Sustained cardiomyocyte apoptosis and left ventricular remodelling after myocardial infarction in experimental diabetes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2004-02

AUTHORS

T. Bäcklund, E. Palojoki, A. Saraste, A. Eriksson, P. Finckenberg, V. Kytö, P. Lakkisto, E. Mervaala, L.-M. Voipio-Pulkki, M. Laine, I. Tikkanen

ABSTRACT

AIMS/HYPOTHESIS: Diabetes is known to reduce survival after myocardial infarction. Our aim was to examine whether diabetes is associated with enhanced cardiomyocyte apoptosis and thus interferes with the post-infarction remodelling process in myocardium in rat. METHODS: Four weeks after intravenous streptozotocin (diabetic groups) or citrate buffer (controls) injection, myocardial infarction was produced by ligation of left descending coronary artery. Level of cardiomyocyte apoptosis was quantified by TUNEL and caspase-3 methods. Collagen volume fraction and connective tissue growth factor were determined under microscope. Left ventricular dimensions were evaluated by echocardiography and planimetry. RESULTS: The number of apoptotic cardiomyocytes was equally high in diabetic and non-diabetic rats after 1 week from infarction. At 12 weeks after infarction the number of apoptotic cells was higher in the diabetic as compared to non-diabetic rats both in the border zone of infarction and in non-infarcted area. Correspondingly, left ventricular end diastolic diameter, relative cardiac weight, connective tissue growth factor-expression and fibrosis were increased in diabetic compared with non-diabetic rats with myocardial infarction. CONCLUSION/INTERPRETATION: Sustained cardiomyocyte apoptosis, left ventricular enlargement, increased cardiac fibrosis and enhanced profibrogenic connective tissue growth factor expression were detected after myocardial infarction in experimental diabetes. Apoptotic myocyte loss could be an important mechanism contributing to progressive dilatation of the heart and poor prognosis after myocardial infarction in diabetes. More... »

PAGES

325-330

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00125-003-1311-5

DOI

http://dx.doi.org/10.1007/s00125-003-1311-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002677428

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/14722653


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Glucose", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Caspase 3", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Caspases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Collagen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Connective Tissue Growth Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Coronary Vessels", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diabetes Mellitus, Experimental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heart", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immediate-Early Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "In Situ Nick-End Labeling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intercellular Signaling Peptides and Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ligation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myocardial Infarction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myocardium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myocytes, Cardiac", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Natriuretic Peptide, Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Organ Size", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Wistar", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ventricular Remodeling", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Helsinki University Central Hospital", 
          "id": "https://www.grid.ac/institutes/grid.15485.3d", 
          "name": [
            "Department of Medicine, Helsinki University Hospital, P.O. Box 340, Haartmaninkatu 4, 00029, HUS, Finland", 
            "Minerva Institute for Medical Research, Helsinki, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "B\u00e4cklund", 
        "givenName": "T.", 
        "id": "sg:person.01205127766.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205127766.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Helsinki University Central Hospital", 
          "id": "https://www.grid.ac/institutes/grid.15485.3d", 
          "name": [
            "Department of Medicine, Helsinki University Hospital, P.O. Box 340, Haartmaninkatu 4, 00029, HUS, Finland", 
            "Minerva Institute for Medical Research, Helsinki, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Palojoki", 
        "givenName": "E.", 
        "id": "sg:person.0752660420.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752660420.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Turku", 
          "id": "https://www.grid.ac/institutes/grid.1374.1", 
          "name": [
            "Department of Anatomy, University of Turku, Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saraste", 
        "givenName": "A.", 
        "id": "sg:person.0607272607.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607272607.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Minerva Institute for Medical Research, Helsinki, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Eriksson", 
        "givenName": "A.", 
        "id": "sg:person.0576255526.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576255526.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Helsinki", 
          "id": "https://www.grid.ac/institutes/grid.7737.4", 
          "name": [
            "Biomedicum and Institute of Biomedicine, University of Helsinki, Helsinki, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Finckenberg", 
        "givenName": "P.", 
        "id": "sg:person.0707331737.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707331737.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Turku", 
          "id": "https://www.grid.ac/institutes/grid.1374.1", 
          "name": [
            "Department of Anatomy, University of Turku, Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kyt\u00f6", 
        "givenName": "V.", 
        "id": "sg:person.01341767014.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341767014.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Minerva Institute for Medical Research, Helsinki, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lakkisto", 
        "givenName": "P.", 
        "id": "sg:person.0704545220.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704545220.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Helsinki", 
          "id": "https://www.grid.ac/institutes/grid.7737.4", 
          "name": [
            "Biomedicum and Institute of Biomedicine, University of Helsinki, Helsinki, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mervaala", 
        "givenName": "E.", 
        "id": "sg:person.01211233057.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211233057.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Helsinki University Central Hospital", 
          "id": "https://www.grid.ac/institutes/grid.15485.3d", 
          "name": [
            "Department of Medicine, Helsinki University Hospital, P.O. Box 340, Haartmaninkatu 4, 00029, HUS, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Voipio-Pulkki", 
        "givenName": "L.-M.", 
        "id": "sg:person.01200347241.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200347241.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Helsinki University Central Hospital", 
          "id": "https://www.grid.ac/institutes/grid.15485.3d", 
          "name": [
            "Department of Medicine, Helsinki University Hospital, P.O. Box 340, Haartmaninkatu 4, 00029, HUS, Finland", 
            "Minerva Institute for Medical Research, Helsinki, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Laine", 
        "givenName": "M.", 
        "id": "sg:person.01272451630.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272451630.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Helsinki University Central Hospital", 
          "id": "https://www.grid.ac/institutes/grid.15485.3d", 
          "name": [
            "Department of Medicine, Helsinki University Hospital, P.O. Box 340, Haartmaninkatu 4, 00029, HUS, Finland", 
            "Minerva Institute for Medical Research, Helsinki, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tikkanen", 
        "givenName": "I.", 
        "id": "sg:person.01041342134.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041342134.14"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00125-002-0882-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004883061", 
          "https://doi.org/10.1007/s00125-002-0882-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-002-0882-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004883061", 
          "https://doi.org/10.1007/s00125-002-0882-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/excr.1996.0232", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007553801"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.51.9.2709", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009585260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m010722200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017409221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.bjp.0704131", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029821613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)63659-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035336591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0735-1097(03)00509-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040915380"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0735-1097(03)00509-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040915380"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2362.1999.00481.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041178787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.24.8.1422", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044173194"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/phrs.1998.0290", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044510908"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/labinvest.3780057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046198423", 
          "https://doi.org/10.1038/labinvest.3780057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/labinvest.3780057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046198423", 
          "https://doi.org/10.1038/labinvest.3780057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1939-1676.1993.tb01015.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050905535"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1939-1676.1993.tb01015.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050905535"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.50.10.2363", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051976369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.51.6.1938", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051989979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0008-6363(02)00721-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054578353"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0008-6363(97)00018-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054579667"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0008-6363(99)00384-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054580661"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.95.2.320", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063337743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.96.11.4002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063338188"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fasebj.13.13.1774", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074528517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.2000.279.1.h422", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074669333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.2001.280.6.h2726", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074815129"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2004-02", 
    "datePublishedReg": "2004-02-01", 
    "description": "AIMS/HYPOTHESIS: Diabetes is known to reduce survival after myocardial infarction. Our aim was to examine whether diabetes is associated with enhanced cardiomyocyte apoptosis and thus interferes with the post-infarction remodelling process in myocardium in rat.\nMETHODS: Four weeks after intravenous streptozotocin (diabetic groups) or citrate buffer (controls) injection, myocardial infarction was produced by ligation of left descending coronary artery. Level of cardiomyocyte apoptosis was quantified by TUNEL and caspase-3 methods. Collagen volume fraction and connective tissue growth factor were determined under microscope. Left ventricular dimensions were evaluated by echocardiography and planimetry.\nRESULTS: The number of apoptotic cardiomyocytes was equally high in diabetic and non-diabetic rats after 1 week from infarction. At 12 weeks after infarction the number of apoptotic cells was higher in the diabetic as compared to non-diabetic rats both in the border zone of infarction and in non-infarcted area. Correspondingly, left ventricular end diastolic diameter, relative cardiac weight, connective tissue growth factor-expression and fibrosis were increased in diabetic compared with non-diabetic rats with myocardial infarction.\nCONCLUSION/INTERPRETATION: Sustained cardiomyocyte apoptosis, left ventricular enlargement, increased cardiac fibrosis and enhanced profibrogenic connective tissue growth factor expression were detected after myocardial infarction in experimental diabetes. Apoptotic myocyte loss could be an important mechanism contributing to progressive dilatation of the heart and poor prognosis after myocardial infarction in diabetes.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00125-003-1311-5", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1001482", 
        "issn": [
          "0012-186X", 
          "1432-0428"
        ], 
        "name": "Diabetologia", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "47"
      }
    ], 
    "name": "Sustained cardiomyocyte apoptosis and left ventricular remodelling after myocardial infarction in experimental diabetes", 
    "pagination": "325-330", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "0cbf902d81fea6926863310bec1c94a0e772ac72573b7d7ab6507768b28574f9"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "14722653"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0006777"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00125-003-1311-5"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1002677428"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00125-003-1311-5", 
      "https://app.dimensions.ai/details/publication/pub.1002677428"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:59", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000347_0000000347/records_89814_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs00125-003-1311-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00125-003-1311-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00125-003-1311-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00125-003-1311-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00125-003-1311-5'


 

This table displays all metadata directly associated to this object as RDF triples.

318 TRIPLES      21 PREDICATES      76 URIs      46 LITERALS      34 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00125-003-1311-5 schema:about N025b93c1f9d6440eb7dd1308b23eca69
2 N0e3fb36fd2174cbf957d49d78da649f5
3 N2c650b796316451d97deee96706b9c6c
4 N312c6de84c804dc0ad0b0539f902b967
5 N423a52a6010141b79b69a02df6ce5dda
6 N5206f4d383c84110914d8f0f6b632c54
7 N570dc7a861a547b4aaddcbe51bdd57df
8 N61bd0e0ecad347fbb03e860d88ef7a54
9 N74a4f0bea7c04136a062bf8c973c8d42
10 N759488e2058d459b91654fd01ad4c809
11 N872d1faebc65419b81e4f5916e416d19
12 N8af60e45c76341aba79c893e69aad774
13 N8dea145139f841c48d81bcd78c47ab87
14 N94c5a19da08e4ef8a93a9e630c2d9138
15 N99025fcf1c2a449c8f337cc3150c6c05
16 Na2facff974ce4639b0ec367c75358c89
17 Nb9a35dc223a74741bd08a92b53a70a7d
18 Nc4547a2c6e2f41fa85ed14c7d6aa1f22
19 Ncce077f70dc34755b3834206836d80ba
20 Nd3bee8bd7c484f4db2807cf7b2b5ef59
21 Nd80b30c02e1543b1b099cd448f321823
22 Nde53abc2d6be428e82e25f03fcb8dd59
23 Nf03d4101c0824ff28c6e199bd028d17a
24 Nf194f92772274c2ab59393692f1d8d7e
25 Nffcab573308b4db3b1a2288a92edad93
26 anzsrc-for:11
27 anzsrc-for:1103
28 schema:author Nd9dc5ff6212744c8a06c16052b6f639d
29 schema:citation sg:pub.10.1007/s00125-002-0882-x
30 sg:pub.10.1038/labinvest.3780057
31 https://doi.org/10.1006/excr.1996.0232
32 https://doi.org/10.1006/phrs.1998.0290
33 https://doi.org/10.1016/s0002-9440(10)63659-0
34 https://doi.org/10.1016/s0008-6363(02)00721-6
35 https://doi.org/10.1016/s0008-6363(97)00018-7
36 https://doi.org/10.1016/s0008-6363(99)00384-3
37 https://doi.org/10.1016/s0735-1097(03)00509-6
38 https://doi.org/10.1038/sj.bjp.0704131
39 https://doi.org/10.1046/j.1365-2362.1999.00481.x
40 https://doi.org/10.1074/jbc.m010722200
41 https://doi.org/10.1096/fasebj.13.13.1774
42 https://doi.org/10.1111/j.1939-1676.1993.tb01015.x
43 https://doi.org/10.1152/ajpheart.2000.279.1.h422
44 https://doi.org/10.1152/ajpheart.2001.280.6.h2726
45 https://doi.org/10.1161/01.cir.95.2.320
46 https://doi.org/10.1161/01.cir.96.11.4002
47 https://doi.org/10.2337/diabetes.50.10.2363
48 https://doi.org/10.2337/diabetes.51.6.1938
49 https://doi.org/10.2337/diabetes.51.9.2709
50 https://doi.org/10.2337/diacare.24.8.1422
51 schema:datePublished 2004-02
52 schema:datePublishedReg 2004-02-01
53 schema:description AIMS/HYPOTHESIS: Diabetes is known to reduce survival after myocardial infarction. Our aim was to examine whether diabetes is associated with enhanced cardiomyocyte apoptosis and thus interferes with the post-infarction remodelling process in myocardium in rat. METHODS: Four weeks after intravenous streptozotocin (diabetic groups) or citrate buffer (controls) injection, myocardial infarction was produced by ligation of left descending coronary artery. Level of cardiomyocyte apoptosis was quantified by TUNEL and caspase-3 methods. Collagen volume fraction and connective tissue growth factor were determined under microscope. Left ventricular dimensions were evaluated by echocardiography and planimetry. RESULTS: The number of apoptotic cardiomyocytes was equally high in diabetic and non-diabetic rats after 1 week from infarction. At 12 weeks after infarction the number of apoptotic cells was higher in the diabetic as compared to non-diabetic rats both in the border zone of infarction and in non-infarcted area. Correspondingly, left ventricular end diastolic diameter, relative cardiac weight, connective tissue growth factor-expression and fibrosis were increased in diabetic compared with non-diabetic rats with myocardial infarction. CONCLUSION/INTERPRETATION: Sustained cardiomyocyte apoptosis, left ventricular enlargement, increased cardiac fibrosis and enhanced profibrogenic connective tissue growth factor expression were detected after myocardial infarction in experimental diabetes. Apoptotic myocyte loss could be an important mechanism contributing to progressive dilatation of the heart and poor prognosis after myocardial infarction in diabetes.
54 schema:genre research_article
55 schema:inLanguage en
56 schema:isAccessibleForFree true
57 schema:isPartOf N39f5f5359482482fad1554cd8d528b21
58 N8d0aec5c1ec54d34ade4b08cb7d6bb28
59 sg:journal.1001482
60 schema:name Sustained cardiomyocyte apoptosis and left ventricular remodelling after myocardial infarction in experimental diabetes
61 schema:pagination 325-330
62 schema:productId N232d84c055334cbdb9805a8f0b91787d
63 N2ce1ecfac70b4d0da46b465aaa34717a
64 N3d2bd58270224a59b16f7fff13c1ac24
65 N61e1e36028314746ad918db6d44d3d0b
66 Nbb951d2367004431ada7932382b1d9f0
67 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002677428
68 https://doi.org/10.1007/s00125-003-1311-5
69 schema:sdDatePublished 2019-04-11T09:59
70 schema:sdLicense https://scigraph.springernature.com/explorer/license/
71 schema:sdPublisher Nd24422e83c634995b6534987c2b3d9e2
72 schema:url https://link.springer.com/10.1007%2Fs00125-003-1311-5
73 sgo:license sg:explorer/license/
74 sgo:sdDataset articles
75 rdf:type schema:ScholarlyArticle
76 N025b93c1f9d6440eb7dd1308b23eca69 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Coronary Vessels
78 rdf:type schema:DefinedTerm
79 N0e3fb36fd2174cbf957d49d78da649f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Myocytes, Cardiac
81 rdf:type schema:DefinedTerm
82 N0f37dfdee69e42e7a942582de74cb22c rdf:first sg:person.01341767014.83
83 rdf:rest N2d5916ac255241a79cba0bc8cd6e4f69
84 N232d84c055334cbdb9805a8f0b91787d schema:name doi
85 schema:value 10.1007/s00125-003-1311-5
86 rdf:type schema:PropertyValue
87 N2c650b796316451d97deee96706b9c6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Natriuretic Peptide, Brain
89 rdf:type schema:DefinedTerm
90 N2ce1ecfac70b4d0da46b465aaa34717a schema:name nlm_unique_id
91 schema:value 0006777
92 rdf:type schema:PropertyValue
93 N2d5916ac255241a79cba0bc8cd6e4f69 rdf:first sg:person.0704545220.47
94 rdf:rest N4cef17c69455408d9623963d87d0e7d6
95 N312c6de84c804dc0ad0b0539f902b967 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Myocardial Infarction
97 rdf:type schema:DefinedTerm
98 N39f5f5359482482fad1554cd8d528b21 schema:issueNumber 2
99 rdf:type schema:PublicationIssue
100 N3d2bd58270224a59b16f7fff13c1ac24 schema:name readcube_id
101 schema:value 0cbf902d81fea6926863310bec1c94a0e772ac72573b7d7ab6507768b28574f9
102 rdf:type schema:PropertyValue
103 N423a52a6010141b79b69a02df6ce5dda schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Apoptosis
105 rdf:type schema:DefinedTerm
106 N48b84c862df04858a61c1db6857dac65 schema:name Minerva Institute for Medical Research, Helsinki, Finland
107 rdf:type schema:Organization
108 N4cef17c69455408d9623963d87d0e7d6 rdf:first sg:person.01211233057.33
109 rdf:rest Nbc57699c48cd4cf786d023d9729408dd
110 N5206f4d383c84110914d8f0f6b632c54 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Blood Glucose
112 rdf:type schema:DefinedTerm
113 N5335f5aa4ea34dc8aabc1642c990eadd rdf:first sg:person.01272451630.99
114 rdf:rest Nc57ed222de0140298f7bfa271ec9e5ab
115 N570dc7a861a547b4aaddcbe51bdd57df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Immediate-Early Proteins
117 rdf:type schema:DefinedTerm
118 N597ec47198374289a5a872a0110a0942 rdf:first sg:person.0607272607.61
119 rdf:rest N8e64c0504d1f4051a626494b21151211
120 N61bd0e0ecad347fbb03e860d88ef7a54 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Rats, Wistar
122 rdf:type schema:DefinedTerm
123 N61e1e36028314746ad918db6d44d3d0b schema:name dimensions_id
124 schema:value pub.1002677428
125 rdf:type schema:PropertyValue
126 N74a4f0bea7c04136a062bf8c973c8d42 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Male
128 rdf:type schema:DefinedTerm
129 N759488e2058d459b91654fd01ad4c809 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Gene Expression
131 rdf:type schema:DefinedTerm
132 N872d1faebc65419b81e4f5916e416d19 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Animals
134 rdf:type schema:DefinedTerm
135 N8af60e45c76341aba79c893e69aad774 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Diabetes Mellitus, Experimental
137 rdf:type schema:DefinedTerm
138 N8b523556eaae4aada98836e658492cb2 schema:name Minerva Institute for Medical Research, Helsinki, Finland
139 rdf:type schema:Organization
140 N8d0aec5c1ec54d34ade4b08cb7d6bb28 schema:volumeNumber 47
141 rdf:type schema:PublicationVolume
142 N8dea145139f841c48d81bcd78c47ab87 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Ligation
144 rdf:type schema:DefinedTerm
145 N8e64c0504d1f4051a626494b21151211 rdf:first sg:person.0576255526.51
146 rdf:rest Na9c8e698a5ad494481b310d7699b9b7a
147 N94c5a19da08e4ef8a93a9e630c2d9138 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Caspases
149 rdf:type schema:DefinedTerm
150 N99025fcf1c2a449c8f337cc3150c6c05 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Heart
152 rdf:type schema:DefinedTerm
153 Na2facff974ce4639b0ec367c75358c89 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Organ Size
155 rdf:type schema:DefinedTerm
156 Na9c8e698a5ad494481b310d7699b9b7a rdf:first sg:person.0707331737.33
157 rdf:rest N0f37dfdee69e42e7a942582de74cb22c
158 Nb9a35dc223a74741bd08a92b53a70a7d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Caspase 3
160 rdf:type schema:DefinedTerm
161 Nbb951d2367004431ada7932382b1d9f0 schema:name pubmed_id
162 schema:value 14722653
163 rdf:type schema:PropertyValue
164 Nbc57699c48cd4cf786d023d9729408dd rdf:first sg:person.01200347241.97
165 rdf:rest N5335f5aa4ea34dc8aabc1642c990eadd
166 Nc4547a2c6e2f41fa85ed14c7d6aa1f22 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Collagen
168 rdf:type schema:DefinedTerm
169 Nc57ed222de0140298f7bfa271ec9e5ab rdf:first sg:person.01041342134.14
170 rdf:rest rdf:nil
171 Ncce077f70dc34755b3834206836d80ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Immunohistochemistry
173 rdf:type schema:DefinedTerm
174 Nd24422e83c634995b6534987c2b3d9e2 schema:name Springer Nature - SN SciGraph project
175 rdf:type schema:Organization
176 Nd3bee8bd7c484f4db2807cf7b2b5ef59 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Intercellular Signaling Peptides and Proteins
178 rdf:type schema:DefinedTerm
179 Nd7fcd1ecc8e14835bc3cbc3742d9b540 rdf:first sg:person.0752660420.46
180 rdf:rest N597ec47198374289a5a872a0110a0942
181 Nd80b30c02e1543b1b099cd448f321823 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Myocardium
183 rdf:type schema:DefinedTerm
184 Nd9dc5ff6212744c8a06c16052b6f639d rdf:first sg:person.01205127766.85
185 rdf:rest Nd7fcd1ecc8e14835bc3cbc3742d9b540
186 Nde53abc2d6be428e82e25f03fcb8dd59 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name In Situ Nick-End Labeling
188 rdf:type schema:DefinedTerm
189 Nf03d4101c0824ff28c6e199bd028d17a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Ventricular Remodeling
191 rdf:type schema:DefinedTerm
192 Nf194f92772274c2ab59393692f1d8d7e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Connective Tissue Growth Factor
194 rdf:type schema:DefinedTerm
195 Nffcab573308b4db3b1a2288a92edad93 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name Rats
197 rdf:type schema:DefinedTerm
198 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
199 schema:name Medical and Health Sciences
200 rdf:type schema:DefinedTerm
201 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
202 schema:name Clinical Sciences
203 rdf:type schema:DefinedTerm
204 sg:journal.1001482 schema:issn 0012-186X
205 1432-0428
206 schema:name Diabetologia
207 rdf:type schema:Periodical
208 sg:person.01041342134.14 schema:affiliation https://www.grid.ac/institutes/grid.15485.3d
209 schema:familyName Tikkanen
210 schema:givenName I.
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041342134.14
212 rdf:type schema:Person
213 sg:person.01200347241.97 schema:affiliation https://www.grid.ac/institutes/grid.15485.3d
214 schema:familyName Voipio-Pulkki
215 schema:givenName L.-M.
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200347241.97
217 rdf:type schema:Person
218 sg:person.01205127766.85 schema:affiliation https://www.grid.ac/institutes/grid.15485.3d
219 schema:familyName Bäcklund
220 schema:givenName T.
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205127766.85
222 rdf:type schema:Person
223 sg:person.01211233057.33 schema:affiliation https://www.grid.ac/institutes/grid.7737.4
224 schema:familyName Mervaala
225 schema:givenName E.
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211233057.33
227 rdf:type schema:Person
228 sg:person.01272451630.99 schema:affiliation https://www.grid.ac/institutes/grid.15485.3d
229 schema:familyName Laine
230 schema:givenName M.
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272451630.99
232 rdf:type schema:Person
233 sg:person.01341767014.83 schema:affiliation https://www.grid.ac/institutes/grid.1374.1
234 schema:familyName Kytö
235 schema:givenName V.
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341767014.83
237 rdf:type schema:Person
238 sg:person.0576255526.51 schema:affiliation N8b523556eaae4aada98836e658492cb2
239 schema:familyName Eriksson
240 schema:givenName A.
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576255526.51
242 rdf:type schema:Person
243 sg:person.0607272607.61 schema:affiliation https://www.grid.ac/institutes/grid.1374.1
244 schema:familyName Saraste
245 schema:givenName A.
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607272607.61
247 rdf:type schema:Person
248 sg:person.0704545220.47 schema:affiliation N48b84c862df04858a61c1db6857dac65
249 schema:familyName Lakkisto
250 schema:givenName P.
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704545220.47
252 rdf:type schema:Person
253 sg:person.0707331737.33 schema:affiliation https://www.grid.ac/institutes/grid.7737.4
254 schema:familyName Finckenberg
255 schema:givenName P.
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707331737.33
257 rdf:type schema:Person
258 sg:person.0752660420.46 schema:affiliation https://www.grid.ac/institutes/grid.15485.3d
259 schema:familyName Palojoki
260 schema:givenName E.
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752660420.46
262 rdf:type schema:Person
263 sg:pub.10.1007/s00125-002-0882-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004883061
264 https://doi.org/10.1007/s00125-002-0882-x
265 rdf:type schema:CreativeWork
266 sg:pub.10.1038/labinvest.3780057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046198423
267 https://doi.org/10.1038/labinvest.3780057
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1006/excr.1996.0232 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007553801
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1006/phrs.1998.0290 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044510908
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/s0002-9440(10)63659-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035336591
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/s0008-6363(02)00721-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054578353
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/s0008-6363(97)00018-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054579667
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/s0008-6363(99)00384-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054580661
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/s0735-1097(03)00509-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040915380
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1038/sj.bjp.0704131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029821613
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1046/j.1365-2362.1999.00481.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041178787
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1074/jbc.m010722200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017409221
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1096/fasebj.13.13.1774 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074528517
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1111/j.1939-1676.1993.tb01015.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050905535
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1152/ajpheart.2000.279.1.h422 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074669333
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1152/ajpheart.2001.280.6.h2726 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074815129
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1161/01.cir.95.2.320 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063337743
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1161/01.cir.96.11.4002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063338188
300 rdf:type schema:CreativeWork
301 https://doi.org/10.2337/diabetes.50.10.2363 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051976369
302 rdf:type schema:CreativeWork
303 https://doi.org/10.2337/diabetes.51.6.1938 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051989979
304 rdf:type schema:CreativeWork
305 https://doi.org/10.2337/diabetes.51.9.2709 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009585260
306 rdf:type schema:CreativeWork
307 https://doi.org/10.2337/diacare.24.8.1422 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044173194
308 rdf:type schema:CreativeWork
309 https://www.grid.ac/institutes/grid.1374.1 schema:alternateName University of Turku
310 schema:name Department of Anatomy, University of Turku, Turku, Finland
311 rdf:type schema:Organization
312 https://www.grid.ac/institutes/grid.15485.3d schema:alternateName Helsinki University Central Hospital
313 schema:name Department of Medicine, Helsinki University Hospital, P.O. Box 340, Haartmaninkatu 4, 00029, HUS, Finland
314 Minerva Institute for Medical Research, Helsinki, Finland
315 rdf:type schema:Organization
316 https://www.grid.ac/institutes/grid.7737.4 schema:alternateName University of Helsinki
317 schema:name Biomedicum and Institute of Biomedicine, University of Helsinki, Helsinki, Finland
318 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...