„Social freezing“ – die männliche Seite View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-11-12

AUTHORS

J. Gromoll, F. Tüttelmann, S. Kliesch

ABSTRACT

BackgroundIn Germany there is an emerging trend for postponing parenthood due to non-medical, sociocultural reasons. This clearly impacts on the reproductive success due to an age-dependent decrease in fertility. Thus, strategies and techniques are currently discussed which could preserve the female fertility status, among which social freezing (cryopreservation of oocytes) for later fertilization is the most realistic one; however, while there is an intensive discussion on the procedure and timing of oocyte cryopreservation, virtually no attention has been paid to the male side and the aging effects on the male germ cells.AimTo evaluate the risk paternal age poses for the integrity of germ cells.MethodsFor this review a literature search using PubMed, data from the Federal Statistical Office of Germany, the German in vitro fertilization (IVF) register as well as own data were used.ResultsSperm cell integrity is clearly affected by age both at the genetic as well as at the epigenetic levels. The estimated mutation rate for spermatozoa doubles every 16.5 years. Monogenic and multifactorial diseases are strongly associated with paternal age. Men aged > 40 years have an increased risk of passing age-related mutations to their children.ConclusionsCryopreservation of spermatozoa is an option for men who postpone planning a family. Genetic counseling is recommended for couples undertaking social freezing and a male age of > 40 years. More... »

PAGES

58-62

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00120-015-3943-8

DOI

http://dx.doi.org/10.1007/s00120-015-3943-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020366440

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26556267


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