Improved vascular engraftment and function of autotransplanted pancreatic islets as a result of partial pancreatectomy in the mouse and rat View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-06

AUTHORS

M. Johansson, L. Jansson, P.-O. Carlsson

ABSTRACT

AIMS/HYPOTHESIS: The few patients subjected to autotransplantation of pancreatic islets after pancreatectomy usually become normoglycaemic after using islets from the resected organ only, whereas allogeneic recipients usually require at least two grafts to retain normoglycaemia. Previous experimental studies have demonstrated that islets transplanted to non-pancreatectomised recipients acquire a markedly decreased blood vessel density, which leads to a hypoxic microenvironment. The aim of the present study was to test the hypothesis that autotransplanted islets have better vascular engraftment and function as a result of the pancreatic surgery involved. MATERIALS AND METHODS: In the present study, athymic mice and inbred rats were subjected to a 60% pancreatectomy and transplanted with human or rat islets, respectively, 4 days later. Control animals underwent sham surgery. Blood flow, oxygen tension, vascular density and endocrine volume in the islet grafts were measured 1 month after transplantation. Separate grafts were used for perfusion experiments and for assessment of beta cell proliferation and endocrine cellular apoptosis at different time periods after transplantation. RESULTS: Islet grafts in partially pancreatectomised recipients had an increased blood flow, oxygen tension, blood vessel density and endocrine mass 1 month post-transplantation compared with control animals. They also exhibited increased insulin release in perfusion experiments performed 1 month post-transplantation, and decreased cellular apoptosis early after transplantation. CONCLUSIONS/INTERPRETATION: The present study shows that the pancreatectomy procedure itself has beneficial effects on the engraftment of transplanted human and rat islets. Our results provide an additional explanation, besides diminished immunological responses, of the much better outcome of islet autotransplantations compared with allogeneic transplantations in the clinic. More... »

PAGES

1257-1266

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00125-007-0649-5

DOI

http://dx.doi.org/10.1007/s00125-007-0649-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039689453

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17406853


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Flow Velocity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Graft Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin Secretion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Islets of Langerhans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Islets of Langerhans Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Nude", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pancreatectomy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Inbred WF", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transplantation, Autologous", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of California, San Francisco", 
          "id": "https://www.grid.ac/institutes/grid.266102.1", 
          "name": [
            "Department of Medical Cell Biology, Uppsala University, Husargatan 3, Box 571, 751 23, Uppsala, Sweden", 
            "Department of Pathology, University of California, 94115, San Francisco, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Johansson", 
        "givenName": "M.", 
        "id": "sg:person.01053131700.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053131700.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Uppsala University", 
          "id": "https://www.grid.ac/institutes/grid.8993.b", 
          "name": [
            "Department of Medical Cell Biology, Uppsala University, Husargatan 3, Box 571, 751 23, Uppsala, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jansson", 
        "givenName": "L.", 
        "id": "sg:person.0771352260.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771352260.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Uppsala University", 
          "id": "https://www.grid.ac/institutes/grid.8993.b", 
          "name": [
            "Department of Medical Cell Biology, Uppsala University, Husargatan 3, Box 571, 751 23, Uppsala, Sweden", 
            "Department of Medical Sciences, Uppsala University, 751 23, Uppsala, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Carlsson", 
        "givenName": "P.-O.", 
        "id": "sg:person.01216166160.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216166160.54"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1093/emboj/18.14.3964", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000096470"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.02-0615fje", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000746252"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm200007273430401", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002510707"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.tp.0000052592.92966.fe", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003035042"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.tp.0000052592.92966.fe", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003035042"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-200002000-00017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006413183"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-200002000-00017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006413183"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1651-2227.1985.tb10134.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009855102"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.53.5.1318", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011444136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.51.1.66", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012103728"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0303-7207(96)03977-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012524272"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.transproceed.2004.04.036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012674827"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1024602", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014446195"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(03)00378-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015085404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(03)00378-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015085404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.tp.0000163506.40189.65", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017999619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.tp.0000163506.40189.65", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017999619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.tp.0000163506.40189.65", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017999619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-002-0827-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018391871", 
          "https://doi.org/10.1007/s00125-002-0827-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-002-0827-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018391871", 
          "https://doi.org/10.1007/s00125-002-0827-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.devcel.2006.01.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018918382"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci118115", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021156360"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.51.5.1362", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021762357"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m210581200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021844436"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.50.3.489", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023932087"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01228134", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025631017", 
          "https://doi.org/10.1007/bf01228134"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01228134", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025631017", 
          "https://doi.org/10.1007/bf01228134"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci110910", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028197846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci115989", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029001869"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.54.7.2060", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029368170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.tp.0000158427.07084.c5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030066998"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.tp.0000158427.07084.c5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030066998"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.tp.0000158427.07084.c5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030066998"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1677/joe.0.1720145", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035204081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1677/joe.0.1720145", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035204081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.50.1.47", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037064655"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.53.4.948", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039534520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.51.7.2148", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040214616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-005-1761-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041202829", 
          "https://doi.org/10.1007/s00125-005-1761-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-005-1761-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041202829", 
          "https://doi.org/10.1007/s00125-005-1761-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-005-1761-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041202829", 
          "https://doi.org/10.1007/s00125-005-1761-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-6143.2006.01299.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044575013"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.52.2.365", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044859986"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.53.4.963", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045528325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1067/msy.2003.250", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046684091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1067/msy.2003.250", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046684091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci114955", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046695208"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2002-020728", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051201330"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1535-6108(02)00031-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053721275"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-200003270-00016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060281934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-200003270-00016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060281934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-200003270-00016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060281934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-200003270-00016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060281934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2005-0997", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064247657"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diab.38.1.s199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070735666"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diab.38.4.510", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070735855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diab.45.9.1161", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070737959"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.38.4.510", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070741578"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.45.9.1161", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070743352"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.47.7.1027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070743889"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074786983", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075035363", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079220413", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082404057", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082404801", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf03401895", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082879546", 
          "https://doi.org/10.1007/bf03401895"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082945796", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083099263", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2007-06", 
    "datePublishedReg": "2007-06-01", 
    "description": "AIMS/HYPOTHESIS: The few patients subjected to autotransplantation of pancreatic islets after pancreatectomy usually become normoglycaemic after using islets from the resected organ only, whereas allogeneic recipients usually require at least two grafts to retain normoglycaemia. Previous experimental studies have demonstrated that islets transplanted to non-pancreatectomised recipients acquire a markedly decreased blood vessel density, which leads to a hypoxic microenvironment. The aim of the present study was to test the hypothesis that autotransplanted islets have better vascular engraftment and function as a result of the pancreatic surgery involved.\nMATERIALS AND METHODS: In the present study, athymic mice and inbred rats were subjected to a 60% pancreatectomy and transplanted with human or rat islets, respectively, 4 days later. Control animals underwent sham surgery. Blood flow, oxygen tension, vascular density and endocrine volume in the islet grafts were measured 1 month after transplantation. Separate grafts were used for perfusion experiments and for assessment of beta cell proliferation and endocrine cellular apoptosis at different time periods after transplantation.\nRESULTS: Islet grafts in partially pancreatectomised recipients had an increased blood flow, oxygen tension, blood vessel density and endocrine mass 1 month post-transplantation compared with control animals. They also exhibited increased insulin release in perfusion experiments performed 1 month post-transplantation, and decreased cellular apoptosis early after transplantation.\nCONCLUSIONS/INTERPRETATION: The present study shows that the pancreatectomy procedure itself has beneficial effects on the engraftment of transplanted human and rat islets. Our results provide an additional explanation, besides diminished immunological responses, of the much better outcome of islet autotransplantations compared with allogeneic transplantations in the clinic.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00125-007-0649-5", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1001482", 
        "issn": [
          "0012-186X", 
          "1432-0428"
        ], 
        "name": "Diabetologia", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "50"
      }
    ], 
    "name": "Improved vascular engraftment and function of autotransplanted pancreatic islets as a result of partial pancreatectomy in the mouse and rat", 
    "pagination": "1257-1266", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "bd100317b91e878b4ca34921cd15808c9860a15a0a19f0a8e5b0b0786cc67b8b"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "17406853"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0006777"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00125-007-0649-5"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1039689453"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00125-007-0649-5", 
      "https://app.dimensions.ai/details/publication/pub.1039689453"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:57", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000365_0000000365/records_71674_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs00125-007-0649-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00125-007-0649-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00125-007-0649-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00125-007-0649-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00125-007-0649-5'


 

This table displays all metadata directly associated to this object as RDF triples.

313 TRIPLES      21 PREDICATES      99 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00125-007-0649-5 schema:about N047d163fbafd489d84a83d1016441066
2 N0638cee6b7fc49ac9b481b97c09d56a6
3 N0c62464a888c4fc5a51f66d596687b1f
4 N172cfbd387ce4d238d2098422b2eb02b
5 N62c78377f2cd4f68aff4216e9b8dc6e4
6 N706f6aead40b4f96a6a674377d1e22fe
7 N759d44220b894e35a0818be722b5359f
8 N8dbc584414874e56a6b798e70dcab565
9 N946a20cbc9f7424ea181270c38dcb8b5
10 N983afe9eef4e472e96075b5b341cfa28
11 Nbdd79eed44714e9d8a012f91a777e3bc
12 Nc7d4bf496be74226bfbbcde661a80109
13 Nd8c805ff7dda4b7eb33b267cbb448a57
14 Ne747a0796ac844e0a3acc6945d592b93
15 Necd0f08ece9045c6954b7fbda3d7c050
16 Nf67e433d084648d5bb4fa254da1cd887
17 Nfb716c3154fa4d45a21b5c22053c5da7
18 Nfe16320ff3a04be7ae05d9da5f844c62
19 anzsrc-for:11
20 anzsrc-for:1103
21 schema:author N50176f6f65ca4d4881c67c436ab60db0
22 schema:citation sg:pub.10.1007/bf01228134
23 sg:pub.10.1007/bf03401895
24 sg:pub.10.1007/s00125-002-0827-4
25 sg:pub.10.1007/s00125-005-1761-z
26 https://app.dimensions.ai/details/publication/pub.1074786983
27 https://app.dimensions.ai/details/publication/pub.1075035363
28 https://app.dimensions.ai/details/publication/pub.1079220413
29 https://app.dimensions.ai/details/publication/pub.1082404057
30 https://app.dimensions.ai/details/publication/pub.1082404801
31 https://app.dimensions.ai/details/publication/pub.1082945796
32 https://app.dimensions.ai/details/publication/pub.1083099263
33 https://doi.org/10.1016/j.devcel.2006.01.015
34 https://doi.org/10.1016/j.transproceed.2004.04.036
35 https://doi.org/10.1016/s0303-7207(96)03977-9
36 https://doi.org/10.1016/s0960-9822(03)00378-6
37 https://doi.org/10.1016/s1535-6108(02)00031-4
38 https://doi.org/10.1056/nejm200007273430401
39 https://doi.org/10.1067/msy.2003.250
40 https://doi.org/10.1074/jbc.m210581200
41 https://doi.org/10.1093/emboj/18.14.3964
42 https://doi.org/10.1096/fj.02-0615fje
43 https://doi.org/10.1097/00000658-200002000-00017
44 https://doi.org/10.1097/00007890-200003270-00016
45 https://doi.org/10.1097/01.tp.0000052592.92966.fe
46 https://doi.org/10.1097/01.tp.0000158427.07084.c5
47 https://doi.org/10.1097/01.tp.0000163506.40189.65
48 https://doi.org/10.1101/gad.1024602
49 https://doi.org/10.1111/j.1600-6143.2006.01299.x
50 https://doi.org/10.1111/j.1651-2227.1985.tb10134.x
51 https://doi.org/10.1172/jci110910
52 https://doi.org/10.1172/jci114955
53 https://doi.org/10.1172/jci115989
54 https://doi.org/10.1172/jci118115
55 https://doi.org/10.1210/en.2005-0997
56 https://doi.org/10.1210/jc.2002-020728
57 https://doi.org/10.1677/joe.0.1720145
58 https://doi.org/10.2337/diab.38.1.s199
59 https://doi.org/10.2337/diab.38.4.510
60 https://doi.org/10.2337/diab.45.9.1161
61 https://doi.org/10.2337/diabetes.38.4.510
62 https://doi.org/10.2337/diabetes.45.9.1161
63 https://doi.org/10.2337/diabetes.47.7.1027
64 https://doi.org/10.2337/diabetes.50.1.47
65 https://doi.org/10.2337/diabetes.50.3.489
66 https://doi.org/10.2337/diabetes.51.1.66
67 https://doi.org/10.2337/diabetes.51.5.1362
68 https://doi.org/10.2337/diabetes.51.7.2148
69 https://doi.org/10.2337/diabetes.52.2.365
70 https://doi.org/10.2337/diabetes.53.4.948
71 https://doi.org/10.2337/diabetes.53.4.963
72 https://doi.org/10.2337/diabetes.53.5.1318
73 https://doi.org/10.2337/diabetes.54.7.2060
74 schema:datePublished 2007-06
75 schema:datePublishedReg 2007-06-01
76 schema:description AIMS/HYPOTHESIS: The few patients subjected to autotransplantation of pancreatic islets after pancreatectomy usually become normoglycaemic after using islets from the resected organ only, whereas allogeneic recipients usually require at least two grafts to retain normoglycaemia. Previous experimental studies have demonstrated that islets transplanted to non-pancreatectomised recipients acquire a markedly decreased blood vessel density, which leads to a hypoxic microenvironment. The aim of the present study was to test the hypothesis that autotransplanted islets have better vascular engraftment and function as a result of the pancreatic surgery involved. MATERIALS AND METHODS: In the present study, athymic mice and inbred rats were subjected to a 60% pancreatectomy and transplanted with human or rat islets, respectively, 4 days later. Control animals underwent sham surgery. Blood flow, oxygen tension, vascular density and endocrine volume in the islet grafts were measured 1 month after transplantation. Separate grafts were used for perfusion experiments and for assessment of beta cell proliferation and endocrine cellular apoptosis at different time periods after transplantation. RESULTS: Islet grafts in partially pancreatectomised recipients had an increased blood flow, oxygen tension, blood vessel density and endocrine mass 1 month post-transplantation compared with control animals. They also exhibited increased insulin release in perfusion experiments performed 1 month post-transplantation, and decreased cellular apoptosis early after transplantation. CONCLUSIONS/INTERPRETATION: The present study shows that the pancreatectomy procedure itself has beneficial effects on the engraftment of transplanted human and rat islets. Our results provide an additional explanation, besides diminished immunological responses, of the much better outcome of islet autotransplantations compared with allogeneic transplantations in the clinic.
77 schema:genre research_article
78 schema:inLanguage en
79 schema:isAccessibleForFree true
80 schema:isPartOf N5d400f07c7d84e8fa72805d253106e76
81 N88feb457504741e790dabdb3829112a8
82 sg:journal.1001482
83 schema:name Improved vascular engraftment and function of autotransplanted pancreatic islets as a result of partial pancreatectomy in the mouse and rat
84 schema:pagination 1257-1266
85 schema:productId N58c25d871ef24542b389d58cf5b20513
86 N61ec4dd96d3c47b5bce53d8c194ed981
87 N704038a94d334a4c81c44a9269eaec92
88 N7af5c9bd728c4118b7d652b2093b32dd
89 Ncf471db807274eb2bb4ed995625f7e07
90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039689453
91 https://doi.org/10.1007/s00125-007-0649-5
92 schema:sdDatePublished 2019-04-11T12:57
93 schema:sdLicense https://scigraph.springernature.com/explorer/license/
94 schema:sdPublisher N45e9e199a5c9476688e70128d5973313
95 schema:url https://link.springer.com/10.1007%2Fs00125-007-0649-5
96 sgo:license sg:explorer/license/
97 sgo:sdDataset articles
98 rdf:type schema:ScholarlyArticle
99 N047d163fbafd489d84a83d1016441066 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Male
101 rdf:type schema:DefinedTerm
102 N0638cee6b7fc49ac9b481b97c09d56a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Animals
104 rdf:type schema:DefinedTerm
105 N0c62464a888c4fc5a51f66d596687b1f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Female
107 rdf:type schema:DefinedTerm
108 N172cfbd387ce4d238d2098422b2eb02b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Transplantation, Autologous
110 rdf:type schema:DefinedTerm
111 N45e9e199a5c9476688e70128d5973313 schema:name Springer Nature - SN SciGraph project
112 rdf:type schema:Organization
113 N50176f6f65ca4d4881c67c436ab60db0 rdf:first sg:person.01053131700.23
114 rdf:rest Nd09071e1f5a44c47b5d6d42229f05923
115 N58c25d871ef24542b389d58cf5b20513 schema:name pubmed_id
116 schema:value 17406853
117 rdf:type schema:PropertyValue
118 N5d400f07c7d84e8fa72805d253106e76 schema:issueNumber 6
119 rdf:type schema:PublicationIssue
120 N61ec4dd96d3c47b5bce53d8c194ed981 schema:name dimensions_id
121 schema:value pub.1039689453
122 rdf:type schema:PropertyValue
123 N62c78377f2cd4f68aff4216e9b8dc6e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Blood Flow Velocity
125 rdf:type schema:DefinedTerm
126 N704038a94d334a4c81c44a9269eaec92 schema:name doi
127 schema:value 10.1007/s00125-007-0649-5
128 rdf:type schema:PropertyValue
129 N706f6aead40b4f96a6a674377d1e22fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Islets of Langerhans Transplantation
131 rdf:type schema:DefinedTerm
132 N759d44220b894e35a0818be722b5359f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Islets of Langerhans
134 rdf:type schema:DefinedTerm
135 N7af5c9bd728c4118b7d652b2093b32dd schema:name readcube_id
136 schema:value bd100317b91e878b4ca34921cd15808c9860a15a0a19f0a8e5b0b0786cc67b8b
137 rdf:type schema:PropertyValue
138 N87f5e71dfd2b41cc92df782e2f71a7c3 rdf:first sg:person.01216166160.54
139 rdf:rest rdf:nil
140 N88feb457504741e790dabdb3829112a8 schema:volumeNumber 50
141 rdf:type schema:PublicationVolume
142 N8dbc584414874e56a6b798e70dcab565 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Rats
144 rdf:type schema:DefinedTerm
145 N946a20cbc9f7424ea181270c38dcb8b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Adult
147 rdf:type schema:DefinedTerm
148 N983afe9eef4e472e96075b5b341cfa28 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Insulin Secretion
150 rdf:type schema:DefinedTerm
151 Nbdd79eed44714e9d8a012f91a777e3bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Mice
153 rdf:type schema:DefinedTerm
154 Nc7d4bf496be74226bfbbcde661a80109 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Mice, Inbred C57BL
156 rdf:type schema:DefinedTerm
157 Ncf471db807274eb2bb4ed995625f7e07 schema:name nlm_unique_id
158 schema:value 0006777
159 rdf:type schema:PropertyValue
160 Nd09071e1f5a44c47b5d6d42229f05923 rdf:first sg:person.0771352260.83
161 rdf:rest N87f5e71dfd2b41cc92df782e2f71a7c3
162 Nd8c805ff7dda4b7eb33b267cbb448a57 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Graft Survival
164 rdf:type schema:DefinedTerm
165 Ne747a0796ac844e0a3acc6945d592b93 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Pancreatectomy
167 rdf:type schema:DefinedTerm
168 Necd0f08ece9045c6954b7fbda3d7c050 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Rats, Inbred WF
170 rdf:type schema:DefinedTerm
171 Nf67e433d084648d5bb4fa254da1cd887 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Humans
173 rdf:type schema:DefinedTerm
174 Nfb716c3154fa4d45a21b5c22053c5da7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Insulin
176 rdf:type schema:DefinedTerm
177 Nfe16320ff3a04be7ae05d9da5f844c62 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Mice, Nude
179 rdf:type schema:DefinedTerm
180 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
181 schema:name Medical and Health Sciences
182 rdf:type schema:DefinedTerm
183 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
184 schema:name Clinical Sciences
185 rdf:type schema:DefinedTerm
186 sg:journal.1001482 schema:issn 0012-186X
187 1432-0428
188 schema:name Diabetologia
189 rdf:type schema:Periodical
190 sg:person.01053131700.23 schema:affiliation https://www.grid.ac/institutes/grid.266102.1
191 schema:familyName Johansson
192 schema:givenName M.
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053131700.23
194 rdf:type schema:Person
195 sg:person.01216166160.54 schema:affiliation https://www.grid.ac/institutes/grid.8993.b
196 schema:familyName Carlsson
197 schema:givenName P.-O.
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216166160.54
199 rdf:type schema:Person
200 sg:person.0771352260.83 schema:affiliation https://www.grid.ac/institutes/grid.8993.b
201 schema:familyName Jansson
202 schema:givenName L.
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771352260.83
204 rdf:type schema:Person
205 sg:pub.10.1007/bf01228134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025631017
206 https://doi.org/10.1007/bf01228134
207 rdf:type schema:CreativeWork
208 sg:pub.10.1007/bf03401895 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082879546
209 https://doi.org/10.1007/bf03401895
210 rdf:type schema:CreativeWork
211 sg:pub.10.1007/s00125-002-0827-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018391871
212 https://doi.org/10.1007/s00125-002-0827-4
213 rdf:type schema:CreativeWork
214 sg:pub.10.1007/s00125-005-1761-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1041202829
215 https://doi.org/10.1007/s00125-005-1761-z
216 rdf:type schema:CreativeWork
217 https://app.dimensions.ai/details/publication/pub.1074786983 schema:CreativeWork
218 https://app.dimensions.ai/details/publication/pub.1075035363 schema:CreativeWork
219 https://app.dimensions.ai/details/publication/pub.1079220413 schema:CreativeWork
220 https://app.dimensions.ai/details/publication/pub.1082404057 schema:CreativeWork
221 https://app.dimensions.ai/details/publication/pub.1082404801 schema:CreativeWork
222 https://app.dimensions.ai/details/publication/pub.1082945796 schema:CreativeWork
223 https://app.dimensions.ai/details/publication/pub.1083099263 schema:CreativeWork
224 https://doi.org/10.1016/j.devcel.2006.01.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018918382
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/j.transproceed.2004.04.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012674827
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/s0303-7207(96)03977-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012524272
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/s0960-9822(03)00378-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015085404
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/s1535-6108(02)00031-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053721275
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1056/nejm200007273430401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002510707
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1067/msy.2003.250 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046684091
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1074/jbc.m210581200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021844436
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1093/emboj/18.14.3964 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000096470
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1096/fj.02-0615fje schema:sameAs https://app.dimensions.ai/details/publication/pub.1000746252
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1097/00000658-200002000-00017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006413183
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1097/00007890-200003270-00016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060281934
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1097/01.tp.0000052592.92966.fe schema:sameAs https://app.dimensions.ai/details/publication/pub.1003035042
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1097/01.tp.0000158427.07084.c5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030066998
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1097/01.tp.0000163506.40189.65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017999619
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1101/gad.1024602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014446195
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1111/j.1600-6143.2006.01299.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044575013
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1111/j.1651-2227.1985.tb10134.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1009855102
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1172/jci110910 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028197846
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1172/jci114955 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046695208
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1172/jci115989 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029001869
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1172/jci118115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021156360
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1210/en.2005-0997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064247657
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1210/jc.2002-020728 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051201330
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1677/joe.0.1720145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035204081
273 rdf:type schema:CreativeWork
274 https://doi.org/10.2337/diab.38.1.s199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070735666
275 rdf:type schema:CreativeWork
276 https://doi.org/10.2337/diab.38.4.510 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070735855
277 rdf:type schema:CreativeWork
278 https://doi.org/10.2337/diab.45.9.1161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070737959
279 rdf:type schema:CreativeWork
280 https://doi.org/10.2337/diabetes.38.4.510 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070741578
281 rdf:type schema:CreativeWork
282 https://doi.org/10.2337/diabetes.45.9.1161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070743352
283 rdf:type schema:CreativeWork
284 https://doi.org/10.2337/diabetes.47.7.1027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070743889
285 rdf:type schema:CreativeWork
286 https://doi.org/10.2337/diabetes.50.1.47 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037064655
287 rdf:type schema:CreativeWork
288 https://doi.org/10.2337/diabetes.50.3.489 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023932087
289 rdf:type schema:CreativeWork
290 https://doi.org/10.2337/diabetes.51.1.66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012103728
291 rdf:type schema:CreativeWork
292 https://doi.org/10.2337/diabetes.51.5.1362 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021762357
293 rdf:type schema:CreativeWork
294 https://doi.org/10.2337/diabetes.51.7.2148 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040214616
295 rdf:type schema:CreativeWork
296 https://doi.org/10.2337/diabetes.52.2.365 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044859986
297 rdf:type schema:CreativeWork
298 https://doi.org/10.2337/diabetes.53.4.948 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039534520
299 rdf:type schema:CreativeWork
300 https://doi.org/10.2337/diabetes.53.4.963 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045528325
301 rdf:type schema:CreativeWork
302 https://doi.org/10.2337/diabetes.53.5.1318 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011444136
303 rdf:type schema:CreativeWork
304 https://doi.org/10.2337/diabetes.54.7.2060 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029368170
305 rdf:type schema:CreativeWork
306 https://www.grid.ac/institutes/grid.266102.1 schema:alternateName University of California, San Francisco
307 schema:name Department of Medical Cell Biology, Uppsala University, Husargatan 3, Box 571, 751 23, Uppsala, Sweden
308 Department of Pathology, University of California, 94115, San Francisco, CA, USA
309 rdf:type schema:Organization
310 https://www.grid.ac/institutes/grid.8993.b schema:alternateName Uppsala University
311 schema:name Department of Medical Cell Biology, Uppsala University, Husargatan 3, Box 571, 751 23, Uppsala, Sweden
312 Department of Medical Sciences, Uppsala University, 751 23, Uppsala, Sweden
313 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...