Quantitative trait locus analysis of fungal disease resistance factors on a molecular map of grapevine View Full Text


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Article Info

DATE

2003-10-22

AUTHORS

B. M. Fischer, I. Salakhutdinov, M. Akkurt, R. Eibach, K. J. Edwards, R. Töpfer, E. M. Zyprian

ABSTRACT

A full-sibling F1 population comprising 153 individuals from the cross of ‘Regent’ × ‘Lemberger’ was employed to construct a genetic map based on 429 molecular markers. The newly-bred red grapevine variety ‘Regent’ has multiple field-resistance to fungal diseases inherited as polygenic traits, while ‘Lemberger’ is a traditional fungus-susceptible cultivar. The progeny segregate quantitatively for resistances to Plasmopara viticola and Uncinula necator, fungal pathogens that threaten viticulture in temperate areas. A double pseudo-testcross strategy was employed to construct the two parental maps under high statistical stringency for linkage to obtain a robust marker frame for subsequent quantitative trait locus (QTL) analysis. In total, 185 amplified fragment length polymorphism, 137 random amplified polymorphic DNA, 85 single sequence repeat and 22 sequence characterized amplified region or cleaved amplified polymorphic sequence markers were mapped. The maps were aligned by co-dominant or doubly heterozygous dominant anchor markers. Twelve pairs of homologous linkage groups could be integrated into consensus linkage groups. Resistance phenotypes and segregating characteristics were scored as quantitative traits in three or four growing seasons. Interval mapping reproducibly localized genetic factors that correlated with fungal disease resistances to specific regions on three linkage groups of the maternal ‘Regent’ map. A QTL for resistance to Uncinula necator was identified on linkage group 16, and QTLs for endurance to Plasmopara viticola on linkage groups 9 and 10 of ‘Regent’. Additional QTLs for the onset of berry ripening (“veraison”), berry size and axillary shoot growth were identified. Berry color segregated as a simple trait in this cross of two red varieties and was mapped as a morphological marker. Six markers derived from functional genes could be localized. This dissection of polygenic fungus disease resistance in grapevine allows the development of marker-assisted selection for breeding, the characterization of genetic resources and the isolation of the corresponding genes. More... »

PAGES

501-515

References to SciGraph publications

  • 2002-03. Identification of resistance gene analogs linked to a powdery mildew resistance locus in grapevine in THEORETICAL AND APPLIED GENETICS
  • 1994-11. Extension of the linkage map in Citrus using random amplified polymorphic DNA (RAPD) markers and RFLP mapping of cold-acclimation-responsive loci in THEORETICAL AND APPLIED GENETICS
  • 2001-12. Establishment of a local map of AFLP markers around the powdery mildew resistance gene Run1 in grapevine and assessment of their usefulness for marker assisted selection in THEORETICAL AND APPLIED GENETICS
  • 1993-04. Repetitive DNA of grapevine: classes present and sequences suitable for cultivar identification in THEORETICAL AND APPLIED GENETICS
  • 1993-09. Microsatellite repeats in grapevine reveal DNA polymorphisms when analysed as sequence-tagged sites (STSs) in THEORETICAL AND APPLIED GENETICS
  • 2002-05-25. Genetic mapping of grapevine (Vitis vinifera L.) applied to the detection of QTLs for seedlessness and berry weight in THEORETICAL AND APPLIED GENETICS
  • 1994-03. Cloning and molecular analysis of structural genes involved in flavonoid and stilbene biosynthesis in grape (Vitis vinifera L.) in PLANT MOLECULAR BIOLOGY
  • 1999-11-01. LOD significance thresholds for QTL analysis in experimental populations of diploid species in HEREDITY
  • 2002-12-10. Molecular linkage maps of Vitis vinifera L. and Vitis riparia Mchx in THEORETICAL AND APPLIED GENETICS
  • 1990-10-01. Toward a Unified Approach to Genetic Mapping of Eukaryotes Based on Sequence Tagged Microsatellite Sites in BIO/TECHNOLOGY
  • 1988-10. Resolution of quantitative traits into Mendelian factors by using a complete linkage map of restriction fragment length polymorphisms in NATURE
  • Identifiers

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    http://scigraph.springernature.com/pub.10.1007/s00122-003-1445-3

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    http://dx.doi.org/10.1007/s00122-003-1445-3

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    PUBMED

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    29 schema:description A full-sibling F1 population comprising 153 individuals from the cross of ‘Regent’ × ‘Lemberger’ was employed to construct a genetic map based on 429 molecular markers. The newly-bred red grapevine variety ‘Regent’ has multiple field-resistance to fungal diseases inherited as polygenic traits, while ‘Lemberger’ is a traditional fungus-susceptible cultivar. The progeny segregate quantitatively for resistances to Plasmopara viticola and Uncinula necator, fungal pathogens that threaten viticulture in temperate areas. A double pseudo-testcross strategy was employed to construct the two parental maps under high statistical stringency for linkage to obtain a robust marker frame for subsequent quantitative trait locus (QTL) analysis. In total, 185 amplified fragment length polymorphism, 137 random amplified polymorphic DNA, 85 single sequence repeat and 22 sequence characterized amplified region or cleaved amplified polymorphic sequence markers were mapped. The maps were aligned by co-dominant or doubly heterozygous dominant anchor markers. Twelve pairs of homologous linkage groups could be integrated into consensus linkage groups. Resistance phenotypes and segregating characteristics were scored as quantitative traits in three or four growing seasons. Interval mapping reproducibly localized genetic factors that correlated with fungal disease resistances to specific regions on three linkage groups of the maternal ‘Regent’ map. A QTL for resistance to Uncinula necator was identified on linkage group 16, and QTLs for endurance to Plasmopara viticola on linkage groups 9 and 10 of ‘Regent’. Additional QTLs for the onset of berry ripening (“veraison”), berry size and axillary shoot growth were identified. Berry color segregated as a simple trait in this cross of two red varieties and was mapped as a morphological marker. Six markers derived from functional genes could be localized. This dissection of polygenic fungus disease resistance in grapevine allows the development of marker-assisted selection for breeding, the characterization of genetic resources and the isolation of the corresponding genes.
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