Non-esterified fatty acids impair insulin-mediated glucose uptake and disposition in the liver View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2004-07

AUTHORS

P. Iozzo, R. Lautamaki, F. Geisler, K. A. Virtanen, V. Oikonen, M. Haaparanta, H. Yki-Jarvinen, E. Ferrannini, J. Knuuti, P. Nuutila

ABSTRACT

AIMS/HYPOTHESIS: We investigated the effect of elevated circulating NEFA on insulin-mediated hepatic glucose uptake (HGU) and whole-body glucose disposal (M) in eight healthy male subjects. METHODS: Studies were performed using positron emission tomography (PET) and [(18)F]-2-fluoro-2-deoxyglucose ([(18)F]FDG) during euglycaemic hyperinsulinaemia (0-120 min) and an Intralipid/heparin infusion (IL/Hep; -90-120 min). On a different day, similar measurements were taken during euglycaemic hyperinsulinaemia and saline infusion (SAL). Graphical and compartmental analyses were used to model liver data. RESULTS: Circulating NEFA increased approximately three-fold during IL/Hep, and declined by 81+/-7% in the SAL study ( p More... »

PAGES

1149-1156

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00125-004-1443-2

DOI

http://dx.doi.org/10.1007/s00125-004-1443-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028998497

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15243703


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biological Transport", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fatty Acids, Nonesterified", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorodeoxyglucose F18", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glucose", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kinetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphorylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Positron-Emission Tomography", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiopharmaceuticals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reference Values", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Istituto di Fisiologia Clinica", 
          "id": "https://www.grid.ac/institutes/grid.418529.3", 
          "name": [
            "Turku PET Centre, University of Turku, Finland", 
            "PET Laboratory, Institute of Clinical Physiology, National Research Council (CNR), Via Moruzzi 1, 56100, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iozzo", 
        "givenName": "P.", 
        "id": "sg:person.01225611056.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225611056.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Turku PET Centre", 
          "id": "https://www.grid.ac/institutes/grid.470895.7", 
          "name": [
            "Turku PET Centre, University of Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lautamaki", 
        "givenName": "R.", 
        "id": "sg:person.0617216003.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617216003.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Turku PET Centre", 
          "id": "https://www.grid.ac/institutes/grid.470895.7", 
          "name": [
            "Turku PET Centre, University of Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Geisler", 
        "givenName": "F.", 
        "id": "sg:person.0677725360.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677725360.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Turku PET Centre", 
          "id": "https://www.grid.ac/institutes/grid.470895.7", 
          "name": [
            "Turku PET Centre, University of Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Virtanen", 
        "givenName": "K. A.", 
        "id": "sg:person.0616433356.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616433356.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Turku PET Centre", 
          "id": "https://www.grid.ac/institutes/grid.470895.7", 
          "name": [
            "Turku PET Centre, University of Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oikonen", 
        "givenName": "V.", 
        "id": "sg:person.0633127700.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633127700.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Turku PET Centre", 
          "id": "https://www.grid.ac/institutes/grid.470895.7", 
          "name": [
            "Turku PET Centre, University of Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Haaparanta", 
        "givenName": "M.", 
        "id": "sg:person.01205342410.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205342410.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Helsinki", 
          "id": "https://www.grid.ac/institutes/grid.7737.4", 
          "name": [
            "Department of Medicine, Division of Diabetes, University of Helsinki, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yki-Jarvinen", 
        "givenName": "H.", 
        "id": "sg:person.01151765525.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151765525.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pisa", 
          "id": "https://www.grid.ac/institutes/grid.5395.a", 
          "name": [
            "PET Laboratory, Institute of Clinical Physiology, National Research Council (CNR), Via Moruzzi 1, 56100, Pisa, Italy", 
            "Department of Internal Medicine, University of Pisa School of Medicine, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ferrannini", 
        "givenName": "E.", 
        "id": "sg:person.010570332762.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010570332762.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Turku PET Centre", 
          "id": "https://www.grid.ac/institutes/grid.470895.7", 
          "name": [
            "Turku PET Centre, University of Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Knuuti", 
        "givenName": "J.", 
        "id": "sg:person.01163336756.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163336756.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Turku", 
          "id": "https://www.grid.ac/institutes/grid.1374.1", 
          "name": [
            "Turku PET Centre, University of Turku, Finland", 
            "Department of Medicine, University of Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nuutila", 
        "givenName": "P.", 
        "id": "sg:person.0763376117.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763376117.17"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.2337/diabetes.50.8.1872", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002395398"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.50.6.1351", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003768791"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci115780", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004516243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.51.6.1663", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005018797"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpendo.00329.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006768572"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.51.2.301", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009244990"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj2510541", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012646077"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj2510541", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012646077"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dmrr.217", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014396272"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.1977.tb10649.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016554520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.1985.87", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016810523"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.1985.87", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016810523"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.1983.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018753419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.1983.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018753419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002590050523", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020976797", 
          "https://doi.org/10.1007/s002590050523"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00270426", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022086003", 
          "https://doi.org/10.1007/bf00270426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00270426", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022086003", 
          "https://doi.org/10.1007/bf00270426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00270426", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022086003", 
          "https://doi.org/10.1007/bf00270426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.1987.39", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022288805"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.1987.39", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022288805"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001250051579", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024438922", 
          "https://doi.org/10.1007/s001250051579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001250051579", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024438922", 
          "https://doi.org/10.1007/s001250051579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diab.46.1.153", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025879234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.49.2.272", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025958587"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpendo.00136.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034276189"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-2952(97)00576-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036692341"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0950-351x(87)80008-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036837526"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.51.10.3043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037148964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00042871-200403002-00132", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037696788"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.53.1.32", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038195112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3580665", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041095072"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3580665", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041095072"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1099-0895(199812)14:4<263::aid-dmr233>3.0.co;2-c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045103159"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.510280316", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046467093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.26.7.2069", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048912112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/0264-6021:3580665", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056715735"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1525-1381.1999.99220.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056743910"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-2007-979899", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057509287"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpendo.00332.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063192325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2002-021446", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064286398"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diab.46.2.187", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070738077"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.48.4.766", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070744137"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.48.5.1198", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070744186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074808961", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074951124", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075281543", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079027957", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079911054", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpendo.1979.237.3.e214", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079974987"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082166653", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082166654", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082687462", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082711152", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082794953", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpendo.1996.271.2.e384", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082947766"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2004-07", 
    "datePublishedReg": "2004-07-01", 
    "description": "AIMS/HYPOTHESIS: We investigated the effect of elevated circulating NEFA on insulin-mediated hepatic glucose uptake (HGU) and whole-body glucose disposal (M) in eight healthy male subjects.\nMETHODS: Studies were performed using positron emission tomography (PET) and [(18)F]-2-fluoro-2-deoxyglucose ([(18)F]FDG) during euglycaemic hyperinsulinaemia (0-120 min) and an Intralipid/heparin infusion (IL/Hep; -90-120 min). On a different day, similar measurements were taken during euglycaemic hyperinsulinaemia and saline infusion (SAL). Graphical and compartmental analyses were used to model liver data.\nRESULTS: Circulating NEFA increased approximately three-fold during IL/Hep, and declined by 81+/-7% in the SAL study ( p
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00125-004-1443-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00125-004-1443-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00125-004-1443-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00125-004-1443-2'


 

This table displays all metadata directly associated to this object as RDF triples.

337 TRIPLES      21 PREDICATES      90 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00125-004-1443-2 schema:about N20e4704b64ef493ebe7d4ab8cf5d80ca
2 N270fbe5889ea436d8aa18a7a154806e0
3 N3eaabfc6e9f847ba957d0ab94f6f644b
4 N410c138a336c4c93a167122b67cfb742
5 N7851d43168ac4f2c991e6fbb4a736663
6 N8d8ab9892b2140ae8f5d4e0a222c5f8f
7 N8e6f32934a0c45cd855ce7021034f771
8 N8fffd3b5153e4148935d2806eab11981
9 N95419c1147884d3b9d94d89b36776410
10 N96c9077dcbe84a1591f7b127c58a4f1e
11 Naad09659383d4564869b463c895b2d40
12 Nab2242429cee4e36a66e27f5536636b4
13 Nd6ec614ac2314e59b5463718687b027a
14 Ndd950a0ca7b144878e28cdc2959cfaab
15 anzsrc-for:11
16 anzsrc-for:1103
17 schema:author Nac450ab9f11843589c9ae39c7268fb0e
18 schema:citation sg:pub.10.1007/bf00270426
19 sg:pub.10.1007/s001250051579
20 sg:pub.10.1007/s002590050523
21 https://app.dimensions.ai/details/publication/pub.1074808961
22 https://app.dimensions.ai/details/publication/pub.1074951124
23 https://app.dimensions.ai/details/publication/pub.1075281543
24 https://app.dimensions.ai/details/publication/pub.1079027957
25 https://app.dimensions.ai/details/publication/pub.1079911054
26 https://app.dimensions.ai/details/publication/pub.1082166653
27 https://app.dimensions.ai/details/publication/pub.1082166654
28 https://app.dimensions.ai/details/publication/pub.1082687462
29 https://app.dimensions.ai/details/publication/pub.1082711152
30 https://app.dimensions.ai/details/publication/pub.1082794953
31 https://doi.org/10.1002/(sici)1099-0895(199812)14:4<263::aid-dmr233>3.0.co;2-c
32 https://doi.org/10.1002/dmrr.217
33 https://doi.org/10.1002/hep.510280316
34 https://doi.org/10.1016/s0006-2952(97)00576-5
35 https://doi.org/10.1016/s0950-351x(87)80008-3
36 https://doi.org/10.1038/jcbfm.1983.1
37 https://doi.org/10.1038/jcbfm.1985.87
38 https://doi.org/10.1038/jcbfm.1987.39
39 https://doi.org/10.1042/0264-6021:3580665
40 https://doi.org/10.1042/bj2510541
41 https://doi.org/10.1042/bj3580665
42 https://doi.org/10.1046/j.1525-1381.1999.99220.x
43 https://doi.org/10.1055/s-2007-979899
44 https://doi.org/10.1097/00042871-200403002-00132
45 https://doi.org/10.1111/j.1471-4159.1977.tb10649.x
46 https://doi.org/10.1152/ajpendo.00136.2001
47 https://doi.org/10.1152/ajpendo.00329.2001
48 https://doi.org/10.1152/ajpendo.00332.2002
49 https://doi.org/10.1152/ajpendo.1979.237.3.e214
50 https://doi.org/10.1152/ajpendo.1996.271.2.e384
51 https://doi.org/10.1172/jci115780
52 https://doi.org/10.1210/jc.2002-021446
53 https://doi.org/10.2337/diab.46.1.153
54 https://doi.org/10.2337/diab.46.2.187
55 https://doi.org/10.2337/diabetes.48.4.766
56 https://doi.org/10.2337/diabetes.48.5.1198
57 https://doi.org/10.2337/diabetes.49.2.272
58 https://doi.org/10.2337/diabetes.50.6.1351
59 https://doi.org/10.2337/diabetes.50.8.1872
60 https://doi.org/10.2337/diabetes.51.10.3043
61 https://doi.org/10.2337/diabetes.51.2.301
62 https://doi.org/10.2337/diabetes.51.6.1663
63 https://doi.org/10.2337/diabetes.53.1.32
64 https://doi.org/10.2337/diacare.26.7.2069
65 schema:datePublished 2004-07
66 schema:datePublishedReg 2004-07-01
67 schema:description AIMS/HYPOTHESIS: We investigated the effect of elevated circulating NEFA on insulin-mediated hepatic glucose uptake (HGU) and whole-body glucose disposal (M) in eight healthy male subjects. METHODS: Studies were performed using positron emission tomography (PET) and [(18)F]-2-fluoro-2-deoxyglucose ([(18)F]FDG) during euglycaemic hyperinsulinaemia (0-120 min) and an Intralipid/heparin infusion (IL/Hep; -90-120 min). On a different day, similar measurements were taken during euglycaemic hyperinsulinaemia and saline infusion (SAL). Graphical and compartmental analyses were used to model liver data. RESULTS: Circulating NEFA increased approximately three-fold during IL/Hep, and declined by 81+/-7% in the SAL study ( p</=0.01). Both M (-28+/-7%) and HGU (-25+/-9%) were significantly lowered by NEFA elevation ( p=0.004 and p=0.035 respectively). In the whole data set, the decreases in M and HGU were positively correlated ( r=0.78, p=0.038). No evidence of [(18)F]FDG outflow was detected during the scanning time. HGU was correlated with the phosphorylation rate parameter ( r=0.71, p=0.003) as derived by compartmental modelling. CONCLUSIONS/INTERPRETATION: In healthy men, NEFA impair insulin-mediated HGU and whole-body glucose uptake to a similar extent. Our data suggest that multiple intracellular NEFA targets may concur to down-regulate glucose uptake by the liver.
68 schema:genre research_article
69 schema:inLanguage en
70 schema:isAccessibleForFree true
71 schema:isPartOf N0e983867395b44aa919851c463ff8e39
72 Nebb9690a5eac481bb26490b7431d88dd
73 sg:journal.1001482
74 schema:name Non-esterified fatty acids impair insulin-mediated glucose uptake and disposition in the liver
75 schema:pagination 1149-1156
76 schema:productId N3345eb5e80c14333a05f4e248d55c344
77 N86393298d7da4c32950dbec8768b8541
78 Naa59bbf6258940a8a90c99f2077aca72
79 Nc7117db72b2f41a8967f9198fafb7088
80 Nc77ecd50706940e0bd068da654c74552
81 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028998497
82 https://doi.org/10.1007/s00125-004-1443-2
83 schema:sdDatePublished 2019-04-11T10:31
84 schema:sdLicense https://scigraph.springernature.com/explorer/license/
85 schema:sdPublisher Ncde2fd5d9f0b4b3998f5d5249438b55b
86 schema:url https://link.springer.com/10.1007%2Fs00125-004-1443-2
87 sgo:license sg:explorer/license/
88 sgo:sdDataset articles
89 rdf:type schema:ScholarlyArticle
90 N0e983867395b44aa919851c463ff8e39 schema:issueNumber 7
91 rdf:type schema:PublicationIssue
92 N20e4704b64ef493ebe7d4ab8cf5d80ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Positron-Emission Tomography
94 rdf:type schema:DefinedTerm
95 N270fbe5889ea436d8aa18a7a154806e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Glucose
97 rdf:type schema:DefinedTerm
98 N293c8c99c9b34ab4869af0a934bfc013 rdf:first sg:person.01205342410.46
99 rdf:rest Nffcb55c01d814504b4832c0077b5cb47
100 N3345eb5e80c14333a05f4e248d55c344 schema:name doi
101 schema:value 10.1007/s00125-004-1443-2
102 rdf:type schema:PropertyValue
103 N3eaabfc6e9f847ba957d0ab94f6f644b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Reference Values
105 rdf:type schema:DefinedTerm
106 N410c138a336c4c93a167122b67cfb742 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Radiopharmaceuticals
108 rdf:type schema:DefinedTerm
109 N4f6c3f2be6384038abe70d4d9e44bc8e rdf:first sg:person.010570332762.30
110 rdf:rest Ne5733f9ef7b94220aeec301b0029a878
111 N7851d43168ac4f2c991e6fbb4a736663 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Adult
113 rdf:type schema:DefinedTerm
114 N834e04bccf7c4df3b3621d45f42a67f3 rdf:first sg:person.0763376117.17
115 rdf:rest rdf:nil
116 N86393298d7da4c32950dbec8768b8541 schema:name dimensions_id
117 schema:value pub.1028998497
118 rdf:type schema:PropertyValue
119 N8d8ab9892b2140ae8f5d4e0a222c5f8f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Fluorodeoxyglucose F18
121 rdf:type schema:DefinedTerm
122 N8e6f32934a0c45cd855ce7021034f771 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Kinetics
124 rdf:type schema:DefinedTerm
125 N8fffd3b5153e4148935d2806eab11981 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Phosphorylation
127 rdf:type schema:DefinedTerm
128 N95419c1147884d3b9d94d89b36776410 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Male
130 rdf:type schema:DefinedTerm
131 N96c9077dcbe84a1591f7b127c58a4f1e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Biological Transport
133 rdf:type schema:DefinedTerm
134 Naa59bbf6258940a8a90c99f2077aca72 schema:name readcube_id
135 schema:value 8a248f0880ec4780d8db6e5ba672fbc536c9be39f3b19bdf5e4bbf7d34d92a16
136 rdf:type schema:PropertyValue
137 Naad09659383d4564869b463c895b2d40 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Liver
139 rdf:type schema:DefinedTerm
140 Nab2242429cee4e36a66e27f5536636b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Humans
142 rdf:type schema:DefinedTerm
143 Nac450ab9f11843589c9ae39c7268fb0e rdf:first sg:person.01225611056.51
144 rdf:rest Nf98d56238ef4488fb7f48955988425d5
145 Naf594bbb0db2498c8767056c0870fae6 rdf:first sg:person.0616433356.09
146 rdf:rest Nb5e1f981d0f946a78dec09203785205b
147 Nb5e1f981d0f946a78dec09203785205b rdf:first sg:person.0633127700.74
148 rdf:rest N293c8c99c9b34ab4869af0a934bfc013
149 Nc6b360545eaf432d93bfcd70bf0840b3 rdf:first sg:person.0677725360.47
150 rdf:rest Naf594bbb0db2498c8767056c0870fae6
151 Nc7117db72b2f41a8967f9198fafb7088 schema:name nlm_unique_id
152 schema:value 0006777
153 rdf:type schema:PropertyValue
154 Nc77ecd50706940e0bd068da654c74552 schema:name pubmed_id
155 schema:value 15243703
156 rdf:type schema:PropertyValue
157 Ncde2fd5d9f0b4b3998f5d5249438b55b schema:name Springer Nature - SN SciGraph project
158 rdf:type schema:Organization
159 Nd6ec614ac2314e59b5463718687b027a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Insulin
161 rdf:type schema:DefinedTerm
162 Ndd950a0ca7b144878e28cdc2959cfaab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Fatty Acids, Nonesterified
164 rdf:type schema:DefinedTerm
165 Ne5733f9ef7b94220aeec301b0029a878 rdf:first sg:person.01163336756.79
166 rdf:rest N834e04bccf7c4df3b3621d45f42a67f3
167 Nebb9690a5eac481bb26490b7431d88dd schema:volumeNumber 47
168 rdf:type schema:PublicationVolume
169 Nf98d56238ef4488fb7f48955988425d5 rdf:first sg:person.0617216003.83
170 rdf:rest Nc6b360545eaf432d93bfcd70bf0840b3
171 Nffcb55c01d814504b4832c0077b5cb47 rdf:first sg:person.01151765525.10
172 rdf:rest N4f6c3f2be6384038abe70d4d9e44bc8e
173 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
174 schema:name Medical and Health Sciences
175 rdf:type schema:DefinedTerm
176 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
177 schema:name Clinical Sciences
178 rdf:type schema:DefinedTerm
179 sg:journal.1001482 schema:issn 0012-186X
180 1432-0428
181 schema:name Diabetologia
182 rdf:type schema:Periodical
183 sg:person.010570332762.30 schema:affiliation https://www.grid.ac/institutes/grid.5395.a
184 schema:familyName Ferrannini
185 schema:givenName E.
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010570332762.30
187 rdf:type schema:Person
188 sg:person.01151765525.10 schema:affiliation https://www.grid.ac/institutes/grid.7737.4
189 schema:familyName Yki-Jarvinen
190 schema:givenName H.
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151765525.10
192 rdf:type schema:Person
193 sg:person.01163336756.79 schema:affiliation https://www.grid.ac/institutes/grid.470895.7
194 schema:familyName Knuuti
195 schema:givenName J.
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163336756.79
197 rdf:type schema:Person
198 sg:person.01205342410.46 schema:affiliation https://www.grid.ac/institutes/grid.470895.7
199 schema:familyName Haaparanta
200 schema:givenName M.
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205342410.46
202 rdf:type schema:Person
203 sg:person.01225611056.51 schema:affiliation https://www.grid.ac/institutes/grid.418529.3
204 schema:familyName Iozzo
205 schema:givenName P.
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225611056.51
207 rdf:type schema:Person
208 sg:person.0616433356.09 schema:affiliation https://www.grid.ac/institutes/grid.470895.7
209 schema:familyName Virtanen
210 schema:givenName K. A.
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616433356.09
212 rdf:type schema:Person
213 sg:person.0617216003.83 schema:affiliation https://www.grid.ac/institutes/grid.470895.7
214 schema:familyName Lautamaki
215 schema:givenName R.
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617216003.83
217 rdf:type schema:Person
218 sg:person.0633127700.74 schema:affiliation https://www.grid.ac/institutes/grid.470895.7
219 schema:familyName Oikonen
220 schema:givenName V.
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633127700.74
222 rdf:type schema:Person
223 sg:person.0677725360.47 schema:affiliation https://www.grid.ac/institutes/grid.470895.7
224 schema:familyName Geisler
225 schema:givenName F.
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677725360.47
227 rdf:type schema:Person
228 sg:person.0763376117.17 schema:affiliation https://www.grid.ac/institutes/grid.1374.1
229 schema:familyName Nuutila
230 schema:givenName P.
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763376117.17
232 rdf:type schema:Person
233 sg:pub.10.1007/bf00270426 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022086003
234 https://doi.org/10.1007/bf00270426
235 rdf:type schema:CreativeWork
236 sg:pub.10.1007/s001250051579 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024438922
237 https://doi.org/10.1007/s001250051579
238 rdf:type schema:CreativeWork
239 sg:pub.10.1007/s002590050523 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020976797
240 https://doi.org/10.1007/s002590050523
241 rdf:type schema:CreativeWork
242 https://app.dimensions.ai/details/publication/pub.1074808961 schema:CreativeWork
243 https://app.dimensions.ai/details/publication/pub.1074951124 schema:CreativeWork
244 https://app.dimensions.ai/details/publication/pub.1075281543 schema:CreativeWork
245 https://app.dimensions.ai/details/publication/pub.1079027957 schema:CreativeWork
246 https://app.dimensions.ai/details/publication/pub.1079911054 schema:CreativeWork
247 https://app.dimensions.ai/details/publication/pub.1082166653 schema:CreativeWork
248 https://app.dimensions.ai/details/publication/pub.1082166654 schema:CreativeWork
249 https://app.dimensions.ai/details/publication/pub.1082687462 schema:CreativeWork
250 https://app.dimensions.ai/details/publication/pub.1082711152 schema:CreativeWork
251 https://app.dimensions.ai/details/publication/pub.1082794953 schema:CreativeWork
252 https://doi.org/10.1002/(sici)1099-0895(199812)14:4<263::aid-dmr233>3.0.co;2-c schema:sameAs https://app.dimensions.ai/details/publication/pub.1045103159
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1002/dmrr.217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014396272
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1002/hep.510280316 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046467093
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/s0006-2952(97)00576-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036692341
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/s0950-351x(87)80008-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036837526
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1038/jcbfm.1983.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018753419
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1038/jcbfm.1985.87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016810523
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1038/jcbfm.1987.39 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022288805
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1042/0264-6021:3580665 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056715735
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1042/bj2510541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012646077
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1042/bj3580665 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041095072
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1046/j.1525-1381.1999.99220.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1056743910
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1055/s-2007-979899 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057509287
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1097/00042871-200403002-00132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037696788
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1111/j.1471-4159.1977.tb10649.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016554520
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1152/ajpendo.00136.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034276189
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1152/ajpendo.00329.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006768572
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1152/ajpendo.00332.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063192325
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1152/ajpendo.1979.237.3.e214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079974987
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1152/ajpendo.1996.271.2.e384 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082947766
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1172/jci115780 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004516243
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1210/jc.2002-021446 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064286398
295 rdf:type schema:CreativeWork
296 https://doi.org/10.2337/diab.46.1.153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025879234
297 rdf:type schema:CreativeWork
298 https://doi.org/10.2337/diab.46.2.187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070738077
299 rdf:type schema:CreativeWork
300 https://doi.org/10.2337/diabetes.48.4.766 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070744137
301 rdf:type schema:CreativeWork
302 https://doi.org/10.2337/diabetes.48.5.1198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070744186
303 rdf:type schema:CreativeWork
304 https://doi.org/10.2337/diabetes.49.2.272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025958587
305 rdf:type schema:CreativeWork
306 https://doi.org/10.2337/diabetes.50.6.1351 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003768791
307 rdf:type schema:CreativeWork
308 https://doi.org/10.2337/diabetes.50.8.1872 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002395398
309 rdf:type schema:CreativeWork
310 https://doi.org/10.2337/diabetes.51.10.3043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037148964
311 rdf:type schema:CreativeWork
312 https://doi.org/10.2337/diabetes.51.2.301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009244990
313 rdf:type schema:CreativeWork
314 https://doi.org/10.2337/diabetes.51.6.1663 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005018797
315 rdf:type schema:CreativeWork
316 https://doi.org/10.2337/diabetes.53.1.32 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038195112
317 rdf:type schema:CreativeWork
318 https://doi.org/10.2337/diacare.26.7.2069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048912112
319 rdf:type schema:CreativeWork
320 https://www.grid.ac/institutes/grid.1374.1 schema:alternateName University of Turku
321 schema:name Department of Medicine, University of Turku, Finland
322 Turku PET Centre, University of Turku, Finland
323 rdf:type schema:Organization
324 https://www.grid.ac/institutes/grid.418529.3 schema:alternateName Istituto di Fisiologia Clinica
325 schema:name PET Laboratory, Institute of Clinical Physiology, National Research Council (CNR), Via Moruzzi 1, 56100, Pisa, Italy
326 Turku PET Centre, University of Turku, Finland
327 rdf:type schema:Organization
328 https://www.grid.ac/institutes/grid.470895.7 schema:alternateName Turku PET Centre
329 schema:name Turku PET Centre, University of Turku, Finland
330 rdf:type schema:Organization
331 https://www.grid.ac/institutes/grid.5395.a schema:alternateName University of Pisa
332 schema:name Department of Internal Medicine, University of Pisa School of Medicine, Italy
333 PET Laboratory, Institute of Clinical Physiology, National Research Council (CNR), Via Moruzzi 1, 56100, Pisa, Italy
334 rdf:type schema:Organization
335 https://www.grid.ac/institutes/grid.7737.4 schema:alternateName University of Helsinki
336 schema:name Department of Medicine, Division of Diabetes, University of Helsinki, Finland
337 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...