Pancreatic NOD beta cells express MHC class II protein and the frequency of I-Ag7 mRNA-expressing beta cells strongly increases during ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2003-08

AUTHORS

U. Walter, T. Toepfer, K. E. J. Dittmar, K. Kretschmer, J. Lauber, S. Weiss, G. Servos, O. Lechner, W. A. Scherbaum, S. R. Bornstein, H. von Boehmer, J. Buer

ABSTRACT

AIMS/HYPOTHESIS: In the NOD mouse model, attempts to show MHC class II expression by pancreatic beta cells were unsuccessful so far. We readdressed this question by analysing I-A(g7) expression in single pancreatic beta cells. METHODS: Single-cell multiplex RT PCR and single-cell immunofluorescence were used to study MHC class II expression in NOD and NOD/SCID beta cells. RESULTS: Pancreatic beta cells from NOD mice express the I-A(g7) protein as well as the corresponding mRNA. The frequency of MHC class II mRNA-expressing beta cells is drastically increased during the progression to overt diabetes. MHC class II protein is accumulated intracellularly, and invariant chain is co-expressed. Beta cells from 9- to 10-week-old NOD/SCID mice express MHC class II at the same low frequency as beta cells from 3-week-old NOD mice. CONCLUSION/INTERPRETATION: NOD beta cells express I-A(g7) and could be a direct target of autoreactive CD4+ T cells. This MHC class II expression is triggered by infiltrating lymphocytes. More... »

PAGES

1106-1114

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00125-003-1164-y

DOI

http://dx.doi.org/10.1007/s00125-003-1164-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023430525

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12856083


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