Involvement of sulfatide in beta cells and type 1 and type 2 diabetes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2005-10

AUTHORS

K. Buschard, M. Blomqvist, T. Osterbye, P. Fredman

ABSTRACT

Mammalian tissues express beta-isoforms of glycosphingolipids and, among these, sulfatide (sulphated galactosylceramide) is present in the beta cells, and it is here that the short fatty acid chain (C16) isoform is predominately found. In vitro studies have shown that sulfatide preserves insulin crystals and facilitates insulin monomerisation under certain biochemical conditions. It also activates beta cell potassium channels and moderates insulin secretion. Anti-sulfatide antibodies are seen in type 1 diabetes, and immunological presentation of glycosphingolipids by the non-classical CD1 molecules has recently been reported. It is via this mechanism that alpha-galactosylceramide and sulfatide are able to influence the innate immune system and inhibit autoimmunity, possibly through regulatory natural killer T cells. Administration of sulfatide substantially reduces the incidence of diabetes in non-obese diabetic mice and prevents antigen-induced experimental autoimmune encephalomyelitis in wild-type mice. Sulfatide has specific anti-inflammatory properties, increasing the number of CD3+CD25+ regulatory T cells and reducing production of several cytokines, including TNF-alpha. Patients with type 2 diabetes have low serum concentrations of sulfatide, and some animal models of type 2 diabetes have low pancreatic expression of C16:0 sulfatide; administration of this increases insulin secretion and improves first-phase insulin response in Zucker fatty rats. Glycosphingolipids in general, and sulfatide in particular, appear relevant to both type 1 and type 2 diabetes. More... »

PAGES

1957-1962

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00125-005-1926-9

DOI

http://dx.doi.org/10.1007/s00125-005-1926-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021965021

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16143863


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diabetes Mellitus, Type 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diabetes Mellitus, Type 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin-Secreting Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sulfoglycosphingolipids", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Bartholin Institute, Copenhagen University Hospital, DK-2100, Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Buschard", 
        "givenName": "K.", 
        "id": "sg:person.075202216.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.075202216.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Institute of Clinical Neuroscience, Experimental Neuroscience Section, The Sahlgrenska Academy at G\u00f6teborg University, Sahlgrenska University Hospital, M\u00f6lndal, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Blomqvist", 
        "givenName": "M.", 
        "id": "sg:person.0714662130.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714662130.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Bartholin Institute, Copenhagen University Hospital, DK-2100, Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Osterbye", 
        "givenName": "T.", 
        "id": "sg:person.01067641015.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067641015.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Institute of Clinical Neuroscience, Experimental Neuroscience Section, The Sahlgrenska Academy at G\u00f6teborg University, Sahlgrenska University Hospital, M\u00f6lndal, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fredman", 
        "givenName": "P.", 
        "id": "sg:person.01146304546.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146304546.11"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)80546-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000702052"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.1830261226", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001333473"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.032068299", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001460371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/clim.2001.5060", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002435534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/34419", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002858497", 
          "https://doi.org/10.1038/34419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/34419", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002858497", 
          "https://doi.org/10.1038/34419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.51.8.2514", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002930588"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0901-1052", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003063342", 
          "https://doi.org/10.1038/nm0901-1052"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0901-1052", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003063342", 
          "https://doi.org/10.1038/nm0901-1052"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.ijo.0802187", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004456164", 
          "https://doi.org/10.1038/sj.ijo.0802187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.ijo.0802187", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004456164", 
          "https://doi.org/10.1038/sj.ijo.0802187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1034/j.1600-0463.2003.1110905.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004619068"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1271/bbb.59.155", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009246904"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/geno.1996.0341", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010320967"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)80093-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010967390"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.121169698", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012122237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.90.22.10494", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013279571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dmrr.519", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014548776"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0198-8859(99)00109-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014759892"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20031389", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015504771"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj2510017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021215503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj2510017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021215503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.52.36827", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022700323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1699-0463.1996.tb04962.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022750991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1699-0463.1996.tb04962.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022750991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1620/tjem.117.79", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024482768"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni948", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025666382", 
          "https://doi.org/10.1038/ni948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni948", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025666382", 
          "https://doi.org/10.1038/ni948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/08916930108994121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026075058"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20011963", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026307003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1464-5491.2005.01613.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026477021"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1464-5491.2005.01613.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026477021"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m005666200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028620783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.188.10.1831", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029140552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri1028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029467832", 
          "https://doi.org/10.1038/nri1028"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri1028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029467832", 
          "https://doi.org/10.1038/nri1028"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.92.25.11931", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030702798"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.53.4.1089", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030814483"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.immunol.17.1.297", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031128809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/glycob/10.1.39", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031733725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00315684", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032229005", 
          "https://doi.org/10.1007/bf00315684"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00315684", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032229005", 
          "https://doi.org/10.1007/bf00315684"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcb.10513", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034436760"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/9442", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034702965", 
          "https://doi.org/10.1038/9442"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/9442", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034702965", 
          "https://doi.org/10.1038/9442"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/glycob/11.6.473", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035826045"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.52.10.2513", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043136686"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00400463", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043752376", 
          "https://doi.org/10.1007/bf00400463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00400463", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043752376", 
          "https://doi.org/10.1007/bf00400463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00400463", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043752376", 
          "https://doi.org/10.1007/bf00400463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.1993.1065", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044339150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2760(94)90262-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045571935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2760(94)90262-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045571935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.imlet.2003.12.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045673672"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/0891693021000047361", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046967064"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-5793(99)00908-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050156902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.190.8.1069", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050723737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0901-1057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051665759", 
          "https://doi.org/10.1038/nm0901-1057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0901-1057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051665759", 
          "https://doi.org/10.1038/nm0901-1057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1699-0463.1991.tb01312.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051729827"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1699-0463.1991.tb01312.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051729827"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(93)92697-r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052484997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/intimm/7.7.1107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059712384"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.277.5324.339", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062557395"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci15832", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063415444"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2002-020760", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064286219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.172.10.5908", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076835101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079036808", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083324893", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2005-10", 
    "datePublishedReg": "2005-10-01", 
    "description": "Mammalian tissues express beta-isoforms of glycosphingolipids and, among these, sulfatide (sulphated galactosylceramide) is present in the beta cells, and it is here that the short fatty acid chain (C16) isoform is predominately found. In vitro studies have shown that sulfatide preserves insulin crystals and facilitates insulin monomerisation under certain biochemical conditions. It also activates beta cell potassium channels and moderates insulin secretion. Anti-sulfatide antibodies are seen in type 1 diabetes, and immunological presentation of glycosphingolipids by the non-classical CD1 molecules has recently been reported. It is via this mechanism that alpha-galactosylceramide and sulfatide are able to influence the innate immune system and inhibit autoimmunity, possibly through regulatory natural killer T cells. Administration of sulfatide substantially reduces the incidence of diabetes in non-obese diabetic mice and prevents antigen-induced experimental autoimmune encephalomyelitis in wild-type mice. Sulfatide has specific anti-inflammatory properties, increasing the number of CD3+CD25+ regulatory T cells and reducing production of several cytokines, including TNF-alpha. Patients with type 2 diabetes have low serum concentrations of sulfatide, and some animal models of type 2 diabetes have low pancreatic expression of C16:0 sulfatide; administration of this increases insulin secretion and improves first-phase insulin response in Zucker fatty rats. Glycosphingolipids in general, and sulfatide in particular, appear relevant to both type 1 and type 2 diabetes.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00125-005-1926-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1001482", 
        "issn": [
          "0012-186X", 
          "1432-0428"
        ], 
        "name": "Diabetologia", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "10", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "48"
      }
    ], 
    "name": "Involvement of sulfatide in beta cells and type 1 and type 2 diabetes", 
    "pagination": "1957-1962", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "68a525e40b3b6bb19118e08a683ed339053a6c1889cdaa02cf429f590393e70d"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "16143863"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0006777"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00125-005-1926-9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1021965021"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00125-005-1926-9", 
      "https://app.dimensions.ai/details/publication/pub.1021965021"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:03", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000360_0000000360/records_118309_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs00125-005-1926-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00125-005-1926-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00125-005-1926-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00125-005-1926-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00125-005-1926-9'


 

This table displays all metadata directly associated to this object as RDF triples.

288 TRIPLES      21 PREDICATES      89 URIs      27 LITERALS      15 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00125-005-1926-9 schema:about N195aec092ca0486498c8b91176d20315
2 N505448c6639e4281af97ce885cd2056c
3 N5eab1eaa51d043e3b2ba24a82aaf21cf
4 N69ba0182886340a293fb200d1c6361bc
5 N934cf5572b8c4f62b9002b82485289a1
6 Ne0fb46e20a9d440ebe56eb7fbe26b015
7 anzsrc-for:11
8 anzsrc-for:1107
9 schema:author N8f918af499a14916a6e3f3612ab2e704
10 schema:citation sg:pub.10.1007/bf00315684
11 sg:pub.10.1007/bf00400463
12 sg:pub.10.1038/34419
13 sg:pub.10.1038/9442
14 sg:pub.10.1038/ni948
15 sg:pub.10.1038/nm0901-1052
16 sg:pub.10.1038/nm0901-1057
17 sg:pub.10.1038/nri1028
18 sg:pub.10.1038/sj.ijo.0802187
19 https://app.dimensions.ai/details/publication/pub.1079036808
20 https://app.dimensions.ai/details/publication/pub.1083324893
21 https://doi.org/10.1002/dmrr.519
22 https://doi.org/10.1002/eji.1830261226
23 https://doi.org/10.1002/jcb.10513
24 https://doi.org/10.1006/bbrc.1993.1065
25 https://doi.org/10.1006/clim.2001.5060
26 https://doi.org/10.1006/geno.1996.0341
27 https://doi.org/10.1016/0005-2760(94)90262-3
28 https://doi.org/10.1016/0140-6736(93)92697-r
29 https://doi.org/10.1016/j.imlet.2003.12.010
30 https://doi.org/10.1016/s0014-5793(99)00908-4
31 https://doi.org/10.1016/s0092-8674(00)80093-8
32 https://doi.org/10.1016/s0092-8674(00)80546-2
33 https://doi.org/10.1016/s0198-8859(99)00109-3
34 https://doi.org/10.1034/j.1600-0463.2003.1110905.x
35 https://doi.org/10.1042/bj2510017
36 https://doi.org/10.1073/pnas.032068299
37 https://doi.org/10.1073/pnas.121169698
38 https://doi.org/10.1073/pnas.90.22.10494
39 https://doi.org/10.1073/pnas.92.25.11931
40 https://doi.org/10.1074/jbc.274.52.36827
41 https://doi.org/10.1074/jbc.m005666200
42 https://doi.org/10.1080/0891693021000047361
43 https://doi.org/10.1084/jem.188.10.1831
44 https://doi.org/10.1084/jem.190.8.1069
45 https://doi.org/10.1084/jem.20011963
46 https://doi.org/10.1084/jem.20031389
47 https://doi.org/10.1093/glycob/10.1.39
48 https://doi.org/10.1093/glycob/11.6.473
49 https://doi.org/10.1093/intimm/7.7.1107
50 https://doi.org/10.1111/j.1464-5491.2005.01613.x
51 https://doi.org/10.1111/j.1699-0463.1991.tb01312.x
52 https://doi.org/10.1111/j.1699-0463.1996.tb04962.x
53 https://doi.org/10.1126/science.277.5324.339
54 https://doi.org/10.1146/annurev.immunol.17.1.297
55 https://doi.org/10.1172/jci15832
56 https://doi.org/10.1210/jc.2002-020760
57 https://doi.org/10.1271/bbb.59.155
58 https://doi.org/10.1620/tjem.117.79
59 https://doi.org/10.2337/diabetes.51.8.2514
60 https://doi.org/10.2337/diabetes.52.10.2513
61 https://doi.org/10.2337/diabetes.53.4.1089
62 https://doi.org/10.3109/08916930108994121
63 https://doi.org/10.4049/jimmunol.172.10.5908
64 schema:datePublished 2005-10
65 schema:datePublishedReg 2005-10-01
66 schema:description Mammalian tissues express beta-isoforms of glycosphingolipids and, among these, sulfatide (sulphated galactosylceramide) is present in the beta cells, and it is here that the short fatty acid chain (C16) isoform is predominately found. In vitro studies have shown that sulfatide preserves insulin crystals and facilitates insulin monomerisation under certain biochemical conditions. It also activates beta cell potassium channels and moderates insulin secretion. Anti-sulfatide antibodies are seen in type 1 diabetes, and immunological presentation of glycosphingolipids by the non-classical CD1 molecules has recently been reported. It is via this mechanism that alpha-galactosylceramide and sulfatide are able to influence the innate immune system and inhibit autoimmunity, possibly through regulatory natural killer T cells. Administration of sulfatide substantially reduces the incidence of diabetes in non-obese diabetic mice and prevents antigen-induced experimental autoimmune encephalomyelitis in wild-type mice. Sulfatide has specific anti-inflammatory properties, increasing the number of CD3+CD25+ regulatory T cells and reducing production of several cytokines, including TNF-alpha. Patients with type 2 diabetes have low serum concentrations of sulfatide, and some animal models of type 2 diabetes have low pancreatic expression of C16:0 sulfatide; administration of this increases insulin secretion and improves first-phase insulin response in Zucker fatty rats. Glycosphingolipids in general, and sulfatide in particular, appear relevant to both type 1 and type 2 diabetes.
67 schema:genre research_article
68 schema:inLanguage en
69 schema:isAccessibleForFree true
70 schema:isPartOf N788113c4fe764b11993f94f54b10d700
71 Nf0c5fee5c7fb4ab78e797795678edd32
72 sg:journal.1001482
73 schema:name Involvement of sulfatide in beta cells and type 1 and type 2 diabetes
74 schema:pagination 1957-1962
75 schema:productId N40e1576e6b93486da82db6b188e24462
76 N718ab3719a7e4d2dafbd10b707e1bc8c
77 N94d06ae576eb48b6891ae57623d881be
78 N9efea073973348a9803ef7b0a4b94fe2
79 Nbf06f5e30e634736bb7aba1db7774aea
80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021965021
81 https://doi.org/10.1007/s00125-005-1926-9
82 schema:sdDatePublished 2019-04-11T12:03
83 schema:sdLicense https://scigraph.springernature.com/explorer/license/
84 schema:sdPublisher N2e81ad737f9540c29a8c19df719cd6c8
85 schema:url https://link.springer.com/10.1007%2Fs00125-005-1926-9
86 sgo:license sg:explorer/license/
87 sgo:sdDataset articles
88 rdf:type schema:ScholarlyArticle
89 N00138ba3c8044014915092d9068b3926 schema:name Bartholin Institute, Copenhagen University Hospital, DK-2100, Copenhagen, Denmark
90 rdf:type schema:Organization
91 N195aec092ca0486498c8b91176d20315 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Sulfoglycosphingolipids
93 rdf:type schema:DefinedTerm
94 N2e81ad737f9540c29a8c19df719cd6c8 schema:name Springer Nature - SN SciGraph project
95 rdf:type schema:Organization
96 N40e1576e6b93486da82db6b188e24462 schema:name nlm_unique_id
97 schema:value 0006777
98 rdf:type schema:PropertyValue
99 N505448c6639e4281af97ce885cd2056c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Diabetes Mellitus, Type 2
101 rdf:type schema:DefinedTerm
102 N5eab1eaa51d043e3b2ba24a82aaf21cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Humans
104 rdf:type schema:DefinedTerm
105 N69ba0182886340a293fb200d1c6361bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Insulin-Secreting Cells
107 rdf:type schema:DefinedTerm
108 N6b8f2901b12447d29933dea3f0fd4ef1 schema:name Bartholin Institute, Copenhagen University Hospital, DK-2100, Copenhagen, Denmark
109 rdf:type schema:Organization
110 N718ab3719a7e4d2dafbd10b707e1bc8c schema:name doi
111 schema:value 10.1007/s00125-005-1926-9
112 rdf:type schema:PropertyValue
113 N72dfb1b38bf44667b9ef4ea0b61ae466 rdf:first sg:person.0714662130.52
114 rdf:rest Nf69c1da31acd4625962a83c9b16434f1
115 N788113c4fe764b11993f94f54b10d700 schema:issueNumber 10
116 rdf:type schema:PublicationIssue
117 N8f918af499a14916a6e3f3612ab2e704 rdf:first sg:person.075202216.50
118 rdf:rest N72dfb1b38bf44667b9ef4ea0b61ae466
119 N934cf5572b8c4f62b9002b82485289a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Diabetes Mellitus, Type 1
121 rdf:type schema:DefinedTerm
122 N94d06ae576eb48b6891ae57623d881be schema:name readcube_id
123 schema:value 68a525e40b3b6bb19118e08a683ed339053a6c1889cdaa02cf429f590393e70d
124 rdf:type schema:PropertyValue
125 N9efea073973348a9803ef7b0a4b94fe2 schema:name dimensions_id
126 schema:value pub.1021965021
127 rdf:type schema:PropertyValue
128 Naa269c20ccb64a2bbd3707d9a6f7c255 schema:name Institute of Clinical Neuroscience, Experimental Neuroscience Section, The Sahlgrenska Academy at Göteborg University, Sahlgrenska University Hospital, Mölndal, Sweden
129 rdf:type schema:Organization
130 Nbf06f5e30e634736bb7aba1db7774aea schema:name pubmed_id
131 schema:value 16143863
132 rdf:type schema:PropertyValue
133 Ncbef4321ec5e41e5975e50acb3adf289 schema:name Institute of Clinical Neuroscience, Experimental Neuroscience Section, The Sahlgrenska Academy at Göteborg University, Sahlgrenska University Hospital, Mölndal, Sweden
134 rdf:type schema:Organization
135 Ne0fb46e20a9d440ebe56eb7fbe26b015 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Animals
137 rdf:type schema:DefinedTerm
138 Nf0c5fee5c7fb4ab78e797795678edd32 schema:volumeNumber 48
139 rdf:type schema:PublicationVolume
140 Nf69c1da31acd4625962a83c9b16434f1 rdf:first sg:person.01067641015.57
141 rdf:rest Nfa9b1f917fc64eef92e4cf3a7a256152
142 Nfa9b1f917fc64eef92e4cf3a7a256152 rdf:first sg:person.01146304546.11
143 rdf:rest rdf:nil
144 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
145 schema:name Medical and Health Sciences
146 rdf:type schema:DefinedTerm
147 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
148 schema:name Immunology
149 rdf:type schema:DefinedTerm
150 sg:journal.1001482 schema:issn 0012-186X
151 1432-0428
152 schema:name Diabetologia
153 rdf:type schema:Periodical
154 sg:person.01067641015.57 schema:affiliation N6b8f2901b12447d29933dea3f0fd4ef1
155 schema:familyName Osterbye
156 schema:givenName T.
157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067641015.57
158 rdf:type schema:Person
159 sg:person.01146304546.11 schema:affiliation Ncbef4321ec5e41e5975e50acb3adf289
160 schema:familyName Fredman
161 schema:givenName P.
162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146304546.11
163 rdf:type schema:Person
164 sg:person.0714662130.52 schema:affiliation Naa269c20ccb64a2bbd3707d9a6f7c255
165 schema:familyName Blomqvist
166 schema:givenName M.
167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714662130.52
168 rdf:type schema:Person
169 sg:person.075202216.50 schema:affiliation N00138ba3c8044014915092d9068b3926
170 schema:familyName Buschard
171 schema:givenName K.
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.075202216.50
173 rdf:type schema:Person
174 sg:pub.10.1007/bf00315684 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032229005
175 https://doi.org/10.1007/bf00315684
176 rdf:type schema:CreativeWork
177 sg:pub.10.1007/bf00400463 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043752376
178 https://doi.org/10.1007/bf00400463
179 rdf:type schema:CreativeWork
180 sg:pub.10.1038/34419 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002858497
181 https://doi.org/10.1038/34419
182 rdf:type schema:CreativeWork
183 sg:pub.10.1038/9442 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034702965
184 https://doi.org/10.1038/9442
185 rdf:type schema:CreativeWork
186 sg:pub.10.1038/ni948 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025666382
187 https://doi.org/10.1038/ni948
188 rdf:type schema:CreativeWork
189 sg:pub.10.1038/nm0901-1052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003063342
190 https://doi.org/10.1038/nm0901-1052
191 rdf:type schema:CreativeWork
192 sg:pub.10.1038/nm0901-1057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051665759
193 https://doi.org/10.1038/nm0901-1057
194 rdf:type schema:CreativeWork
195 sg:pub.10.1038/nri1028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029467832
196 https://doi.org/10.1038/nri1028
197 rdf:type schema:CreativeWork
198 sg:pub.10.1038/sj.ijo.0802187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004456164
199 https://doi.org/10.1038/sj.ijo.0802187
200 rdf:type schema:CreativeWork
201 https://app.dimensions.ai/details/publication/pub.1079036808 schema:CreativeWork
202 https://app.dimensions.ai/details/publication/pub.1083324893 schema:CreativeWork
203 https://doi.org/10.1002/dmrr.519 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014548776
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1002/eji.1830261226 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001333473
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1002/jcb.10513 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034436760
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1006/bbrc.1993.1065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044339150
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1006/clim.2001.5060 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002435534
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1006/geno.1996.0341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010320967
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/0005-2760(94)90262-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045571935
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1016/0140-6736(93)92697-r schema:sameAs https://app.dimensions.ai/details/publication/pub.1052484997
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1016/j.imlet.2003.12.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045673672
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/s0014-5793(99)00908-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050156902
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/s0092-8674(00)80093-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010967390
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/s0092-8674(00)80546-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000702052
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/s0198-8859(99)00109-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014759892
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1034/j.1600-0463.2003.1110905.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004619068
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1042/bj2510017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021215503
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1073/pnas.032068299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001460371
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1073/pnas.121169698 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012122237
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1073/pnas.90.22.10494 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013279571
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1073/pnas.92.25.11931 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030702798
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1074/jbc.274.52.36827 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022700323
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1074/jbc.m005666200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028620783
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1080/0891693021000047361 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046967064
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1084/jem.188.10.1831 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029140552
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1084/jem.190.8.1069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050723737
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1084/jem.20011963 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026307003
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1084/jem.20031389 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015504771
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1093/glycob/10.1.39 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031733725
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1093/glycob/11.6.473 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035826045
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1093/intimm/7.7.1107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059712384
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1111/j.1464-5491.2005.01613.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026477021
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1111/j.1699-0463.1991.tb01312.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051729827
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1111/j.1699-0463.1996.tb04962.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022750991
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1126/science.277.5324.339 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062557395
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1146/annurev.immunol.17.1.297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031128809
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1172/jci15832 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063415444
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1210/jc.2002-020760 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064286219
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1271/bbb.59.155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009246904
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1620/tjem.117.79 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024482768
278 rdf:type schema:CreativeWork
279 https://doi.org/10.2337/diabetes.51.8.2514 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002930588
280 rdf:type schema:CreativeWork
281 https://doi.org/10.2337/diabetes.52.10.2513 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043136686
282 rdf:type schema:CreativeWork
283 https://doi.org/10.2337/diabetes.53.4.1089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030814483
284 rdf:type schema:CreativeWork
285 https://doi.org/10.3109/08916930108994121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026075058
286 rdf:type schema:CreativeWork
287 https://doi.org/10.4049/jimmunol.172.10.5908 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076835101
288 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...