Overexpression of lipoprotein lipase improves insulin resistance induced by a high-fat diet in transgenic rabbits View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2004-07-01

AUTHORS

S. Kitajima, M. Morimoto, E. Liu, T. Koike, Y. Higaki, Y. Taura, K. Mamba, K. Itamoto, T. Watanabe, K. Tsutsumi, N. Yamada, J. Fan

ABSTRACT

Aims/hypothesisDysfunctions of lipoprotein lipase (LPL) have been found to be associated with dyslipidaemias, atherosclerosis, obesity and insulin resistance. There are two conflicting hypotheses regarding the roles of LPL in glucose metabolism and insulin resistance. Whether systemically increased LPL activity would be beneficial or detrimental to insulin sensitivity is yet to be resolved. To address this issue, we studied transgenic rabbits overexpressing human LPL transgene.MethodsLPL transgenic and control rabbits were fed a 10% high-fat diet (HFD) for 16 weeks. To evaluate glucose metabolism, we compared plasma levels of glucose and insulin in transgenic rabbits with control rabbits and performed an intravenous glucose tolerance test. In addition, we measured adipose tissue accumulation in HFD-fed rabbits.ResultsIncreased LPL activity in transgenic rabbits resulted in a significant reduction of plasma triglycerides and non-esterified fatty acids, but not in basal levels of glucose and insulin. HFD feeding induced an elevation of plasma glucose levels accompanied by hyperinsulinaemia in control rabbits, but was significantly inhibited in transgenic rabbits. The intravenous glucose tolerance test showed that transgenic rabbits had faster glucose clearance associated with lower levels of insulin secretion than control rabbits. In addition, there was a significant reduction of body adipose tissue in transgenic rabbits compared with in control rabbits fed an HFD. Scanning electron microscopic examination revealed that adipocytes in transgenic rabbits were predominately small cells.Conclusions/interpretationOur results showed that systemically increased LPL activity improves insulin resistance and reduces adipose accumulation in transgenic rabbits, indicating that systemic elevation of LPL may have potential benefits for the treatment of insulin resistance and obesity. More... »

PAGES

1202-1209

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00125-004-1429-0

DOI

http://dx.doi.org/10.1007/s00125-004-1429-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049808848

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15221136


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