Neuroanatomie des Morbus Parkinson Veränderungen des neuronalen Zytoskeletts in nur wenigen für den Krankheitsprozess empfänglichen Nervenzelltypen führen zur progredienten Zerstörung ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-06

AUTHORS

H. Braak, U. Rüb, E. Braak

ABSTRACT

Morbus Parkinson is a progressive degenerative disease of the human central, peripheral, and enteric nervous systems. In the course of the disease, not only the substantia nigra, but also extranigral components of the motor system, as well as numerous limbic system and autonomic centers undergo serious damage. Accordingly, Parkinson's disease is a multisystem disorder. Only specific types of projection neurons fall victim to it. The first manifestation of the pathological process which causes the disease are abnormalities of the neuronal cytoskeleton. Intracytoplasmic inclusions evolving in the form of Lewy bodies in perikarya and Lewy neurites in the neuronal processes result in premature cell death of the affected neurons. On the basis of this selective neuronal vulnerability, a categorization emerges of the pathological changes within the nervous system and corresponding functional impairments. More... »

PAGES

459-469

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s001150050607

DOI

http://dx.doi.org/10.1007/s001150050607

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003059754

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10919140


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