Diabetes mellitus among young adults in Sri Lanka—role of GAD antibodies in classification and treatment: The Sri Lanka Young Diabetes ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-06-05

AUTHORS

P. Katulanda, B. Shine, G. W. Katulanda, A. Silva, E. L. Asfir, R. Sheriff, N. Somasundaram, A. E. Long, P. J. Bingley, M. I. McCarthy, A. Clark, D. R. Matthews

ABSTRACT

Aims/hypothesisDiabetes mellitus is increasing among young adult South Asians. The aim of this study was to determine the prevalence and phenotypic characteristics of diabetes subtypes based on GAD65 autoantibody (GADA) status in those with young adult-onset diabetes in Sri Lanka.MethodsClinical, metabolic and GADA data were available for 992 consecutively recruited individuals with diabetes aged ≤45 years (age at diagnosis 16–40 years). Participants were classified according to the following definitions: type 1 diabetes, insulin-dependent <6 months from diagnosis; latent autoimmune diabetes in adults (LADA), GADA-positive, age ≥30 years and insulin-independent ≥6 months from diagnosis; type 2 diabetes, GADA-negative and insulin-independent ≥6 months from diagnosis.ResultsThe median (interquartile range) age at diagnosis and diabetes duration were 33.0 (29.0–36.1) and 4.0 (1.1–7.1) years, respectively; 42.1% were male. GADA positivity was seen in 5.4% of participants (n = 54) and GADA levels negatively correlated with age at diagnosis (p < 0.0001), BMI (p < 0.0001) and time to insulin requirement (p = 0.006). Type 1 diabetes, type 2 diabetes and LADA were present in 7.0%, 89.7% and 2.6%, respectively. The remaining 0.7% of the participants were GADA-positive, insulin independent ≥6 months from diagnosis and were diagnosed at age <30 years. The metabolic syndrome and homeostasis model assessment of beta cell function (HOMA %B) were lowest in GADA-positive type 1 diabetes and increased progressively in latent autoimmune diabetes, GADA-negative type 1 diabetes and type 2 diabetes. Among those requiring insulin, 69.2% had fasting C-peptide levels in the lowest quartile, whereas only 19.5% were GADA-positive (p < 0.0001).Conclusions/interpretationThe prevalence of GADA-positive autoimmune diabetes is low among individuals with young adult-onset diabetes in Sri Lanka. Young-onset diabetic phenotypes appear as a continuum from autoimmune type 1 diabetes to type 2 diabetes. More... »

PAGES

1368

References to SciGraph publications

  • 2006-07-18. Type 2 diabetes and cardiovascular risk in the UK south Asian community in DIABETOLOGIA
  • 1987-08. The HLA-D associations of Type 1 (insulin-dependent) diabetes in Punjabi Asians in the United Kingdom in DIABETOLOGIA
  • 2006-03-29. Secular trends in the prevalence of diabetes and impaired glucose tolerance in urban South India—the Chennai Urban Rural Epidemiology Study (CURES-17) in DIABETOLOGIA
  • 2007-07-27. GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77 in DIABETOLOGIA
  • 1997-11. Anti-GAD antibodies in Chinese patients with youth and adult-onset IDDM and NIDDM in DIABETOLOGIA
  • 2001-01. Diabetes and gender in DIABETOLOGIA
  • 2004-03-01. The epidemiology of Type 1 diabetes mellitus is not the same in young adults as in children in DIABETOLOGIA
  • 2003-03. Lessons learned from young-onset diabetes in China in CURRENT DIABETES REPORTS
  • 2005-09-29. Latent autoimmune diabetes in adults: a guide for the perplexed in DIABETOLOGIA
  • 1985-07. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man in DIABETOLOGIA
  • 2004-04-28. Temporal changes in prevalence of diabetes and impaired glucose tolerance associated with lifestyle transition occurring in the rural population in India in DIABETOLOGIA
  • 1992-01. Male predominance of Type 1 (insulin-dependent) diabetes mellitus in young adults: results from a 5-year prospective nationwide study of the 15–34-year age group in Sweden in DIABETOLOGIA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00125-008-1052-6

    DOI

    http://dx.doi.org/10.1007/s00125-008-1052-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1026020524

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/18528678


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adolescent", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Autoantibodies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Body Mass Index", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Diabetes Mellitus, Type 1", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Glutamate Decarboxylase", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Glycated Hemoglobin A", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hypoglycemic Agents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Insulin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sri Lanka", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Waist-Hip Ratio", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Diabetes Research Unit, Department of Clinical Medicine, University of Colombo, Colombo, Sri Lanka", 
              "id": "http://www.grid.ac/institutes/grid.8065.b", 
              "name": [
                "Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Old Road, Headington, OX3 7LJ, Oxford, UK", 
                "Diabetes Research Unit, Department of Clinical Medicine, University of Colombo, Colombo, Sri Lanka"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Katulanda", 
            "givenName": "P.", 
            "id": "sg:person.01221545265.99", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221545265.99"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Clinical Biochemistry, John Radcliffe Hospital, Oxford, UK", 
              "id": "http://www.grid.ac/institutes/grid.8348.7", 
              "name": [
                "Department of Clinical Biochemistry, John Radcliffe Hospital, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shine", 
            "givenName": "B.", 
            "id": "sg:person.01015310422.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015310422.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Clinical Biochemistry, John Radcliffe Hospital, Oxford, UK", 
              "id": "http://www.grid.ac/institutes/grid.8348.7", 
              "name": [
                "Department of Clinical Biochemistry, John Radcliffe Hospital, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Katulanda", 
            "givenName": "G. W.", 
            "id": "sg:person.01070674173.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070674173.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Diabetes Research Unit, Department of Clinical Medicine, University of Colombo, Colombo, Sri Lanka", 
              "id": "http://www.grid.ac/institutes/grid.8065.b", 
              "name": [
                "Diabetes Research Unit, Department of Clinical Medicine, University of Colombo, Colombo, Sri Lanka"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Silva", 
            "givenName": "A.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Diabetes Research Unit, Department of Clinical Medicine, University of Colombo, Colombo, Sri Lanka", 
              "id": "http://www.grid.ac/institutes/grid.8065.b", 
              "name": [
                "Diabetes Research Unit, Department of Clinical Medicine, University of Colombo, Colombo, Sri Lanka"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Asfir", 
            "givenName": "E. L.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Diabetes Research Unit, Department of Clinical Medicine, University of Colombo, Colombo, Sri Lanka", 
              "id": "http://www.grid.ac/institutes/grid.8065.b", 
              "name": [
                "Diabetes Research Unit, Department of Clinical Medicine, University of Colombo, Colombo, Sri Lanka"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sheriff", 
            "givenName": "R.", 
            "id": "sg:person.01311106562.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311106562.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Hospital of Sri Lanka, Colombo, Sri Lanka", 
              "id": "http://www.grid.ac/institutes/grid.415398.2", 
              "name": [
                "National Hospital of Sri Lanka, Colombo, Sri Lanka"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Somasundaram", 
            "givenName": "N.", 
            "id": "sg:person.01062503634.84", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062503634.84"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Clinical Science at North Bristol, University of Bristol, Bristol, UK", 
              "id": "http://www.grid.ac/institutes/grid.5337.2", 
              "name": [
                "Department of Clinical Science at North Bristol, University of Bristol, Bristol, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Long", 
            "givenName": "A. E.", 
            "id": "sg:person.01261132331.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261132331.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Clinical Science at North Bristol, University of Bristol, Bristol, UK", 
              "id": "http://www.grid.ac/institutes/grid.5337.2", 
              "name": [
                "Department of Clinical Science at North Bristol, University of Bristol, Bristol, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bingley", 
            "givenName": "P. J.", 
            "id": "sg:person.0740770547.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740770547.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Old Road, Headington, OX3 7LJ, Oxford, UK", 
              "id": "http://www.grid.ac/institutes/grid.415719.f", 
              "name": [
                "Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Old Road, Headington, OX3 7LJ, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "McCarthy", 
            "givenName": "M. I.", 
            "id": "sg:person.016704245502.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016704245502.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Old Road, Headington, OX3 7LJ, Oxford, UK", 
              "id": "http://www.grid.ac/institutes/grid.415719.f", 
              "name": [
                "Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Old Road, Headington, OX3 7LJ, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Clark", 
            "givenName": "A.", 
            "id": "sg:person.0747270127.65", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747270127.65"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Old Road, Headington, OX3 7LJ, Oxford, UK", 
              "id": "http://www.grid.ac/institutes/grid.415719.f", 
              "name": [
                "Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Old Road, Headington, OX3 7LJ, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Matthews", 
            "givenName": "D. R.", 
            "id": "sg:person.01216556762.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216556762.76"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s11892-003-0032-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030788656", 
              "https://doi.org/10.1007/s11892-003-0032-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00280883", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027902786", 
              "https://doi.org/10.1007/bf00280883"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00125-006-0325-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019508803", 
              "https://doi.org/10.1007/s00125-006-0325-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s001250051573", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033712832", 
              "https://doi.org/10.1007/s001250051573"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00125-004-1387-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017781273", 
              "https://doi.org/10.1007/s00125-004-1387-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s001250050845", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045914024", 
              "https://doi.org/10.1007/s001250050845"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00125-005-1954-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032072655", 
              "https://doi.org/10.1007/s00125-005-1954-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00125-004-1331-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031776101", 
              "https://doi.org/10.1007/s00125-004-1331-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00400852", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006075533", 
              "https://doi.org/10.1007/bf00400852"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00125-006-0219-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046070357", 
              "https://doi.org/10.1007/s00125-006-0219-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00125-007-0745-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012458684", 
              "https://doi.org/10.1007/s00125-007-0745-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00277317", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079878534", 
              "https://doi.org/10.1007/bf00277317"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2008-06-05", 
        "datePublishedReg": "2008-06-05", 
        "description": "Aims/hypothesisDiabetes mellitus is increasing among young adult South Asians. The aim of this study was to determine the prevalence and phenotypic characteristics of diabetes subtypes based on GAD65 autoantibody (GADA) status in those with young adult-onset diabetes in Sri Lanka.MethodsClinical, metabolic and GADA data were available for 992 consecutively recruited individuals with diabetes aged \u226445\u00a0years (age at diagnosis 16\u201340\u00a0years). Participants were classified according to the following definitions: type 1 diabetes, insulin-dependent <6\u00a0months from diagnosis; latent autoimmune diabetes in adults (LADA), GADA-positive, age \u226530\u00a0years and insulin-independent \u22656\u00a0months from diagnosis; type 2 diabetes, GADA-negative and insulin-independent \u22656\u00a0months from diagnosis.ResultsThe median (interquartile range) age at diagnosis and diabetes duration were 33.0 (29.0\u201336.1) and 4.0 (1.1\u20137.1) years, respectively; 42.1% were male. GADA positivity was seen in 5.4% of participants (n\u2009=\u200954) and GADA levels negatively correlated with age at diagnosis (p\u2009<\u20090.0001), BMI (p\u2009<\u20090.0001) and time to insulin requirement (p\u2009=\u20090.006). Type 1 diabetes, type 2 diabetes and LADA were present in 7.0%, 89.7% and 2.6%, respectively. The remaining 0.7% of the participants were GADA-positive, insulin independent \u22656\u00a0months from diagnosis and were diagnosed at age <30\u00a0years. The metabolic syndrome and homeostasis model assessment of beta cell function (HOMA %B) were lowest in GADA-positive type 1 diabetes and increased progressively in latent autoimmune diabetes, GADA-negative type 1 diabetes and type 2 diabetes. Among those requiring insulin, 69.2% had fasting C-peptide levels in the lowest quartile, whereas only 19.5% were GADA-positive (p\u2009<\u20090.0001).Conclusions/interpretationThe prevalence of GADA-positive autoimmune diabetes is low among individuals with young adult-onset diabetes in Sri Lanka. Young-onset diabetic phenotypes appear as a continuum from autoimmune type 1 diabetes to type 2 diabetes.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s00125-008-1052-6", 
        "inLanguage": "en", 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1001482", 
            "issn": [
              "0012-186X", 
              "1432-0428"
            ], 
            "name": "Diabetologia", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "8", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "51"
          }
        ], 
        "keywords": [
          "type 1 diabetes", 
          "type 2 diabetes", 
          "young adult-onset diabetes", 
          "adult-onset diabetes", 
          "autoimmune diabetes", 
          "Conclusions/interpretationThe prevalence", 
          "autoimmune type 1 diabetes", 
          "adult South Asians", 
          "latent autoimmune diabetes", 
          "Aims/hypothesisDiabetes mellitus", 
          "homeostasis model assessment", 
          "beta-cell function", 
          "GADA levels", 
          "autoantibody status", 
          "diabetes subtypes", 
          "diabetes duration", 
          "insulin requirements", 
          "median age", 
          "GAD antibodies", 
          "metabolic syndrome", 
          "diabetes mellitus", 
          "GADA positivity", 
          "Diabetes Study", 
          "insulin independent", 
          "peptide levels", 
          "diabetic phenotype", 
          "diabetes", 
          "model assessment", 
          "diagnosis", 
          "cell function", 
          "young adults", 
          "months", 
          "mellitus", 
          "age", 
          "South Asians", 
          "GADA", 
          "prevalence", 
          "adults", 
          "participants", 
          "years", 
          "phenotypic characteristics", 
          "MethodsClinical", 
          "BMI", 
          "syndrome", 
          "subtypes", 
          "insulin", 
          "Sri Lanka", 
          "individuals", 
          "positivity", 
          "antibodies", 
          "levels", 
          "treatment", 
          "study", 
          "LADA", 
          "duration", 
          "status", 
          "Asians", 
          "phenotype", 
          "aim", 
          "assessment", 
          "independent", 
          "latent", 
          "Lanka", 
          "function", 
          "data", 
          "classification", 
          "time", 
          "characteristics", 
          "definition", 
          "continuum", 
          "requirements", 
          "hypothesisDiabetes mellitus", 
          "young adult South Asians", 
          "GAD65 autoantibody (GADA) status", 
          "GADA data", 
          "GADA-positive type 1 diabetes", 
          "GADA-negative type 1 diabetes", 
          "interpretationThe prevalence", 
          "GADA-positive autoimmune diabetes", 
          "Young-onset diabetic phenotypes", 
          "Sri Lanka\u2014role", 
          "Lanka\u2014role", 
          "Sri Lanka Young Diabetes study", 
          "Lanka Young Diabetes study", 
          "Young Diabetes study"
        ], 
        "name": "Diabetes mellitus among young adults in Sri Lanka\u2014role of GAD antibodies in classification and treatment: The Sri Lanka Young Diabetes study", 
        "pagination": "1368", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1026020524"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00125-008-1052-6"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "18528678"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00125-008-1052-6", 
          "https://app.dimensions.ai/details/publication/pub.1026020524"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-01-01T18:17", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_457.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s00125-008-1052-6"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00125-008-1052-6'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00125-008-1052-6'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00125-008-1052-6'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00125-008-1052-6'


     

    This table displays all metadata directly associated to this object as RDF triples.

    339 TRIPLES      22 PREDICATES      137 URIs      117 LITERALS      21 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00125-008-1052-6 schema:about N160ee9518b2f4deeaa5c102dde484f6a
    2 N25f8bee66f3240e0b5cc04d624981acb
    3 N38b42a6fc43646389dd8a88e6d2746ea
    4 N816ae251aa194617bb7f52d12d7d7865
    5 N835bb74a222542e2aedaa883cca6a5c2
    6 N8cd76419042e45a49bdeae71873b6973
    7 Nb5f2a1e0cc80406d897ae0d942f2155b
    8 Nc76fb0d44dca45089bc103f792758b45
    9 Ndbfc4f59f3a44881940fc8a8e81ee894
    10 Ne2721212b7df499ea3dfe2f9c96a5804
    11 Ne4b4053f6d3c4bc9a4af7b0226b0a6cb
    12 Nea26a8e2a7a64872b092860f247619b0
    13 Nee1dab8687404dad9917e064fe6ad652
    14 Nfa0d5d9ea4e94d85aecc5faf1fdf38a7
    15 anzsrc-for:11
    16 anzsrc-for:1103
    17 schema:author N88500f1576a44a598dc855e77f9370c9
    18 schema:citation sg:pub.10.1007/bf00277317
    19 sg:pub.10.1007/bf00280883
    20 sg:pub.10.1007/bf00400852
    21 sg:pub.10.1007/s00125-004-1331-9
    22 sg:pub.10.1007/s00125-004-1387-6
    23 sg:pub.10.1007/s00125-005-1954-5
    24 sg:pub.10.1007/s00125-006-0219-2
    25 sg:pub.10.1007/s00125-006-0325-1
    26 sg:pub.10.1007/s00125-007-0745-6
    27 sg:pub.10.1007/s001250050845
    28 sg:pub.10.1007/s001250051573
    29 sg:pub.10.1007/s11892-003-0032-y
    30 schema:datePublished 2008-06-05
    31 schema:datePublishedReg 2008-06-05
    32 schema:description Aims/hypothesisDiabetes mellitus is increasing among young adult South Asians. The aim of this study was to determine the prevalence and phenotypic characteristics of diabetes subtypes based on GAD65 autoantibody (GADA) status in those with young adult-onset diabetes in Sri Lanka.MethodsClinical, metabolic and GADA data were available for 992 consecutively recruited individuals with diabetes aged ≤45 years (age at diagnosis 16–40 years). Participants were classified according to the following definitions: type 1 diabetes, insulin-dependent <6 months from diagnosis; latent autoimmune diabetes in adults (LADA), GADA-positive, age ≥30 years and insulin-independent ≥6 months from diagnosis; type 2 diabetes, GADA-negative and insulin-independent ≥6 months from diagnosis.ResultsThe median (interquartile range) age at diagnosis and diabetes duration were 33.0 (29.0–36.1) and 4.0 (1.1–7.1) years, respectively; 42.1% were male. GADA positivity was seen in 5.4% of participants (n = 54) and GADA levels negatively correlated with age at diagnosis (p < 0.0001), BMI (p < 0.0001) and time to insulin requirement (p = 0.006). Type 1 diabetes, type 2 diabetes and LADA were present in 7.0%, 89.7% and 2.6%, respectively. The remaining 0.7% of the participants were GADA-positive, insulin independent ≥6 months from diagnosis and were diagnosed at age <30 years. The metabolic syndrome and homeostasis model assessment of beta cell function (HOMA %B) were lowest in GADA-positive type 1 diabetes and increased progressively in latent autoimmune diabetes, GADA-negative type 1 diabetes and type 2 diabetes. Among those requiring insulin, 69.2% had fasting C-peptide levels in the lowest quartile, whereas only 19.5% were GADA-positive (p < 0.0001).Conclusions/interpretationThe prevalence of GADA-positive autoimmune diabetes is low among individuals with young adult-onset diabetes in Sri Lanka. Young-onset diabetic phenotypes appear as a continuum from autoimmune type 1 diabetes to type 2 diabetes.
    33 schema:genre article
    34 schema:inLanguage en
    35 schema:isAccessibleForFree true
    36 schema:isPartOf N3355ee24f23445f0b5a171f2e1d75929
    37 N7e7b882ae9724d6aa457a31524dc917b
    38 sg:journal.1001482
    39 schema:keywords Aims/hypothesisDiabetes mellitus
    40 Asians
    41 BMI
    42 Conclusions/interpretationThe prevalence
    43 Diabetes Study
    44 GAD antibodies
    45 GAD65 autoantibody (GADA) status
    46 GADA
    47 GADA data
    48 GADA levels
    49 GADA positivity
    50 GADA-negative type 1 diabetes
    51 GADA-positive autoimmune diabetes
    52 GADA-positive type 1 diabetes
    53 LADA
    54 Lanka
    55 Lanka Young Diabetes study
    56 Lanka—role
    57 MethodsClinical
    58 South Asians
    59 Sri Lanka
    60 Sri Lanka Young Diabetes study
    61 Sri Lanka—role
    62 Young Diabetes study
    63 Young-onset diabetic phenotypes
    64 adult South Asians
    65 adult-onset diabetes
    66 adults
    67 age
    68 aim
    69 antibodies
    70 assessment
    71 autoantibody status
    72 autoimmune diabetes
    73 autoimmune type 1 diabetes
    74 beta-cell function
    75 cell function
    76 characteristics
    77 classification
    78 continuum
    79 data
    80 definition
    81 diabetes
    82 diabetes duration
    83 diabetes mellitus
    84 diabetes subtypes
    85 diabetic phenotype
    86 diagnosis
    87 duration
    88 function
    89 homeostasis model assessment
    90 hypothesisDiabetes mellitus
    91 independent
    92 individuals
    93 insulin
    94 insulin independent
    95 insulin requirements
    96 interpretationThe prevalence
    97 latent
    98 latent autoimmune diabetes
    99 levels
    100 median age
    101 mellitus
    102 metabolic syndrome
    103 model assessment
    104 months
    105 participants
    106 peptide levels
    107 phenotype
    108 phenotypic characteristics
    109 positivity
    110 prevalence
    111 requirements
    112 status
    113 study
    114 subtypes
    115 syndrome
    116 time
    117 treatment
    118 type 1 diabetes
    119 type 2 diabetes
    120 years
    121 young adult South Asians
    122 young adult-onset diabetes
    123 young adults
    124 schema:name Diabetes mellitus among young adults in Sri Lanka—role of GAD antibodies in classification and treatment: The Sri Lanka Young Diabetes study
    125 schema:pagination 1368
    126 schema:productId N13fbe83be48c4cca8efabe7910b649ff
    127 Nbf907d449fe346d5babf53fe171f69a4
    128 Ne1a1af9ad600474db60e509b243d61da
    129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026020524
    130 https://doi.org/10.1007/s00125-008-1052-6
    131 schema:sdDatePublished 2022-01-01T18:17
    132 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    133 schema:sdPublisher Ndbc028a9151f4de0a6418ad16af693de
    134 schema:url https://doi.org/10.1007/s00125-008-1052-6
    135 sgo:license sg:explorer/license/
    136 sgo:sdDataset articles
    137 rdf:type schema:ScholarlyArticle
    138 N13fbe83be48c4cca8efabe7910b649ff schema:name dimensions_id
    139 schema:value pub.1026020524
    140 rdf:type schema:PropertyValue
    141 N160ee9518b2f4deeaa5c102dde484f6a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    142 schema:name Adult
    143 rdf:type schema:DefinedTerm
    144 N1fbd82627d7248e1ace9ae508ec07995 rdf:first sg:person.01015310422.08
    145 rdf:rest Ne05067be7c3c44fbb283f47934f1db3c
    146 N25f8bee66f3240e0b5cc04d624981acb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Diabetes Mellitus, Type 1
    148 rdf:type schema:DefinedTerm
    149 N26dbaeb2362b4fa2951d0e6f89593714 rdf:first sg:person.01261132331.29
    150 rdf:rest N7d1b213ca4ce4f0da32d438058c64964
    151 N3355ee24f23445f0b5a171f2e1d75929 schema:issueNumber 8
    152 rdf:type schema:PublicationIssue
    153 N38b42a6fc43646389dd8a88e6d2746ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    154 schema:name Waist-Hip Ratio
    155 rdf:type schema:DefinedTerm
    156 N3b0d65461f424a3e84f9a22f93a2e6e7 schema:affiliation grid-institutes:grid.8065.b
    157 schema:familyName Asfir
    158 schema:givenName E. L.
    159 rdf:type schema:Person
    160 N4bb17835d735451b829b467469cda37f rdf:first N3b0d65461f424a3e84f9a22f93a2e6e7
    161 rdf:rest N8d26fdd8ec0f4343a0ca3b4526776961
    162 N7d1b213ca4ce4f0da32d438058c64964 rdf:first sg:person.0740770547.38
    163 rdf:rest Ne9d484a0b67349ac9fcca22cfe12529f
    164 N7e7b882ae9724d6aa457a31524dc917b schema:volumeNumber 51
    165 rdf:type schema:PublicationVolume
    166 N816ae251aa194617bb7f52d12d7d7865 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Autoantibodies
    168 rdf:type schema:DefinedTerm
    169 N835bb74a222542e2aedaa883cca6a5c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Insulin
    171 rdf:type schema:DefinedTerm
    172 N88500f1576a44a598dc855e77f9370c9 rdf:first sg:person.01221545265.99
    173 rdf:rest N1fbd82627d7248e1ace9ae508ec07995
    174 N8bccd5844a9a4c41b135fd21a4da23f4 rdf:first sg:person.01216556762.76
    175 rdf:rest rdf:nil
    176 N8cd76419042e45a49bdeae71873b6973 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    177 schema:name Sri Lanka
    178 rdf:type schema:DefinedTerm
    179 N8d26fdd8ec0f4343a0ca3b4526776961 rdf:first sg:person.01311106562.39
    180 rdf:rest Ndbf09b7c3aee492081b17ece1138eaac
    181 Nae76b154db764667acf4a314ee7a8882 rdf:first Nf0bc1ebd05dd477bb05586344fe8ad72
    182 rdf:rest N4bb17835d735451b829b467469cda37f
    183 Nb5f2a1e0cc80406d897ae0d942f2155b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    184 schema:name Adolescent
    185 rdf:type schema:DefinedTerm
    186 Nbf907d449fe346d5babf53fe171f69a4 schema:name doi
    187 schema:value 10.1007/s00125-008-1052-6
    188 rdf:type schema:PropertyValue
    189 Nc76fb0d44dca45089bc103f792758b45 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    190 schema:name Glycated Hemoglobin A
    191 rdf:type schema:DefinedTerm
    192 Ndbc028a9151f4de0a6418ad16af693de schema:name Springer Nature - SN SciGraph project
    193 rdf:type schema:Organization
    194 Ndbf09b7c3aee492081b17ece1138eaac rdf:first sg:person.01062503634.84
    195 rdf:rest N26dbaeb2362b4fa2951d0e6f89593714
    196 Ndbfc4f59f3a44881940fc8a8e81ee894 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    197 schema:name Female
    198 rdf:type schema:DefinedTerm
    199 Ne05067be7c3c44fbb283f47934f1db3c rdf:first sg:person.01070674173.26
    200 rdf:rest Nae76b154db764667acf4a314ee7a8882
    201 Ne1a1af9ad600474db60e509b243d61da schema:name pubmed_id
    202 schema:value 18528678
    203 rdf:type schema:PropertyValue
    204 Ne2721212b7df499ea3dfe2f9c96a5804 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    205 schema:name Glutamate Decarboxylase
    206 rdf:type schema:DefinedTerm
    207 Ne4b4053f6d3c4bc9a4af7b0226b0a6cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    208 schema:name Hypoglycemic Agents
    209 rdf:type schema:DefinedTerm
    210 Ne9d484a0b67349ac9fcca22cfe12529f rdf:first sg:person.016704245502.43
    211 rdf:rest Nf049b36542ca4971a115626d1ccc08cf
    212 Nea26a8e2a7a64872b092860f247619b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    213 schema:name Humans
    214 rdf:type schema:DefinedTerm
    215 Nee1dab8687404dad9917e064fe6ad652 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    216 schema:name Male
    217 rdf:type schema:DefinedTerm
    218 Nf049b36542ca4971a115626d1ccc08cf rdf:first sg:person.0747270127.65
    219 rdf:rest N8bccd5844a9a4c41b135fd21a4da23f4
    220 Nf0bc1ebd05dd477bb05586344fe8ad72 schema:affiliation grid-institutes:grid.8065.b
    221 schema:familyName Silva
    222 schema:givenName A.
    223 rdf:type schema:Person
    224 Nfa0d5d9ea4e94d85aecc5faf1fdf38a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    225 schema:name Body Mass Index
    226 rdf:type schema:DefinedTerm
    227 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    228 schema:name Medical and Health Sciences
    229 rdf:type schema:DefinedTerm
    230 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    231 schema:name Clinical Sciences
    232 rdf:type schema:DefinedTerm
    233 sg:journal.1001482 schema:issn 0012-186X
    234 1432-0428
    235 schema:name Diabetologia
    236 schema:publisher Springer Nature
    237 rdf:type schema:Periodical
    238 sg:person.01015310422.08 schema:affiliation grid-institutes:grid.8348.7
    239 schema:familyName Shine
    240 schema:givenName B.
    241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015310422.08
    242 rdf:type schema:Person
    243 sg:person.01062503634.84 schema:affiliation grid-institutes:grid.415398.2
    244 schema:familyName Somasundaram
    245 schema:givenName N.
    246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062503634.84
    247 rdf:type schema:Person
    248 sg:person.01070674173.26 schema:affiliation grid-institutes:grid.8348.7
    249 schema:familyName Katulanda
    250 schema:givenName G. W.
    251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070674173.26
    252 rdf:type schema:Person
    253 sg:person.01216556762.76 schema:affiliation grid-institutes:grid.415719.f
    254 schema:familyName Matthews
    255 schema:givenName D. R.
    256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216556762.76
    257 rdf:type schema:Person
    258 sg:person.01221545265.99 schema:affiliation grid-institutes:grid.8065.b
    259 schema:familyName Katulanda
    260 schema:givenName P.
    261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221545265.99
    262 rdf:type schema:Person
    263 sg:person.01261132331.29 schema:affiliation grid-institutes:grid.5337.2
    264 schema:familyName Long
    265 schema:givenName A. E.
    266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261132331.29
    267 rdf:type schema:Person
    268 sg:person.01311106562.39 schema:affiliation grid-institutes:grid.8065.b
    269 schema:familyName Sheriff
    270 schema:givenName R.
    271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311106562.39
    272 rdf:type schema:Person
    273 sg:person.016704245502.43 schema:affiliation grid-institutes:grid.415719.f
    274 schema:familyName McCarthy
    275 schema:givenName M. I.
    276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016704245502.43
    277 rdf:type schema:Person
    278 sg:person.0740770547.38 schema:affiliation grid-institutes:grid.5337.2
    279 schema:familyName Bingley
    280 schema:givenName P. J.
    281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740770547.38
    282 rdf:type schema:Person
    283 sg:person.0747270127.65 schema:affiliation grid-institutes:grid.415719.f
    284 schema:familyName Clark
    285 schema:givenName A.
    286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747270127.65
    287 rdf:type schema:Person
    288 sg:pub.10.1007/bf00277317 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079878534
    289 https://doi.org/10.1007/bf00277317
    290 rdf:type schema:CreativeWork
    291 sg:pub.10.1007/bf00280883 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027902786
    292 https://doi.org/10.1007/bf00280883
    293 rdf:type schema:CreativeWork
    294 sg:pub.10.1007/bf00400852 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006075533
    295 https://doi.org/10.1007/bf00400852
    296 rdf:type schema:CreativeWork
    297 sg:pub.10.1007/s00125-004-1331-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031776101
    298 https://doi.org/10.1007/s00125-004-1331-9
    299 rdf:type schema:CreativeWork
    300 sg:pub.10.1007/s00125-004-1387-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017781273
    301 https://doi.org/10.1007/s00125-004-1387-6
    302 rdf:type schema:CreativeWork
    303 sg:pub.10.1007/s00125-005-1954-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032072655
    304 https://doi.org/10.1007/s00125-005-1954-5
    305 rdf:type schema:CreativeWork
    306 sg:pub.10.1007/s00125-006-0219-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046070357
    307 https://doi.org/10.1007/s00125-006-0219-2
    308 rdf:type schema:CreativeWork
    309 sg:pub.10.1007/s00125-006-0325-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019508803
    310 https://doi.org/10.1007/s00125-006-0325-1
    311 rdf:type schema:CreativeWork
    312 sg:pub.10.1007/s00125-007-0745-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012458684
    313 https://doi.org/10.1007/s00125-007-0745-6
    314 rdf:type schema:CreativeWork
    315 sg:pub.10.1007/s001250050845 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045914024
    316 https://doi.org/10.1007/s001250050845
    317 rdf:type schema:CreativeWork
    318 sg:pub.10.1007/s001250051573 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033712832
    319 https://doi.org/10.1007/s001250051573
    320 rdf:type schema:CreativeWork
    321 sg:pub.10.1007/s11892-003-0032-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1030788656
    322 https://doi.org/10.1007/s11892-003-0032-y
    323 rdf:type schema:CreativeWork
    324 grid-institutes:grid.415398.2 schema:alternateName National Hospital of Sri Lanka, Colombo, Sri Lanka
    325 schema:name National Hospital of Sri Lanka, Colombo, Sri Lanka
    326 rdf:type schema:Organization
    327 grid-institutes:grid.415719.f schema:alternateName Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Old Road, Headington, OX3 7LJ, Oxford, UK
    328 schema:name Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Old Road, Headington, OX3 7LJ, Oxford, UK
    329 rdf:type schema:Organization
    330 grid-institutes:grid.5337.2 schema:alternateName Department of Clinical Science at North Bristol, University of Bristol, Bristol, UK
    331 schema:name Department of Clinical Science at North Bristol, University of Bristol, Bristol, UK
    332 rdf:type schema:Organization
    333 grid-institutes:grid.8065.b schema:alternateName Diabetes Research Unit, Department of Clinical Medicine, University of Colombo, Colombo, Sri Lanka
    334 schema:name Diabetes Research Unit, Department of Clinical Medicine, University of Colombo, Colombo, Sri Lanka
    335 Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Old Road, Headington, OX3 7LJ, Oxford, UK
    336 rdf:type schema:Organization
    337 grid-institutes:grid.8348.7 schema:alternateName Department of Clinical Biochemistry, John Radcliffe Hospital, Oxford, UK
    338 schema:name Department of Clinical Biochemistry, John Radcliffe Hospital, Oxford, UK
    339 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...