Quantitative trait locus analysis of fungal disease resistance factors on a molecular map of grapevine View Full Text


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Article Info

DATE

2003-10-22

AUTHORS

B. M. Fischer, I. Salakhutdinov, M. Akkurt, R. Eibach, K. J. Edwards, R. Töpfer, E. M. Zyprian

ABSTRACT

A full-sibling F1 population comprising 153 individuals from the cross of ‘Regent’ × ‘Lemberger’ was employed to construct a genetic map based on 429 molecular markers. The newly-bred red grapevine variety ‘Regent’ has multiple field-resistance to fungal diseases inherited as polygenic traits, while ‘Lemberger’ is a traditional fungus-susceptible cultivar. The progeny segregate quantitatively for resistances to Plasmopara viticola and Uncinula necator, fungal pathogens that threaten viticulture in temperate areas. A double pseudo-testcross strategy was employed to construct the two parental maps under high statistical stringency for linkage to obtain a robust marker frame for subsequent quantitative trait locus (QTL) analysis. In total, 185 amplified fragment length polymorphism, 137 random amplified polymorphic DNA, 85 single sequence repeat and 22 sequence characterized amplified region or cleaved amplified polymorphic sequence markers were mapped. The maps were aligned by co-dominant or doubly heterozygous dominant anchor markers. Twelve pairs of homologous linkage groups could be integrated into consensus linkage groups. Resistance phenotypes and segregating characteristics were scored as quantitative traits in three or four growing seasons. Interval mapping reproducibly localized genetic factors that correlated with fungal disease resistances to specific regions on three linkage groups of the maternal ‘Regent’ map. A QTL for resistance to Uncinula necator was identified on linkage group 16, and QTLs for endurance to Plasmopara viticola on linkage groups 9 and 10 of ‘Regent’. Additional QTLs for the onset of berry ripening (“veraison”), berry size and axillary shoot growth were identified. Berry color segregated as a simple trait in this cross of two red varieties and was mapped as a morphological marker. Six markers derived from functional genes could be localized. This dissection of polygenic fungus disease resistance in grapevine allows the development of marker-assisted selection for breeding, the characterization of genetic resources and the isolation of the corresponding genes. More... »

PAGES

501-515

References to SciGraph publications

  • 2002-03. Identification of resistance gene analogs linked to a powdery mildew resistance locus in grapevine in THEORETICAL AND APPLIED GENETICS
  • 1994-11. Extension of the linkage map in Citrus using random amplified polymorphic DNA (RAPD) markers and RFLP mapping of cold-acclimation-responsive loci in THEORETICAL AND APPLIED GENETICS
  • 2001-12. Establishment of a local map of AFLP markers around the powdery mildew resistance gene Run1 in grapevine and assessment of their usefulness for marker assisted selection in THEORETICAL AND APPLIED GENETICS
  • 1993-04. Repetitive DNA of grapevine: classes present and sequences suitable for cultivar identification in THEORETICAL AND APPLIED GENETICS
  • 1993-09. Microsatellite repeats in grapevine reveal DNA polymorphisms when analysed as sequence-tagged sites (STSs) in THEORETICAL AND APPLIED GENETICS
  • 2002-05-25. Genetic mapping of grapevine (Vitis vinifera L.) applied to the detection of QTLs for seedlessness and berry weight in THEORETICAL AND APPLIED GENETICS
  • 1994-03. Cloning and molecular analysis of structural genes involved in flavonoid and stilbene biosynthesis in grape (Vitis vinifera L.) in PLANT MOLECULAR BIOLOGY
  • 1999-11-01. LOD significance thresholds for QTL analysis in experimental populations of diploid species in HEREDITY
  • 2002-12-10. Molecular linkage maps of Vitis vinifera L. and Vitis riparia Mchx in THEORETICAL AND APPLIED GENETICS
  • 1990-10-01. Toward a Unified Approach to Genetic Mapping of Eukaryotes Based on Sequence Tagged Microsatellite Sites in BIO/TECHNOLOGY
  • 1988-10. Resolution of quantitative traits into Mendelian factors by using a complete linkage map of restriction fragment length polymorphisms in NATURE
  • Identifiers

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    http://scigraph.springernature.com/pub.10.1007/s00122-003-1445-3

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    29 schema:description A full-sibling F1 population comprising 153 individuals from the cross of ‘Regent’ × ‘Lemberger’ was employed to construct a genetic map based on 429 molecular markers. The newly-bred red grapevine variety ‘Regent’ has multiple field-resistance to fungal diseases inherited as polygenic traits, while ‘Lemberger’ is a traditional fungus-susceptible cultivar. The progeny segregate quantitatively for resistances to Plasmopara viticola and Uncinula necator, fungal pathogens that threaten viticulture in temperate areas. A double pseudo-testcross strategy was employed to construct the two parental maps under high statistical stringency for linkage to obtain a robust marker frame for subsequent quantitative trait locus (QTL) analysis. In total, 185 amplified fragment length polymorphism, 137 random amplified polymorphic DNA, 85 single sequence repeat and 22 sequence characterized amplified region or cleaved amplified polymorphic sequence markers were mapped. The maps were aligned by co-dominant or doubly heterozygous dominant anchor markers. Twelve pairs of homologous linkage groups could be integrated into consensus linkage groups. Resistance phenotypes and segregating characteristics were scored as quantitative traits in three or four growing seasons. Interval mapping reproducibly localized genetic factors that correlated with fungal disease resistances to specific regions on three linkage groups of the maternal ‘Regent’ map. A QTL for resistance to Uncinula necator was identified on linkage group 16, and QTLs for endurance to Plasmopara viticola on linkage groups 9 and 10 of ‘Regent’. Additional QTLs for the onset of berry ripening (“veraison”), berry size and axillary shoot growth were identified. Berry color segregated as a simple trait in this cross of two red varieties and was mapped as a morphological marker. Six markers derived from functional genes could be localized. This dissection of polygenic fungus disease resistance in grapevine allows the development of marker-assisted selection for breeding, the characterization of genetic resources and the isolation of the corresponding genes.
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    37 F1 population
    38 Lemberger
    39 Plasmopara viticola
    40 QTL
    41 Uncinula necator
    42 additional QTL
    43 analysis
    44 anchor markers
    45 area
    46 axillary shoot growth
    47 berry color
    48 berry ripening
    49 berry size
    50 breeding
    51 characteristics
    52 characterization
    53 color
    54 consensus linkage groups
    55 corresponding genes
    56 cross
    57 cultivars
    58 development
    59 disease
    60 disease resistance
    61 disease resistance factors
    62 dissection
    63 dominant anchor markers
    64 double pseudo-testcross strategy
    65 endurance
    66 factors
    67 fragment length polymorphism
    68 frame
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    71 fungal disease resistance factors
    72 fungal diseases
    73 fungal pathogens
    74 fungus disease resistance
    75 fungus-susceptible cultivar
    76 genes
    77 genetic factors
    78 genetic map
    79 genetic resources
    80 grapevine
    81 grapevine varieties
    82 group
    83 group 16
    84 group 9
    85 growth
    86 heterozygous dominant anchor markers
    87 high statistical stringency
    88 homologous linkage groups
    89 individuals
    90 interval mapping
    91 isolation
    92 length polymorphism
    93 linkage
    94 linkage group 16
    95 linkage group 9
    96 linkage groups
    97 locus (QTL) analysis
    98 mapping
    99 maps
    100 marker frame
    101 marker-assisted selection
    102 markers
    103 molecular map
    104 molecular markers
    105 morphological markers
    106 necator
    107 onset
    108 pairs
    109 parental maps
    110 pathogens
    111 phenotype
    112 polygenic fungus disease resistance
    113 polygenic trait
    114 polymorphic DNA
    115 polymorphic sequence (CAPS) markers
    116 polymorphism
    117 population
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    119 pseudo-testcross strategy
    120 quantitative trait locus (QTL) analysis
    121 quantitative traits
    122 red grapevine varieties
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    124 regents
    125 region
    126 repeats
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    130 resources
    131 ripening
    132 robust marker frame
    133 season
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    139 simple traits
    140 single sequence repeats
    141 size
    142 specific regions
    143 statistical stringency
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    145 stringency
    146 subsequent quantitative trait loci analyses
    147 temperate areas
    148 traditional fungus-susceptible cultivar
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