Salt supplementation blunts the blood pressure response to telmisartan with or without hydrochlorothiazide in hypertensive patients with type 2 diabetes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-07

AUTHORS

E. I. Ekinci, G. Thomas, R. J. MacIsaac, C. Johnson, C. Houlihan, S. Panagiotopoulos, E. Premaratne, H. Hao, S. Finch, C. O’Callaghan, G. Jerums

ABSTRACT

AIMS/HYPOTHESIS: We assessed the effects of sodium chloride (NaCl) supplementation on the blood pressure response to treatment with telmisartan with or without hydrochlorothiazide in hypertensive patients with type 2 diabetes and habitually high (HDS, sodium excretion >200 mmol/24 h on two out of three consecutive occasions) or low (LDS, sodium excretion <100 mmol/24 h on two out of three consecutive occasions) salt intake. METHODS: Patients received 4 weeks of telmisartan followed by 4 weeks of telmisartan plus hydrochlorothiazide. In a double-blind randomised fashion, patients received sodium chloride (NaCl, 100 mmol/24 h) or placebo capsules in addition to their habitual salt intake during the last 2 weeks of telmisartan and telmisartan plus hydrochlorothiazide therapy. The protocol was repeated with NaCl and placebo capsules administered in reverse order to allow each participant to act as his or her own control. At 0, 4, 8, 14, 18 and 22 weeks, 24 h ambulatory blood pressure (ABP) and 24 h urine collections were performed. RESULTS: No statistically significant differences were seen in the ABP response in the LDS vs HDS groups to any of the interventions (p = 0.58). NaCl supplementation reduced the effect of telmisartan with or without hydrochlorothiazide on systolic BP by approximately 50% (-5.8 mmHg during NaCl supplementation vs -11.3 mmHg during placebo, mean difference 5.6 mmHg [95% CI 1.7-9.4 mmHg], p = 0.005), irrespective of habitual salt intake. By contrast, addition of hydrochlorothiazide increased the antihypertensive effect of telmisartan on systolic BP by approximately 35% (p = 0.048) in both groups of patients. CONCLUSIONS/INTERPRETATION: NaCl supplementation blunts the effectiveness of telmisartan with or without hydrochlorothiazide in hypertensive patients with type 2 diabetes, independently of habitual low or high salt intake. More... »

PAGES

1295-1303

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00125-010-1711-2

DOI

http://dx.doi.org/10.1007/s00125-010-1711-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001568322

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20372874


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1116", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Physiology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antihypertensive Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Benzimidazoles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Benzoates", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Pressure", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diabetes Mellitus, Type 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Double-Blind Method", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hydrochlorothiazide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypertension", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sodium Chloride, Dietary", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Telmisartan", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Austin Health", 
          "id": "https://www.grid.ac/institutes/grid.410678.c", 
          "name": [
            "Department of Endocrinology, Austin Health and the University of Melbourne, Level 2 Centaur Building, Repatriation Campus, Austin Health, Heidelberg West, 3081, Melbourne, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ekinci", 
        "givenName": "E. I.", 
        "id": "sg:person.01240032256.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240032256.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Austin Health", 
          "id": "https://www.grid.ac/institutes/grid.410678.c", 
          "name": [
            "Department of Endocrinology, Austin Health and the University of Melbourne, Level 2 Centaur Building, Repatriation Campus, Austin Health, Heidelberg West, 3081, Melbourne, VIC, Australia", 
            "Department of Endocrinology, Austin Health and the University of Melbourne, Level 2 Centaur Building, Repatriation Campus, Austin Health, Heidelberg West, 3081, Melbourne, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thomas", 
        "givenName": "G.", 
        "id": "sg:person.01306145456.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306145456.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Austin Health", 
          "id": "https://www.grid.ac/institutes/grid.410678.c", 
          "name": [
            "Department of Endocrinology, Austin Health and the University of Melbourne, Level 2 Centaur Building, Repatriation Campus, Austin Health, Heidelberg West, 3081, Melbourne, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "MacIsaac", 
        "givenName": "R. J.", 
        "id": "sg:person.01212715662.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212715662.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Austin Health", 
          "id": "https://www.grid.ac/institutes/grid.410678.c", 
          "name": [
            "Department of Endocrinology, Austin Health and the University of Melbourne, Level 2 Centaur Building, Repatriation Campus, Austin Health, Heidelberg West, 3081, Melbourne, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Johnson", 
        "givenName": "C.", 
        "id": "sg:person.0630654556.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630654556.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Austin Health", 
          "id": "https://www.grid.ac/institutes/grid.410678.c", 
          "name": [
            "Department of Endocrinology, Austin Health and the University of Melbourne, Level 2 Centaur Building, Repatriation Campus, Austin Health, Heidelberg West, 3081, Melbourne, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Houlihan", 
        "givenName": "C.", 
        "id": "sg:person.01001014263.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001014263.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Austin Health", 
          "id": "https://www.grid.ac/institutes/grid.410678.c", 
          "name": [
            "Department of Endocrinology, Austin Health and the University of Melbourne, Level 2 Centaur Building, Repatriation Campus, Austin Health, Heidelberg West, 3081, Melbourne, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Panagiotopoulos", 
        "givenName": "S.", 
        "id": "sg:person.01117117405.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117117405.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Austin Health", 
          "id": "https://www.grid.ac/institutes/grid.410678.c", 
          "name": [
            "Department of Endocrinology, Austin Health and the University of Melbourne, Level 2 Centaur Building, Repatriation Campus, Austin Health, Heidelberg West, 3081, Melbourne, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Premaratne", 
        "givenName": "E.", 
        "id": "sg:person.0734555605.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734555605.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Austin Health", 
          "id": "https://www.grid.ac/institutes/grid.410678.c", 
          "name": [
            "Vascular Laboratory, Austin Health, Melbourne, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hao", 
        "givenName": "H.", 
        "id": "sg:person.01225505523.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225505523.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Statistical Consulting Service, The University of Melbourne, Melbourne, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Finch", 
        "givenName": "S.", 
        "id": "sg:person.01354630070.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354630070.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Austin Health", 
          "id": "https://www.grid.ac/institutes/grid.410678.c", 
          "name": [
            "Department of Clinical Pharmacology, Austin Health, Melbourne, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "O\u2019Callaghan", 
        "givenName": "C.", 
        "id": "sg:person.01127444756.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127444756.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Austin Health", 
          "id": "https://www.grid.ac/institutes/grid.410678.c", 
          "name": [
            "Department of Endocrinology, Austin Health and the University of Melbourne, Level 2 Centaur Building, Repatriation Campus, Austin Health, Heidelberg West, 3081, Melbourne, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jerums", 
        "givenName": "G.", 
        "id": "sg:person.01343430360.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343430360.16"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1056/nejmra064486", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002874210"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00400605", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003352618", 
          "https://doi.org/10.1007/bf00400605"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00400605", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003352618", 
          "https://doi.org/10.1007/bf00400605"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00400605", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003352618", 
          "https://doi.org/10.1007/bf00400605"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.298.6668.227", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006325882"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0002-9343(90)90144-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007374943"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1681/asn.2007060693", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010558359"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1681/asn.2007060693", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010558359"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.289.19.2560", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013958161"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3317/jraas.2003.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021018288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3317/jraas.2003.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021018288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(87)90127-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022359315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(87)90127-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022359315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/14651858.cd004937", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024581975"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1445-5994.1989.tb01681.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024765414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.7.6_pt_2.ii43", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030660365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hypertensionaha.109.133223", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031632292"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hypertensionaha.109.133223", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031632292"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.17.6.798", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033009798"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pcad.2006.07.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034311972"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.289.6442.406", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039028490"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2796.2004.01390.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039277132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1677/joe-08-0295", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043730069"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004872-200208000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046008266"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004872-200208000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046008266"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(03)12655-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047719649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/dc08-2297", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047903257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.25.4.663", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048722888"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.0000091267.39066.72", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049517110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.0000091267.39066.72", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049517110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/07315724.1991.10718167", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053096391"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1751-7176.2009.00136.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053252547"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1751-7176.2009.00136.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053252547"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.25.5.1042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063338973"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/157340209788921103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069207571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082192717", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-07", 
    "datePublishedReg": "2010-07-01", 
    "description": "AIMS/HYPOTHESIS: We assessed the effects of sodium chloride (NaCl) supplementation on the blood pressure response to treatment with telmisartan with or without hydrochlorothiazide in hypertensive patients with type 2 diabetes and habitually high (HDS, sodium excretion >200 mmol/24 h on two out of three consecutive occasions) or low (LDS, sodium excretion <100 mmol/24 h on two out of three consecutive occasions) salt intake.\nMETHODS: Patients received 4 weeks of telmisartan followed by 4 weeks of telmisartan plus hydrochlorothiazide. In a double-blind randomised fashion, patients received sodium chloride (NaCl, 100 mmol/24 h) or placebo capsules in addition to their habitual salt intake during the last 2 weeks of telmisartan and telmisartan plus hydrochlorothiazide therapy. The protocol was repeated with NaCl and placebo capsules administered in reverse order to allow each participant to act as his or her own control. At 0, 4, 8, 14, 18 and 22 weeks, 24 h ambulatory blood pressure (ABP) and 24 h urine collections were performed.\nRESULTS: No statistically significant differences were seen in the ABP response in the LDS vs HDS groups to any of the interventions (p = 0.58). NaCl supplementation reduced the effect of telmisartan with or without hydrochlorothiazide on systolic BP by approximately 50% (-5.8 mmHg during NaCl supplementation vs -11.3 mmHg during placebo, mean difference 5.6 mmHg [95% CI 1.7-9.4 mmHg], p = 0.005), irrespective of habitual salt intake. By contrast, addition of hydrochlorothiazide increased the antihypertensive effect of telmisartan on systolic BP by approximately 35% (p = 0.048) in both groups of patients.\nCONCLUSIONS/INTERPRETATION: NaCl supplementation blunts the effectiveness of telmisartan with or without hydrochlorothiazide in hypertensive patients with type 2 diabetes, independently of habitual low or high salt intake.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00125-010-1711-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1001482", 
        "issn": [
          "0012-186X", 
          "1432-0428"
        ], 
        "name": "Diabetologia", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "53"
      }
    ], 
    "name": "Salt supplementation blunts the blood pressure response to telmisartan with or without hydrochlorothiazide in hypertensive patients with type 2 diabetes", 
    "pagination": "1295-1303", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "077857ab45c4ad476191ba7b25f3da6ddc70cc7ada9c9c2c1d91268ce39c6014"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "20372874"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0006777"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00125-010-1711-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1001568322"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00125-010-1711-2", 
      "https://app.dimensions.ai/details/publication/pub.1001568322"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:17", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000348_0000000348/records_54313_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs00125-010-1711-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00125-010-1711-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00125-010-1711-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00125-010-1711-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00125-010-1711-2'


 

This table displays all metadata directly associated to this object as RDF triples.

281 TRIPLES      21 PREDICATES      70 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00125-010-1711-2 schema:about N0b63c46f0a034f3ca4e7c0ade2e88460
2 N5402caa07c9f4453b28417b17c71ed1e
3 N5953badf792c4de1b21667654f8579d8
4 N6760065c8f564c7f869bfbdba08eb871
5 N71f0e580461d4e4d908ad2eaeb1d7a0b
6 N79186bfd6ebf4c3aaf4745af0aa12061
7 N8f562c1ebf01457987604bc9440488a6
8 N93d444a59e61452db88e865fbc7e9702
9 Nafe20b40ff244009813d1dc09538ad31
10 Nb31e8861d590427a9c6c7f8bb97894da
11 Nbb4ce55d7d7a49a9bf94204caf560d50
12 Nddd0572d8301436393a4d60fa38286e0
13 Nfb445837581d477b86cf9299a7b9cbfa
14 Nfc622fdfa8ca40bbbbe01d4071f3f866
15 anzsrc-for:11
16 anzsrc-for:1116
17 schema:author Ne0feed58e45146f092b841f23dc42a96
18 schema:citation sg:pub.10.1007/bf00400605
19 https://app.dimensions.ai/details/publication/pub.1082192717
20 https://doi.org/10.1001/jama.289.19.2560
21 https://doi.org/10.1002/14651858.cd004937
22 https://doi.org/10.1016/0002-9343(90)90144-3
23 https://doi.org/10.1016/j.pcad.2006.07.001
24 https://doi.org/10.1016/s0140-6736(03)12655-4
25 https://doi.org/10.1016/s0140-6736(87)90127-9
26 https://doi.org/10.1056/nejmra064486
27 https://doi.org/10.1080/07315724.1991.10718167
28 https://doi.org/10.1097/00004872-200208000-00001
29 https://doi.org/10.1111/j.1365-2796.2004.01390.x
30 https://doi.org/10.1111/j.1445-5994.1989.tb01681.x
31 https://doi.org/10.1111/j.1751-7176.2009.00136.x
32 https://doi.org/10.1136/bmj.289.6442.406
33 https://doi.org/10.1136/bmj.298.6668.227
34 https://doi.org/10.1161/01.hyp.0000091267.39066.72
35 https://doi.org/10.1161/01.hyp.17.6.798
36 https://doi.org/10.1161/01.hyp.25.5.1042
37 https://doi.org/10.1161/01.hyp.7.6_pt_2.ii43
38 https://doi.org/10.1161/hypertensionaha.109.133223
39 https://doi.org/10.1677/joe-08-0295
40 https://doi.org/10.1681/asn.2007060693
41 https://doi.org/10.2174/157340209788921103
42 https://doi.org/10.2337/dc08-2297
43 https://doi.org/10.2337/diacare.25.4.663
44 https://doi.org/10.3317/jraas.2003.001
45 schema:datePublished 2010-07
46 schema:datePublishedReg 2010-07-01
47 schema:description AIMS/HYPOTHESIS: We assessed the effects of sodium chloride (NaCl) supplementation on the blood pressure response to treatment with telmisartan with or without hydrochlorothiazide in hypertensive patients with type 2 diabetes and habitually high (HDS, sodium excretion >200 mmol/24 h on two out of three consecutive occasions) or low (LDS, sodium excretion <100 mmol/24 h on two out of three consecutive occasions) salt intake. METHODS: Patients received 4 weeks of telmisartan followed by 4 weeks of telmisartan plus hydrochlorothiazide. In a double-blind randomised fashion, patients received sodium chloride (NaCl, 100 mmol/24 h) or placebo capsules in addition to their habitual salt intake during the last 2 weeks of telmisartan and telmisartan plus hydrochlorothiazide therapy. The protocol was repeated with NaCl and placebo capsules administered in reverse order to allow each participant to act as his or her own control. At 0, 4, 8, 14, 18 and 22 weeks, 24 h ambulatory blood pressure (ABP) and 24 h urine collections were performed. RESULTS: No statistically significant differences were seen in the ABP response in the LDS vs HDS groups to any of the interventions (p = 0.58). NaCl supplementation reduced the effect of telmisartan with or without hydrochlorothiazide on systolic BP by approximately 50% (-5.8 mmHg during NaCl supplementation vs -11.3 mmHg during placebo, mean difference 5.6 mmHg [95% CI 1.7-9.4 mmHg], p = 0.005), irrespective of habitual salt intake. By contrast, addition of hydrochlorothiazide increased the antihypertensive effect of telmisartan on systolic BP by approximately 35% (p = 0.048) in both groups of patients. CONCLUSIONS/INTERPRETATION: NaCl supplementation blunts the effectiveness of telmisartan with or without hydrochlorothiazide in hypertensive patients with type 2 diabetes, independently of habitual low or high salt intake.
48 schema:genre research_article
49 schema:inLanguage en
50 schema:isAccessibleForFree true
51 schema:isPartOf N48e79002766f472ea19d86b24071cc36
52 N5d6d903df7954c609d548d54b52331ed
53 sg:journal.1001482
54 schema:name Salt supplementation blunts the blood pressure response to telmisartan with or without hydrochlorothiazide in hypertensive patients with type 2 diabetes
55 schema:pagination 1295-1303
56 schema:productId N00647979170c457a9b0114519b88051d
57 N40cde1ee3a6f441c837e39551a17e6bd
58 Na98fc78d8ca9436f9f79a044f2232cb8
59 Nb990169495634678853f03a74e33e44d
60 Necccb32fa1d14df5a6dab1d132b54b5f
61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001568322
62 https://doi.org/10.1007/s00125-010-1711-2
63 schema:sdDatePublished 2019-04-11T10:17
64 schema:sdLicense https://scigraph.springernature.com/explorer/license/
65 schema:sdPublisher Nb445c173e8754cb2b859ccdccad7410e
66 schema:url https://link.springer.com/10.1007%2Fs00125-010-1711-2
67 sgo:license sg:explorer/license/
68 sgo:sdDataset articles
69 rdf:type schema:ScholarlyArticle
70 N00647979170c457a9b0114519b88051d schema:name nlm_unique_id
71 schema:value 0006777
72 rdf:type schema:PropertyValue
73 N0b63c46f0a034f3ca4e7c0ade2e88460 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Diabetes Mellitus, Type 2
75 rdf:type schema:DefinedTerm
76 N11bf3bb755e24f7ea8e9a9f5278bcbdf rdf:first sg:person.0734555605.67
77 rdf:rest N695d8b83a5f042c389cea971d84a75a0
78 N144260051d5844278d9e748afeab7d64 rdf:first sg:person.01001014263.74
79 rdf:rest N95892cb8eb834994947b0ccf2bdabd49
80 N40cde1ee3a6f441c837e39551a17e6bd schema:name pubmed_id
81 schema:value 20372874
82 rdf:type schema:PropertyValue
83 N44b0a9312d8a4203a7e47fa945efdd77 rdf:first sg:person.01306145456.17
84 rdf:rest N79561f7a945a47cfa61c6f06b7310547
85 N48e79002766f472ea19d86b24071cc36 schema:issueNumber 7
86 rdf:type schema:PublicationIssue
87 N4c12934eb76941f48f8596bd9bad2e8f rdf:first sg:person.01354630070.38
88 rdf:rest Ncbc6cbcaa27c4787ad3982836df86780
89 N5402caa07c9f4453b28417b17c71ed1e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Telmisartan
91 rdf:type schema:DefinedTerm
92 N5953badf792c4de1b21667654f8579d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Male
94 rdf:type schema:DefinedTerm
95 N5d6d903df7954c609d548d54b52331ed schema:volumeNumber 53
96 rdf:type schema:PublicationVolume
97 N609a6a126c13487eaa3369e015015fe0 rdf:first sg:person.01343430360.16
98 rdf:rest rdf:nil
99 N6760065c8f564c7f869bfbdba08eb871 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Female
101 rdf:type schema:DefinedTerm
102 N695d8b83a5f042c389cea971d84a75a0 rdf:first sg:person.01225505523.11
103 rdf:rest N4c12934eb76941f48f8596bd9bad2e8f
104 N71f0e580461d4e4d908ad2eaeb1d7a0b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Hypertension
106 rdf:type schema:DefinedTerm
107 N79186bfd6ebf4c3aaf4745af0aa12061 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Sodium Chloride, Dietary
109 rdf:type schema:DefinedTerm
110 N79561f7a945a47cfa61c6f06b7310547 rdf:first sg:person.01212715662.16
111 rdf:rest Nc34e874116cf408faf4cdcd82a9c200d
112 N8f562c1ebf01457987604bc9440488a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Benzoates
114 rdf:type schema:DefinedTerm
115 N93d444a59e61452db88e865fbc7e9702 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Hydrochlorothiazide
117 rdf:type schema:DefinedTerm
118 N95892cb8eb834994947b0ccf2bdabd49 rdf:first sg:person.01117117405.17
119 rdf:rest N11bf3bb755e24f7ea8e9a9f5278bcbdf
120 Na98fc78d8ca9436f9f79a044f2232cb8 schema:name doi
121 schema:value 10.1007/s00125-010-1711-2
122 rdf:type schema:PropertyValue
123 Nafe20b40ff244009813d1dc09538ad31 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Blood Pressure
125 rdf:type schema:DefinedTerm
126 Nb31e8861d590427a9c6c7f8bb97894da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Humans
128 rdf:type schema:DefinedTerm
129 Nb445c173e8754cb2b859ccdccad7410e schema:name Springer Nature - SN SciGraph project
130 rdf:type schema:Organization
131 Nb990169495634678853f03a74e33e44d schema:name readcube_id
132 schema:value 077857ab45c4ad476191ba7b25f3da6ddc70cc7ada9c9c2c1d91268ce39c6014
133 rdf:type schema:PropertyValue
134 Nbb4ce55d7d7a49a9bf94204caf560d50 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Middle Aged
136 rdf:type schema:DefinedTerm
137 Nc34e874116cf408faf4cdcd82a9c200d rdf:first sg:person.0630654556.24
138 rdf:rest N144260051d5844278d9e748afeab7d64
139 Ncbc6cbcaa27c4787ad3982836df86780 rdf:first sg:person.01127444756.98
140 rdf:rest N609a6a126c13487eaa3369e015015fe0
141 Nddd0572d8301436393a4d60fa38286e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Benzimidazoles
143 rdf:type schema:DefinedTerm
144 Ne0feed58e45146f092b841f23dc42a96 rdf:first sg:person.01240032256.75
145 rdf:rest N44b0a9312d8a4203a7e47fa945efdd77
146 Necccb32fa1d14df5a6dab1d132b54b5f schema:name dimensions_id
147 schema:value pub.1001568322
148 rdf:type schema:PropertyValue
149 Nfb445837581d477b86cf9299a7b9cbfa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Antihypertensive Agents
151 rdf:type schema:DefinedTerm
152 Nfc622fdfa8ca40bbbbe01d4071f3f866 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Double-Blind Method
154 rdf:type schema:DefinedTerm
155 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
156 schema:name Medical and Health Sciences
157 rdf:type schema:DefinedTerm
158 anzsrc-for:1116 schema:inDefinedTermSet anzsrc-for:
159 schema:name Medical Physiology
160 rdf:type schema:DefinedTerm
161 sg:journal.1001482 schema:issn 0012-186X
162 1432-0428
163 schema:name Diabetologia
164 rdf:type schema:Periodical
165 sg:person.01001014263.74 schema:affiliation https://www.grid.ac/institutes/grid.410678.c
166 schema:familyName Houlihan
167 schema:givenName C.
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001014263.74
169 rdf:type schema:Person
170 sg:person.01117117405.17 schema:affiliation https://www.grid.ac/institutes/grid.410678.c
171 schema:familyName Panagiotopoulos
172 schema:givenName S.
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117117405.17
174 rdf:type schema:Person
175 sg:person.01127444756.98 schema:affiliation https://www.grid.ac/institutes/grid.410678.c
176 schema:familyName O’Callaghan
177 schema:givenName C.
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127444756.98
179 rdf:type schema:Person
180 sg:person.01212715662.16 schema:affiliation https://www.grid.ac/institutes/grid.410678.c
181 schema:familyName MacIsaac
182 schema:givenName R. J.
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212715662.16
184 rdf:type schema:Person
185 sg:person.01225505523.11 schema:affiliation https://www.grid.ac/institutes/grid.410678.c
186 schema:familyName Hao
187 schema:givenName H.
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225505523.11
189 rdf:type schema:Person
190 sg:person.01240032256.75 schema:affiliation https://www.grid.ac/institutes/grid.410678.c
191 schema:familyName Ekinci
192 schema:givenName E. I.
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240032256.75
194 rdf:type schema:Person
195 sg:person.01306145456.17 schema:affiliation https://www.grid.ac/institutes/grid.410678.c
196 schema:familyName Thomas
197 schema:givenName G.
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306145456.17
199 rdf:type schema:Person
200 sg:person.01343430360.16 schema:affiliation https://www.grid.ac/institutes/grid.410678.c
201 schema:familyName Jerums
202 schema:givenName G.
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343430360.16
204 rdf:type schema:Person
205 sg:person.01354630070.38 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
206 schema:familyName Finch
207 schema:givenName S.
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354630070.38
209 rdf:type schema:Person
210 sg:person.0630654556.24 schema:affiliation https://www.grid.ac/institutes/grid.410678.c
211 schema:familyName Johnson
212 schema:givenName C.
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630654556.24
214 rdf:type schema:Person
215 sg:person.0734555605.67 schema:affiliation https://www.grid.ac/institutes/grid.410678.c
216 schema:familyName Premaratne
217 schema:givenName E.
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734555605.67
219 rdf:type schema:Person
220 sg:pub.10.1007/bf00400605 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003352618
221 https://doi.org/10.1007/bf00400605
222 rdf:type schema:CreativeWork
223 https://app.dimensions.ai/details/publication/pub.1082192717 schema:CreativeWork
224 https://doi.org/10.1001/jama.289.19.2560 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013958161
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1002/14651858.cd004937 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024581975
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/0002-9343(90)90144-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007374943
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/j.pcad.2006.07.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034311972
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/s0140-6736(03)12655-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047719649
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/s0140-6736(87)90127-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022359315
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1056/nejmra064486 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002874210
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1080/07315724.1991.10718167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053096391
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1097/00004872-200208000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046008266
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1111/j.1365-2796.2004.01390.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039277132
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1111/j.1445-5994.1989.tb01681.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024765414
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1111/j.1751-7176.2009.00136.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1053252547
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1136/bmj.289.6442.406 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039028490
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1136/bmj.298.6668.227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006325882
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1161/01.hyp.0000091267.39066.72 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049517110
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1161/01.hyp.17.6.798 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033009798
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1161/01.hyp.25.5.1042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063338973
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1161/01.hyp.7.6_pt_2.ii43 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030660365
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1161/hypertensionaha.109.133223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031632292
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1677/joe-08-0295 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043730069
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1681/asn.2007060693 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010558359
265 rdf:type schema:CreativeWork
266 https://doi.org/10.2174/157340209788921103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069207571
267 rdf:type schema:CreativeWork
268 https://doi.org/10.2337/dc08-2297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047903257
269 rdf:type schema:CreativeWork
270 https://doi.org/10.2337/diacare.25.4.663 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048722888
271 rdf:type schema:CreativeWork
272 https://doi.org/10.3317/jraas.2003.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021018288
273 rdf:type schema:CreativeWork
274 https://www.grid.ac/institutes/grid.1008.9 schema:alternateName University of Melbourne
275 schema:name Statistical Consulting Service, The University of Melbourne, Melbourne, VIC, Australia
276 rdf:type schema:Organization
277 https://www.grid.ac/institutes/grid.410678.c schema:alternateName Austin Health
278 schema:name Department of Clinical Pharmacology, Austin Health, Melbourne, VIC, Australia
279 Department of Endocrinology, Austin Health and the University of Melbourne, Level 2 Centaur Building, Repatriation Campus, Austin Health, Heidelberg West, 3081, Melbourne, VIC, Australia
280 Vascular Laboratory, Austin Health, Melbourne, VIC, Australia
281 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...