Sex differences in glucose levels: a consequence of physiology or methodological convenience? The Inter99 study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-05

AUTHORS

K. Færch, K. Borch-Johnsen, A. Vaag, T. Jørgensen, D. R. Witte

ABSTRACT

AIMS/HYPOTHESIS: We aimed to examine whether sex differences in fasting plasma glucose (FPG), 2 h post-OGTT plasma glucose (2hPG) and HbA(1c) could be explained by differences in body size and/or body composition between men and women in a general non-diabetic Danish population. Moreover, we aimed to study to what degree the newly suggested high-risk HbA(1c) criteria overlapped with the current OGTT-based criteria of glucose intolerance. METHODS: We used cross-sectional data from 6,006 non-diabetic men and women. HbA(1c) and FPG levels were measured and a 75 g OGTT was performed in all individuals. Height, weight and waist and hip circumferences were measured and BMI was calculated. Data were analysed in age-adjusted linear regression models. RESULTS: Men had higher FPG and HbA(1c) levels than women, and women had higher 2hPG levels than men. Sex differences in 2hPG levels were explained by differences in height and FPG levels, but sex differences in FPG or HbA(1c) levels were not explained by anthropometric measures. Among individuals with HbA(1c) in the high-risk range (6.0-6.5%), 73% had normal glucose tolerance. CONCLUSIONS/INTERPRETATION: Sex differences in 2hPG levels after an OGTT may to some extent be a consequence of giving the same amount of glucose to individuals with different body size. In contrast, sex differences in FPG and HbA(1c) levels are likely to have a true physiological basis. In clinical practice, the HbA(1c) assay may be more convenient than the OGTT, but it is important to note that different populations are identified by the two methods. More... »

PAGES

858-865

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00125-010-1673-4

DOI

http://dx.doi.org/10.1007/s00125-010-1673-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035619901

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20182862


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Public Health and Health Services", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Analysis of Variance", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Glucose", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Body Composition", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Body Mass Index", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cross-Sectional Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Denmark", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fasting", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glucose Tolerance Test", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glycated Hemoglobin A", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin Resistance", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Regression Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sex Characteristics", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Steno Diabetes Center", 
          "id": "https://www.grid.ac/institutes/grid.419658.7", 
          "name": [
            "Steno Diabetes Center, Niels Steensens Vej 2, DK-2820, Gentofte, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "F\u00e6rch", 
        "givenName": "K.", 
        "id": "sg:person.01005557512.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005557512.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Aarhus University", 
          "id": "https://www.grid.ac/institutes/grid.7048.b", 
          "name": [
            "Steno Diabetes Center, Niels Steensens Vej 2, DK-2820, Gentofte, Denmark", 
            "Faculty of Health Sciences, University of Aarhus, Aarhus, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Borch-Johnsen", 
        "givenName": "K.", 
        "id": "sg:person.01032545707.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032545707.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Steno Diabetes Center", 
          "id": "https://www.grid.ac/institutes/grid.419658.7", 
          "name": [
            "Steno Diabetes Center, Niels Steensens Vej 2, DK-2820, Gentofte, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vaag", 
        "givenName": "A.", 
        "id": "sg:person.01040410202.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040410202.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Copenhagen", 
          "id": "https://www.grid.ac/institutes/grid.5254.6", 
          "name": [
            "Research Centre for Prevention and Health, Glostrup, Denmark", 
            "Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "J\u00f8rgensen", 
        "givenName": "T.", 
        "id": "sg:person.01002106575.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002106575.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Steno Diabetes Center", 
          "id": "https://www.grid.ac/institutes/grid.419658.7", 
          "name": [
            "Steno Diabetes Center, Niels Steensens Vej 2, DK-2820, Gentofte, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Witte", 
        "givenName": "D. R.", 
        "id": "sg:person.0662552055.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662552055.53"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/j.1464-5491.2008.02578.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000097701"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa012512", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001036745"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.26.8.2335", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001458980"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00403292", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002847909", 
          "https://doi.org/10.1007/bf00403292"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00403292", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002847909", 
          "https://doi.org/10.1007/bf00403292"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00403292", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002847909", 
          "https://doi.org/10.1007/bf00403292"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/dc07-0912", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003990454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1464-5491.2007.02362.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004371670"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.52.10.2490", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013009105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1096-9136(199807)15:7<539::aid-dia668>3.0.co;2-s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016868849"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.51.4.1271", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020739764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.49.6.975", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021920985"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001250051022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025608707", 
          "https://doi.org/10.1007/s001250051022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001250051022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025608707", 
          "https://doi.org/10.1007/s001250051022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00280883", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027902786", 
          "https://doi.org/10.1007/bf00280883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00280883", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027902786", 
          "https://doi.org/10.1007/bf00280883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00280883", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027902786", 
          "https://doi.org/10.1007/bf00280883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.26.1.61", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031847639"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/dc09-9033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034182990"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm200105033441801", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034342241"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/eje.0.1350425", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037456481"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/db05-1200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038239102"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-009-1443-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038558372", 
          "https://doi.org/10.1007/s00125-009-1443-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-009-1443-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038558372", 
          "https://doi.org/10.1007/s00125-009-1443-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-009-1443-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038558372", 
          "https://doi.org/10.1007/s00125-009-1443-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-009-1443-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038558372", 
          "https://doi.org/10.1007/s00125-009-1443-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1464-5491.2009.02688.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046529004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1464-5491.2003.01059.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051839232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.hjr.0000096541.30533.82", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060329929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.hjr.0000096541.30533.82", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060329929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.315.7104.341", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062780437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.315.7104.341", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062780437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1900/rds.2008.5.163", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068727908"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diab.27.1.42", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070733164"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.27.1.42", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070739509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.18.9.1270", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070746838"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.20.4.537", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070747641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.22.9.1462", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070748909"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081952033", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-05", 
    "datePublishedReg": "2010-05-01", 
    "description": "AIMS/HYPOTHESIS: We aimed to examine whether sex differences in fasting plasma glucose (FPG), 2 h post-OGTT plasma glucose (2hPG) and HbA(1c) could be explained by differences in body size and/or body composition between men and women in a general non-diabetic Danish population. Moreover, we aimed to study to what degree the newly suggested high-risk HbA(1c) criteria overlapped with the current OGTT-based criteria of glucose intolerance.\nMETHODS: We used cross-sectional data from 6,006 non-diabetic men and women. HbA(1c) and FPG levels were measured and a 75 g OGTT was performed in all individuals. Height, weight and waist and hip circumferences were measured and BMI was calculated. Data were analysed in age-adjusted linear regression models.\nRESULTS: Men had higher FPG and HbA(1c) levels than women, and women had higher 2hPG levels than men. Sex differences in 2hPG levels were explained by differences in height and FPG levels, but sex differences in FPG or HbA(1c) levels were not explained by anthropometric measures. Among individuals with HbA(1c) in the high-risk range (6.0-6.5%), 73% had normal glucose tolerance.\nCONCLUSIONS/INTERPRETATION: Sex differences in 2hPG levels after an OGTT may to some extent be a consequence of giving the same amount of glucose to individuals with different body size. In contrast, sex differences in FPG and HbA(1c) levels are likely to have a true physiological basis. In clinical practice, the HbA(1c) assay may be more convenient than the OGTT, but it is important to note that different populations are identified by the two methods.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00125-010-1673-4", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2768217", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1001482", 
        "issn": [
          "0012-186X", 
          "1432-0428"
        ], 
        "name": "Diabetologia", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "53"
      }
    ], 
    "name": "Sex differences in glucose levels: a consequence of physiology or methodological convenience? The Inter99 study", 
    "pagination": "858-865", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a9ae4669883472e9c15a76537c3402e51d7cef19cf3eb4a0c8174f92d2440eca"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "20182862"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0006777"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00125-010-1673-4"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1035619901"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00125-010-1673-4", 
      "https://app.dimensions.ai/details/publication/pub.1035619901"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:28", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000349_0000000349/records_113641_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs00125-010-1673-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00125-010-1673-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00125-010-1673-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00125-010-1673-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00125-010-1673-4'


 

This table displays all metadata directly associated to this object as RDF triples.

265 TRIPLES      21 PREDICATES      75 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00125-010-1673-4 schema:about N015e862e395d42ce85f262b02f9268b1
2 N1287a76346c14081923fac602a21602e
3 N18c3e7f1c0c14c76aef45f3ba69d4048
4 N1975ea9342ec45b9998883e9592b0640
5 N29e880ec33594e2b8bc6d6790fe3f4bf
6 N39faa443212340a98d03ebecd94238b2
7 N4cfe4ebdb7764de0a4c50e11e5ea659b
8 N54f35fab71a04a11a13d899299ad9bec
9 N5d37f01573c048899e614b51df217c7d
10 N6539a131419a4c868ad3d4f366f60a7e
11 N67ecebef036d4c9aac157686b09ba1de
12 N9acca1e78059448fbb18eb97213cd30d
13 N9cb6d60003e3421587b0d074fd795c3d
14 Nbe052dac4e6c49c38032a13abaedc05a
15 Nc418320404774d648fef014c30ff5f83
16 Ncae24f7499bf40a88e192799a626d088
17 Nd5646a1249c04170ad54ddd507dea197
18 anzsrc-for:11
19 anzsrc-for:1117
20 schema:author N25e50253daa5442e8d5f0ebe3a686e8c
21 schema:citation sg:pub.10.1007/bf00280883
22 sg:pub.10.1007/bf00403292
23 sg:pub.10.1007/s00125-009-1443-3
24 sg:pub.10.1007/s001250051022
25 https://app.dimensions.ai/details/publication/pub.1081952033
26 https://doi.org/10.1002/(sici)1096-9136(199807)15:7<539::aid-dia668>3.0.co;2-s
27 https://doi.org/10.1046/j.1464-5491.2003.01059.x
28 https://doi.org/10.1056/nejm200105033441801
29 https://doi.org/10.1056/nejmoa012512
30 https://doi.org/10.1097/01.hjr.0000096541.30533.82
31 https://doi.org/10.1111/j.1464-5491.2007.02362.x
32 https://doi.org/10.1111/j.1464-5491.2008.02578.x
33 https://doi.org/10.1111/j.1464-5491.2009.02688.x
34 https://doi.org/10.1136/bmj.315.7104.341
35 https://doi.org/10.1530/eje.0.1350425
36 https://doi.org/10.1900/rds.2008.5.163
37 https://doi.org/10.2337/db05-1200
38 https://doi.org/10.2337/dc07-0912
39 https://doi.org/10.2337/dc09-9033
40 https://doi.org/10.2337/diab.27.1.42
41 https://doi.org/10.2337/diabetes.27.1.42
42 https://doi.org/10.2337/diabetes.49.6.975
43 https://doi.org/10.2337/diabetes.51.4.1271
44 https://doi.org/10.2337/diabetes.52.10.2490
45 https://doi.org/10.2337/diacare.18.9.1270
46 https://doi.org/10.2337/diacare.20.4.537
47 https://doi.org/10.2337/diacare.22.9.1462
48 https://doi.org/10.2337/diacare.26.1.61
49 https://doi.org/10.2337/diacare.26.8.2335
50 schema:datePublished 2010-05
51 schema:datePublishedReg 2010-05-01
52 schema:description AIMS/HYPOTHESIS: We aimed to examine whether sex differences in fasting plasma glucose (FPG), 2 h post-OGTT plasma glucose (2hPG) and HbA(1c) could be explained by differences in body size and/or body composition between men and women in a general non-diabetic Danish population. Moreover, we aimed to study to what degree the newly suggested high-risk HbA(1c) criteria overlapped with the current OGTT-based criteria of glucose intolerance. METHODS: We used cross-sectional data from 6,006 non-diabetic men and women. HbA(1c) and FPG levels were measured and a 75 g OGTT was performed in all individuals. Height, weight and waist and hip circumferences were measured and BMI was calculated. Data were analysed in age-adjusted linear regression models. RESULTS: Men had higher FPG and HbA(1c) levels than women, and women had higher 2hPG levels than men. Sex differences in 2hPG levels were explained by differences in height and FPG levels, but sex differences in FPG or HbA(1c) levels were not explained by anthropometric measures. Among individuals with HbA(1c) in the high-risk range (6.0-6.5%), 73% had normal glucose tolerance. CONCLUSIONS/INTERPRETATION: Sex differences in 2hPG levels after an OGTT may to some extent be a consequence of giving the same amount of glucose to individuals with different body size. In contrast, sex differences in FPG and HbA(1c) levels are likely to have a true physiological basis. In clinical practice, the HbA(1c) assay may be more convenient than the OGTT, but it is important to note that different populations are identified by the two methods.
53 schema:genre research_article
54 schema:inLanguage en
55 schema:isAccessibleForFree true
56 schema:isPartOf N05ee5bb6daa14de5bcf8d47889a66c19
57 N3a051b3fe4474969bac243cc63a41a4b
58 sg:journal.1001482
59 schema:name Sex differences in glucose levels: a consequence of physiology or methodological convenience? The Inter99 study
60 schema:pagination 858-865
61 schema:productId N243087965edf42899531aec9db94f66e
62 N4c9692ebc2a542de836eaf91aae6d670
63 N93dfe215ae8d43f9b8fe0ae0fcf859aa
64 Nd38c07b7696c4afa9627f671555a4110
65 Nd931e27c581b4e299ca4880f405cd716
66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035619901
67 https://doi.org/10.1007/s00125-010-1673-4
68 schema:sdDatePublished 2019-04-11T10:28
69 schema:sdLicense https://scigraph.springernature.com/explorer/license/
70 schema:sdPublisher N7f8ecf31abea488c805c9c3c47d139fc
71 schema:url https://link.springer.com/10.1007%2Fs00125-010-1673-4
72 sgo:license sg:explorer/license/
73 sgo:sdDataset articles
74 rdf:type schema:ScholarlyArticle
75 N015e862e395d42ce85f262b02f9268b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Denmark
77 rdf:type schema:DefinedTerm
78 N05ee5bb6daa14de5bcf8d47889a66c19 schema:volumeNumber 53
79 rdf:type schema:PublicationVolume
80 N1287a76346c14081923fac602a21602e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Male
82 rdf:type schema:DefinedTerm
83 N18c3e7f1c0c14c76aef45f3ba69d4048 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Middle Aged
85 rdf:type schema:DefinedTerm
86 N1975ea9342ec45b9998883e9592b0640 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Humans
88 rdf:type schema:DefinedTerm
89 N243087965edf42899531aec9db94f66e schema:name dimensions_id
90 schema:value pub.1035619901
91 rdf:type schema:PropertyValue
92 N25e50253daa5442e8d5f0ebe3a686e8c rdf:first sg:person.01005557512.99
93 rdf:rest Nd02c39c44885457196e0670b12607e75
94 N29e880ec33594e2b8bc6d6790fe3f4bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Adult
96 rdf:type schema:DefinedTerm
97 N39faa443212340a98d03ebecd94238b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Body Composition
99 rdf:type schema:DefinedTerm
100 N3a051b3fe4474969bac243cc63a41a4b schema:issueNumber 5
101 rdf:type schema:PublicationIssue
102 N4c9692ebc2a542de836eaf91aae6d670 schema:name nlm_unique_id
103 schema:value 0006777
104 rdf:type schema:PropertyValue
105 N4cfe4ebdb7764de0a4c50e11e5ea659b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Glucose Tolerance Test
107 rdf:type schema:DefinedTerm
108 N54f35fab71a04a11a13d899299ad9bec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Analysis of Variance
110 rdf:type schema:DefinedTerm
111 N5d37f01573c048899e614b51df217c7d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Fasting
113 rdf:type schema:DefinedTerm
114 N64b7853aa1ac40e2b2fa3fd7b99db864 rdf:first sg:person.01002106575.49
115 rdf:rest Nce1e30f902594d38a882dea5a59d4cf3
116 N6539a131419a4c868ad3d4f366f60a7e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Blood Glucose
118 rdf:type schema:DefinedTerm
119 N67ecebef036d4c9aac157686b09ba1de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Cross-Sectional Studies
121 rdf:type schema:DefinedTerm
122 N7f8ecf31abea488c805c9c3c47d139fc schema:name Springer Nature - SN SciGraph project
123 rdf:type schema:Organization
124 N93dfe215ae8d43f9b8fe0ae0fcf859aa schema:name readcube_id
125 schema:value a9ae4669883472e9c15a76537c3402e51d7cef19cf3eb4a0c8174f92d2440eca
126 rdf:type schema:PropertyValue
127 N9acca1e78059448fbb18eb97213cd30d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Glycated Hemoglobin A
129 rdf:type schema:DefinedTerm
130 N9cb6d60003e3421587b0d074fd795c3d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Regression Analysis
132 rdf:type schema:DefinedTerm
133 Nbe052dac4e6c49c38032a13abaedc05a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Body Mass Index
135 rdf:type schema:DefinedTerm
136 Nc418320404774d648fef014c30ff5f83 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Insulin Resistance
138 rdf:type schema:DefinedTerm
139 Nc86d9e0c515048ef9dd17e277250eac5 rdf:first sg:person.01040410202.61
140 rdf:rest N64b7853aa1ac40e2b2fa3fd7b99db864
141 Ncae24f7499bf40a88e192799a626d088 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Sex Characteristics
143 rdf:type schema:DefinedTerm
144 Nce1e30f902594d38a882dea5a59d4cf3 rdf:first sg:person.0662552055.53
145 rdf:rest rdf:nil
146 Nd02c39c44885457196e0670b12607e75 rdf:first sg:person.01032545707.92
147 rdf:rest Nc86d9e0c515048ef9dd17e277250eac5
148 Nd38c07b7696c4afa9627f671555a4110 schema:name pubmed_id
149 schema:value 20182862
150 rdf:type schema:PropertyValue
151 Nd5646a1249c04170ad54ddd507dea197 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Female
153 rdf:type schema:DefinedTerm
154 Nd931e27c581b4e299ca4880f405cd716 schema:name doi
155 schema:value 10.1007/s00125-010-1673-4
156 rdf:type schema:PropertyValue
157 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
158 schema:name Medical and Health Sciences
159 rdf:type schema:DefinedTerm
160 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
161 schema:name Public Health and Health Services
162 rdf:type schema:DefinedTerm
163 sg:grant.2768217 http://pending.schema.org/fundedItem sg:pub.10.1007/s00125-010-1673-4
164 rdf:type schema:MonetaryGrant
165 sg:journal.1001482 schema:issn 0012-186X
166 1432-0428
167 schema:name Diabetologia
168 rdf:type schema:Periodical
169 sg:person.01002106575.49 schema:affiliation https://www.grid.ac/institutes/grid.5254.6
170 schema:familyName Jørgensen
171 schema:givenName T.
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002106575.49
173 rdf:type schema:Person
174 sg:person.01005557512.99 schema:affiliation https://www.grid.ac/institutes/grid.419658.7
175 schema:familyName Færch
176 schema:givenName K.
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005557512.99
178 rdf:type schema:Person
179 sg:person.01032545707.92 schema:affiliation https://www.grid.ac/institutes/grid.7048.b
180 schema:familyName Borch-Johnsen
181 schema:givenName K.
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032545707.92
183 rdf:type schema:Person
184 sg:person.01040410202.61 schema:affiliation https://www.grid.ac/institutes/grid.419658.7
185 schema:familyName Vaag
186 schema:givenName A.
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040410202.61
188 rdf:type schema:Person
189 sg:person.0662552055.53 schema:affiliation https://www.grid.ac/institutes/grid.419658.7
190 schema:familyName Witte
191 schema:givenName D. R.
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662552055.53
193 rdf:type schema:Person
194 sg:pub.10.1007/bf00280883 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027902786
195 https://doi.org/10.1007/bf00280883
196 rdf:type schema:CreativeWork
197 sg:pub.10.1007/bf00403292 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002847909
198 https://doi.org/10.1007/bf00403292
199 rdf:type schema:CreativeWork
200 sg:pub.10.1007/s00125-009-1443-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038558372
201 https://doi.org/10.1007/s00125-009-1443-3
202 rdf:type schema:CreativeWork
203 sg:pub.10.1007/s001250051022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025608707
204 https://doi.org/10.1007/s001250051022
205 rdf:type schema:CreativeWork
206 https://app.dimensions.ai/details/publication/pub.1081952033 schema:CreativeWork
207 https://doi.org/10.1002/(sici)1096-9136(199807)15:7<539::aid-dia668>3.0.co;2-s schema:sameAs https://app.dimensions.ai/details/publication/pub.1016868849
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1046/j.1464-5491.2003.01059.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051839232
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1056/nejm200105033441801 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034342241
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1056/nejmoa012512 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001036745
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1097/01.hjr.0000096541.30533.82 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060329929
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1111/j.1464-5491.2007.02362.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004371670
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1111/j.1464-5491.2008.02578.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000097701
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1111/j.1464-5491.2009.02688.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046529004
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1136/bmj.315.7104.341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062780437
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1530/eje.0.1350425 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037456481
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1900/rds.2008.5.163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068727908
228 rdf:type schema:CreativeWork
229 https://doi.org/10.2337/db05-1200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038239102
230 rdf:type schema:CreativeWork
231 https://doi.org/10.2337/dc07-0912 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003990454
232 rdf:type schema:CreativeWork
233 https://doi.org/10.2337/dc09-9033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034182990
234 rdf:type schema:CreativeWork
235 https://doi.org/10.2337/diab.27.1.42 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070733164
236 rdf:type schema:CreativeWork
237 https://doi.org/10.2337/diabetes.27.1.42 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070739509
238 rdf:type schema:CreativeWork
239 https://doi.org/10.2337/diabetes.49.6.975 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021920985
240 rdf:type schema:CreativeWork
241 https://doi.org/10.2337/diabetes.51.4.1271 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020739764
242 rdf:type schema:CreativeWork
243 https://doi.org/10.2337/diabetes.52.10.2490 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013009105
244 rdf:type schema:CreativeWork
245 https://doi.org/10.2337/diacare.18.9.1270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070746838
246 rdf:type schema:CreativeWork
247 https://doi.org/10.2337/diacare.20.4.537 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070747641
248 rdf:type schema:CreativeWork
249 https://doi.org/10.2337/diacare.22.9.1462 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070748909
250 rdf:type schema:CreativeWork
251 https://doi.org/10.2337/diacare.26.1.61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031847639
252 rdf:type schema:CreativeWork
253 https://doi.org/10.2337/diacare.26.8.2335 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001458980
254 rdf:type schema:CreativeWork
255 https://www.grid.ac/institutes/grid.419658.7 schema:alternateName Steno Diabetes Center
256 schema:name Steno Diabetes Center, Niels Steensens Vej 2, DK-2820, Gentofte, Denmark
257 rdf:type schema:Organization
258 https://www.grid.ac/institutes/grid.5254.6 schema:alternateName University of Copenhagen
259 schema:name Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
260 Research Centre for Prevention and Health, Glostrup, Denmark
261 rdf:type schema:Organization
262 https://www.grid.ac/institutes/grid.7048.b schema:alternateName Aarhus University
263 schema:name Faculty of Health Sciences, University of Aarhus, Aarhus, Denmark
264 Steno Diabetes Center, Niels Steensens Vej 2, DK-2820, Gentofte, Denmark
265 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...