Ontology type: schema:ScholarlyArticle
2014-02
AUTHORSA. Stenzinger, M. Kriegsmann, W. Weichert
ABSTRACTCancers of unknown primary (CUP) origin account for 2-3 % of all malignancies in Germany and represent a heterogeneous, often aggressive and clinically challenging group of tumors with early metastatic dissemination for which a standardized diagnostic work-up initially fails to identify the primary site of origin at the time of diagnosis. This article reviews the options and challenges of tissue-based conventional as well as molecular diagnostic procedures to categorize this heterogeneous group of neoplasms. The role of pathology in the diagnostics of CUP syndrome is described as part of a multidisciplinary effort involving oncologists, surgeons and radiologists with the ultimate goal of assisting clinical reasoning and decision-making. More... »
PAGES124-133
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DOIhttp://dx.doi.org/10.1007/s00117-013-2546-x
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