Polyol-pathway-dependent disturbances in renal medullary metabolism in experimental insulin-deficient diabetes mellitus in rats View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2004-07

AUTHORS

F. Palm, P. Hansell, G. Ronquist, A. Waldenström, P. Liss, P.-O. Carlsson

ABSTRACT

AIMS/HYPOTHESIS: The renal medullary region is particularly vulnerable to reduced oxygen concentration because of its low blood perfusion and high basal oxygen consumption. This study investigated renal metabolic changes in relation to the previously observed decreased oxygen tension in streptozotocin-induced diabetic rats. METHODS: Blood perfusion, oxygen tension and consumption, interstitial pH, and glycolytic and purine-based metabolites were determined in the renal cortex and the medulla of non-diabetic and diabetic animals by, respectively, laser Doppler flowmetry, oxygen and pH microelectrodes, and microdialysis. The importance of increased polyol pathway activity for the observed alterations was investigated by daily treatment with the aldose reductase inhibitor AL-1576 throughout the course of diabetes. RESULTS: The diabetes-induced decrease in renal oxygen tension, due to augmented oxygen consumption, did not result in manifest hypoxia in either the cortical or the medullary region, as evaluated by microdialysis measurements of purine-based metabolites. The profound alterations in medullary oxygen metabolism were, however, associated with an increased lactate : pyruvate ratio and a concomitantly decreased pH. Notably, the renal medullary changes in oxygen tension, oxygen consumption, lactate : pyruvate ratio and pH were preventable by inhibition of aldose reductase. CONCLUSIONS/INTERPRETATION: Substantial metabolic changes were observed in the renal medulla in diabetic animals. These disturbances seemed to be mediated by increased polyol pathway activity and could be prevented by inhibition of aldose reductase. More... »

PAGES

1223-1231

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00125-004-1434-3

DOI

http://dx.doi.org/10.1007/s00125-004-1434-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028079306

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15232683


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Glucose", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diabetes Mellitus, Experimental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney Medulla", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Laser-Doppler Flowmetry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oxygen Consumption", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Inbred WF", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reference Values", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Renal Circulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ultrasonography", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Uppsala University", 
          "id": "https://www.grid.ac/institutes/grid.8993.b", 
          "name": [
            "Department of Medical Cell Biology, Biomedical Center, Uppsala University, Box 571, 751 23, Uppsala, Sweden", 
            "Department of Diagnostic Radiology, Uppsala University, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Palm", 
        "givenName": "F.", 
        "id": "sg:person.0720075272.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720075272.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Uppsala University", 
          "id": "https://www.grid.ac/institutes/grid.8993.b", 
          "name": [
            "Department of Medical Cell Biology, Biomedical Center, Uppsala University, Box 571, 751 23, Uppsala, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hansell", 
        "givenName": "P.", 
        "id": "sg:person.0732033424.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732033424.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Uppsala University", 
          "id": "https://www.grid.ac/institutes/grid.8993.b", 
          "name": [
            "Department of Clinical Chemistry, Uppsala University, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ronquist", 
        "givenName": "G.", 
        "id": "sg:person.01007621020.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007621020.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Cardiology, Ume\u00e5 Hospital, Ume\u00e5, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Waldenstr\u00f6m", 
        "givenName": "A.", 
        "id": "sg:person.01025365361.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025365361.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Uppsala University", 
          "id": "https://www.grid.ac/institutes/grid.8993.b", 
          "name": [
            "Department of Diagnostic Radiology, Uppsala University, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liss", 
        "givenName": "P.", 
        "id": "sg:person.01327252772.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327252772.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Uppsala University", 
          "id": "https://www.grid.ac/institutes/grid.8993.b", 
          "name": [
            "Department of Medical Cell Biology, Biomedical Center, Uppsala University, Box 571, 751 23, Uppsala, Sweden", 
            "Department of Medical Sciences, Uppsala University, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Carlsson", 
        "givenName": "P.-O.", 
        "id": "sg:person.01216166160.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216166160.54"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0272-6386(97)90023-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003036804"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199309303291401", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004144761"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0026-0495(97)90244-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006388187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.0954-6820.1951.tb17171.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014535794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.0954-6820.1951.tb17171.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014535794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001250051646", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015529506", 
          "https://doi.org/10.1007/s001250051646"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001250051646", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015529506", 
          "https://doi.org/10.1007/s001250051646"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/toxsci/53.1.145", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018389292"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001250050916", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022659349", 
          "https://doi.org/10.1007/s001250050916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001250050916", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022659349", 
          "https://doi.org/10.1007/s001250050916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci117406", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022784144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/2000-1967-147", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022936261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1046/j.1523-1755.1999.00474.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024476894", 
          "https://doi.org/10.1046/j.1523-1755.1999.00474.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-003-1155-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028746482", 
          "https://doi.org/10.1007/s00125-003-1155-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-003-1155-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028746482", 
          "https://doi.org/10.1007/s00125-003-1155-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4757-1850-8_17", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028808241", 
          "https://doi.org/10.1007/978-1-4757-1850-8_17"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0026-0495(87)90048-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029139674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1046/j.1523-1755.2000.07705.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030488538", 
          "https://doi.org/10.1046/j.1523-1755.2000.07705.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00041552-199809000-00013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030781414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00041552-199809000-00013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030781414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci112977", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031451200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35008121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031794389", 
          "https://doi.org/10.1038/35008121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35008121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031794389", 
          "https://doi.org/10.1038/35008121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004240050455", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037632142", 
          "https://doi.org/10.1007/s004240050455"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1984.185", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045707127", 
          "https://doi.org/10.1038/ki.1984.185"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199503093321006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050463480"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1997.420", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052984781", 
          "https://doi.org/10.1038/ki.1997.420"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.6612330", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062639188"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpendo.00156.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063192135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajprenal.00330.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063197548"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1064244126", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/endo.140.10.7035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064282684"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diab.31.9.789", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070734218"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diab.39.5.557", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070736099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diab.42.6.801", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070737079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diab.43.5.629", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070737316"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diab.46.2.s31", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070738107"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.42.6.801", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070742584"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.48.10.2090", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070744009"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074701089", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074719413", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076770369", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082430545", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.eurheartj.a060951", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082460362"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.eurheartj.a060916", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082508458"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082564842", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082764232", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083304096", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajprenal.1998.275.4.f595", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083323080"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajprenal.1998.275.4.f595", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083323080"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2004-07", 
    "datePublishedReg": "2004-07-01", 
    "description": "AIMS/HYPOTHESIS: The renal medullary region is particularly vulnerable to reduced oxygen concentration because of its low blood perfusion and high basal oxygen consumption. This study investigated renal metabolic changes in relation to the previously observed decreased oxygen tension in streptozotocin-induced diabetic rats.\nMETHODS: Blood perfusion, oxygen tension and consumption, interstitial pH, and glycolytic and purine-based metabolites were determined in the renal cortex and the medulla of non-diabetic and diabetic animals by, respectively, laser Doppler flowmetry, oxygen and pH microelectrodes, and microdialysis. The importance of increased polyol pathway activity for the observed alterations was investigated by daily treatment with the aldose reductase inhibitor AL-1576 throughout the course of diabetes.\nRESULTS: The diabetes-induced decrease in renal oxygen tension, due to augmented oxygen consumption, did not result in manifest hypoxia in either the cortical or the medullary region, as evaluated by microdialysis measurements of purine-based metabolites. The profound alterations in medullary oxygen metabolism were, however, associated with an increased lactate : pyruvate ratio and a concomitantly decreased pH. Notably, the renal medullary changes in oxygen tension, oxygen consumption, lactate : pyruvate ratio and pH were preventable by inhibition of aldose reductase.\nCONCLUSIONS/INTERPRETATION: Substantial metabolic changes were observed in the renal medulla in diabetic animals. These disturbances seemed to be mediated by increased polyol pathway activity and could be prevented by inhibition of aldose reductase.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00125-004-1434-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1001482", 
        "issn": [
          "0012-186X", 
          "1432-0428"
        ], 
        "name": "Diabetologia", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "47"
      }
    ], 
    "name": "Polyol-pathway-dependent disturbances in renal medullary metabolism in experimental insulin-deficient diabetes mellitus in rats", 
    "pagination": "1223-1231", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "85c2f80c5fee040f293f45bcb6feefb499897bd619035f6195484acba4c08a4c"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "15232683"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0006777"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00125-004-1434-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1028079306"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00125-004-1434-3", 
      "https://app.dimensions.ai/details/publication/pub.1028079306"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T14:31", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000373_0000000373/records_13096_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs00125-004-1434-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00125-004-1434-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00125-004-1434-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00125-004-1434-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00125-004-1434-3'


 

This table displays all metadata directly associated to this object as RDF triples.

292 TRIPLES      21 PREDICATES      85 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00125-004-1434-3 schema:about N025743dc56bf46fca792a23af8324b00
2 N41285ae483d745dd9082c3513e46d0e8
3 N5a93d923ef324d60bd148de280c3544b
4 N5ed6014519594f29899cf21dd60f1945
5 N5f4474e57c0c4749b1b5c27b94eca454
6 N963c96eea6f14d67bf8cd25142a87d8d
7 Na793731a99bd446e869c525076ef48af
8 Nc3c0450c7bab4272a723f50790f2eaa0
9 Nca4323959d4240ee9cdd83408606b3db
10 Nd1b10ba250a84aec9cfe429276dbf3ce
11 Ndcbe4fa415fa43a4b0a6d2881b77297f
12 Nf7773d590d3542b2a21aa2652c75614e
13 Nff5c9483b0a2466496807c3a022a7085
14 anzsrc-for:11
15 anzsrc-for:1103
16 schema:author N1950b81aec6c4c398024ebb79ca35aa1
17 schema:citation sg:pub.10.1007/978-1-4757-1850-8_17
18 sg:pub.10.1007/s00125-003-1155-z
19 sg:pub.10.1007/s001250050916
20 sg:pub.10.1007/s001250051646
21 sg:pub.10.1007/s004240050455
22 sg:pub.10.1038/35008121
23 sg:pub.10.1038/ki.1984.185
24 sg:pub.10.1038/ki.1997.420
25 sg:pub.10.1046/j.1523-1755.1999.00474.x
26 sg:pub.10.1046/j.1523-1755.2000.07705.x
27 https://app.dimensions.ai/details/publication/pub.1064244126
28 https://app.dimensions.ai/details/publication/pub.1074701089
29 https://app.dimensions.ai/details/publication/pub.1074719413
30 https://app.dimensions.ai/details/publication/pub.1076770369
31 https://app.dimensions.ai/details/publication/pub.1082430545
32 https://app.dimensions.ai/details/publication/pub.1082564842
33 https://app.dimensions.ai/details/publication/pub.1082764232
34 https://app.dimensions.ai/details/publication/pub.1083304096
35 https://doi.org/10.1016/0026-0495(87)90048-5
36 https://doi.org/10.1016/s0026-0495(97)90244-4
37 https://doi.org/10.1016/s0272-6386(97)90023-8
38 https://doi.org/10.1056/nejm199309303291401
39 https://doi.org/10.1056/nejm199503093321006
40 https://doi.org/10.1093/oxfordjournals.eurheartj.a060916
41 https://doi.org/10.1093/oxfordjournals.eurheartj.a060951
42 https://doi.org/10.1093/toxsci/53.1.145
43 https://doi.org/10.1097/00041552-199809000-00013
44 https://doi.org/10.1111/j.0954-6820.1951.tb17171.x
45 https://doi.org/10.1126/science.6612330
46 https://doi.org/10.1152/ajpendo.00156.2002
47 https://doi.org/10.1152/ajprenal.00330.2001
48 https://doi.org/10.1152/ajprenal.1998.275.4.f595
49 https://doi.org/10.1172/jci112977
50 https://doi.org/10.1172/jci117406
51 https://doi.org/10.1210/endo.140.10.7035
52 https://doi.org/10.2337/diab.31.9.789
53 https://doi.org/10.2337/diab.39.5.557
54 https://doi.org/10.2337/diab.42.6.801
55 https://doi.org/10.2337/diab.43.5.629
56 https://doi.org/10.2337/diab.46.2.s31
57 https://doi.org/10.2337/diabetes.42.6.801
58 https://doi.org/10.2337/diabetes.48.10.2090
59 https://doi.org/10.3109/2000-1967-147
60 schema:datePublished 2004-07
61 schema:datePublishedReg 2004-07-01
62 schema:description AIMS/HYPOTHESIS: The renal medullary region is particularly vulnerable to reduced oxygen concentration because of its low blood perfusion and high basal oxygen consumption. This study investigated renal metabolic changes in relation to the previously observed decreased oxygen tension in streptozotocin-induced diabetic rats. METHODS: Blood perfusion, oxygen tension and consumption, interstitial pH, and glycolytic and purine-based metabolites were determined in the renal cortex and the medulla of non-diabetic and diabetic animals by, respectively, laser Doppler flowmetry, oxygen and pH microelectrodes, and microdialysis. The importance of increased polyol pathway activity for the observed alterations was investigated by daily treatment with the aldose reductase inhibitor AL-1576 throughout the course of diabetes. RESULTS: The diabetes-induced decrease in renal oxygen tension, due to augmented oxygen consumption, did not result in manifest hypoxia in either the cortical or the medullary region, as evaluated by microdialysis measurements of purine-based metabolites. The profound alterations in medullary oxygen metabolism were, however, associated with an increased lactate : pyruvate ratio and a concomitantly decreased pH. Notably, the renal medullary changes in oxygen tension, oxygen consumption, lactate : pyruvate ratio and pH were preventable by inhibition of aldose reductase. CONCLUSIONS/INTERPRETATION: Substantial metabolic changes were observed in the renal medulla in diabetic animals. These disturbances seemed to be mediated by increased polyol pathway activity and could be prevented by inhibition of aldose reductase.
63 schema:genre research_article
64 schema:inLanguage en
65 schema:isAccessibleForFree true
66 schema:isPartOf N10695ac307f24a6a80acbd24454f8fef
67 N31a81e401c3d49609267f48d22e7cb02
68 sg:journal.1001482
69 schema:name Polyol-pathway-dependent disturbances in renal medullary metabolism in experimental insulin-deficient diabetes mellitus in rats
70 schema:pagination 1223-1231
71 schema:productId N0d0cd213288244b6b9ae5e324f879a5f
72 N1c141faa01f542dd9f48a1250f101819
73 N4892dff5b3cd4562b5b050d5ea8b6fb7
74 N667e013df1ff432f8cd9307c2c4708f7
75 N88ab6a0ce79f4dddb9872cdf09b0710e
76 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028079306
77 https://doi.org/10.1007/s00125-004-1434-3
78 schema:sdDatePublished 2019-04-11T14:31
79 schema:sdLicense https://scigraph.springernature.com/explorer/license/
80 schema:sdPublisher N8d7de7e45ffe4328bd81316c3c0d6523
81 schema:url https://link.springer.com/10.1007%2Fs00125-004-1434-3
82 sgo:license sg:explorer/license/
83 sgo:sdDataset articles
84 rdf:type schema:ScholarlyArticle
85 N025743dc56bf46fca792a23af8324b00 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Oxygen Consumption
87 rdf:type schema:DefinedTerm
88 N03f030143c924727bbba5585bb7325f3 rdf:first sg:person.01007621020.36
89 rdf:rest N2af431cf72ad4e568b45e0d706f26b2f
90 N0d0cd213288244b6b9ae5e324f879a5f schema:name dimensions_id
91 schema:value pub.1028079306
92 rdf:type schema:PropertyValue
93 N10695ac307f24a6a80acbd24454f8fef schema:volumeNumber 47
94 rdf:type schema:PublicationVolume
95 N1950b81aec6c4c398024ebb79ca35aa1 rdf:first sg:person.0720075272.18
96 rdf:rest Nc49bd395001543a79dee137c1f75082a
97 N1c141faa01f542dd9f48a1250f101819 schema:name pubmed_id
98 schema:value 15232683
99 rdf:type schema:PropertyValue
100 N2af431cf72ad4e568b45e0d706f26b2f rdf:first sg:person.01025365361.13
101 rdf:rest Na5547d63a08542d095d5183a2890485a
102 N31a81e401c3d49609267f48d22e7cb02 schema:issueNumber 7
103 rdf:type schema:PublicationIssue
104 N41285ae483d745dd9082c3513e46d0e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Rats
106 rdf:type schema:DefinedTerm
107 N4892dff5b3cd4562b5b050d5ea8b6fb7 schema:name readcube_id
108 schema:value 85c2f80c5fee040f293f45bcb6feefb499897bd619035f6195484acba4c08a4c
109 rdf:type schema:PropertyValue
110 N4b0c51a316fe4e01b0fcc1a0526c8d81 schema:name Department of Cardiology, Umeå Hospital, Umeå, Sweden
111 rdf:type schema:Organization
112 N54d8cedf45924bcb8aea30940ffb5927 rdf:first sg:person.01216166160.54
113 rdf:rest rdf:nil
114 N5a93d923ef324d60bd148de280c3544b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Kidney Medulla
116 rdf:type schema:DefinedTerm
117 N5ed6014519594f29899cf21dd60f1945 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Reference Values
119 rdf:type schema:DefinedTerm
120 N5f4474e57c0c4749b1b5c27b94eca454 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Diabetes Mellitus, Experimental
122 rdf:type schema:DefinedTerm
123 N667e013df1ff432f8cd9307c2c4708f7 schema:name doi
124 schema:value 10.1007/s00125-004-1434-3
125 rdf:type schema:PropertyValue
126 N88ab6a0ce79f4dddb9872cdf09b0710e schema:name nlm_unique_id
127 schema:value 0006777
128 rdf:type schema:PropertyValue
129 N8d7de7e45ffe4328bd81316c3c0d6523 schema:name Springer Nature - SN SciGraph project
130 rdf:type schema:Organization
131 N963c96eea6f14d67bf8cd25142a87d8d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Renal Circulation
133 rdf:type schema:DefinedTerm
134 Na5547d63a08542d095d5183a2890485a rdf:first sg:person.01327252772.29
135 rdf:rest N54d8cedf45924bcb8aea30940ffb5927
136 Na793731a99bd446e869c525076ef48af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Animals
138 rdf:type schema:DefinedTerm
139 Nc3c0450c7bab4272a723f50790f2eaa0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Polymers
141 rdf:type schema:DefinedTerm
142 Nc49bd395001543a79dee137c1f75082a rdf:first sg:person.0732033424.03
143 rdf:rest N03f030143c924727bbba5585bb7325f3
144 Nca4323959d4240ee9cdd83408606b3db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Ultrasonography
146 rdf:type schema:DefinedTerm
147 Nd1b10ba250a84aec9cfe429276dbf3ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Rats, Inbred WF
149 rdf:type schema:DefinedTerm
150 Ndcbe4fa415fa43a4b0a6d2881b77297f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Blood Glucose
152 rdf:type schema:DefinedTerm
153 Nf7773d590d3542b2a21aa2652c75614e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Male
155 rdf:type schema:DefinedTerm
156 Nff5c9483b0a2466496807c3a022a7085 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Laser-Doppler Flowmetry
158 rdf:type schema:DefinedTerm
159 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
160 schema:name Medical and Health Sciences
161 rdf:type schema:DefinedTerm
162 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
163 schema:name Clinical Sciences
164 rdf:type schema:DefinedTerm
165 sg:journal.1001482 schema:issn 0012-186X
166 1432-0428
167 schema:name Diabetologia
168 rdf:type schema:Periodical
169 sg:person.01007621020.36 schema:affiliation https://www.grid.ac/institutes/grid.8993.b
170 schema:familyName Ronquist
171 schema:givenName G.
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007621020.36
173 rdf:type schema:Person
174 sg:person.01025365361.13 schema:affiliation N4b0c51a316fe4e01b0fcc1a0526c8d81
175 schema:familyName Waldenström
176 schema:givenName A.
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025365361.13
178 rdf:type schema:Person
179 sg:person.01216166160.54 schema:affiliation https://www.grid.ac/institutes/grid.8993.b
180 schema:familyName Carlsson
181 schema:givenName P.-O.
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216166160.54
183 rdf:type schema:Person
184 sg:person.01327252772.29 schema:affiliation https://www.grid.ac/institutes/grid.8993.b
185 schema:familyName Liss
186 schema:givenName P.
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327252772.29
188 rdf:type schema:Person
189 sg:person.0720075272.18 schema:affiliation https://www.grid.ac/institutes/grid.8993.b
190 schema:familyName Palm
191 schema:givenName F.
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720075272.18
193 rdf:type schema:Person
194 sg:person.0732033424.03 schema:affiliation https://www.grid.ac/institutes/grid.8993.b
195 schema:familyName Hansell
196 schema:givenName P.
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732033424.03
198 rdf:type schema:Person
199 sg:pub.10.1007/978-1-4757-1850-8_17 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028808241
200 https://doi.org/10.1007/978-1-4757-1850-8_17
201 rdf:type schema:CreativeWork
202 sg:pub.10.1007/s00125-003-1155-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1028746482
203 https://doi.org/10.1007/s00125-003-1155-z
204 rdf:type schema:CreativeWork
205 sg:pub.10.1007/s001250050916 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022659349
206 https://doi.org/10.1007/s001250050916
207 rdf:type schema:CreativeWork
208 sg:pub.10.1007/s001250051646 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015529506
209 https://doi.org/10.1007/s001250051646
210 rdf:type schema:CreativeWork
211 sg:pub.10.1007/s004240050455 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037632142
212 https://doi.org/10.1007/s004240050455
213 rdf:type schema:CreativeWork
214 sg:pub.10.1038/35008121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031794389
215 https://doi.org/10.1038/35008121
216 rdf:type schema:CreativeWork
217 sg:pub.10.1038/ki.1984.185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045707127
218 https://doi.org/10.1038/ki.1984.185
219 rdf:type schema:CreativeWork
220 sg:pub.10.1038/ki.1997.420 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052984781
221 https://doi.org/10.1038/ki.1997.420
222 rdf:type schema:CreativeWork
223 sg:pub.10.1046/j.1523-1755.1999.00474.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024476894
224 https://doi.org/10.1046/j.1523-1755.1999.00474.x
225 rdf:type schema:CreativeWork
226 sg:pub.10.1046/j.1523-1755.2000.07705.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030488538
227 https://doi.org/10.1046/j.1523-1755.2000.07705.x
228 rdf:type schema:CreativeWork
229 https://app.dimensions.ai/details/publication/pub.1064244126 schema:CreativeWork
230 https://app.dimensions.ai/details/publication/pub.1074701089 schema:CreativeWork
231 https://app.dimensions.ai/details/publication/pub.1074719413 schema:CreativeWork
232 https://app.dimensions.ai/details/publication/pub.1076770369 schema:CreativeWork
233 https://app.dimensions.ai/details/publication/pub.1082430545 schema:CreativeWork
234 https://app.dimensions.ai/details/publication/pub.1082564842 schema:CreativeWork
235 https://app.dimensions.ai/details/publication/pub.1082764232 schema:CreativeWork
236 https://app.dimensions.ai/details/publication/pub.1083304096 schema:CreativeWork
237 https://doi.org/10.1016/0026-0495(87)90048-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029139674
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1016/s0026-0495(97)90244-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006388187
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1016/s0272-6386(97)90023-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003036804
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1056/nejm199309303291401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004144761
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1056/nejm199503093321006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050463480
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1093/oxfordjournals.eurheartj.a060916 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082508458
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1093/oxfordjournals.eurheartj.a060951 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082460362
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1093/toxsci/53.1.145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018389292
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1097/00041552-199809000-00013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030781414
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1111/j.0954-6820.1951.tb17171.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014535794
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1126/science.6612330 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062639188
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1152/ajpendo.00156.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063192135
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1152/ajprenal.00330.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063197548
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1152/ajprenal.1998.275.4.f595 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083323080
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1172/jci112977 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031451200
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1172/jci117406 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022784144
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1210/endo.140.10.7035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064282684
270 rdf:type schema:CreativeWork
271 https://doi.org/10.2337/diab.31.9.789 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070734218
272 rdf:type schema:CreativeWork
273 https://doi.org/10.2337/diab.39.5.557 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070736099
274 rdf:type schema:CreativeWork
275 https://doi.org/10.2337/diab.42.6.801 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070737079
276 rdf:type schema:CreativeWork
277 https://doi.org/10.2337/diab.43.5.629 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070737316
278 rdf:type schema:CreativeWork
279 https://doi.org/10.2337/diab.46.2.s31 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070738107
280 rdf:type schema:CreativeWork
281 https://doi.org/10.2337/diabetes.42.6.801 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070742584
282 rdf:type schema:CreativeWork
283 https://doi.org/10.2337/diabetes.48.10.2090 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070744009
284 rdf:type schema:CreativeWork
285 https://doi.org/10.3109/2000-1967-147 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022936261
286 rdf:type schema:CreativeWork
287 https://www.grid.ac/institutes/grid.8993.b schema:alternateName Uppsala University
288 schema:name Department of Clinical Chemistry, Uppsala University, Sweden
289 Department of Diagnostic Radiology, Uppsala University, Sweden
290 Department of Medical Cell Biology, Biomedical Center, Uppsala University, Box 571, 751 23, Uppsala, Sweden
291 Department of Medical Sciences, Uppsala University, Sweden
292 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...