Association of exposure to diabetes in utero with adiposity and fat distribution in a multiethnic population of youth: the Exploring ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-01

AUTHORS

T. L. Crume, L. Ogden, N. A. West, K. S. Vehik, A. Scherzinger, S. Daniels, R. McDuffie, K. Bischoff, R. F. Hamman, J. M. Norris, D. Dabelea

ABSTRACT

AIMS/HYPOTHESIS: To evaluate whether exposure to maternal gestational diabetes (GDM) is associated with adiposity and fat distribution in a multiethnic population of children. METHODS: Retrospective cohort study of 82 children exposed to maternal GDM and 379 unexposed youths 6-13 years of age with measured BMI, waist circumference, skinfold thickness, and visceral and subcutaneous abdominal fat. RESULTS: Exposure to maternal GDM was associated with higher BMI (p = 0.02), larger waist circumference (p = 0.004), more subcutaneous abdominal fat (p = 0.01) and increased subscapular to triceps skinfold thickness ratio (p = 0.01) in models adjusted for age, sex, race/ethnicity and Tanner stage. Adjustment for socioeconomic factors, birthweight and gestational age, maternal smoking during pregnancy and current diet and physical activity did not influence associations; however, adjustment for maternal pre-pregnancy BMI attenuated all associations. CONCLUSIONS/INTERPRETATION: Exposure to maternal GDM is associated with increased overall and abdominal adiposity, and a more central fat distribution pattern in 6- to 13-year-old youths from a multi-ethnic population, providing further support for the fetal overnutrition hypothesis. More... »

PAGES

87-92

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00125-010-1925-3

DOI

http://dx.doi.org/10.1007/s00125-010-1925-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052958789

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20953862


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