.ac/institutes/grid.412041.2
244 schema:familyName Papin
245 schema:givenName J.
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220716115.02
247 rdf:type schema:Person
248 sg:person.01231042207.18 schema:affiliation https://www.grid.ac/institutes/grid.411461.7
249 schema:familyName Voy
250 schema:givenName B. H.
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231042207.18
252 rdf:type schema:Person
253 sg:person.012523726354.80 schema:affiliation https://www.grid.ac/institutes/grid.411461.7
254 schema:familyName Moustaïd-Moussa
255 schema:givenName N.
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012523726354.80
257 rdf:type schema:Person
258 sg:person.01257053263.38 schema:affiliation https://www.grid.ac/institutes/grid.412304.0
259 schema:familyName Kerr-Conte
260 schema:givenName J.
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257053263.38
262 rdf:type schema:Person
263 sg:person.01363421447.87 schema:affiliation https://www.grid.ac/institutes/grid.412041.2
264 schema:familyName Vacher
265 schema:givenName P.
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363421447.87
267 rdf:type schema:Person
268 sg:person.0730003023.17 schema:affiliation https://www.grid.ac/institutes/grid.412041.2
269 schema:familyName Raoux
270 schema:givenName M.
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730003023.17
272 rdf:type schema:Person
273 sg:person.0773217120.07 schema:affiliation https://www.grid.ac/institutes/grid.7942.8
274 schema:familyName Jonas
275 schema:givenName J.-C.
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773217120.07
277 rdf:type schema:Person
278 sg:pub.10.1007/bf00273856 schema:sameAs https://app.dimensions.ai/details/publication/pub.1080015905
279 https://doi.org/10.1007/bf00273856
280 rdf:type schema:CreativeWork
281 sg:pub.10.1007/bf00281991 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037834209
282 https://doi.org/10.1007/bf00281991
283 rdf:type schema:CreativeWork
284 sg:pub.10.1007/s00125-003-1203-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005326937
285 https://doi.org/10.1007/s00125-003-1203-8
286 rdf:type schema:CreativeWork
287 sg:pub.10.1007/s00125-004-1347-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024194969
288 https://doi.org/10.1007/s00125-004-1347-1
289 rdf:type schema:CreativeWork
290 sg:pub.10.1007/s00125-008-1195-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027457320
291 https://doi.org/10.1007/s00125-008-1195-5
292 rdf:type schema:CreativeWork
293 sg:pub.10.1007/s00125-008-1245-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1025147179
294 https://doi.org/10.1007/s00125-008-1245-z
295 rdf:type schema:CreativeWork
296 sg:pub.10.1007/s00125-009-1314-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1022670888
297 https://doi.org/10.1007/s00125-009-1314-y
298 rdf:type schema:CreativeWork
299 sg:pub.10.1007/s00335-005-0130-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1041946394
300 https://doi.org/10.1007/s00335-005-0130-z
301 rdf:type schema:CreativeWork
302 sg:pub.10.1038/ng.520 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004642598
303 https://doi.org/10.1038/ng.520
304 rdf:type schema:CreativeWork
305 sg:pub.10.1038/ng.521 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029752947
306 https://doi.org/10.1038/ng.521
307 rdf:type schema:CreativeWork
308 sg:pub.10.1186/1755-8794-2-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037046290
309 https://doi.org/10.1186/1755-8794-2-3
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1016/j.bcp.2008.07.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013102629
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1016/j.biopsych.2009.06.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034166239
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1016/j.ceca.2003.10.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021641646
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1016/j.cmet.2008.06.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012252034
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1038/sj.emboj.7601008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028077569
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1042/bj20021288 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019772533
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1046/j.1432-1327.1999.00043.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026547327
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1073/pnas.0800796105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014480269
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1074/jbc.272.5.3091 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020307541
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1074/jbc.m307612200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018434383
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1074/jbc.m510528200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047791224
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1074/jbc.m807359200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032795220
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1085/jgp.200810044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037971592
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1111/j.1469-7793.1997.105bl.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016657133
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1113/jphysiol.2006.119644 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044752330
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1126/science.1176827 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022009282
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1128/mcb.00325-07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050456894
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1128/mcb.24.7.2831-2841.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015290993
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1152/ajpcell.00216.2008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043770966
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1152/ajpcell.00555.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021565112
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1152/ajpendo.00070.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024572717
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1152/ajpendo.00426.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050814397
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1152/physiol.00047.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005812197
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1152/physrev.00034.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045521074
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1152/physrev.00049.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036867550
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1172/jci109665 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014786437
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1172/jci24867 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036084765
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1172/jci32994 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063417025
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1210/en.2006-1022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064248256
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1210/er.2007-0023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064285903
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1523/jneurosci.5317-07.2008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050511038
372 rdf:type schema:CreativeWork
373 https://doi.org/10.2337/db05-1618 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004930216
374 rdf:type schema:CreativeWork
375 https://doi.org/10.2337/db06-1033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008695127
376 rdf:type schema:CreativeWork
377 https://doi.org/10.2337/db06-1150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011384132
378 rdf:type schema:CreativeWork
379 https://doi.org/10.2337/db07-0100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019123707
380 rdf:type schema:CreativeWork
381 https://doi.org/10.2337/db07-1414 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020753094
382 rdf:type schema:CreativeWork
383 https://doi.org/10.2337/diabetes.44.7.767 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070743056
384 rdf:type schema:CreativeWork
385 https://doi.org/10.2337/diabetes.52.1.124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027527210
386 rdf:type schema:CreativeWork
387 https://doi.org/10.2337/diabetes.52.4.974 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041152624
388 rdf:type schema:CreativeWork
389 https://doi.org/10.2337/diabetes.55.04.06.db05-1577 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049906164
390 rdf:type schema:CreativeWork
391 https://www.grid.ac/institutes/grid.411461.7 schema:alternateName University of Tennessee at Knoxville
392 schema:name Obesity Research Center and Department of Animal Science, University of Tennessee, Knoxville, TN, USA
393 rdf:type schema:Organization
394 https://www.grid.ac/institutes/grid.412041.2 schema:alternateName University of Bordeaux
395 schema:name Institut Bergonié, Université de Bordeaux 2, INSERM U916, Bordeaux, France
396 UFR de Pharmacie, Université de Bordeaux 2, Bordeaux, France
397 Université de Bordeaux 1, Institut Européen de Chimie et Biologie, UMR CNRS 5248, 2 Av Robert Escarpit, 33607, Pessac, France
398 rdf:type schema:Organization
399 https://www.grid.ac/institutes/grid.412304.0 schema:alternateName University of Lille Nord de France
400 schema:name Biotherapies for Diabetes, Université Lille-Nord de France, INSERM U859, Lille, France
401 rdf:type schema:Organization
402 https://www.grid.ac/institutes/grid.7942.8 schema:alternateName Université Catholique de Louvain
403 schema:name Secteur des Sciences de la Santé, Institut de Recherche Expérimentale et Clinique, Pôle de Recherche en Endocrinologie, Diabète et Nutrition, Université Catholique de Louvain, Brussels, Belgium
404 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...